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Jonas Wietek

@jwietek.bsky.social

2.1K followers 540 following 480 posts

Synapse modulation, biophysics, optogenetics, opsins, optoGPCRs & channelrhodopsins... garden stuff, photography, cats, cycling, parenting...still postdocing. Patch-clamper with imaging ambitions https://scholar.google.com/citations?user=4xDsEF4AAAAJ&hl=en

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Jonas Wietek @jwietek.bsky.social · May 30

Against all odds: PdCO, a versatile switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo is finally published @naturemethods #neuroskyence #optogenetics
www.nature.com/articles/s41...

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits - Nature Methods

PdCO is a switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo, as demonstrated in a variety of contexts mainly in the mouse.

www.nature.com

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Reposted by Jonas Wietek

Patrick Piantadosi @ppiantad.bsky.social · 1d

for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...

amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.

Risk reshapes amygdala representation of choice

Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...

biorxiv.org

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Jonas Wietek @jwietek.bsky.social · 1d

You are more than welcome. I also stopped to trust any other opsin 😉😅

Jonas Wietek @jwietek.bsky.social · 1d

Conferencing

Reposted by Jonas Wietek

Maxim Greenberg @maxvcg.bsky.social · 2d

I'm glad that most academic institutions are on Bluesky now, so we can get the press releases I used to love on Twitter that are like "Congratulations to this year's Nobel Prize winner _______, who once used our third-floor bathroom."

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Jonas Wietek @jwietek.bsky.social · 2d

Congratulations to everyone involved!

a cartoon of a boy and a girl dancing on a wooden floor .

ALT: a cartoon of a boy and a girl dancing on a wooden floor .

media.tenor.com

Jonas Wietek @jwietek.bsky.social · 2d

Great body of work led by @ppiantad.bsky.social

First use of PdCO in the wild to perform closed-loop pre-choice modulation 🤩

www.biorxiv.org/content/10.1...

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Jonas Wietek @jwietek.bsky.social · 2d

🚨Big News🚨

The application for my continued employment for the next 10 months has been submitted.😅

#loveacademia
#science
#IchBinHanna
🧪🔬🧠

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Jonas Wietek @jwietek.bsky.social · 2d

Patch Clamp <-> Ca2+ imaging, by age, I'd say.

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Jonas Wietek @jwietek.bsky.social · 3d

For those who are still searching

Jonas Wietek @jwietek.bsky.social · May 30

Here you can find an up-to-date overview of available resources (all plasmids @addgene.bsky.social and many AAV variants):
docs.google.com/spreadsheets...

PdCO resources - Google Drive

docs.google.com

Jonas Wietek @jwietek.bsky.social · 4d

Frittierter Nudelteig!

Jonas Wietek @jwietek.bsky.social · 5d

There is always light...

Jonas Wietek @jwietek.bsky.social · 6d

www.science.org/doi/10.1126/...

Holy canelloni

Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families

Synthetic carbohydrate receptors prevent viral infections by binding to conserved enveloped virus glycans on viral surfaces.

www.science.org

Jonas Wietek @jwietek.bsky.social · 9d

Congratulations 🎉

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Jonas Wietek @jwietek.bsky.social · 10d

More data!

Matteo Carandini @carandinilab.net · 10d

Neuropixels Ultra!

By @steinmetzneuro.bsky.social, who led a big collaboration

www.sciencedirect.com/science/arti...

Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings

To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single-neuron and single-spike re…

www.sciencedirect.com

Jonas Wietek @jwietek.bsky.social · 14d

How your email finds me

Jonas Wietek @jwietek.bsky.social · 18d

How your email finds me!

Me, sitting in a chair looking unto the Atlantic Ocean

Jonas Wietek @jwietek.bsky.social · 20d

Happy weekend, you all!

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Reposted by Jonas Wietek

Ofer Yizhar @oyiz.bsky.social · 28d

Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).

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Jonas Wietek @jwietek.bsky.social · 28d

Led by the awesome @dzelmanoff.bsky.social

Jonas Wietek @jwietek.bsky.social · 29d

www.science.org/doi/10.1126/...

From the one and only @oyiz.bsky.social lab

Oxytocin signaling regulates maternally directed behavior during early life

Oxytocin is essential in shaping social behavior across the lifespan. Although the role of oxytocin signaling in parental care has been widely investigated, little is known about its function in socia...

www.science.org

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Jonas Wietek @jwietek.bsky.social · 29d

www.thetransmitter.org/oxytocin/oxy...

Oxytocin shapes both mouse mom and pup behavior

Distressed pups emit distinct cries for help, which depend on oxytocin neurons in their hypothalamus.

www.thetransmitter.org

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Jonas Wietek @jwietek.bsky.social · 29d

www.science.org/doi/10.1126/...

From the one and only @oyiz.bsky.social lab

Oxytocin signaling regulates maternally directed behavior during early life

www.science.org

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Reposted by Jonas Wietek

Noa Matosevich @nmatosevich.bsky.social · 29d

Thanks Jonas! PdCO was great to work with ☺️

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Jonas Wietek @jwietek.bsky.social · Sep 11

Very nice work and use of PdCO for synaptic inhibition 😉

Congratulations 🎉

Yuval Nir @labnir.bsky.social · Sep 10

🚨 New paper alert! 🚨(1/6)

Excited to share our work, out now in Science Advances

We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening

The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.

www.science.org

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Jonas Wietek @jwietek.bsky.social · Sep 10

somehow missed this FLIM direct voltage paper www.biorxiv.org/content/10.1...

Absolute Membrane Potential Recording with ASAP-Type Genetically Encoded Voltage Indicators Using Fluorescence Lifetime Imaging

The electrical membrane voltage ( V m) characterizes the functional state of biological cells, thus requiring precise, non-invasive V m-sensing techniques. While voltage-dependent fluorescence intensi...

www.biorxiv.org

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Jonas Wietek @jwietek.bsky.social · Sep 7

Lunar eclipse in 4 acts