Keith Grimes
@keithgrimes.bsky.social
Digital Health & Innovation Consultant and founder of Curistica. GP by background, I’m a doctor that practices medicine through the products I build, not the patients I see.
Particularly interested in AI / GenAI & Governance informed Product Development.
Particularly interested in AI / GenAI & Governance informed Product Development.
Reposted by Keith Grimes
Claude just got “Skills”—modular folders that turn it into a specialist on demand. ⚙
Key stats
Products: Apps, Code, API.
Features: composable, portable, efficient, powerful (code exec).
Use cases: Excel/PowerPoint/Word/PDF.
Key stats
Products: Apps, Code, API.
Features: composable, portable, efficient, powerful (code exec).
Use cases: Excel/PowerPoint/Word/PDF.
October 17, 2025 at 4:36 AM
Claude just got “Skills”—modular folders that turn it into a specialist on demand. ⚙
Key stats
Products: Apps, Code, API.
Features: composable, portable, efficient, powerful (code exec).
Use cases: Excel/PowerPoint/Word/PDF.
Key stats
Products: Apps, Code, API.
Features: composable, portable, efficient, powerful (code exec).
Use cases: Excel/PowerPoint/Word/PDF.
Anthropic models now available to Microsoft co-pilot users - great!
Microsoft shipping data outside its secure cloud to do so, and losing all warranties re residency, copyright protection, etc, into the bargain - not great!
Microsoft shipping data outside its secure cloud to do so, and losing all warranties re residency, copyright protection, etc, into the bargain - not great!
September 26, 2025 at 5:22 PM
Anthropic models now available to Microsoft co-pilot users - great!
Microsoft shipping data outside its secure cloud to do so, and losing all warranties re residency, copyright protection, etc, into the bargain - not great!
Microsoft shipping data outside its secure cloud to do so, and losing all warranties re residency, copyright protection, etc, into the bargain - not great!
UK emergency messaging test this Sunday 7th at 3pm
Anyone who has covert phone may need to take steps to avoid potential discovery, such as those in domestic violence situations
educationhub.blog.gov.uk/2025/09/what...
Anyone who has covert phone may need to take steps to avoid potential discovery, such as those in domestic violence situations
educationhub.blog.gov.uk/2025/09/what...
What you need to know about the Emergency Alerts test on 7 September
The government will be testing the Emergency Alerts system this Sunday, and your phone is likely to make a loud noise even if it's on silent. Here's everything you need to know about what's happening ...
educationhub.blog.gov.uk
September 3, 2025 at 8:18 AM
UK emergency messaging test this Sunday 7th at 3pm
Anyone who has covert phone may need to take steps to avoid potential discovery, such as those in domestic violence situations
educationhub.blog.gov.uk/2025/09/what...
Anyone who has covert phone may need to take steps to avoid potential discovery, such as those in domestic violence situations
educationhub.blog.gov.uk/2025/09/what...
The two sides of living in a seaside town
August 28, 2025 at 6:16 AM
The two sides of living in a seaside town
Agentic browser plugins - very tempting, but also potentially very risky. Especially in healthcare context
www.curistica.com/insights/age...
www.curistica.com/insights/age...
Agentic Browser Plugins in Healthcare: A warning — CURISTICA: a radical clinical innovation consultancy
Last night I received an email from Anthropic offering me the opportunity to join a waiting list for their new chrome plugin. It promises a great deal - an AI within the main tool I use to interact wi...
www.curistica.com
August 27, 2025 at 11:59 AM
Agentic browser plugins - very tempting, but also potentially very risky. Especially in healthcare context
www.curistica.com/insights/age...
www.curistica.com/insights/age...
Now is an absolute golden age for Product Engineers.
If your team already has a PM, encourage them to be a vibe coder. If not, hire one who can vibe code. A working prototype is invaluable for gathering user feedback.
If you are a PM, learn to vibe code.
If you are a PM, learn to vibe code.
August 12, 2025 at 9:04 AM
Now is an absolute golden age for Product Engineers.
Reposted by Keith Grimes
If your team already has a PM, encourage them to be a vibe coder. If not, hire one who can vibe code. A working prototype is invaluable for gathering user feedback.
If you are a PM, learn to vibe code.
If you are a PM, learn to vibe code.
August 12, 2025 at 12:57 AM
If your team already has a PM, encourage them to be a vibe coder. If not, hire one who can vibe code. A working prototype is invaluable for gathering user feedback.
If you are a PM, learn to vibe code.
If you are a PM, learn to vibe code.
Is Chain-of-thought and “reasoning” merely a simulation of reasoning, and therefore constrained by pre-training data?
arxiv.org/pdf/2508.01191
arxiv.org/pdf/2508.01191
arxiv.org
August 11, 2025 at 8:55 AM
Is Chain-of-thought and “reasoning” merely a simulation of reasoning, and therefore constrained by pre-training data?
arxiv.org/pdf/2508.01191
arxiv.org/pdf/2508.01191
Can confirm
What happens to body weight after discontinuation of GLP-1 drugs? A systematic review for effect at various time points
bmcmedicine.biomedcentral.com/articles/10....
bmcmedicine.biomedcentral.com/articles/10....
Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications - BMC Medicine
Background Globally, obesity has emerged as a significant public health concern, imposing detrimental impacts on human health. The purpose of our study was to explore the long-term effects of anti-obe...
bmcmedicine.biomedcentral.com
July 22, 2025 at 7:48 PM
Can confirm
I’m about 18 months into learning the alto saxophone, having never played an instrument or studied music before. It’s been a total joy - sharing because if you are wondering if and when you should learn to play something: don’t. Go for it.
July 21, 2025 at 7:47 AM
I’m about 18 months into learning the alto saxophone, having never played an instrument or studied music before. It’s been a total joy - sharing because if you are wondering if and when you should learn to play something: don’t. Go for it.
Reposted by Keith Grimes
A Trust in Cornwall said to their board that cyber security of health systems underwrites #patientsafety. Absolutely and an avoidable death sadly proves that 😥
Featured on the hub today, an interview on BBC London yesterday with our Chief Executive @helenh49.bsky.social, in the wake of the news that a patient’s death was contributed to by a cyber attack on NHS pathology provider last year. www.pslhub.org/learn/commis... #patientsafety
Interview with Helen Hughes on the cyber attack on a NHS pathology provider (26 June 2025)
Interview with Helen Hughes on BBC London on the death of a patient due to the cyber attack on a NHS pathology provider
www.pslhub.org
June 27, 2025 at 2:26 PM
A Trust in Cornwall said to their board that cyber security of health systems underwrites #patientsafety. Absolutely and an avoidable death sadly proves that 😥
For all me AI savvy followers, I’d welcome any links or refs to SotA eval approaches for translation using LLMs. It’s an area that seems to be a little stuck, but I could be looking in the wrong places
May 29, 2025 at 6:08 AM
For all me AI savvy followers, I’d welcome any links or refs to SotA eval approaches for translation using LLMs. It’s an area that seems to be a little stuck, but I could be looking in the wrong places
Reposted by Keith Grimes
In September, 2024, physicians working with AI did better at the Healthbench doctor benchmark than either AI or physicians alone.
With the release of o3 and GPT-4.1, AI answers are no longer improved on by physicians
Error rates appear to be dropping for newer AI models. openai.com/index/health...
With the release of o3 and GPT-4.1, AI answers are no longer improved on by physicians
Error rates appear to be dropping for newer AI models. openai.com/index/health...
May 13, 2025 at 4:23 AM
In September, 2024, physicians working with AI did better at the Healthbench doctor benchmark than either AI or physicians alone.
With the release of o3 and GPT-4.1, AI answers are no longer improved on by physicians
Error rates appear to be dropping for newer AI models. openai.com/index/health...
With the release of o3 and GPT-4.1, AI answers are no longer improved on by physicians
Error rates appear to be dropping for newer AI models. openai.com/index/health...
I’m new to the MCP game, but running Claude desktop with custom extensions has really opened my eyes to what can be achieved. Connected Notion, Gmail, and WhatsApp in short order. Wow
May 10, 2025 at 1:26 PM
I’m new to the MCP game, but running Claude desktop with custom extensions has really opened my eyes to what can be achieved. Connected Notion, Gmail, and WhatsApp in short order. Wow
I’ve built a automated eval platform in 2 hours today. Something that would have been well beyond my capabilities pre-copilot, and even with help would have taken weeks. Incredible
May 5, 2025 at 2:51 PM
I’ve built a automated eval platform in 2 hours today. Something that would have been well beyond my capabilities pre-copilot, and even with help would have taken weeks. Incredible
Soggy walk with Maneesh Juneja, still a great way to start Easter Sunday
April 20, 2025 at 9:48 AM
Soggy walk with Maneesh Juneja, still a great way to start Easter Sunday
This is quite an affecting piece of writing, and something that will stay with me for a while. It speaks to that which we individually have control over, which is also nice in current times
“You will see wonders beyond your imagination, nod, think “that’s a cool wonder”, and become inured to it”
A thought-provoking essay on reconstructing meaning in a world of AI content, and the role of our agency in finding meaning & wonder for ourselves. www.astralcodexten.com/p/the-colors...
A thought-provoking essay on reconstructing meaning in a world of AI content, and the role of our agency in finding meaning & wonder for ourselves. www.astralcodexten.com/p/the-colors...
April 7, 2025 at 2:53 PM
This is quite an affecting piece of writing, and something that will stay with me for a while. It speaks to that which we individually have control over, which is also nice in current times
It’s an incredible time to be building a startup
I totally get how right now is an amazing time to be a startup, with the huge multiplier that LLMs can provide to founders... but VCs and their LPs get paid on exit. And exit requires a strategy that lasts for the next decade. Given the uncertainty over timelines, what is that?
April 6, 2025 at 6:00 PM
It’s an incredible time to be building a startup
Reposted by Keith Grimes
"I don't want a Disney vacation of our history! I don't a whitewashed history, I don't want a homogenized history. Tell me the wretched truth about America, because that speaks to our greatness" -- 20 hours into his speech, Cory Booker is spitting absolute 🔥
April 1, 2025 at 7:47 PM
"I don't want a Disney vacation of our history! I don't a whitewashed history, I don't want a homogenized history. Tell me the wretched truth about America, because that speaks to our greatness" -- 20 hours into his speech, Cory Booker is spitting absolute 🔥
Reposted by Keith Grimes
So it looks like there's a third scaling law: you can make models better by (1) training them with more compute, by (2) having them "think" for longer about an answer, or by (now 3) generating large numbers of answers in parallel & picking good ones
Both 2 & 3 seem to have lots of low-hanging fruit
Both 2 & 3 seem to have lots of low-hanging fruit
March 18, 2025 at 3:53 AM
So it looks like there's a third scaling law: you can make models better by (1) training them with more compute, by (2) having them "think" for longer about an answer, or by (now 3) generating large numbers of answers in parallel & picking good ones
Both 2 & 3 seem to have lots of low-hanging fruit
Both 2 & 3 seem to have lots of low-hanging fruit
This is a keen observation. Specific prompting techniques have become less valuable as the tech develops, but familiarity with the tools and the ability to clearly describe tasks is taking over
I suspect that a lot of "AI training" in companies and schools has become obsolete in the last few months
As models get larger, the prompting tricks that used to be useful are no longer good; reasoners don't play well with Chain-of-Thought; hallucination rates have dropped, etc.
As models get larger, the prompting tricks that used to be useful are no longer good; reasoners don't play well with Chain-of-Thought; hallucination rates have dropped, etc.
March 17, 2025 at 7:33 AM
This is a keen observation. Specific prompting techniques have become less valuable as the tech develops, but familiarity with the tools and the ability to clearly describe tasks is taking over
The incredible Minack theatre, about 5 miles from Lands End
March 12, 2025 at 1:56 PM
The incredible Minack theatre, about 5 miles from Lands End
Watergate Bay in Cornwall.
March 12, 2025 at 8:17 AM
Watergate Bay in Cornwall.
I present this as an example of how humans can still misstep when dealing with AI. Particularly when it comes to naming conventions
Anus: Open-source alternative to Manus AI?
Anus (Autonomous Networked Utility System) is a powerful, flexible, and accessible open-source AI agent framework designed to revolutionize task automation.
github.com/nikmcfly/ANUS
Anus (Autonomous Networked Utility System) is a powerful, flexible, and accessible open-source AI agent framework designed to revolutionize task automation.
github.com/nikmcfly/ANUS
GitHub - nikmcfly/ANUS
Contribute to nikmcfly/ANUS development by creating an account on GitHub.
github.com
March 10, 2025 at 9:30 AM
I present this as an example of how humans can still misstep when dealing with AI. Particularly when it comes to naming conventions
