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Shubharthi Kar

@karnephro.bsky.social

850 followers 300 following 54 posts

Nephrologist #Bangladesh #ISNeducation #SOME Social Media Team Member #SARB #SACA member International Society of Hypertension

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Reposted by Shubharthi Kar

Preeclampsia Foundation @preeclampsia.org · Sep 5

September is #PCOSAwarenessMonth. Women who have polycystic ovary syndrome #PCOS have a risk of developing #preeclampsia in their #pregnancy.

Learn more here: www.preeclampsia.org/faqs

Preeclampsia - FAQs

Preeclampsia Treatment, Eclampsia, Eclampsia Treatment, Toxemia, PET and PIH, HELLP Syndrome, Causes Preeclampsia, Preeclampsia Affect Pregnancy, Preeclampsia Affect the Baby

www.preeclampsia.org

Reposted by Shubharthi Kar

ISNkidneycare @theisn.org · Jul 28

🎬 Share your story! Submit your short film for the 2026 #ISNFilmEvent — real stories from those affected by kidney disease and their care teams. Open to ISN members. Deadline: Nov 5 (midnight CET).
🎥 Info & submissions ➡️ http://lite.spr.ly/6... #ThisIsISN #ISNWCN

Reposted by Shubharthi Kar

ISNkidneycare @theisn.org · Jul 16

1/ July 16 is #WorldSnakeDay - raising awareness of the incredible diversity of snakes and their vital role in our ecosystems. But did you know snakebites can also cause acute kidney injury? Join me, Dr. Fong Voon Ken, as we discuss their impact, management, and the need for awareness.

Reposted by Shubharthi Kar

ISNkidneycare @theisn.org · Jul 7

𝗡𝗘𝗪 𝗥𝗘𝗦𝗢𝗨𝗥𝗖𝗘 𝗔𝗟𝗘𝗥𝗧: Download our #ADPKD infographic for a quick overview of diagnosis, delaying progression, complications & more. A handy resource for clinicians and patients alike!
⬇️https://www.theisn.org/wp-content/uploads/2025/07/ADPKD-Infographic.pdf

Reposted by Shubharthi Kar

ISNkidneycare @theisn.org · Jul 8

📢 The kidney community urges UN Member States to include kidney disease in the 2025 Political Declaration on NCDs & Mental Health.

🧬 850M affected
📈 5th leading cause of death by 2050
💡 Early care = 45% cost savings

📄 Read the letter: www.theisn.org/wp-co... #KidneyHealthMatters #HLM4 #NCDs

Reposted by Shubharthi Kar

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Jul 6

Interesting data from Alberta

www.kidney-international.org/article/S008... in @kidneyint.bsky.social

GFR < 15 is classified as ‘kidney failure’ in most studies - but about a third of them die before starting RRT.

Is that glass half full or half empty? 🥃

#NephSky

Visual abstract - still needs work since KI doesn’t get professionals to do it! 🤷🏽‍♂️

Reposted by Shubharthi Kar

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Jul 2

We don’t get to discuss every important study that comes out on #NephJC

Hence #NephJCShorts

www.nephjc.com/news/nephjc-...

Introducing NephJC Shorts — NephJC

In just over a decade of critical appraisal on NephJC, we have done several experiments. Some of them have worked out phenomenally well, such as the Freely Filtered podcast. Others were not ready for ...

Shubharthi Kar @karnephro.bsky.social · Jun 30

⚡️Let’s have a closer look at the associations of each of these antigens
#ECNeph
@arvindcanchi.bsky.social
indianjnephrol.org/an-updated-r...

Shubharthi Kar @karnephro.bsky.social · Jun 30

Now that’s a roll! Thanks for joining tonight’s #ECNeph discussion
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

⚡️PLA2R antibody seropositivity doesn’t mean that we do not investigate for underlying malignancies.
Here is a Case Report showing PLA2rAb MN having Carcinoma Oesophagus
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

KDIGO recommends Population and Age-appropriate Screening for malignancies irrespective of antigen status
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

KDIGO Approach When to Biopsy in MN patients
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social @rheaultm.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

3 approaches Contd
2. Panel approach: Alternatively, a laboratory could employ a standard panel of antibodies for antigens that can vary depending on volume and demographics
3. Proteomic approach: Laser microdissection of MN glomeruli, followed by mass spectrometry. #ECneph

Shubharthi Kar @karnephro.bsky.social · Jun 30

3 approaches suggested by the Mayo clinic consensus report
1. Targeted approach: Perform antigen testing based on clinical disease association
Cont #ECNeph
www.kidney-international.org/article/S008...

Shubharthi Kar @karnephro.bsky.social · Jun 30

Here’s a timeline of the auto-antigens found in MN
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
indianjnephrol.org/an-updated-r...

Shubharthi Kar @karnephro.bsky.social · Jun 30

👉 🫣 Can IF differentiate from Primary and Secondary MN?
IgG 4 is the dominant class in primary MN
👉 IgG1,IgG2, IgG3 are dominant Immunoglobulins in Secondary MN

#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

👉 MN is a pattern of glomerular injury
👉 Deposition of immune complex along subepithelial aspect of GBM
👉 On Light Microscopy GBM is thickened. GBM spikes or holes can be seen
👉 IHC/IF shows IgG with C3 along capillary wall
#ECNeph
@theisn.org @dramiliflores.bsky.social @arvindcanchi.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

If it is malignancy associated MN then no role of IS. Treatment of cancer is priority #ECneph

Shubharthi Kar @karnephro.bsky.social · Jun 30

👉 5-22 % of Adults having Membranous Nephropathy had been diagnosed malignancy within a few years of the MN Diagnosis
👉 Lung, Colon, Breast, Stomach, Prostate cancers are commonest
www.kidney-international.org/article/S008...
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

Membranous Nephropathy and Malignancy — a deadly duo ☠️
👉 Let’s start with some trivia
❓How many older adults develop malignancy post diagnosis of Membranous Nephropathy?
A. < 1%
B. 5% - 22%
C. 30% - 40%
D. > 50%
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

❓ How do we treat cancer associated MN?
👉 RAAS Inhibition
👉 Statin
👉 Anticoagulants as needed
👉 Specific treatment for cancer
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

Shubharthi Kar @karnephro.bsky.social · Jun 30

Different types of tumor secrete different types of antigen.
Here is the proposed mechanism of malignancy associated MN. #ECneph
@dramiliflores.bsky.social @myadla.bsky.social @theisn.org

www.frontiersin.org/journals/med...

Shubharthi Kar @karnephro.bsky.social · Jun 30

Yes Patient was PLA2R Negative #ECneph

Shubharthi Kar @karnephro.bsky.social · Jun 30

🫣 So, let us now reveal the diagnosis. It is malignancy associated Membranous Nephropathy
👉 The association between malignancy and MN was first described in 1968
⚡️They also gave the 4 stages of MN
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social