Julien GIRAUD
@juliengiraud.bsky.social
3rd year PhD student in Eric Cascales Lab working on the fabulous T6SS 🏹 #T6SS
Fantastic work from the fantastic @maellepllt.bsky.social 😍
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae
Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...
www.nature.com
November 15, 2025 at 8:21 PM
Fantastic work from the fantastic @maellepllt.bsky.social 😍
Reposted by Julien GIRAUD
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
November 12, 2025 at 4:21 PM
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
Reposted by Julien GIRAUD
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
www.science.org
November 7, 2025 at 7:58 PM
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Reposted by Julien GIRAUD
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!
October 4, 2025 at 7:55 AM
Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!
Reposted by Julien GIRAUD
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...
doi.org
September 29, 2025 at 5:51 AM
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
Reposted by Julien GIRAUD
Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins
Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition
and host interactions by delivering diverse cytotoxic domains through specialized
secretion systems. Here, we ...
www.jbc.org
September 28, 2025 at 9:20 AM
Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Reposted by Julien GIRAUD
Grateful to my PIs, team, collaborators, and colleagues for their support. Excited to share our paper from my PhD journey!
Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins
Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition
and host interactions by delivering diverse cytotoxic domains through specialized
secretion systems. Here, we ...
www.jbc.org
September 28, 2025 at 8:44 PM
Grateful to my PIs, team, collaborators, and colleagues for their support. Excited to share our paper from my PhD journey!
Reposted by Julien GIRAUD
Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
September 28, 2025 at 9:24 AM
Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Reposted by Julien GIRAUD
We recently described how T3SS effectors reach the injectisome with a shuttle system. But what about their chaperones? With live microscopy, proximity labeling and functional assays, @keithpint.bsky.social showed the Yersinia chaperone SycH already hands over its cargo in the cytosol. bit.ly/47hq6rM
August 27, 2025 at 9:22 AM
We recently described how T3SS effectors reach the injectisome with a shuttle system. But what about their chaperones? With live microscopy, proximity labeling and functional assays, @keithpint.bsky.social showed the Yersinia chaperone SycH already hands over its cargo in the cytosol. bit.ly/47hq6rM
Reposted by Julien GIRAUD
🚨🔥 Happy to share our latest Preprint! 🔥🚨
We describe some very simple experimental approaches employed in our group to assess CRISPRi effectiveness in Mycobacteria 🧬 🦠 🧫
Project co-led by Vanessa, Wafaa, Janïs & Eliana - Our Fantastic 4 Female Scientists💫🙌🧨
www.biorxiv.org/cgi/content/...
We describe some very simple experimental approaches employed in our group to assess CRISPRi effectiveness in Mycobacteria 🧬 🦠 🧫
Project co-led by Vanessa, Wafaa, Janïs & Eliana - Our Fantastic 4 Female Scientists💫🙌🧨
www.biorxiv.org/cgi/content/...
July 13, 2025 at 7:17 AM
🚨🔥 Happy to share our latest Preprint! 🔥🚨
We describe some very simple experimental approaches employed in our group to assess CRISPRi effectiveness in Mycobacteria 🧬 🦠 🧫
Project co-led by Vanessa, Wafaa, Janïs & Eliana - Our Fantastic 4 Female Scientists💫🙌🧨
www.biorxiv.org/cgi/content/...
We describe some very simple experimental approaches employed in our group to assess CRISPRi effectiveness in Mycobacteria 🧬 🦠 🧫
Project co-led by Vanessa, Wafaa, Janïs & Eliana - Our Fantastic 4 Female Scientists💫🙌🧨
www.biorxiv.org/cgi/content/...
Reposted by Julien GIRAUD
We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested:
emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Ingénieur d'Etude en Microbiologie (H/F)
emploi.cnrs.fr
July 8, 2025 at 2:55 PM
We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested:
emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr/Offres/CDD/U...
Reposted by Julien GIRAUD
Kicking off the week with exciting news:
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: [email protected]
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: [email protected]
May 26, 2025 at 7:56 AM
Kicking off the week with exciting news:
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: [email protected]
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: [email protected]
👉Reminder : ONE WEEK LEFT👈
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 20 via the following link: docs.google.com/forms/d/e/1F...
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 20 via the following link: docs.google.com/forms/d/e/1F...
Journées Sécrétion 2025
Contact: [email protected]
docs.google.com
May 13, 2025 at 12:32 PM
👉Reminder : ONE WEEK LEFT👈
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 20 via the following link: docs.google.com/forms/d/e/1F...
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 20 via the following link: docs.google.com/forms/d/e/1F...
👉Don’t forget👈
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 15 via the following link:
🔗 docs.google.com/forms/d/e/1F...
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 15 via the following link:
🔗 docs.google.com/forms/d/e/1F...
Journées Sécrétion 2025
Contact: [email protected]
docs.google.com
April 28, 2025 at 12:31 PM
👉Don’t forget👈
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 15 via the following link:
🔗 docs.google.com/forms/d/e/1F...
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 15 via the following link:
🔗 docs.google.com/forms/d/e/1F...
Reposted by Julien GIRAUD
You are a young researcher working on the bacterial cell envelope ? Don't miss this opportunity !!
The Journées Sécrétion are back!
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
March 18, 2025 at 12:25 PM
You are a young researcher working on the bacterial cell envelope ? Don't miss this opportunity !!
Thrilled and honored to join the organizing committee of the 2nd edition of the Journées Sécrétion!
We look forward to seeing you there, in Marseille🌞, reconnecting, and discovering exciting new research. See you soon!
We look forward to seeing you there, in Marseille🌞, reconnecting, and discovering exciting new research. See you soon!
The Journées Sécrétion are back!
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
March 17, 2025 at 5:12 PM
Thrilled and honored to join the organizing committee of the 2nd edition of the Journées Sécrétion!
We look forward to seeing you there, in Marseille🌞, reconnecting, and discovering exciting new research. See you soon!
We look forward to seeing you there, in Marseille🌞, reconnecting, and discovering exciting new research. See you soon!
Reposted by Julien GIRAUD
The Journées Sécrétion are back!
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
March 17, 2025 at 2:05 PM
The Journées Sécrétion are back!
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
Reposted by Julien GIRAUD
Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
February 24, 2025 at 7:48 PM
Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
Reposted by Julien GIRAUD
We have an open PhD position to work on bacterial secretion systems. Please RT, write us or apply through the CNRS job portal:
t.co/HxX23Od1oa
https://emploi.cnrs.fr/Offres/Doctorant/UMR7255-ERICAS-004/Default.aspx?lang=EN
t.co
January 18, 2025 at 11:56 AM
We have an open PhD position to work on bacterial secretion systems. Please RT, write us or apply through the CNRS job portal:
t.co/HxX23Od1oa
Reposted by Julien GIRAUD
Une médecin marchande d'esclaves, de fausses princesses, des voyageuses travesties parcourant l'Europe du XVIIIe siècle... Il est question de tout cela dans ce "Raconte-moi ta thèse" consacré à mes travaux de recherches au sein de l'EHESS.
À découvrir ici :
alumni-ehess.fr/fr/article/r...
À découvrir ici :
alumni-ehess.fr/fr/article/r...
Raconte-moi ta thèse #22 | L'invention des aventurières. Sociabilités, récits de soi et mobilités au féminin dans l'Europe du XVIIIe siècle, par Maxence Joscht | EHESS Alumni | Votre communauté ...
Maxence Joscht est doctorant à l'EHESS au sein du Centre de recherche sur les circulations, les liens et les échanges (CeRCLEs - EHESS), sous la direction dEleonora Canepari....
alumni-ehess.fr
January 7, 2025 at 3:33 PM
Une médecin marchande d'esclaves, de fausses princesses, des voyageuses travesties parcourant l'Europe du XVIIIe siècle... Il est question de tout cela dans ce "Raconte-moi ta thèse" consacré à mes travaux de recherches au sein de l'EHESS.
À découvrir ici :
alumni-ehess.fr/fr/article/r...
À découvrir ici :
alumni-ehess.fr/fr/article/r...