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Journal of Endocrinology @joendocrinology.bsky.social · 3d

☣️ Cadmium, an endocrine disruptor, is a known reproductive toxin.

New research by Yorgui Santiago-Andres et al. reveals the role of cadmium in testicular dysfunction via direct testicular damage & disrupted gonadotroph calcium signalling & hormone secretion.

🔓 doi.org/10.1530/JOE-25-0161

In vivo effects of cadmium on signaling and secretion of pituitary gonadotrophs in male mice are time-dependent. Journal of Endocrinology. By Yorgui Santiago-Andres et al.
Figure 1. Effects of cadmium on testicular morphology and function. (A) Representative images of H&E staining on the testes showing structural modifications in the seminiferous tubules. Scale bars: 100 µm. Immunofluorescence analysis of apoptosis in testis sections using an antibody against caspase-3 (green); nuclei were counterstained with DAPI (blue). Scale bars: 200 µm. (B) Cadmium caused hemorrhage in the testes (scale bar shown in cm). (C) Testis weight was significantly reduced after cadmium injection (*P = 0.035, ****P < 0.001; n = 9 for control, 11 for Cd21, 9 for Cd35, and 18 for Cd56). (D) Quantification of sperm cell number in the caudal epididymis (**P = 0.001, ***P = 0.001; n = 7 for control, and 8 for all other groups). (E and F) ... Journal of Endocrinology 267, 1; 10.1530/JOE-25-0161.
Published in Bioscientifica. Society for Endocrinology.

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Journal of Endocrinology @joendocrinology.bsky.social · 10d

We recognise impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award.

Q3 winner: Figure 2F in 'Obesity duration is linked to bariatric surgery outcomes via adipose tissue response'
By Julia Sánchez-Ceinos et al.

doi.org/10.1530/JOE-25-0013

Editors' Choice Figure.

Obesity duration is linked to bariatric surgery outcomes via adipose tissue response in Journal of Endocrinology. By Julia Sánchez-Ceinos et al.

Figure 2. (F) Schematic representation of significantly up- (red) and down- (blue) regulated proteins in post- vs pre-BS SAT from SSO (left panel) and LSO (right panel) individuals; circle size and the scale in the colour bar represent P value and Log2 (fold change), respectively, while grey connecting lines indicate functional association networks according to STRING.

Figure picked by: Co-Editors-in-Chief, Professor Ruth Andrew and Associate Professor Gabriela da Silva Xavier.

Journal of Endocrinology @joendocrinology.bsky.social · 14d

🏆 We're thrilled to award this quarter's Editors' Choice Award to:

The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner (doi.org/10.1530/JOE-...)
By Sekar Galuh et al.

Thank you to the authors for your contribution!

Editors' Choice Award.
The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner. By Sekar Galuh et al.
Paper picked by: Co-Editors-in-Chief, Professor Ruth Andrew and Associate Professor Gabriela da Silva Xavier.

Journal of Endocrinology @joendocrinology.bsky.social · Sep 30

Intrauterine exposure to triclosan, used in personal care products, may increase susceptibility to thyroid hypofunction in adulthood, highlighting its potential role as a developmental thyroid disruptor.

Subscribers to Journal of Endocrinology can read the full article: doi.org/10.1530/JOE-25-0069

Sex Effects in Endocrine Health and Disease Special Collection.

Intrauterine triclosan exposure disrupts hypothalamus–pituitary–thyroid axis function in offspring rats in Journal of Endocrinology. By Guilherme Henrique et al.

Journal of Endocrinology @joendocrinology.bsky.social · Sep 24

As part of our Exploring Osteoporosis and Sarcopenia Special Collection, a new review by Qinzuo Dong et al. examines the pathophysiological mechanisms underpinning osteosarcopenia, providing insights that could shape precision targeting.

🔗Subscribers can read the review: doi.org/10.1530/JOE-25-0234

Exploring Osteoporosis and Sarcopenia Special Collection. Muscle-bone biochemical crosstalk in osteosarcopenia: focusing on mechanisms and potential therapeutic strategies. By Qinzuo Dong et al. New Review. Journal of Endocrinology.

Journal of Endocrinology @joendocrinology.bsky.social · Sep 16

What role do adipokines play in testicular development?

Research by Preehi Riba et al. investigates vaspin & GRP78 expression in postnatal mouse testes & the impact on germ cell proliferation & cell death.

Subscribers to Journal of Endocrinology can read the article: doi.org/10.1530/JOE-25-0208

New Research: Exogenous vaspin suppresses germ cell proliferation, apoptosis, and promotes autophagy in pubertal mouse testes in Journal of Endocrinology. By Preethi Riba, Guruswami Gurusubramanian, and Vikas Kumar Roy.
Published by Bioscientifica. Society for Endocrinology.

Journal of Endocrinology @joendocrinology.bsky.social · Sep 10

Comparative Endocrinology: Insights from Domesticated Animals🐄

This special collection is open to original research and review submissions that advance our understanding of endocrine disorders through the study of domesticated animal models.

📩Submit your proposal to [email protected]🐎

Journal of Endocrinology @joendocrinology.bsky.social · Sep 4

Research by Dora A Mendez (@ucmerced.bsky.social) et al. suggests that thyroid hormones may enhance antioxidant defenses & protective pathways, pointing towards a cardioprotective role in metabolic syndrome.

Subscribers to Journal of Endocrinology can read the article: doi.org/10.1530/JOE-25-0164

New Research: Exogenous thyroxine increases cardiac Nrf2-TRX and reduces oxidative injury in insulin-resistant male OLETF rats in Journal of Endocrinology. By Dora A Mendez et al.

Published by bioscientifica. Society for Endocrinology.

Journal of Endocrinology @joendocrinology.bsky.social · Aug 26

🦴New research by Jing Chen et al. explores miR-127-3p in osteoporosis, investigating its regulatory role in human bone mesenchymal stem cells.

The study reveals insights into miR-127-3p as a diagnostic biomarker & predictor of osteoporosis.

🔗Full article #OpenAccess: doi.org/10.1530/JOE-25-0032

Journal of Endocrinology. New Research: miR-127-3p regulates osteoporosis progression by targeting VAMP2 to modulate cell differentiation. By Jing Chen et al.
Published by bioscientifica. Society for Endocrinology.
Figure 1. Diagnostic value of miR-127-3p for OP. (A) miR-127-3p expression in patients with OP and healthy individuals. (B) ROC curve for the diagnostic accuracy of miR-127-3p in patients with OP. ***P < 0.001. Citation: Journal of Endocrinology 266, 2; 10.1530/JOE-25-0032.

Journal of Endocrinology @joendocrinology.bsky.social · Aug 19

Tributyltin (TBT) is known for its endocrine-disrupting properties & now recent research by Rosiane Aparecida Miranda et al. reveals that maternal TBT exposure may increase susceptibility to conditions like PCOS in female offspring.

📖 Subscribers can read the article: doi.org/10.1530/JOE-24-0357

Journal of Endocrinology @joendocrinology.bsky.social · Aug 12

Does obesity duration affect bariatric surgery outcomes?

Julia Sánchez-Ceinos (@imibic.bsky.social) et al. link weight loss & metabolic improvements to proteomic changes in subcutaneous adipose tissue, highlighting obesity duration as a factor in individual response.

🔗 doi.org/10.1530/JOE-25-0013

New Research: Obesity duration is linked to bariatric surgery outcomes via adipose tissue response in Journal of Endocrinology. By Julia Sánchez-Ceinos et al.

Published by bioscientifica. Society of Endocrinology.

Journal of Endocrinology @joendocrinology.bsky.social · Aug 7

🌾 How do pesticides impact reproductive health?

A new review by Mariana de Souza Pomacena et al. explores how endocrine-disrupting pesticides may alter reproductive function in both sexes.

🔬 Subscribers can read the review in Journal of Endocrinology: doi.org/10.1530/JOE-...

Sex Effects in Endocrine Health and Disease Special Collection.
New Research: Impact of pesticides on reproductive health: insights from animal and in vitro models in both sexes in Journal of Endocrinology. By Mariana de Souza Pomacena et al.

Journal of Endocrinology @joendocrinology.bsky.social · Jul 30

🧬 Cortisol-induced ZBTB16 may restore baseline cellular state after inflammation & enhance glucocorticoid receptor anti-inflammatory effects. This could guide drug development that reduces side effects while retaining glucocorticoid benefits.

🔗Read the research #OA: doi.org/10.1530/JOE-24-0283

New Research: The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner in Journal of Endocrinology. Authors: Sekar Galuh et al.
Figure 7. Schematic figure of cortisol-induced ZBTB16 as part of intracellular feedback regulation of GR signaling. Baseline 1: Under low cortisol baseline condition, there is low basal GR transcriptional activity. Induction 2: Under stimulated (high cortisol) conditions, GR induces target genes via transactivation, including ZBTB16, and represses other GR target genes. Adaptation 3: Cortisol-induced ZBTB16 protein modulates GR-mediated transcriptional activities by potentiating transrepression and attenuating transactivation effects in a gene-specific manner. This orchestrated activity of glucocorticoid-induced ZBTB16 restores the cellular condition to its baseline state and therefore may be part of an intracellular negative feedback loop.

Journal of Endocrinology @joendocrinology.bsky.social · Jul 16

🔗Juliana Woyames et al. explores the link between gestational fish oil supplementation and sex- & muscle-specific alterations in myokine expression in weanling offspring exposed to a maternal high fat diet.

Subscribers to Journal of Endocrinology can access the article 👉 doi.org/10.1530/JOE-25-0033

New Research in Sex Effects in Endocrine Health and Disease Special Collection. Gestational fish oil supplementation in a high-fat diet induces sex-specific myokine changes in weanling offspring by Juliana Woyames et al.

Journal of Endocrinology @joendocrinology.bsky.social · Jul 10

New research by Paula Urones et al. investigate the changes in circulating GDF15 levels in #Obesity and after bariatric surgery. Their research provides important insight into the relevance of GDF15 as a biomarker for clinical outcomes.

Check out the article #OpenAccess: doi.org/10.1530/JOE-25-0010

New Open-Access Research: Relevance of GDF15 as a biomarker for clinical outcomes after bariatric surgery in Journal of Endocrinology.
Authors: Paula Urones et al.

Reposted by Journal of Endocrinology

Society for Endocrinology @socendocrinology.bsky.social · Jul 4

Have you read the summer issue of The #Endocrinologist yet? 📰

Here are our editorial board’s picks of the ‘hot’ papers from the Society's journals and beyond. @joendocrinology.bsky.social @endocancer.bsky.social @natmetabolism.nature.com

Dive into the latest hot topics here 👉 bit.ly/3TTIn6f

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Journal of Endocrinology @joendocrinology.bsky.social · Jul 3

🏆 Editors’ Choice Figure Award

We're thrilled to award this quarter's Editors' Choice Figure to:
Glucose and energy metabolism are impaired in mice deficient for orexins
By Mélodie Devère et al.

📖 Read the article: doi.org/10.1530/JOE-24-0329

Thank you to the authors for your contribution! 🎉

Text reads: Editors' Choice Figure. Glucose and energy metabolism are impaired in mice deficient for orexins. By Mélodie Devère et al. Figure picked by: *Images of Co-Editors-in-Chief* Co-Editor-in-Chief Professor Ruth Andrew and Co-Editor-in-Chief Associate Professor Gabriela de Silva Xavier.

Journal of Endocrinology @joendocrinology.bsky.social · Jul 2

🏆 This quarter the Journal of Endocrinology Editors' Choice Award goes to:

📌 Maternal sucrose consumption alters steroid levels in the mother, placenta and fetus
By Désirée R Seib, Minseon M Jung, and Kiran K Soma

Congratulations to the authors! 🎉

📖 Read the full article: doi.org/10.1530/JOE-...

Rosette icons either side of heading text that reads 'Editors' Choice Award'. Below this heading text reads 'Maternal sucrose consumption alters steroid levels in the mother, placenta and fetus by Désirée R Seib Minseon M Jung, and Kiran K Soma'. Paper picked by: image of Co-Editor-in-Chief Professor Ruth Andrew and image of Co-Editor-in-Chief Associate Professor Gabriela da Silva Xavier.

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Reposted by Journal of Endocrinology

Sakeneh Zraika @sakenehzraika.bsky.social · Jul 2

Excited to share our new review article published in @joendocrinology.bsky.social

From cholesterol to glucose: uncovering how statins induce β-cell dysfunction to promote type 2 diabetes doi.org/10.1530/JOE-...

doi.org

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Journal of Endocrinology @joendocrinology.bsky.social · Jun 20

We are delighted to have achieved an increased Journal Impact Factor of 3.9 in the latest #JCR2025 report🎉

Thanks to our authors, reviewers and editors for your valued collaboration & contributions.

Explore the top-cited articles that contributed 👉 buff.ly/CHqJQDS

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Journal of Endocrinology @joendocrinology.bsky.social · Jun 17

Discover how preventive #cardiovascular care could be improved for females in the latest review by Thulani Ashcroft et al.

⭐️Published in the Sex Effects in Endocrine Health and Disease special collection: joe.bioscientifica.com/page/sex-effects

Read the full article👉 doi.org/10.1530/JOE-25-0084

New review: Tailoring cardiovascular risk prediction to females
in Journal of Endocrinology. Authors: Thulani Ashcroft et al.
This paper forms part of a special collection on the theme of sex effects in endocrine health and disease.

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Journal of Endocrinology @joendocrinology.bsky.social · Jun 13

🧬New research in gestational #diabetes: Alan C Maloney et al. investigate molecular mechanisms in adipose tissue that may contribute to GDM pathology.

🔗 Subscribers to Journal of Endocrinology can read the full article here: doi.org/10.1530/JOE-...

Latest Research: Metabolic dysfunction is exacerbated in visceral, not subcutaneous, adipose tissue in gestational diabetes. By Alan C Maloney et al.

Journal of Endocrinology @joendocrinology.bsky.social · May 22

New research by Napatsorn Imerb et al. explores how lifestyle interventions like #exercise and #CaloricRestriction impact #BoneHealth in obesity-induced bone loss.

🔗 Subscribers to Journal of Endocrinology can read the full article here: doi.org/10.1530/JOE-25-0023

Journal of Endocrinology @joendocrinology.bsky.social · May 12

📢 FINAL CALL FOR PAPERS
Contribute to our special collection: Exploring Osteoporosis and Sarcopenia.
We welcome original research and reviews on bone-muscle cross-talk, metabolic factors, therapeutic targets and translational aspects of osteosarcopenia.
📩[email protected]

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Journal of Endocrinology @joendocrinology.bsky.social · May 9

Check out this latest study by Jianhong Zhang et al. exploring how cold aerobic exercise may influence #fibrosis in NAFLD via the UBAP2L-regulated TGF-β/SMAD2 pathway.

Subscribers to Journal of Endocrinology can access the full article here: doi.org/10.1530/JOE-24-0351

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