Jaison J Sequeira
@jaisonjseq.bsky.social
Human population diversity is astonishing!
Reposted by Jaison J Sequeira
We are excited to share with you the latest SPAAM Newsletter!
Inside, you’ll find: announcements, opportunities and publication highlights.
www.spaam-community.org/assets/media...
We hope you enjoy this edition!
#SPAAM #aDNA #Newsletter #paleogenomics #metagenomics
Inside, you’ll find: announcements, opportunities and publication highlights.
www.spaam-community.org/assets/media...
We hope you enjoy this edition!
#SPAAM #aDNA #Newsletter #paleogenomics #metagenomics
SPAAM Newsletter #8
Hello from the SPAAM Steering Committee in the New Year 2026!
www.spaam-community.org
January 10, 2026 at 8:36 AM
We are excited to share with you the latest SPAAM Newsletter!
Inside, you’ll find: announcements, opportunities and publication highlights.
www.spaam-community.org/assets/media...
We hope you enjoy this edition!
#SPAAM #aDNA #Newsletter #paleogenomics #metagenomics
Inside, you’ll find: announcements, opportunities and publication highlights.
www.spaam-community.org/assets/media...
We hope you enjoy this edition!
#SPAAM #aDNA #Newsletter #paleogenomics #metagenomics
Reposted by Jaison J Sequeira
Interesting new multi-population aDNA selection scan from Colbran, Terhorst, Mathieson. Loci that are estimated to be under selection in one population also show enrichment in other populations, consistent with parallel or pre-split selection.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 9, 2026 at 2:37 PM
Interesting new multi-population aDNA selection scan from Colbran, Terhorst, Mathieson. Loci that are estimated to be under selection in one population also show enrichment in other populations, consistent with parallel or pre-split selection.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Jaison J Sequeira
Reposted by Jaison J Sequeira
Oh, look! A paper about the coolest piece of software I've ever built!
demografr: A toolkit for simulation-based inference in population genetics https://www.biorxiv.org/content/10.64898/2025.12.18.694482v1
January 6, 2026 at 10:07 PM
Oh, look! A paper about the coolest piece of software I've ever built!
Reposted by Jaison J Sequeira
Abstract submission & Award applications for SMBE 2026 are now open!
Submit your research and apply for SMBE awards via the submission portal.
📝 Read more & submit here: smbe2026.org/abstracts
And symposium selection is now finalized!
👉 See all accepted symposia: smbe2026.org/programme
#SMBE2026
Submit your research and apply for SMBE awards via the submission portal.
📝 Read more & submit here: smbe2026.org/abstracts
And symposium selection is now finalized!
👉 See all accepted symposia: smbe2026.org/programme
#SMBE2026
December 1, 2025 at 9:52 AM
Abstract submission & Award applications for SMBE 2026 are now open!
Submit your research and apply for SMBE awards via the submission portal.
📝 Read more & submit here: smbe2026.org/abstracts
And symposium selection is now finalized!
👉 See all accepted symposia: smbe2026.org/programme
#SMBE2026
Submit your research and apply for SMBE awards via the submission portal.
📝 Read more & submit here: smbe2026.org/abstracts
And symposium selection is now finalized!
👉 See all accepted symposia: smbe2026.org/programme
#SMBE2026
Reposted by Jaison J Sequeira
The story about #ancientsouthernafricans in the #ScienceNews now: www.sciencenews.org/article/anci... #media #humanevolutionprogram
Ancient southern Africans took genetic evolution in a new direction
An ancient, shared set of human-specific genes underwent changes in a geographically isolated population after around 300,000 years ago, scientists say.
www.sciencenews.org
December 4, 2025 at 10:05 AM
The story about #ancientsouthernafricans in the #ScienceNews now: www.sciencenews.org/article/anci... #media #humanevolutionprogram
Precious high coverage genomes from Africa! Congratulations @cschlebu.bsky.social and team. Exciting times indeed.
December 4, 2025 at 2:29 PM
Precious high coverage genomes from Africa! Congratulations @cschlebu.bsky.social and team. Exciting times indeed.
Reposted by Jaison J Sequeira
Our new ancient DNA paper has just been published!
We present 28 new genomes from southern Africa - several of them high-coverage whole genomes.
Exciting to be moving towards population-level representation of ancient southern African genetic diversity!
www.nature.com/articles/s41...
We present 28 new genomes from southern Africa - several of them high-coverage whole genomes.
Exciting to be moving towards population-level representation of ancient southern African genetic diversity!
www.nature.com/articles/s41...
Homo sapiens-specific evolution unveiled by ancient southern African genomes - Nature
The genomes of 28 ancient southern African individuals dated to between 10,200 and 150 years before present offer insights into the evolution of Homo sapiens.
www.nature.com
December 3, 2025 at 4:42 PM
Our new ancient DNA paper has just been published!
We present 28 new genomes from southern Africa - several of them high-coverage whole genomes.
Exciting to be moving towards population-level representation of ancient southern African genetic diversity!
www.nature.com/articles/s41...
We present 28 new genomes from southern Africa - several of them high-coverage whole genomes.
Exciting to be moving towards population-level representation of ancient southern African genetic diversity!
www.nature.com/articles/s41...
Reposted by Jaison J Sequeira
We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
Robustness of Ancestral Recombination Graph Inference Tools to Phasing Errors
Ancestral Recombination Graphs (ARGs) are fundamental population genetic structures that encode the genealogical history of a sample of haplotypes along the genome. They have recently received substan...
biorxiv.org
November 26, 2025 at 5:09 PM
We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
Reposted by Jaison J Sequeira
we made a tool!
ybyra is a lightweight, flexible Y-chromosome haplogroup caller. It is faster, easier to tune and more robust than other tools particularly for low-coverage or ancient DNA data. And it has lots of detailed output – including plots!
www.biorxiv.org/content/10.1...
ybyra is a lightweight, flexible Y-chromosome haplogroup caller. It is faster, easier to tune and more robust than other tools particularly for low-coverage or ancient DNA data. And it has lots of detailed output – including plots!
www.biorxiv.org/content/10.1...
November 26, 2025 at 8:29 AM
we made a tool!
ybyra is a lightweight, flexible Y-chromosome haplogroup caller. It is faster, easier to tune and more robust than other tools particularly for low-coverage or ancient DNA data. And it has lots of detailed output – including plots!
www.biorxiv.org/content/10.1...
ybyra is a lightweight, flexible Y-chromosome haplogroup caller. It is faster, easier to tune and more robust than other tools particularly for low-coverage or ancient DNA data. And it has lots of detailed output – including plots!
www.biorxiv.org/content/10.1...
Reposted by Jaison J Sequeira
Our special issue on popgen methods and software is on a roll with the second paper out! Looking forward to many exciting papers to come! Submission open until 15 January. www.pivotscipub.com/hpgg/special...
Next paper published in the @hpgg-pivot.bsky.social special issue on popgen methods and software!
Coll Macià & Skov "Best practices and pitfalls in using hmmix for reference-free detection of introgressed sequences"
doi.org/10.47248/hpg...
Submission for contributions still open to 15 January!
Coll Macià & Skov "Best practices and pitfalls in using hmmix for reference-free detection of introgressed sequences"
doi.org/10.47248/hpg...
Submission for contributions still open to 15 January!
Best practices and pitfalls in using <monospace>hmmix</monospace> for reference-free detection of introgressed sequences
Best practices and pitfalls in using <monospace>hmmix</monospace> for reference-free detection of introgressed sequences
doi.org
November 21, 2025 at 3:29 PM
Our special issue on popgen methods and software is on a roll with the second paper out! Looking forward to many exciting papers to come! Submission open until 15 January. www.pivotscipub.com/hpgg/special...
Reposted by Jaison J Sequeira
🚨 Reminder to send in your abstracts for the palaeogenomics conference in Stockholm! 🧬🦠🐕💃🏼
If your results are still preliminary, my tip is to keep the abstract broad rather than skip submitting altogether 😉
See the post below for the price estimate and looking forward to seeing you there 🥳! #aDNA
If your results are still preliminary, my tip is to keep the abstract broad rather than skip submitting altogether 😉
See the post below for the price estimate and looking forward to seeing you there 🥳! #aDNA
⏰ The clock is ticking❗
LESS THAN 10 DAYS LEFT to submit your abstracts (30th Nov).
Do it here👉 icp2026.palaeogenomics.org/abstracts/
Many of you are asking for the registration fees 💸. We are still working out the details, but we estimate 400-500€ for regular attendees and 300-400€ for students.
LESS THAN 10 DAYS LEFT to submit your abstracts (30th Nov).
Do it here👉 icp2026.palaeogenomics.org/abstracts/
Many of you are asking for the registration fees 💸. We are still working out the details, but we estimate 400-500€ for regular attendees and 300-400€ for students.
Abstracts – International Conference on Palaeogenomics 2026
icp2026.palaeogenomics.org
November 23, 2025 at 10:38 AM
🚨 Reminder to send in your abstracts for the palaeogenomics conference in Stockholm! 🧬🦠🐕💃🏼
If your results are still preliminary, my tip is to keep the abstract broad rather than skip submitting altogether 😉
See the post below for the price estimate and looking forward to seeing you there 🥳! #aDNA
If your results are still preliminary, my tip is to keep the abstract broad rather than skip submitting altogether 😉
See the post below for the price estimate and looking forward to seeing you there 🥳! #aDNA
Thank you for sharing my story! More power to you and GHIST ⭐
November 17, 2025 at 4:29 PM
Thank you for sharing my story! More power to you and GHIST ⭐
Reposted by Jaison J Sequeira
🦴🧬🦴🧬🦴
Abstract submission is now open for the 1st International Conference on Palaeogenomics!
June 23–26 2026, in Stockholm.
Join researchers from across the field for 4 days and >100 talks (+ poster sessions)!
Submit abstracts here 👉
icp2026.palaeogenomics.org/abstracts/
Deadline: Nov 30th
Abstract submission is now open for the 1st International Conference on Palaeogenomics!
June 23–26 2026, in Stockholm.
Join researchers from across the field for 4 days and >100 talks (+ poster sessions)!
Submit abstracts here 👉
icp2026.palaeogenomics.org/abstracts/
Deadline: Nov 30th
October 1, 2025 at 1:28 PM
🦴🧬🦴🧬🦴
Abstract submission is now open for the 1st International Conference on Palaeogenomics!
June 23–26 2026, in Stockholm.
Join researchers from across the field for 4 days and >100 talks (+ poster sessions)!
Submit abstracts here 👉
icp2026.palaeogenomics.org/abstracts/
Deadline: Nov 30th
Abstract submission is now open for the 1st International Conference on Palaeogenomics!
June 23–26 2026, in Stockholm.
Join researchers from across the field for 4 days and >100 talks (+ poster sessions)!
Submit abstracts here 👉
icp2026.palaeogenomics.org/abstracts/
Deadline: Nov 30th
Thank you very much for helping me experience all of this ❤️
November 15, 2025 at 1:36 AM
Thank you very much for helping me experience all of this ❤️
Reposted by Jaison J Sequeira
Pre @gensocuk.bsky.social talk @crick.ac.uk by Svante Pääbo, and interesting thoughts on how to define a “modern” human. More tomorrow!
November 13, 2025 at 8:43 PM
Pre @gensocuk.bsky.social talk @crick.ac.uk by Svante Pääbo, and interesting thoughts on how to define a “modern” human. More tomorrow!
Check out my blog summarising my experience at the SMBE2024 conference. You can also learn about my recent work on the Proto-Dravidian ancestry component. @official-smbe.bsky.social @mitopr.bsky.social @mashaals.bsky.social @ryangutenkunst.bsky.social popgenworld.blogspot.com/2025/11/from...
From Conference Attendee to Co-Author: The Journey I Never Expected
F or years, I dreamed of it: standing in a room full of international scientists, sharing my research, and being a part of the global conv...
popgenworld.blogspot.com
November 14, 2025 at 2:14 AM
Check out my blog summarising my experience at the SMBE2024 conference. You can also learn about my recent work on the Proto-Dravidian ancestry component. @official-smbe.bsky.social @mitopr.bsky.social @mashaals.bsky.social @ryangutenkunst.bsky.social popgenworld.blogspot.com/2025/11/from...
I am happy to share our manuscript summarising the outcome of GHIST2024 (ghist.bio). With so many statistical tools and software, population genetics research seems easy. But every case is different. The approaches used vary! doi.org/10.1093/molbev/msaf257 @ryangutenkunst.bsky.social
GHIST 2024: The First Genomic History Inference Strategies Tournament
Abstract. Evaluating population genetic inference methods is challenging due to the complexity of evolutionary histories, potential model misspecification,
doi.org
November 14, 2025 at 2:05 AM
I am happy to share our manuscript summarising the outcome of GHIST2024 (ghist.bio). With so many statistical tools and software, population genetics research seems easy. But every case is different. The approaches used vary! doi.org/10.1093/molbev/msaf257 @ryangutenkunst.bsky.social
Our article describing the "Proto-Dravidian" ancestry has been published in the European Journal of Human Genetics @ejhg-journal.bsky.social Here is a simplified summary of the scientific findings. #protodravidian #ivc #ancientcivilisation popgenworld.blogspot.com/2025/10/trac...
Tracing the Roots of the Koraga: The Discovery of a Lost Ancestor in India's Genetic Story
I n the lush, coastal districts of South India, the Koraga people have lived for generations on the margins. Historically labelled as "untou...
popgenworld.blogspot.com
October 26, 2025 at 7:54 AM
Our article describing the "Proto-Dravidian" ancestry has been published in the European Journal of Human Genetics @ejhg-journal.bsky.social Here is a simplified summary of the scientific findings. #protodravidian #ivc #ancientcivilisation popgenworld.blogspot.com/2025/10/trac...
We are migrants. We move to survive. All of us! Political boundaries do not define who we are, who we will be.
news.harvard.edu/gazette/stor...
news.harvard.edu/gazette/stor...
Pure bloodlines? Ancestral homelands? DNA science says no. — Harvard Gazette
Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.
news.harvard.edu
September 21, 2025 at 6:24 AM
We are migrants. We move to survive. All of us! Political boundaries do not define who we are, who we will be.
news.harvard.edu/gazette/stor...
news.harvard.edu/gazette/stor...
Reposted by Jaison J Sequeira
Adaptations to water stress and pastoralism in the Turkana of northwest Kenya | Science www.science.org/doi/10.1126/...
Adaptations to water stress and pastoralism in the Turkana of northwest Kenya
The Turkana pastoralists of Kenya inhabit arid, water-limited environments and rely largely on livestock for subsistence. Working with Turkana communities, we sequenced 367 whole genomes and identifie...
www.science.org
September 20, 2025 at 12:03 AM
Adaptations to water stress and pastoralism in the Turkana of northwest Kenya | Science www.science.org/doi/10.1126/...
Reposted by Jaison J Sequeira
Multi-ancestry GWAS can increase power and precision, but how should we analyze them? Pooled or stratified? We answer that question in a paper out today in AJHG, led by Julie Dias and Haoyu Zhang. 1/7 www.cell.com/ajhg/fulltex...
Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications
Multi-ancestry GWASs enhance discovery in diverse populations, but optimal methods
remain debated. Using theory, simulations, and analyses from the UK Biobank and All
of Us, we show that pooled analys...
www.cell.com
September 2, 2025 at 3:26 PM
Multi-ancestry GWAS can increase power and precision, but how should we analyze them? Pooled or stratified? We answer that question in a paper out today in AJHG, led by Julie Dias and Haoyu Zhang. 1/7 www.cell.com/ajhg/fulltex...
Reposted by Jaison J Sequeira
Interested in learning more about how researchers analyze ancient DNA? Here you can find the free lectures from the SPAAM Summer School 2025 - Introduction to Ancient Metagenomics: tinyurl.com/3u9mhmd2
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
SPAAM Summer School (2025): Introduction to Ancient Metagenomics
Share your videos with friends, family, and the world
tinyurl.com
September 2, 2025 at 12:57 PM
Interested in learning more about how researchers analyze ancient DNA? Here you can find the free lectures from the SPAAM Summer School 2025 - Introduction to Ancient Metagenomics: tinyurl.com/3u9mhmd2
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
Reposted by Jaison J Sequeira
Nice review of polygenic prediction of traits based on ancient DNA, by @mathiesoniain.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Polygenic prediction of human complex traits using ancient DNA
Ancient DNA has revolutionized our understanding of human history and clarified many aspects of human evolution on a molecular level. In this article,…
www.sciencedirect.com
September 1, 2025 at 8:47 AM
Nice review of polygenic prediction of traits based on ancient DNA, by @mathiesoniain.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...