Jelte van der Vaart
@jeltevdv.bsky.social
170 followers
140 following
6 posts
Postdoc 👨🏻🔬 Maurice Lab, Center for Molecular Medicine, Utrecht, The Netherlands | Peutz-Jeghers Syndrome | Adrenal cortex
Fascinated by using human representative organoid models to study (endocrine) biology and disease
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Reposted by Jelte van der Vaart
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Jelte van der Vaart
@jeltevdv.bsky.social
· Feb 28
Reposted by Jelte van der Vaart
Reposted by Jelte van der Vaart
Reposted by Jelte van der Vaart
Cristina L Ronchi
@cronchi.bsky.social
· Jan 25
Reposted by Jelte van der Vaart
Maurice Lab
@mauricelab.bsky.social
· Dec 22
WNT7B drives a program for pancreatic cancer subtype switching and progression
Hyperactivation of WNT signaling is a well-established hallmark of cancer. Various epithelial cancers express high levels of WNT7B and WNT10A that are not commonly expressed during tissue homeostasis,...
www.biorxiv.org
Reposted by Jelte van der Vaart
Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1
Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1
In healthy cells, AXIN1 organizes assembly of a large destruction complex that mediates proteolysis
www.biorxiv.org
Reposted by Jelte van der Vaart
Jens Puschhof
@jenspuschhof.bsky.social
· Nov 24