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Klaus Kaestner @kkaestner.bsky.social · Aug 28

house mouse maintains constant telomere length throughout life url: academic.oup.com/nar/article/...

The house mouse maintains constant telomere length throughout life

Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length

academic.oup.com

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Klaus Kaestner @kkaestner.bsky.social · Jun 30

Dear Erik, not sure if you have added me yet to the feed.
If not, here the link to my lab page. Best, Klaus

www.med.upenn.edu/kaestnerlab/

Welcome to the Kaestner Lab | Kaestner Lab | Perelman School of Medicine at the University of Pennsylvania

www.med.upenn.edu

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Klaus Kaestner @kkaestner.bsky.social · Jun 30

Happy to announce that HPAP now has some 180 human pancreatic analyzed by highly multiplexed CODEX analysis. Thanks to Dr. Powers and the whole HPAP team! Here is the link to the experiment data download page: hpap.pmacs.upenn.edu/explore/down...
🧪

hpap.pmacs.upenn.edu

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Klaus Kaestner @kkaestner.bsky.social · Jun 25

Very proud indeed to have been together on a stage celebrating NIDDK's 75th anniversary at the recent ADA meeting in Chicago with Drs Rogers, Cefalu, Gubitosi-Klug and Kirscher. Always grateful for NIDDK's support of our research! 🧪

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Klaus Kaestner @kkaestner.bsky.social · Jun 25

@aoxing2.bsky.social

Klaus Kaestner @kkaestner.bsky.social · Jun 18

Very happy to share the results of a multi-national scientific collaboration on the factors that control telomere length. Hope you like it! Best, Klaus

academic.oup.com/nar/article-...

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1

Abstract. RTEL1 is an essential DNA helicase that plays multiple roles in genome stability and telomere length regulation. The ultra-long telomeres of the

academic.oup.com

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Klaus Kaestner @kkaestner.bsky.social · Jun 17

I was truly honored to contribute as Keynote speaker to the 25th meeting of the European Islet Study Group in Malmo, Sweden. Fantastic meeting, lots of progress on all fronts! See you all next year in Barcelona!

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Klaus Kaestner @kkaestner.bsky.social · Jun 13

Thank you, Christos, for the shoutout! It was a great honor to be invited as Keynote speaker to the European Islet Study Group conference in Malmo. Great meeting, I learned a lot!

Christos Karampelias @ckarampelias.bsky.social · Jun 13

Great overview of HPAP consortium and exciting new projects by @kkaestner.bsky.social to start day 3 at @eisg2025.bsky.social #eisg2025

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Klaus Kaestner @kkaestner.bsky.social · May 23

What really happens at the onset of type 1 diabetes? The HPAP team profiled the immune system of the lymph nodes near the pancreas, the reservoir of the relevant immune cells. Read more here: www.nature.com/articles/s41...
🧪

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset - Nature Communications

The status of immune cells within human pancreatic lymphatic tissues during the onset and progression of type 1 diabetes (T1D) is underexplored. Here, by flow cytometry and CITEseq, the authors profil...

www.nature.com

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Klaus Kaestner @kkaestner.bsky.social · May 23

🧪 Postdoc positions open! Fully funded

Reposted by Klaus Kaestner

Klaus Kaestner @kkaestner.bsky.social · May 20

Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to [email protected]

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Klaus Kaestner @kkaestner.bsky.social · May 20

A wonderful day, celebration the recently graduated Dr. Michelle Lee at the UPenn hooding ceremony.

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Klaus Kaestner @kkaestner.bsky.social · May 20

Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to [email protected]

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Klaus Kaestner @kkaestner.bsky.social · Apr 28

Do the islet biology community, we have good news.
Good news- the HPAP islet perifusion dashboard for glucagon and insulin secretion is now live on PANC-DB:

hpap.pmacs.upenn.edu/explore/peri...

🧪

hpap.pmacs.upenn.edu

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Klaus Kaestner @kkaestner.bsky.social · Apr 4

It appears that Biotech is no longer an attractive option 🧪

www.inquirer.com/health/spark...

Spark Therapeutics is laying off 337 people, more than half its workforce, starting in May

The layoffs at the gene therapy company are part of restructuring of Spark Therapeutics by its owner, Roche Group.

www.inquirer.com

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Klaus Kaestner @kkaestner.bsky.social · Mar 22

True indeed. Another problem it considered by the government is that gaps in funding force us to lay off well-trained, efficient people. Even is funding is restored later, these scientists will have moved on, and retraining new staff takes time and impairs research progress

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Klaus Kaestner @kkaestner.bsky.social · Mar 11

Indeed. Mr Musk lost over 90 billion in the last three months
May be he should focus on his business

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Reposted by Klaus Kaestner

Mike Schatz @mikeschatz.bsky.social · Mar 8

One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social

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Klaus Kaestner @kkaestner.bsky.social · Mar 7

Amazing that so many people came out!

Klaus Kaestner @kkaestner.bsky.social · Mar 7

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Klaus Kaestner @kkaestner.bsky.social · Mar 7

Great to see thousands at the rally to save science in Philadelphia today! A truly inspiring event!

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Klaus Kaestner @kkaestner.bsky.social · Feb 25

Yes, I am extremely worried about this. Several universities, including UPenn, are considering or have decided to accept fewer PhD students this year - who will staff the high tech labs and regulatory agencies in the future?

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Klaus Kaestner @kkaestner.bsky.social · Feb 25

Of course - make the rich richer while taking health care aware from those who cannot afford it

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Klaus Kaestner @kkaestner.bsky.social · Feb 20

Dear Friends,
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...

Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas

Spontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin secreting beta cells has been observed in mouse but not in human islets1. Here, we analyzed the largest single cell d...

www.biorxiv.org

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