Ke Xie
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kexie.bsky.social
Ke Xie
@kexie.bsky.social
91 followers 170 following 16 posts
PhD candidate @MICA Lab (https://mica-mni.github.io/index.html) @McGill University @Montreal Neurological Institute
epilepsy | neuroimaging | connectomics
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kexie.bsky.social
Ke Xie @kexie.bsky.social · 1d
📢 Publication Alter!
🎉 Excited to share that our work, “Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy”, is now out in Nature Communications #TLE #MRI #biomarker

🔗 Full paper: rdcu.be/eQKLX
📣 Full post (credit to @borismontreal.bsky.social): bit.ly/48uJL7r
kexie.bsky.social
📢 Publication Alter!
🎉 Excited to share that our work, “Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy”, is now out in Nature Communications #TLE #MRI #biomarker

🔗 Full paper: rdcu.be/eQKLX
📣 Full post (credit to @borismontreal.bsky.social): bit.ly/48uJL7r
November 24, 2025 at 2:17 PM
Reposted by Ke Xie
pjawinski.bsky.social
🧠 Why do some brains age faster than others?
🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age.
nature.com/articles/s43587-025-00962-7

Thread below 👇
Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging
This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type 2 diabetes as causal factors of brain aging.
nature.com
October 7, 2025 at 9:38 AM
Reposted by Ke Xie
randolph-helfrich.bsky.social
New work from the lab published in @cp-neuron.bsky.social by @jonasterlau.bsky.social and Jan Martini. We describe that trial-by-trial variability indexes recurrent connectivity across the cortical hierarchy, which supports reliable and flexible coding www.cell.com/neuron/abstr... (1/4)
Structure in noise: Recurrent connectivity shapes neural variability to balance perceptual and cognitive demands in the human brain
Does neural variability reflect random noise or a feature that benefits adaptive behavior? Using intracranial recordings in humans, Terlau et al. demonstrate that neural variability results from the r...
www.cell.com
November 10, 2025 at 5:06 PM
Reposted by Ke Xie
jonahpadawercurry.bsky.social
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵

nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
nature.com
October 15, 2025 at 8:18 PM
Reposted by Ke Xie
borismontreal.bsky.social
🚨 New paper in Nature Methods:
HippoMaps: multiscale cartography of the human hippocampus

Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)

Led by @jordandekraker.bsky.social

docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...
October 2, 2025 at 11:50 AM
Reposted by Ke Xie
vw1234.bsky.social
This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app.

Article: www.nature.com/articles/s41...
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
www.nature.com
October 1, 2025 at 4:05 PM
Reposted by Ke Xie
francescasaviola.bsky.social
Excited to share such a career milestone 🌟 Our new @pnas.org paper shows how E–I balance drives dynamic brain adaptation.

Thanks to @jorgejovicich.bsky.social, @dimitrivdv.bsky.social, @asiaferrari.bsky.social, @bcassone.bsky.social & amazing co-authors 🙏
🔗 www.pnas.org/doi/10.1073/...
Disentangling metabolic and neurovascular timescales supporting cognitive processes | PNAS
The balance between neural excitation and inhibition (EIB), governed by glutamatergic and GABAergic neurotransmission, is an essential mechanism su...
www.pnas.org
September 24, 2025 at 7:41 AM
Reposted by Ke Xie
jingnandu.bsky.social
Our new paper is out now in Neuron! 🎉 With @vaibhavtripathi.bsky.social @maxwellelliott.bsky.social Joanna Ladopoulou, Wendy Sun, Mark Eldaief, and Randy Buckner

Paper link: www.sciencedirect.com/science/arti...
September 26, 2025 at 3:25 PM
Reposted by Ke Xie
zachrosenthal.bsky.social
Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology
Arousal as a universal embedding for spatiotemporal brain dynamics - Nature
Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.
www.nature.com
September 24, 2025 at 9:52 PM
Reposted by Ke Xie
julianneumann.bsky.social
New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !

We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.

www.nature.com/articles/s41...
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering
A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.
www.nature.com
September 24, 2025 at 12:01 PM
Reposted by Ke Xie
fraser-a.bsky.social
Our review discussing the potential use of laminar fMRI for probing the role of cortical layers in epileptic seizure propagation and spread as well as it possible future clinical applications out in Brain (well as accepted manuscript!)

academic.oup.com/brain/advanc...
The potential of laminar functional MRI in refining the understanding of epilepsy in humans
Aitken et al. highlight laminar fMRI as a tool to connect the neural effects of anti-seizure medications with the microcircuits that generate seizures in e
academic.oup.com
September 3, 2025 at 7:24 PM
Reposted by Ke Xie
jwirsich.bsky.social
Interested in Epileptic Discharges? In need of a data set to validate your source reconstruction models based on clinical outcome? Check out our newest: www.nature.com/articles/s41...
Big thanks to B. Vorderwülbecke, S. Vuillémoz et al. ! - @seeber.bsky.social @cibm.bsky.social
High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome - Scientific Data
Scientific Data - High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome
www.nature.com
August 18, 2025 at 11:33 AM
Reposted by Ke Xie
misicbata.bsky.social
Integrating and interpreting brain maps | doi.org/10.1016/j.ti...

Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
August 4, 2025 at 2:27 PM
Reposted by Ke Xie
mattperich.bsky.social
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!

🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
A neural manifold view of the brain - Nature Neuroscience
Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...
www.nature.com
July 29, 2025 at 7:06 PM
Reposted by Ke Xie
bttyeo.bsky.social
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...
July 17, 2025 at 1:36 AM
Reposted by Ke Xie
drdamienfair.bsky.social
Alert! ... for the child development world!

@fluxsociety.bsky.social @fitngin.bsky.social ‪

The Healthy Brain and Child Development (HBCD) Study has released its first data wave - it’s massive.

Check here:
docs.hbcdstudy.org

and here:
nbdc-datahub.org

Here’s why it matters 🧠🍼
June 29, 2025 at 2:18 AM
Reposted by Ke Xie
laurenahart.bsky.social
🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:24 PM
Reposted by Ke Xie
peternealtaylor.bsky.social
Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery - Kozma - Epilepsia - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery
Objective Drug-resistant focal epilepsy is associated with abnormalities in the brain in both gray matter (GM) and superficial white matter (SWM). However, it is unknown if both types of abnormaliti...
onlinelibrary.wiley.com
June 11, 2025 at 7:49 AM
Reposted by Ke Xie
peternealtaylor.bsky.social
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities - Horsley - Epilepsia - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities
Objective Successful epilepsy surgery requires accurate localization and removal of the epileptogenic zone. Neuroimaging helps detect structural brain abnormalities to guide surgery, but current cli...
onlinelibrary.wiley.com
June 11, 2025 at 7:50 AM
Reposted by Ke Xie
amykooz.bsky.social
RELEASE THE KRAKEN(CODER)!
Ever struggle deciding which connectome pipeline to use or want to map between structure and function? Our multi-modal connectome mapping and fusion tool-the Krakencoder-can help! Brilliant Keith Jamison led this work, code available! www.nature.com/articles/s41...
June 5, 2025 at 1:55 PM
Reposted by Ke Xie
lucinauddin.bsky.social
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
The history and future of resting-state functional magnetic resonance imaging - Nature
This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...
www.nature.com
May 28, 2025 at 3:52 PM
Reposted by Ke Xie
gradientsworkshop.bsky.social
The gradients workshop is happening soon! Please join us on June 23rd in Brisbane for a full day of gradient fun! 🌈

✅ Amazing speaker line up
✅ Poster presentation
✅ Flash talks for selected abstracts

Deets on program, abstract submission, and registration 👉 gradients-workshop.github.io
Gradients of Brain Organisation, Brisbane 2025
GRADIENTS WORKSHOP
gradients-workshop.github.io
May 12, 2025 at 1:55 PM
Reposted by Ke Xie
tsbolt.bsky.social
First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ...

www.nature.com/articles/s41...

Read here:
rdcu.be/ek01F
Autonomic physiological coupling of the global fMRI signal
Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.
rdcu.be
May 7, 2025 at 1:42 PM
Reposted by Ke Xie
saratheriver.bsky.social
My lab has two fully funded MSc/PhD positions available!

* Cool research on neuroimaging, epilepsy, and brain development ⚡️
* Located in a brand new building with lots of natural light 🌱
* Worldwide collaborations 🤝🏼
* Fun and inclusive environment 🤩

Learn more and apply 👉🏼 slic-lab.github.io
Sherbrooke Laboratory for Integrative Connectomics | SLIC
Exploring cutting-edge research in neuroimaging, epilepsy, brain development, and so much more!
slic-lab.github.io
May 4, 2025 at 2:08 PM
kexie.bsky.social
✨ What makes the brain's functional organization different in each #TLE patient? 🧠
✨ We used a large sample (298 healthy adults, 282 TLE, 45 disease controls) + normative modeling to capture individualized functional disruptions. 🔎 #epilepsy #neuroimaging #precisionmedicine
doi.org/10.1101/2025...
Personalized Biomarkers of Multiscale Functional Alterations in Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) presents with substantial inter-patient variability in clinical and neuroimaging manifestations. This multicenter study examined inter-individual differences in spatial pa...
doi.org
April 27, 2025 at 7:48 AM