Heatwave in London as seen from the Crick’s roof terrace at lunchtime ☀️

Do you want to hear more about ubiquitin? Are you free on Friday 14:00 BST? If so, why not join the Biochemical Society early career researcher webinar series where my fellow UCL alumnus Michele Frison and I will be presenting! 💻 💡

Registration: register.gotowebinar.com/register/821...

Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣

If you're in #immunity #cancer #neurodegeneration or #TPD fields, this might just tickle your fancy:
❓What are the biochemical functions TRIM proteins that have been implicated in these diseases?
❓What are the key catalytic features of RING domains?
❓Which TRIMs could work as #PROTAC components?

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

Well put!
theguardian.com/commentisfre...

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs
Register here: tinyurl.com/mr3p49f9

Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...

Mixing a leaving party with our Christmas party; house music with high res imaging… #Crickmas @crick.ac.uk

Thanks so much! Such a lovely idea ☺️ can’t wait to tuck into these over the holiday…

Christmas is looking very jolly here at the Crick! @thecrick.bsky.social 🎄✨ takes the edge off early starts with such short daylight hours…

CONFIRMED: Oxford University Press select 'brain rot' as the 2024 Oxford Word of the Year 🧠📱

#OxfordWOTY