Jonas Wietek
@jwietek.bsky.social
Synapse modulation, biophysics, optogenetics, opsins, optoGPCRs & channelrhodopsins... garden stuff, photography, cats, cycling, parenting...still postdocing. Patch-clamper with imaging ambitions
https://scholar.google.com/citations?user=4xDsEF4AAAAJ&hl=en
https://scholar.google.com/citations?user=4xDsEF4AAAAJ&hl=en
Pinned
Jonas Wietek
@jwietek.bsky.social
· May 30
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits - Nature Methods
PdCO is a switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo, as demonstrated in a variety of contexts mainly in the mouse.
www.nature.com
Against all odds: PdCO, a versatile switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo is finally published @naturemethods #neuroskyence #optogenetics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The dregs of neuroscience - optogenetics. Lovely
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Heard an established successful neuroscientist dismissing junior scientists as "people at the bottom" 🤦♀️
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
November 23, 2025 at 8:27 PM
The dregs of neuroscience - optogenetics. Lovely
Oh wow. Congratulations!
November 13, 2025 at 9:28 PM
Oh wow. Congratulations!
Reposted by Jonas Wietek
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain - Nature Communications
Synapses are diverse within a single neuron. Here, the authors present a method for single-cell synaptome imaging of endogenous protein subpopulations in the mouse brain, enabling spatial mapping of s...
www.nature.com
November 11, 2025 at 6:19 PM
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
Reposted by Jonas Wietek
We’re bringing our latest progress in neuromodulator imaging to #SfN2025! Don’t miss Dr. Li’s talk (Nov 19) and our lab’s posters (Nov 16). We look forward to connecting, exchanging ideas, and exploring collaborations. #neuroscience #neuroimaging #biosensors @sfn.org
November 10, 2025 at 3:02 PM
We’re bringing our latest progress in neuromodulator imaging to #SfN2025! Don’t miss Dr. Li’s talk (Nov 19) and our lab’s posters (Nov 16). We look forward to connecting, exchanging ideas, and exploring collaborations. #neuroscience #neuroimaging #biosensors @sfn.org
But does it have AI? 🤣🤣🤣
November 9, 2025 at 5:34 PM
But does it have AI? 🤣🤣🤣
Some told me it might be a pumpkin...
November 8, 2025 at 1:50 PM
Some told me it might be a pumpkin...
Two neurons went into a bar...
November 6, 2025 at 11:52 AM
Two neurons went into a bar...
Reposted by Jonas Wietek
a century of glaciers melting 🧪🌐
November 3, 2025 at 5:21 PM
a century of glaciers melting 🧪🌐
October 30, 2025 at 10:47 AM
Rescheduled for today!
October 30, 2025 at 9:24 AM
Rescheduled for today!
Reposted by Jonas Wietek
Mind over matter, matter over mind?
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
October 28, 2025 at 6:52 AM
Mind over matter, matter over mind?
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
Check out our fine mini-special (mini by our standards) special issue on how #brain and #body interact.
🧠🕺
www.cell.com/current-biol...
Very cool work!
Now online @nature.com!
Want to change the consequences of receptor activation?
Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥
So many new possibilities! 🧪🧠🟦
www.nature.com/articles/s41...
🧵👇
Want to change the consequences of receptor activation?
Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥
So many new possibilities! 🧪🧠🟦
www.nature.com/articles/s41...
🧵👇
Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature
Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...
www.nature.com
October 27, 2025 at 9:59 PM
Very cool work!
Mine should be around 1 😅
October 26, 2025 at 3:37 PM
Mine should be around 1 😅
The only important metric is the Kardashian index! But we need it for blusky instead of Twitter.
October 26, 2025 at 11:49 AM
The only important metric is the Kardashian index! But we need it for blusky instead of Twitter.
Seems like Nature is launching a @qedscience.bsky.social clone @odedrechavi.bsky.social
October 22, 2025 at 2:30 PM
Seems like Nature is launching a @qedscience.bsky.social clone @odedrechavi.bsky.social
Neuroscience projects last several years, and you are usually a bit jaded by the time you wrap it up. Not this one– spending several months on an island in the middle of nowhere, away from all the craziness of the world reminds you how beautiful the world really is.
www.youtube.com/watch?v=46sv...
www.youtube.com/watch?v=46sv...
Bat Island: The New Era of Science
YouTube video by Weizmann Institute of Science
www.youtube.com
October 17, 2025 at 10:43 AM
Reposted by Jonas Wietek
Neuroscience projects last several years, and you are usually a bit jaded by the time you wrap it up. Not this one– spending several months on an island in the middle of nowhere, away from all the craziness of the world reminds you how beautiful the world really is.
www.youtube.com/watch?v=46sv...
www.youtube.com/watch?v=46sv...
Bat Island: The New Era of Science
YouTube video by Weizmann Institute of Science
www.youtube.com
October 17, 2025 at 7:07 AM
Neuroscience projects last several years, and you are usually a bit jaded by the time you wrap it up. Not this one– spending several months on an island in the middle of nowhere, away from all the craziness of the world reminds you how beautiful the world really is.
www.youtube.com/watch?v=46sv...
www.youtube.com/watch?v=46sv...
I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
October 17, 2025 at 10:20 AM
Awesome work from great people that spend a while on a remote and tiny Island to do this!
Congratulations to everyone involved @shakedpa.bsky.social @ray-neuro.bsky.social 🧠🧪💐🥳🔬🦇
www.science.org/doi/10.1126/...
Congratulations to everyone involved @shakedpa.bsky.social @ray-neuro.bsky.social 🧠🧪💐🥳🔬🦇
www.science.org/doi/10.1126/...
Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island
Animals and humans rely on their navigation skills to survive. However, spatial neurons in the brain’s “navigation circuit” had not previously been studied under real-world conditions. We conducted an...
www.science.org
October 17, 2025 at 10:19 AM
Awesome work from great people that spend a while on a remote and tiny Island to do this!
Congratulations to everyone involved @shakedpa.bsky.social @ray-neuro.bsky.social 🧠🧪💐🥳🔬🦇
www.science.org/doi/10.1126/...
Congratulations to everyone involved @shakedpa.bsky.social @ray-neuro.bsky.social 🧠🧪💐🥳🔬🦇
www.science.org/doi/10.1126/...
October 16, 2025 at 5:34 PM
