JAMA Psychiatry
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JAMA Psychiatry is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. 🌐 JAMAPsychiatry.com
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Viewpoint: As closed-loop neuromodulation advances, its clinical adoption requires rigorous comparative trials, well-matched neural biomarkers, and careful assessment of clinical effort versus benefit.

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Article titled 'Is Psychiatry Ready for Closed-Loop Invasive Neuromodulation?' by Sameer A. Sheth et al., discusses intracranial neuromodulation for neurological and psychiatric disorders. It questions the readiness of closed-loop strategies for clinical practice.
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Among individuals with psychosis, cannabis use increased by 9.53 percentage points after recreational cannabis legalization, a sharper rise than in the general population.

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Graph: "Event Study Plot of Recreational Cannabis Legalization (RCL) on 30-Day Cannabis Use." X-axis: "No. of years prelegalization and postlegalization." Y-axis: "Percentage-point change in 30-d cannabis use."
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There is an urgent need for research on strategies to manage psychiatric disorders associated with restricted reproductive health services. Learn more in this Special Communication. ja.ma/4q5Q20o
US Abortion Restrictions and the Neuropsychiatric Health of Pregnant Individuals and Families
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Brief cognitive behavioral therapy significantly reduced suicide attempts among US military personnel and veterans compared to present-centered therapy.

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A research paper titled "Brief Cognitive Behavioral Therapy for Suicidal Military Personnel and Veterans" discusses a randomized clinical trial on BCBT's effectiveness. It found BCBT reduced suicide attempts among military personnel/veterans.
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Pain reprocessing therapy (PRT) showed durable reductions in chronic back pain compared to placebo and usual care, with 55% of PRT participants nearly or completely pain-free.

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Two graphs show pain intensity scores. Graph A tracks trajectories through 5-year follow-up for PRT, Placebo, and Usual care. Graph B displays pain scores at 5 years for the same three categories. PRT shows lower pain intensity over time.
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Attending #WCP25? Read this timely article from @jamapsychiatry.com: 👇

RCT: In patients with #schizophrenia, #prediabetes, and #obesity, once-weekly #semaglutide injections, up to 1.0 mg/week, were safe and effective.

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JAMA Psychiatry graphic shows RCT: Semaglutide treatment of patients with schizophrenia, prediabetes, and obesity. Population: 66 males, 87 females. Intervention: 154 patients randomized. Findings: Semaglutide reduced HbA1c vs. placebo at week 30.
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Don't miss this article from @jamapsychiatry.com, selected to enhance your #WCP25 takeaways: 👇

Liafensine was efficacious and well tolerated in ANK3-positive patients with treatment-resistant #depression.

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Infographic titled JAMA Psychiatry: RCT: ANK3 as a Novel Genetic Biomarker for Liafensine. Key findings: Liafensine, 1mg and 2mg, demonstrated clinically meaningful improvement in MADRS score vs placebo in ANK3-positive patients with treatment-resistant depression.
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While at #WCP25, dive into recent research from @jamapsychiatry.com:

Higher polygenic risk scores for bipolar disorder were associated with favorable treatment outcomes after lithium augmentation in antidepressant non-responders with unipolar depression.

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Fig 1. Polygenic Associations with Lithium Augmentation Treatment Outcomes. A: Effect of PRS increase on remission to LA. B: Variability in remission following LA explained by each PRS. Graphs show Remission, Response, Hazard Ratio, and PRS values for BIP, MDD, and SCZ.
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At #WCP25? Consider this article from @jamapsychiatry.com:

Low-dose #semaglutide reduced alcohol craving and consumption in adults with alcohol use disorder.

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JAMA Psychiatry infographic detailing a study on Semaglutide for alcohol use disorder. Population: 14 men, 34 women. Intervention: 48 participants, 24 Semaglutide, 24 Placebo. Findings show reduced alcohol consumption in the Semaglutide group.
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Looking for more to discuss at #WCP25?

A study published in @jamapsychiatry.com found that gut bacteria may be behind the association of soft drink consumption and #depression.

Watch the video and read the full study: ja.ma/4o4PQg1
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Are you at #WCP25? JAMA Psychiatry is now on Bluesky! 🦋

Stay connected for innovative, clinically relevant research that covers the field broadly, from genetic mechanisms to psychotherapeutic intervention trials.
JAMA Psychiatry is now on Bluesky. Blue butterfly icon. Search bar shows @jamapsychiatry.com with a cursor hovering over it and a magnifying glass icon on the right.