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Journal of Endocrinology
@joendocrinology.bsky.social
350 followers 43 following 47 posts
The flagship journal of @socendocrinology.bsky.social
Publishing basic and translational studies on endocrine physiology and metabolism. joe.bioscientifica.com
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New research by C. Yan et al. compared effects of BIBO3304 on diet-induced obesity & glucose intolerance at room temp. (21–22°C) & thermoneutrality (TN, 30°C).

Findings support the temperature-dependent efficacy of metabolic drugs.

Explore the results: doi.org/10.1530/JOE-25-0233
Journal of Endocrinology logo. New Research. Ambient temperature modulates the effects of peripheral Y1R antagonism on diet-induced obesity and glucose intolerance. By Chenxu Yan et al. Published by bioscientifica logo. Society for Endocrinology logo. Thermometer icon.
December 9, 2025 at 8:43 AM
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🐾 Does your research explore multifactorial endocrine disorders with domesticated animals as models?

We're dedicating a Special Collection to Comparative Endocrinology. Collection Editors, Dr Eleanor Raffan & Dr Ruth Morgan, welcome submissions of original research & review articles.
bit.ly/3KlpdVZ
December 3, 2025 at 1:55 PM
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A new review by Rakesh Meher et al. explores the pathophysiological links between diabetes & cognitive decline.

By integrating molecular, genetic and clinical insights, the review highlights how these insights can guide development of personalised dementia therapies.

🔗 doi.org/10.1530/JOE-25-0016
Journal of Endocrinology logo. New Review: Pathomechanisms, genetic insights, and therapeutics in diabetes-associated dementia. By Rakesh Meher et al. Published by Bioscientifica logo. Society for Endocrinology logo.
November 26, 2025 at 9:39 AM
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🔬 New study by Alana Mullins et al. introduces IsletAnalytics, semi-automated workflow for segmentation of immunofluorescent-stained human pancreatic islets, revealing altered islet architecture & OXPHOS proteins in T2D β‑cells.

Open-access article: doi.org/10.1530/JOE-25-0253
Top right: Journal of Endocrinology. Text reads: New Research. Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes. By Alana Mullins et al. Figure 1 IsletAnalytics: semi-automated workflow for segmentation of immunofluorescent-stained human pancreatic islets. Data conversion and preparation (stage 1). i) Image acquisition: human pancreatic islet immunofluorescent images are acquired. File conversion: images are converted from czi to .tiff format. Channel splitting: images are processed to split the channels into their respective fluorophores. Iterative Ilastik training (stage 2). ii) Pixel classification: Ilastik’s random forest classifier is used for iterative training to segment complete islets through machine learning-based pixel classification...Journal of Endocrinology 267, 1; 10.1530/JOE-25-0253 Bottom left: Published by Bioscientifica. Bottom right: Society for Endocrinology.
November 20, 2025 at 1:10 PM
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🪩As we approach the end of 2025, we’re launching the Journal of Endocrinology Best Paper Award.

Join us to celebrate the year’s most outstanding contributions to the field of endocrinology - winners will be announced in early 2026. 🎆

Learn more: joe.bioscientifica.com/page/award/best-paper-award
Journal of Endocrinology logo. 2025 Best Paper Award. Bioscientifica logo. Society for Endocrinology logo.
November 12, 2025 at 1:10 PM
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New research by M. Mashayekhi (@vanderbilt.edu) et al. explores how the GLP-1R rs6923761 (Gly168Ser) variant modulates response to liraglutide in obesity and pre-diabetes.

🔗Subscribers to Journal of Endocrinology can read the article: doi.org/10.1530/JOE-25-0174
Rising Stars Special Collection: Effects of a GLP-1 receptor polymorphism on responses to liraglutide in Journal of Endocrinology. By Mona Mashayekhi et al.
November 6, 2025 at 10:35 AM
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☣️ Cadmium, an endocrine disruptor, is a known reproductive toxin.

New research by Yorgui Santiago-Andres et al. reveals the role of cadmium in testicular dysfunction via direct testicular damage & disrupted gonadotroph calcium signalling & hormone secretion.

🔓 doi.org/10.1530/JOE-25-0161
In vivo effects of cadmium on signaling and secretion of pituitary gonadotrophs in male mice are time-dependent. Journal of Endocrinology. By Yorgui Santiago-Andres et al. Figure 1. Effects of cadmium on testicular morphology and function. (A) Representative images of H&E staining on the testes showing structural modifications in the seminiferous tubules. Scale bars: 100 µm. Immunofluorescence analysis of apoptosis in testis sections using an antibody against caspase-3 (green); nuclei were counterstained with DAPI (blue). Scale bars: 200 µm. (B) Cadmium caused hemorrhage in the testes (scale bar shown in cm). (C) Testis weight was significantly reduced after cadmium injection (*P = 0.035, ****P < 0.001; n = 9 for control, 11 for Cd21, 9 for Cd35, and 18 for Cd56). (D) Quantification of sperm cell number in the caudal epididymis (**P = 0.001, ***P = 0.001; n = 7 for control, and 8 for all other groups). (E and F) ... Journal of Endocrinology 267, 1; 10.1530/JOE-25-0161. Published in Bioscientifica. Society for Endocrinology.
October 28, 2025 at 12:57 PM
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We recognise impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award.

Q3 winner: Figure 2F in 'Obesity duration is linked to bariatric surgery outcomes via adipose tissue response'
By Julia Sánchez-Ceinos et al.

doi.org/10.1530/JOE-25-0013
Editors' Choice Figure. Obesity duration is linked to bariatric surgery outcomes via adipose tissue response in Journal of Endocrinology. By Julia Sánchez-Ceinos et al. Figure 2. (F) Schematic representation of significantly up- (red) and down- (blue) regulated proteins in post- vs pre-BS SAT from SSO (left panel) and LSO (right panel) individuals; circle size and the scale in the colour bar represent P value and Log2 (fold change), respectively, while grey connecting lines indicate functional association networks according to STRING. Figure picked by: Co-Editors-in-Chief, Professor Ruth Andrew and Associate Professor Gabriela da Silva Xavier.
October 21, 2025 at 11:06 AM
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🏆 We're thrilled to award this quarter's Editors' Choice Award to:

The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner (doi.org/10.1530/JOE-...)
By Sekar Galuh et al.

Thank you to the authors for your contribution!
Editors' Choice Award. The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner. By Sekar Galuh et al. Paper picked by: Co-Editors-in-Chief, Professor Ruth Andrew and Associate Professor Gabriela da Silva Xavier.
October 17, 2025 at 11:55 AM
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Intrauterine exposure to triclosan, used in personal care products, may increase susceptibility to thyroid hypofunction in adulthood, highlighting its potential role as a developmental thyroid disruptor.

Subscribers to Journal of Endocrinology can read the full article: doi.org/10.1530/JOE-25-0069
Sex Effects in Endocrine Health and Disease Special Collection. Intrauterine triclosan exposure disrupts hypothalamus–pituitary–thyroid axis function in offspring rats in Journal of Endocrinology. By Guilherme Henrique et al.
September 30, 2025 at 1:40 PM
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As part of our Exploring Osteoporosis and Sarcopenia Special Collection, a new review by Qinzuo Dong et al. examines the pathophysiological mechanisms underpinning osteosarcopenia, providing insights that could shape precision targeting.

🔗Subscribers can read the review: doi.org/10.1530/JOE-25-0234
Exploring Osteoporosis and Sarcopenia Special Collection. Muscle-bone biochemical crosstalk in osteosarcopenia: focusing on mechanisms and potential therapeutic strategies. By Qinzuo Dong et al. New Review. Journal of Endocrinology.
September 24, 2025 at 2:39 PM
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What role do adipokines play in testicular development?

Research by Preehi Riba et al. investigates vaspin & GRP78 expression in postnatal mouse testes & the impact on germ cell proliferation & cell death.

Subscribers to Journal of Endocrinology can read the article: doi.org/10.1530/JOE-25-0208
New Research: Exogenous vaspin suppresses germ cell proliferation, apoptosis, and promotes autophagy in pubertal mouse testes in Journal of Endocrinology. By Preethi Riba, Guruswami Gurusubramanian, and Vikas Kumar Roy. Published by Bioscientifica. Society for Endocrinology.
September 16, 2025 at 12:25 PM
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Comparative Endocrinology: Insights from Domesticated Animals🐄

This special collection is open to original research and review submissions that advance our understanding of endocrine disorders through the study of domesticated animal models.

📩Submit your proposal to [email protected]🐎
September 10, 2025 at 12:14 PM
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Research by Dora A Mendez (@ucmerced.bsky.social) et al. suggests that thyroid hormones may enhance antioxidant defenses & protective pathways, pointing towards a cardioprotective role in metabolic syndrome.

Subscribers to Journal of Endocrinology can read the article: doi.org/10.1530/JOE-25-0164
New Research: Exogenous thyroxine increases cardiac Nrf2-TRX and reduces oxidative injury in insulin-resistant male OLETF rats in Journal of Endocrinology. By Dora A Mendez et al. Published by bioscientifica. Society for Endocrinology.
September 4, 2025 at 2:39 PM
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🦴New research by Jing Chen et al. explores miR-127-3p in osteoporosis, investigating its regulatory role in human bone mesenchymal stem cells.

The study reveals insights into miR-127-3p as a diagnostic biomarker & predictor of osteoporosis.

🔗Full article #OpenAccess: doi.org/10.1530/JOE-25-0032
Journal of Endocrinology. New Research: miR-127-3p regulates osteoporosis progression by targeting VAMP2 to modulate cell differentiation. By Jing Chen et al. Published by bioscientifica. Society for Endocrinology. Figure 1. Diagnostic value of miR-127-3p for OP. (A) miR-127-3p expression in patients with OP and healthy individuals. (B) ROC curve for the diagnostic accuracy of miR-127-3p in patients with OP. ***P < 0.001. Citation: Journal of Endocrinology 266, 2; 10.1530/JOE-25-0032.
August 26, 2025 at 10:26 AM
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Tributyltin (TBT) is known for its endocrine-disrupting properties & now recent research by Rosiane Aparecida Miranda et al. reveals that maternal TBT exposure may increase susceptibility to conditions like PCOS in female offspring.

📖 Subscribers can read the article: doi.org/10.1530/JOE-24-0357
August 19, 2025 at 1:49 PM
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Does obesity duration affect bariatric surgery outcomes?

Julia Sánchez-Ceinos (@imibic.bsky.social) et al. link weight loss & metabolic improvements to proteomic changes in subcutaneous adipose tissue, highlighting obesity duration as a factor in individual response.

🔗 doi.org/10.1530/JOE-25-0013
New Research: Obesity duration is linked to bariatric surgery outcomes via adipose tissue response in Journal of Endocrinology. By Julia Sánchez-Ceinos et al. Published by bioscientifica. Society of Endocrinology.
August 12, 2025 at 10:56 AM
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🌾 How do pesticides impact reproductive health?

A new review by Mariana de Souza Pomacena et al. explores how endocrine-disrupting pesticides may alter reproductive function in both sexes.

🔬 Subscribers can read the review in Journal of Endocrinology: doi.org/10.1530/JOE-...
Sex Effects in Endocrine Health and Disease Special Collection. New Research: Impact of pesticides on reproductive health: insights from animal and in vitro models in both sexes in Journal of Endocrinology. By Mariana de Souza Pomacena et al.
August 7, 2025 at 3:13 PM
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🧬 Cortisol-induced ZBTB16 may restore baseline cellular state after inflammation & enhance glucocorticoid receptor anti-inflammatory effects. This could guide drug development that reduces side effects while retaining glucocorticoid benefits.

🔗Read the research #OA: doi.org/10.1530/JOE-24-0283
New Research: The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner in Journal of Endocrinology. Authors: Sekar Galuh et al. Figure 7. Schematic figure of cortisol-induced ZBTB16 as part of intracellular feedback regulation of GR signaling. Baseline 1: Under low cortisol baseline condition, there is low basal GR transcriptional activity. Induction 2: Under stimulated (high cortisol) conditions, GR induces target genes via transactivation, including ZBTB16, and represses other GR target genes. Adaptation 3: Cortisol-induced ZBTB16 protein modulates GR-mediated transcriptional activities by potentiating transrepression and attenuating transactivation effects in a gene-specific manner. This orchestrated activity of glucocorticoid-induced ZBTB16 restores the cellular condition to its baseline state and therefore may be part of an intracellular negative feedback loop.
July 30, 2025 at 8:34 AM
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🔗Juliana Woyames et al. explores the link between gestational fish oil supplementation and sex- & muscle-specific alterations in myokine expression in weanling offspring exposed to a maternal high fat diet.

Subscribers to Journal of Endocrinology can access the article 👉 doi.org/10.1530/JOE-25-0033
New Research in Sex Effects in Endocrine Health and Disease Special Collection. Gestational fish oil supplementation in a high-fat diet induces sex-specific myokine changes in weanling offspring by Juliana Woyames et al.
July 16, 2025 at 9:15 AM
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New research by Paula Urones et al. investigate the changes in circulating GDF15 levels in #Obesity and after bariatric surgery. Their research provides important insight into the relevance of GDF15 as a biomarker for clinical outcomes.

Check out the article #OpenAccess: doi.org/10.1530/JOE-25-0010
New Open-Access Research: Relevance of GDF15 as a biomarker for clinical outcomes after bariatric surgery in Journal of Endocrinology. Authors: Paula Urones et al.
July 10, 2025 at 11:57 AM
Reposted by Journal of Endocrinology
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Have you read the summer issue of The #Endocrinologist yet? 📰

Here are our editorial board’s picks of the ‘hot’ papers from the Society's journals and beyond. @joendocrinology.bsky.social @endocancer.bsky.social @natmetabolism.nature.com

Dive into the latest hot topics here 👉 bit.ly/3TTIn6f
Purple graphic featuring cuts from the summer issue of The Endocrinologist and the Society for Endocrinology logo. Text reads "Discover the latest hot topics from The Endocrinologist!"
July 4, 2025 at 3:00 PM
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🏆 Editors’ Choice Figure Award

We're thrilled to award this quarter's Editors' Choice Figure to:
Glucose and energy metabolism are impaired in mice deficient for orexins
By Mélodie Devère et al.

📖 Read the article: doi.org/10.1530/JOE-24-0329

Thank you to the authors for your contribution! 🎉
Text reads: Editors' Choice Figure. Glucose and energy metabolism are impaired in mice deficient for orexins. By Mélodie Devère et al. Figure picked by: *Images of Co-Editors-in-Chief* Co-Editor-in-Chief Professor Ruth Andrew and Co-Editor-in-Chief Associate Professor Gabriela de Silva Xavier.
July 3, 2025 at 8:00 AM
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🏆 This quarter the Journal of Endocrinology Editors' Choice Award goes to:

📌 Maternal sucrose consumption alters steroid levels in the mother, placenta and fetus
By Désirée R Seib, Minseon M Jung, and Kiran K Soma

Congratulations to the authors! 🎉

📖 Read the full article: doi.org/10.1530/JOE-...
Rosette icons either side of heading text that reads 'Editors' Choice Award'. Below this heading text reads 'Maternal sucrose consumption alters steroid levels in the mother, placenta and fetus by Désirée R Seib Minseon M Jung, and Kiran K Soma'. Paper picked by: image of Co-Editor-in-Chief Professor Ruth Andrew and image of Co-Editor-in-Chief Associate Professor Gabriela da Silva Xavier.
July 2, 2025 at 10:15 AM
Reposted by Journal of Endocrinology
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Excited to share our new review article published in @joendocrinology.bsky.social

From cholesterol to glucose: uncovering how statins induce β-cell dysfunction to promote type 2 diabetes doi.org/10.1530/JOE-...
doi.org
July 2, 2025 at 4:15 AM