John Rubinstein
@johnrubinstein.bsky.social
CryoEM, Bioenergetics, V-ATPases (especially in synaptic vesicles and lysosomes), OxPhos (especially in mycobacteria as a TB drug target)
Scientist, The Hospital for Sick Children
Professor, U of Toronto
👨👩👧🔬🚲
rubinsteinlab.org
COI: structura.bio
Scientist, The Hospital for Sick Children
Professor, U of Toronto
👨👩👧🔬🚲
rubinsteinlab.org
COI: structura.bio
Pinned
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Reposted by John Rubinstein
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
Assistant Professor - Virology
Assistant Professor - Virology
jobs.utoronto.ca
January 15, 2026 at 8:04 PM
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
Reposted by John Rubinstein
Western University is looking for a Canada Research Chair (CRC)
Tier 1 in Metabolomics. We are intent on building capacity in this system and the ideal candidate will help build infrastructure and mentor junior faculty.
Please see the job ad at: uwo.ca/facultyrelat...
Tier 1 in Metabolomics. We are intent on building capacity in this system and the ideal candidate will help build infrastructure and mentor junior faculty.
Please see the job ad at: uwo.ca/facultyrelat...
uwo.ca
January 12, 2026 at 9:12 PM
Western University is looking for a Canada Research Chair (CRC)
Tier 1 in Metabolomics. We are intent on building capacity in this system and the ideal candidate will help build infrastructure and mentor junior faculty.
Please see the job ad at: uwo.ca/facultyrelat...
Tier 1 in Metabolomics. We are intent on building capacity in this system and the ideal candidate will help build infrastructure and mentor junior faculty.
Please see the job ad at: uwo.ca/facultyrelat...
Like most 🇨🇦 scientists, I believe Canada Impact+ Research Chairs program is an idiotic use of $ in an underfunded ecosystem
That said, $ is now on the table and Unis can take or leave it
If you want to start or move your lab to 🇨🇦, you're about to see lots of opportunities with excellent funding
That said, $ is now on the table and Unis can take or leave it
If you want to start or move your lab to 🇨🇦, you're about to see lots of opportunities with excellent funding
January 10, 2026 at 2:14 PM
Like most 🇨🇦 scientists, I believe Canada Impact+ Research Chairs program is an idiotic use of $ in an underfunded ecosystem
That said, $ is now on the table and Unis can take or leave it
If you want to start or move your lab to 🇨🇦, you're about to see lots of opportunities with excellent funding
That said, $ is now on the table and Unis can take or leave it
If you want to start or move your lab to 🇨🇦, you're about to see lots of opportunities with excellent funding
Reposted by John Rubinstein
OPPORTUNITY: McGill Plant Science is looking for an expert in plant pathology, plant breeding, or horticulture in the context of the Canada Impact+ Research Chairs Program (senior established researcher).
Contact: www.mcgill.ca/plant/contact
Program: lnkd.in/eavfNu7e
Please re-post.
Contact: www.mcgill.ca/plant/contact
Program: lnkd.in/eavfNu7e
Please re-post.
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
January 7, 2026 at 9:24 PM
OPPORTUNITY: McGill Plant Science is looking for an expert in plant pathology, plant breeding, or horticulture in the context of the Canada Impact+ Research Chairs Program (senior established researcher).
Contact: www.mcgill.ca/plant/contact
Program: lnkd.in/eavfNu7e
Please re-post.
Contact: www.mcgill.ca/plant/contact
Program: lnkd.in/eavfNu7e
Please re-post.
Reposted by John Rubinstein
Very pleased to be on the organizing committee of the EMBO course Structural Characterization of Macromolecular Complexes in 2026! We have a fantastic line up of speakers and tutors, please share widely!
👉apply here: www.embl.org/about/info/c...
👉apply here: www.embl.org/about/info/c...
January 9, 2026 at 12:38 PM
Very pleased to be on the organizing committee of the EMBO course Structural Characterization of Macromolecular Complexes in 2026! We have a fantastic line up of speakers and tutors, please share widely!
👉apply here: www.embl.org/about/info/c...
👉apply here: www.embl.org/about/info/c...
I'm looking forward to speaking at this course (and finally seeing my PhD-labmate @mattbowler.bsky.social's institute in Grenoble)!
Very pleased to be on the organizing committee of the EMBO course Structural Characterization of Macromolecular Complexes in 2026! We have a fantastic line up of speakers and tutors, please share widely!
👉apply here: www.embl.org/about/info/c...
👉apply here: www.embl.org/about/info/c...
January 9, 2026 at 6:19 PM
I'm looking forward to speaking at this course (and finally seeing my PhD-labmate @mattbowler.bsky.social's institute in Grenoble)!
Reposted by John Rubinstein
Congrats to our former summer student🥳
January 9, 2026 at 2:31 PM
Congrats to our former summer student🥳
Congratulations to the new Doctor of Philosophy @courbongautier.bsky.social on a spectacular PhD defense following a groundbreaking PhD!
Thanks to external examiner Damian Ekiert from JHU and the rest of the examining committee.
Next stop, Oxford University for a postdoctoral fellowship.
🇫🇷🇨🇦🇬🇧
Thanks to external examiner Damian Ekiert from JHU and the rest of the examining committee.
Next stop, Oxford University for a postdoctoral fellowship.
🇫🇷🇨🇦🇬🇧
January 9, 2026 at 2:56 AM
Congratulations to the new Doctor of Philosophy @courbongautier.bsky.social on a spectacular PhD defense following a groundbreaking PhD!
Thanks to external examiner Damian Ekiert from JHU and the rest of the examining committee.
Next stop, Oxford University for a postdoctoral fellowship.
🇫🇷🇨🇦🇬🇧
Thanks to external examiner Damian Ekiert from JHU and the rest of the examining committee.
Next stop, Oxford University for a postdoctoral fellowship.
🇫🇷🇨🇦🇬🇧
Reposted by John Rubinstein
THREAD
The first full year of tracking research on @bsky.app
Hi, we are Altmetric, and we track how research is communicated across the web.
We now have one full calendar year of Bluesky research data and thought we'd have a looksie.
The first full year of tracking research on @bsky.app
Hi, we are Altmetric, and we track how research is communicated across the web.
We now have one full calendar year of Bluesky research data and thought we'd have a looksie.
January 8, 2026 at 1:08 PM
THREAD
The first full year of tracking research on @bsky.app
Hi, we are Altmetric, and we track how research is communicated across the web.
We now have one full calendar year of Bluesky research data and thought we'd have a looksie.
The first full year of tracking research on @bsky.app
Hi, we are Altmetric, and we track how research is communicated across the web.
We now have one full calendar year of Bluesky research data and thought we'd have a looksie.
Reposted by John Rubinstein
Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!
2026 Summer Intern - Agents for Structural Biology in South San Francisco, California, United States of America | Students & Graduates at Genentech
Apply for 2026 Summer Intern - Agents for Structural Biology job with Genentech in South San Francisco, California, United States of America. Students & Graduates at Genentech
careers.gene.com
January 5, 2026 at 8:56 PM
Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!
In Jan 2006 I started my dream job: running my own research group at The Hospital for Sick Children in my home town, Toronto. Stephanie Bueler started as lab manager on Day 1.
Many students, postdocs, papers, and microscopes later we're still going strong - and Stephanie is still putting up with me!
Many students, postdocs, papers, and microscopes later we're still going strong - and Stephanie is still putting up with me!
January 6, 2026 at 12:28 AM
In Jan 2006 I started my dream job: running my own research group at The Hospital for Sick Children in my home town, Toronto. Stephanie Bueler started as lab manager on Day 1.
Many students, postdocs, papers, and microscopes later we're still going strong - and Stephanie is still putting up with me!
Many students, postdocs, papers, and microscopes later we're still going strong - and Stephanie is still putting up with me!
Reposted by John Rubinstein
Lab-grown lung models have traditionally been grown from a mixture of cells, making it hard to tell how a disease or treatment will affect an individual person.
These new models by @maxgg.bsky.social’s team and AlveoliX are grown from a single person’s stem cells ⤵️ www.crick.ac.uk/news/2026-01...
These new models by @maxgg.bsky.social’s team and AlveoliX are grown from a single person’s stem cells ⤵️ www.crick.ac.uk/news/2026-01...
Built to breathe: mini ‘lungs’ recreate individual response to infection
Lung-on-chip device exposes earliest stages of tuberculosis infection, and opens doors to investigate diversity in disease progression and personalised treatment.
www.crick.ac.uk
January 1, 2026 at 7:58 PM
Lab-grown lung models have traditionally been grown from a mixture of cells, making it hard to tell how a disease or treatment will affect an individual person.
These new models by @maxgg.bsky.social’s team and AlveoliX are grown from a single person’s stem cells ⤵️ www.crick.ac.uk/news/2026-01...
These new models by @maxgg.bsky.social’s team and AlveoliX are grown from a single person’s stem cells ⤵️ www.crick.ac.uk/news/2026-01...
Reposted by John Rubinstein
New Year, new paper from our lab. Emily Kramer used 3D light-sheet imaging and tissue clearing to examine the spatial architecture of mouse amygdala engram ensembles.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Examining the Three‐Dimensional Spatial Architecture of Mouse Amygdala Engram Ensembles
Memories are stored in a sparse population of neurons active at the time of an event, an engram ensemble, and reactivation of the engram ensemble drives memory recall. Although the amygdala is essent...
onlinelibrary.wiley.com
January 1, 2026 at 2:43 PM
New Year, new paper from our lab. Emily Kramer used 3D light-sheet imaging and tissue clearing to examine the spatial architecture of mouse amygdala engram ensembles.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by John Rubinstein
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Team Leader – Life Science Cryo-Electron Microscopy (Cryo-EM) Facility
Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C) at Forschungszentrum Jülich houses some of the world`s most advanced electron microscopes and tools for nanocharacterisation. U...
www.fz-juelich.de
December 23, 2025 at 9:42 AM
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Reposted by John Rubinstein
Five big global health wins in 2025 that will save millions of lives. From HIV to TB, scientists and doctors made breakthroughs in treatment and prevention of some of the world’s deadliest diseases, by @katlay.bsky.social www.theguardian.com/global-devel... via @theguardian.com
Five big global health wins in 2025 that will save millions of lives
From HIV to TB, scientists and doctors made breakthroughs in treatment and prevention of some of the world’s deadliest diseases
www.theguardian.com
December 22, 2025 at 5:53 PM
Five big global health wins in 2025 that will save millions of lives. From HIV to TB, scientists and doctors made breakthroughs in treatment and prevention of some of the world’s deadliest diseases, by @katlay.bsky.social www.theguardian.com/global-devel... via @theguardian.com
Reposted by John Rubinstein
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Reposted by John Rubinstein
We have an opening for a research support officer. Come and join us! Please share.
Are you an enthusiastic and ambitious scientist looking for a challenging project?
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
December 22, 2025 at 12:09 PM
We have an opening for a research support officer. Come and join us! Please share.
Reposted by John Rubinstein
As 2025 comes to a close, my university (Dalhousie U in Halifax, Canada) is recruiting faculty, including outstanding early career researchers, and Canada Research Chairs. Applications are due January 19 2026 (was just notified today!). Please repost.
Dalhousie University is recruiting up to 30 tenure and tenure-track faculty positions
Backed by the Government of Canada’s $1.7 billion Global Impact+ Research Talent Initiative, Dalhousie University is undertaking one of the most ambitious research-leader recruitment efforts in its hi...
www.dal.ca
December 19, 2025 at 8:17 PM
As 2025 comes to a close, my university (Dalhousie U in Halifax, Canada) is recruiting faculty, including outstanding early career researchers, and Canada Research Chairs. Applications are due January 19 2026 (was just notified today!). Please repost.
Reposted by John Rubinstein
Great news in the fight against antimicrobial resistance!
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
December 19, 2025 at 12:09 PM
Great news in the fight against antimicrobial resistance!
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
Reposted by John Rubinstein
UBC and BC Cancer are recruiting a cancer stem cell faculty member at the Associate Professor or Professor rank for the new Connie Eaves Chair in Cancer Stem Cell Research. A great position recognizing a giant in the field. Please share. #Vancouver
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
ubc.wd10.myworkdayjobs.com
December 18, 2025 at 11:19 PM
UBC and BC Cancer are recruiting a cancer stem cell faculty member at the Associate Professor or Professor rank for the new Connie Eaves Chair in Cancer Stem Cell Research. A great position recognizing a giant in the field. Please share. #Vancouver
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
Reposted by John Rubinstein
Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...
Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum
AMPA receptors (AMPARs) are multimodal transducers of glutamatergic signals throughout the brain. Their diversity is exemplified in the cerebellum; at afferent synapses, AMPARs mediate high-frequency ...
www.science.org
December 12, 2025 at 5:35 AM
Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...
I never get tired of this view from the lab
December 16, 2025 at 11:22 PM
I never get tired of this view from the lab
The lab's entry into the annual Cell Biology + Molecular Medicine gingerbread house competition (no contribution from me).
The faux Greek writing pains me, but the construction is brilliant!
The faux Greek writing pains me, but the construction is brilliant!
December 12, 2025 at 1:10 AM
The lab's entry into the annual Cell Biology + Molecular Medicine gingerbread house competition (no contribution from me).
The faux Greek writing pains me, but the construction is brilliant!
The faux Greek writing pains me, but the construction is brilliant!
Reposted by John Rubinstein
The Gonzalez Lab at Columbia University is seeking a scientific leader!
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
December 10, 2025 at 12:16 PM
The Gonzalez Lab at Columbia University is seeking a scientific leader!
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
Reposted by John Rubinstein
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research