Bryan Roth
@zenbrainest.bsky.social
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Pinned
Bryan Roth
@zenbrainest.bsky.social
· Dec 20
Psychedelics can both cause brain cancer and heart disease?
Perhaps.....
open.substack.com
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease: open.substack.com/pub/zendudes...
Reposted by Bryan Roth
Revisiting the SSRI-TRKB Mechanism: Lack of Evidence for Interaction in the Human Brain https://www.biorxiv.org/content/10.64898/2026.01.07.698082v1
January 7, 2026 at 3:15 PM
Revisiting the SSRI-TRKB Mechanism: Lack of Evidence for Interaction in the Human Brain https://www.biorxiv.org/content/10.64898/2026.01.07.698082v1
Reposted by Bryan Roth
Reposted by Bryan Roth
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
January 4, 2026 at 6:17 AM
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice: Cell Reports www.cell.com/cell-reports...
An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice
Song et al. find a subpopulation of neurotensin (NTS)-expressing neurons in the interpeduncular
nucleus (IPN) that co-release NTS and GABA in the dorsal raphe nucleus, and they demonstrate
the neurons...
www.cell.com
January 1, 2026 at 10:25 PM
An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice: Cell Reports www.cell.com/cell-reports...
The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice: Cell Reports www.cell.com/cell-reports...
The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice
Xia et al. reveal two separate pathways that regulate chronic pain and comorbid depression.
They demonstrate that NAcMedD1-MSNs regulate comorbid depressive symptoms via the
NAcMedD1-MSNs→MD circuit, ...
www.cell.com
January 1, 2026 at 10:22 PM
The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice: Cell Reports www.cell.com/cell-reports...
The sigma enigma revealed:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SigmaR1 is an auxiliary translocon factor with lipid-binding activity that regulates protein and lipid droplet homeostasis - Nature Communications
This study identifies the ER sheet protein SigmaR1 as an auxiliary translocon factor. By directly binding phosphatidylcholine and specific translocon components, SigmaR1 maintains protein and lipid ho...
www.nature.com
January 1, 2026 at 6:06 PM
The sigma enigma revealed:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bryan Roth
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective).
Read!
elizabethginexi.substack.com/p/the-quiet-...
Read!
elizabethginexi.substack.com/p/the-quiet-...
The Quiet Power of Program Officers
How invisible decisions shape what science gets done—and whether it matters
elizabethginexi.substack.com
December 28, 2025 at 11:56 AM
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective).
Read!
elizabethginexi.substack.com/p/the-quiet-...
Read!
elizabethginexi.substack.com/p/the-quiet-...
Reposted by Bryan Roth
Is the 5-HT2A Receptor the Key to Psychedelic Effects?
YouTube video by Xylo Bio
www.youtube.com
December 23, 2025 at 6:47 PM
Reposted by Bryan Roth
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
December 27, 2025 at 3:51 PM
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
December 27, 2025 at 3:51 PM
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
Reposted by Bryan Roth
Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex https://www.biorxiv.org/content/10.64898/2025.12.22.696123v1
December 26, 2025 at 4:15 PM
Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex https://www.biorxiv.org/content/10.64898/2025.12.22.696123v1
Is the 5-HT2A Receptor the Key to Psychedelic Effects?
YouTube video by Xylo Bio
www.youtube.com
December 23, 2025 at 6:47 PM
Mapping cellular targets of covalent cancer drugs in the entire mammalian body: Cell www.cell.com/cell/fulltex...
Mapping cellular targets of covalent cancer drugs in the entire mammalian body
vCATCH is a volumetric tissue labeling technique enabling cellular-resolution mapping
of covalent drug targets throughout the entire mammalian body.
www.cell.com
December 22, 2025 at 6:29 PM
Mapping cellular targets of covalent cancer drugs in the entire mammalian body: Cell www.cell.com/cell/fulltex...
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats www.jneurosci.org/content/earl...
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
N , N -dimethyltryptamine (DMT) is a serotonergic psychedelic that is being investigated clinically for the treatment of psychiatric disorders. Although the neurophysiological effects of DMT in humans...
www.jneurosci.org
December 22, 2025 at 5:57 PM
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats www.jneurosci.org/content/earl...
Reposted by Bryan Roth
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice - Molecular Psychiatry
Molecular Psychiatry - The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
www.nature.com
December 21, 2025 at 7:50 PM
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bryan Roth
Lysergic acid diethylamide pretreatment prolongs brain-stimulation induced neural activity https://www.biorxiv.org/content/10.64898/2025.12.16.694720v1
December 19, 2025 at 11:17 AM
Lysergic acid diethylamide pretreatment prolongs brain-stimulation induced neural activity https://www.biorxiv.org/content/10.64898/2025.12.16.694720v1
Reposted by Bryan Roth
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease: open.substack.com/pub/zendudes...
Psychedelics can both cause brain cancer and heart disease?
Perhaps.....
open.substack.com
December 20, 2025 at 1:31 AM
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease: open.substack.com/pub/zendudes...
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease: open.substack.com/pub/zendudes...
Psychedelics can both cause brain cancer and heart disease?
Perhaps.....
open.substack.com
December 20, 2025 at 1:31 AM
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease: open.substack.com/pub/zendudes...
Reposted by Bryan Roth
Born #OnThisDay in 1922, Esther Lederberg was the first to isolate the lambda phage in 1951. She characterised the lysogenic phase, whereby the phage are able to integrate into the bacterial genome, staying dormant. This discovery made them a model tool of study, leading to many more breakthroughs.
December 18, 2025 at 10:21 AM
Born #OnThisDay in 1922, Esther Lederberg was the first to isolate the lambda phage in 1951. She characterised the lysogenic phase, whereby the phage are able to integrate into the bacterial genome, staying dormant. This discovery made them a model tool of study, leading to many more breakthroughs.
Reposted by Bryan Roth
This article suggests that cancer treatment contributes to mutagenesis:
"More than 25% of driver mutations in normal tissue exposed to systemic anti-cancer therapy, including in TP53, could be attributed to treatment."
"More than 25% of driver mutations in normal tissue exposed to systemic anti-cancer therapy, including in TP53, could be attributed to treatment."
December 18, 2025 at 1:55 PM
This article suggests that cancer treatment contributes to mutagenesis:
"More than 25% of driver mutations in normal tissue exposed to systemic anti-cancer therapy, including in TP53, could be attributed to treatment."
"More than 25% of driver mutations in normal tissue exposed to systemic anti-cancer therapy, including in TP53, could be attributed to treatment."
Brainstem circuit for sickness-induced sleep | Science Advances www.science.org/doi/10.1126/...
Brainstem circuit for sickness-induced sleep
Brainstem circuit mediates sickness-induced NREM sleep.
www.science.org
December 15, 2025 at 3:30 PM
Brainstem circuit for sickness-induced sleep | Science Advances www.science.org/doi/10.1126/...
Reposted by Bryan Roth
The YouTube lectures
December 14, 2025 at 8:02 PM
The YouTube lectures
The YouTube lectures
December 14, 2025 at 8:02 PM
The YouTube lectures
Relates to this paper:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 13, 2025 at 12:06 AM
Relates to this paper:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Bryan Roth
Intriguing--YES!
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
December 13, 2025 at 12:05 AM
Intriguing--YES!
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...