JAMA Internal Medicine
@jamainternalmed.com
JAMA Internal Medicine is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
🌐 JAMAInternalMed.com
🌐 JAMAInternalMed.com
In the SURMOUNT-4 trial, 82.5% of adults with obesity regained ≥25% of initial weight lost within one year of tirzepatide withdrawal; most showed reversal of cardiometabolic improvements. ja.ma/3WZY11K
November 25, 2025 at 3:00 PM
In the SURMOUNT-4 trial, 82.5% of adults with obesity regained ≥25% of initial weight lost within one year of tirzepatide withdrawal; most showed reversal of cardiometabolic improvements. ja.ma/3WZY11K
Continuous glucose monitoring (CGM) enables real-time assessment of glucose trends in individuals with type 2 #diabetes, complementing or replacing fingerstick and HbA1c monitoring.
💡 This @jama.com Insights discusses CGM use for type 2 diabetes.
ja.ma/3LOHueK
💡 This @jama.com Insights discusses CGM use for type 2 diabetes.
ja.ma/3LOHueK
November 24, 2025 at 6:00 PM
Continuous glucose monitoring (CGM) enables real-time assessment of glucose trends in individuals with type 2 #diabetes, complementing or replacing fingerstick and HbA1c monitoring.
💡 This @jama.com Insights discusses CGM use for type 2 diabetes.
ja.ma/3LOHueK
💡 This @jama.com Insights discusses CGM use for type 2 diabetes.
ja.ma/3LOHueK
From @jama.com: #GLP-1 receptor agonist exposure with discontinuation before or during early #pregnancy was associated with greater gestational weight gain and increased risk of preterm delivery, gestational #diabetes, and hypertensive disorders.
ja.ma/4rmK4Jg
ja.ma/4rmK4Jg
November 24, 2025 at 5:30 PM
From @jama.com: #GLP-1 receptor agonist exposure with discontinuation before or during early #pregnancy was associated with greater gestational weight gain and increased risk of preterm delivery, gestational #diabetes, and hypertensive disorders.
ja.ma/4rmK4Jg
ja.ma/4rmK4Jg
Among US veterans aged 60 and over, #RSV vaccine effectiveness against infection declined from 82.5% at 1 month post-vaccination to 59.4% at 18 months.
ja.ma/3JP2rWk
ja.ma/3JP2rWk
November 24, 2025 at 5:00 PM
Among US veterans aged 60 and over, #RSV vaccine effectiveness against infection declined from 82.5% at 1 month post-vaccination to 59.4% at 18 months.
ja.ma/3JP2rWk
ja.ma/3JP2rWk
From <a href="https://bsky.app/profile/did:plc:q5ogl3twkcqyhvz4zebonw3z" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@jama.com: Postpartum prescription of #GLP-1RAs in Denmark increased between 2018 and 2024, with #semaglutide accounting for most prescriptions since 2023.
Most users had #overweight or #obesity, and only 23% had a #diabetes diagnosis.
ja.ma/3K62gWE
Most users had #overweight or #obesity, and only 23% had a #diabetes diagnosis.
ja.ma/3K62gWE
November 24, 2025 at 5:00 PM
From <a href="https://bsky.app/profile/did:plc:q5ogl3twkcqyhvz4zebonw3z" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@jama.com: Postpartum prescription of #GLP-1RAs in Denmark increased between 2018 and 2024, with #semaglutide accounting for most prescriptions since 2023.
Most users had #overweight or #obesity, and only 23% had a #diabetes diagnosis.
ja.ma/3K62gWE
Most users had #overweight or #obesity, and only 23% had a #diabetes diagnosis.
ja.ma/3K62gWE
💬 Editorial: #RSV vaccine effectiveness in adults aged 60 and over is high at 1 month (82.5%), then declines over 18 months (59.4%), raising considerations for booster dosing in future guidance.
ja.ma/3XLCvOp
ja.ma/3XLCvOp
November 24, 2025 at 4:30 PM
💬 Editorial: #RSV vaccine effectiveness in adults aged 60 and over is high at 1 month (82.5%), then declines over 18 months (59.4%), raising considerations for booster dosing in future guidance.
ja.ma/3XLCvOp
ja.ma/3XLCvOp
💬 Editorial: Proposals to apply clinician-style licensure to #AI tools may allow adaptive oversight as AI models grow more complex. Implementation challenges include defining responsible parties and ensuring adequate regulatory expertise.
ja.ma/4raFQUZ
ja.ma/4raFQUZ
November 22, 2025 at 3:00 PM
💬 Editorial: Proposals to apply clinician-style licensure to #AI tools may allow adaptive oversight as AI models grow more complex. Implementation challenges include defining responsible parties and ensuring adequate regulatory expertise.
ja.ma/4raFQUZ
ja.ma/4raFQUZ
💬 Viewpoint: The #Medicare hospice benefit's limited custodial care burden on families highlights the need for reform to meet the growing caregiving demands of end-of-life care.
ja.ma/47UCwFN
ja.ma/47UCwFN
November 22, 2025 at 1:00 PM
💬 Viewpoint: The #Medicare hospice benefit's limited custodial care burden on families highlights the need for reform to meet the growing caregiving demands of end-of-life care.
ja.ma/47UCwFN
ja.ma/47UCwFN
This case report describes a woman in her 50s who presented for evaluation of fatigue and exertional dyspnea. ja.ma/4ifkDoP
November 21, 2025 at 3:00 PM
This case report describes a woman in her 50s who presented for evaluation of fatigue and exertional dyspnea. ja.ma/4ifkDoP
💬 Viewpoint: An external medical review board for compassionate release could reduce the incarceration of terminally ill patients by focusing on medical criteria, addressing ethical concerns, and promoting dignified end-of-life care.
ja.ma/4a18FNd
ja.ma/4a18FNd
November 21, 2025 at 1:00 PM
💬 Viewpoint: An external medical review board for compassionate release could reduce the incarceration of terminally ill patients by focusing on medical criteria, addressing ethical concerns, and promoting dignified end-of-life care.
ja.ma/4a18FNd
ja.ma/4a18FNd
💡Clinical Insight: New ASAM guidelines for Benzodiazepine advise gradual dose reductions, flexible timelines, and frequent reassessment for withdrawal symptoms; dose reductions, rather than discontinuation, may be suitable for high-risk patients.
ja.ma/3KcENTC
ja.ma/3KcENTC
November 20, 2025 at 3:00 PM
💡Clinical Insight: New ASAM guidelines for Benzodiazepine advise gradual dose reductions, flexible timelines, and frequent reassessment for withdrawal symptoms; dose reductions, rather than discontinuation, may be suitable for high-risk patients.
ja.ma/3KcENTC
ja.ma/3KcENTC
In a patient with squamous cell carcinoma receiving sintilimab therapy, symptoms and ECG findings indicated immune checkpoint inhibitor-induced myocarditis rather than STEMI. ja.ma/4nZeQVn
November 20, 2025 at 1:00 PM
In a patient with squamous cell carcinoma receiving sintilimab therapy, symptoms and ECG findings indicated immune checkpoint inhibitor-induced myocarditis rather than STEMI. ja.ma/4nZeQVn
The Competitive Generic Therapy pathway led to 83.5% of approved generics launching within 75 days, with a median drug price reduction of 18% after market entry. ja.ma/3K5nl3j
November 19, 2025 at 3:00 PM
The Competitive Generic Therapy pathway led to 83.5% of approved generics launching within 75 days, with a median drug price reduction of 18% after market entry. ja.ma/3K5nl3j
This case report describes a man in his 60s with South African flag sign on electrocardiography. ja.ma/3K3JZcj
November 19, 2025 at 1:00 PM
This case report describes a man in his 60s with South African flag sign on electrocardiography. ja.ma/3K3JZcj
Most countries hosting trials for FDA-approved medicines do not gain timely physical access to those treatments, especially low- and middle-income countries, with only 24% accessible in all trial locations at 5 years. ja.ma/47Xoge3
November 18, 2025 at 3:00 PM
Most countries hosting trials for FDA-approved medicines do not gain timely physical access to those treatments, especially low- and middle-income countries, with only 24% accessible in all trial locations at 5 years. ja.ma/47Xoge3
A woman in her 50s with #obesity, #diabetes, and #hypertension was treated for mild autonomous cortisol secretion caused by an adrenal nodule and improved following an adrenalectomy. Learn more in this Teachable Moment: ja.ma/445srU2
November 18, 2025 at 1:00 PM
A woman in her 50s with #obesity, #diabetes, and #hypertension was treated for mild autonomous cortisol secretion caused by an adrenal nodule and improved following an adrenalectomy. Learn more in this Teachable Moment: ja.ma/445srU2
Female individuals with stage 5 #ChronicKidneyDisease show greater excess mortality than males, especially before age 55, with the female survival advantage found in the general population absent or reversed in this cohort. ja.ma/4i4tTvz
November 17, 2025 at 5:00 PM
Female individuals with stage 5 #ChronicKidneyDisease show greater excess mortality than males, especially before age 55, with the female survival advantage found in the general population absent or reversed in this cohort. ja.ma/4i4tTvz
Between February and August 2025, 1 in 30 NIH-funded clinical trials lost grant funding, affecting over 74,000 participants, with disproportionate impact on prevention, infectious disease, and behavioral trials. ja.ma/4i4tSYx
November 17, 2025 at 4:30 PM
Between February and August 2025, 1 in 30 NIH-funded clinical trials lost grant funding, affecting over 74,000 participants, with disproportionate impact on prevention, infectious disease, and behavioral trials. ja.ma/4i4tSYx
First-year over-the-counter naloxone sales showed limited uptake and did not effectively bridge gaps from pharmacy or distribution programs, likely due to high prices. ja.ma/4ogyhcJ
November 16, 2025 at 1:00 PM
First-year over-the-counter naloxone sales showed limited uptake and did not effectively bridge gaps from pharmacy or distribution programs, likely due to high prices. ja.ma/4ogyhcJ
From 2017 to 2023, #Medicare Advantage beneficiaries saw disproportionately greater increases in hospital length of stay compared to traditional Medicare, particularly for discharges to skilled nursing facilities. ja.ma/4qSkafY
November 15, 2025 at 1:00 PM
From 2017 to 2023, #Medicare Advantage beneficiaries saw disproportionately greater increases in hospital length of stay compared to traditional Medicare, particularly for discharges to skilled nursing facilities. ja.ma/4qSkafY
This Review explores the factors that predispose Hispanic/Latino patients to metabolic dysfunction–associated steatotic liver disease and metabolic dysfunction–associated steatohepatitis. ja.ma/3JD2ww6
November 13, 2025 at 1:00 PM
This Review explores the factors that predispose Hispanic/Latino patients to metabolic dysfunction–associated steatotic liver disease and metabolic dysfunction–associated steatohepatitis. ja.ma/3JD2ww6
JAMA Internal Medicine is looking for research on how AI is transforming patient care in areas such as clinical outcomes, diagnosis, system redesign, ethics, equity, and women’s health.
🔗 Learn more about submission criteria: ja.ma/3KJBqng
🔗 Learn more about submission criteria: ja.ma/3KJBqng
November 13, 2025 at 12:00 AM
JAMA Internal Medicine is looking for research on how AI is transforming patient care in areas such as clinical outcomes, diagnosis, system redesign, ethics, equity, and women’s health.
🔗 Learn more about submission criteria: ja.ma/3KJBqng
🔗 Learn more about submission criteria: ja.ma/3KJBqng
This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching. ja.ma/47IsMx8
November 12, 2025 at 2:00 PM
This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching. ja.ma/47IsMx8
The Mighty-Heart trial found mobile integrated health offered no overall benefit over care coordination alone for #HeartFailure patients' health status or 30-day readmissions, but younger patients showed potential health improvements. ja.ma/4p0lpI9
November 12, 2025 at 1:00 PM
The Mighty-Heart trial found mobile integrated health offered no overall benefit over care coordination alone for #HeartFailure patients' health status or 30-day readmissions, but younger patients showed potential health improvements. ja.ma/4p0lpI9
Editor’s Note: Schwartz et al show risk-based provider contracts in Medicare Advantage do not consistently alter care use or low-value service rates. ja.ma/4qY9NYc
November 11, 2025 at 3:30 PM
Editor’s Note: Schwartz et al show risk-based provider contracts in Medicare Advantage do not consistently alter care use or low-value service rates. ja.ma/4qY9NYc