Thank you so much Mark!

The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.

But, hitchhiking effects near functional regions are relatively unaffected by rescaling the population. Finally, we discuss how to accurately rescale simulations.

Similarly, the increase in the number of deleterious mutations per individual (in highly rescaled simulations of large regions) leads to excessive Hill-Robertson interference, causing a skewed offspring distribution.

These deviations occur particularly when substantial multiple-crossover events are likely to occur within individuals, which reduces the effective rate of genetic recombination, causing an increase in the linked effects of selection.

We find that while rescaling has minimal effects with most length and scaling factor combinations, simulating long regions with large scaling factors can introduce biases.

We thoroughly test the effects of rescaling in populations experiencing direct and linked effects of selection for various scaling factors and genomic lengths in D. melanogaster-like populations. Whenever possible, we compare our observations from simulations to expected theoretical predictions.

(a) When is rescaling reasonably accurate, and when does it break down? (b) Why does rescaling lead to the observed biases? (c) Can we realistically simulate whole genomes?

Recently, multiple studies have shown that rescaling forward simulations does not accurately capture the evolutionary dynamics of an unscaled population. However, some important questions remain unanswered –

Our latest preprint about the effects of rescaling forward-in-time simulations in population genetics - www.biorxiv.org/content/10.1...

Excited to share my first PhD project with my mentor, @johriparul.bsky.social! We examine how Hill–Robertson interference (HRI) in highly selfing species biases estimates of the distribution of fitness effects of new mutations (DFE).
doi.org/10.1093/evol...
@journal-evo.bsky.social #popgen #evobio

Thank you so much for the super fun visit @evolscientist.bsky.social ! Had so many fun science chats yesterday!

Short thread on my updated work with @gutengroup.mcb.arizona.edu "Detection of Domestication Signals through the Analysis of the Full Distribution of Fitness Effects", latest version at: www.biorxiv.org/content/10.1... Here we simulate a kind of canonical and idealised domestication process.

Come join us in Tucson!! I am excited to announce a tenure track faculty position on the genomics of resilience
@uofa-eeb.bsky.social! Read more about the position in the updated link below! We will begin reviewing applications on December 9! arizona.csod.com/ux/ats/caree...

Nominations due soon for the 2025 Dobzhansky Prize! This award recognizes the accomplishments and future promise of an outstanding early-career evolutionary biologist. Submit your nomination now! https://buff.ly/4fNJk9k