Bryan Roth
@zenbrainest.bsky.social
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
The YouTube lectures
December 14, 2025 at 8:02 PM
The YouTube lectures
Relates to this paper:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 13, 2025 at 12:06 AM
Relates to this paper:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Intriguing--YES!
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
December 13, 2025 at 12:05 AM
Intriguing--YES!
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
Surprising--perhaps not so much
One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
November 23, 2025 at 11:49 PM
Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly
November 22, 2025 at 11:23 PM
Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly
By far, the highlight of my visit to the Big Apple!
November 15, 2025 at 9:09 PM
By far, the highlight of my visit to the Big Apple!
Before you throw tomatoes at me, please read the F***ing literature, dude
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
November 1, 2025 at 1:18 PM
Before you throw tomatoes at me, please read the F***ing literature, dude
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
My parting thought to all my scientific friends in Germany
October 31, 2025 at 7:29 AM
My parting thought to all my scientific friends in Germany
Be there or be square
October 30, 2025 at 9:19 AM
Be there or be square
My unvarnished thoughts on todays Nobel Prize and prizes and 'high impact journals'
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
October 6, 2025 at 8:14 PM
My unvarnished thoughts on todays Nobel Prize and prizes and 'high impact journals'
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
So glad to hear I’m potentially qualified to be an Assistant Professor!
September 19, 2025 at 4:12 PM
So glad to hear I’m potentially qualified to be an Assistant Professor!
My unvarnished thoughts on psychedelics
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
August 10, 2025 at 4:38 PM
My unvarnished thoughts on psychedelics
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
My recent email to @NIHDirector_Jay
@RobertKennedyJr
Please RT!
@RobertKennedyJr
Please RT!
August 6, 2025 at 6:15 PM
My recent email to @NIHDirector_Jay
@RobertKennedyJr
Please RT!
@RobertKennedyJr
Please RT!
The psychedelic GRC so far:
July 14, 2025 at 2:15 PM
The psychedelic GRC so far:
Cool--thanks for sharing. Today I'll provide my opinion on how to use this information for targeted drug discovery. A glimmer is better than darkness!
May 29, 2025 at 5:44 PM
Cool--thanks for sharing. Today I'll provide my opinion on how to use this information for targeted drug discovery. A glimmer is better than darkness!
Lisuride causes plasticity according to Olson patent: "FIG. 2E shows images of increased structural plasticity of neurons after treatment with Lisuride vs. the vehicle (DMSO)."
US 2020/0030309 A1
US 2020/0030309 A1
May 27, 2025 at 8:31 PM
Lisuride causes plasticity according to Olson patent: "FIG. 2E shows images of increased structural plasticity of neurons after treatment with Lisuride vs. the vehicle (DMSO)."
US 2020/0030309 A1
US 2020/0030309 A1
View from garden today
May 20, 2025 at 10:47 PM
View from garden today
Quite a nice image of 5-HT2A receptor distribution by Blake in the lab using our mice (I think now at JAX)
pubmed.ncbi.nlm.nih.gov/37808655/
pubmed.ncbi.nlm.nih.gov/37808655/
May 8, 2025 at 7:27 PM
Quite a nice image of 5-HT2A receptor distribution by Blake in the lab using our mice (I think now at JAX)
pubmed.ncbi.nlm.nih.gov/37808655/
pubmed.ncbi.nlm.nih.gov/37808655/
Many drugs used in treating Parkinson's Disease are quite similar potency agonists at 5-HT2A and D2/D3 but do not normally cause a psychedelic experience AND are not typically useful for depression, PTSD and so on.
#psychedelics
#psychedelics
May 6, 2025 at 7:28 PM
Many drugs used in treating Parkinson's Disease are quite similar potency agonists at 5-HT2A and D2/D3 but do not normally cause a psychedelic experience AND are not typically useful for depression, PTSD and so on.
#psychedelics
#psychedelics