Esak (Isaac) Lee
@isaacleelab.bsky.social
18 followers
28 following
10 posts
Assistant Professor of Biomedical Engineering at Cornell University
*Research Interests: Tissue engineering, organ-on-chip, lymphatics, cancer, neurological disease (eye and brain)
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Esak (Isaac) Lee
@isaacleelab.bsky.social
· Sep 12
Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation - Molecular Cancer
Breaching the vascular barrier is a critical step in pancreatic ductal adenocarcinoma (PDAC) metastasis, yet the mechanisms enabling this process remain incompletely understood. Transforming growth fa...
molecular-cancer.biomedcentral.com
Esak (Isaac) Lee
@isaacleelab.bsky.social
· Aug 29
Glaucoma discovery on a chip - Nature Cardiovascular Research
Increased intraocular pressure due to decreased outflow of aqueous humor from the anterior chamber of the eye is a major risk factor for the development of glaucoma, a leading cause of blindness. A ne...
www.nature.com
Esak (Isaac) Lee
@isaacleelab.bsky.social
· Aug 27
‘Eye-on-a-chip’ reveals trigger for steroid-induced glaucoma | Cornell Chronicle
Cornell researchers have identified the signaling mechanism that triggers steroid-induced glaucoma by creating a 3D “eye-on-a-chip” platform that mimics the flow of ocular fluids.
news.cornell.edu
Esak (Isaac) Lee
@isaacleelab.bsky.social
· Aug 27
Human ocular fluid outflow on-chip reveals trabecular meshwork-mediated Schlemm’s canal endothelial dysfunction in steroid-induced glaucoma - Nature Cardiovascular Research
Lu et al. created a human ocular outflow on-chip, composed of 3D Schlemm’s canal endothelium surrounded by trabecular meshwork and draining interstitial fluid, revealing ALK5/VEGFC signaling as a ther...
www.nature.com