Kate Michie
@kmichie.bsky.social
Interested in Structural Biology, deep learning, NextFlow, HPC, viruses, missense mutations archaea, bacteria, evolution & random quirks of nature. (Protein Cosmos feed 🧶🧬) Leads a research group & Structural biology Facility,UNSW Sydney. Opinions my own.
Reposted by Kate Michie
Celebrating the scientific legacy of Shin-Ho Chung to #biophysics at the @aus-soc-biophys.bsky.social meeting #ASB2025 on the Gold Coast with excellent presentations by Toby Allen, Ben Corry, Evelyne Deplazes, Elaine Tao, Jennifer Deuis, and @ciarawallis.bsky.social
November 25, 2025 at 2:03 PM
Celebrating the scientific legacy of Shin-Ho Chung to #biophysics at the @aus-soc-biophys.bsky.social meeting #ASB2025 on the Gold Coast with excellent presentations by Toby Allen, Ben Corry, Evelyne Deplazes, Elaine Tao, Jennifer Deuis, and @ciarawallis.bsky.social
Reposted by Kate Michie
Hearty congratulations to Assoc. Prof. Matthew Baker @phatmattbaker.bsky.social who was awarded the MacAulay-Hope Prize for originality and innovation in #biophysics at the @aus-soc-biophys.bsky.social meeting #ASB2025 at Griffith University Gold Coast campus.
November 25, 2025 at 2:37 PM
Hearty congratulations to Assoc. Prof. Matthew Baker @phatmattbaker.bsky.social who was awarded the MacAulay-Hope Prize for originality and innovation in #biophysics at the @aus-soc-biophys.bsky.social meeting #ASB2025 at Griffith University Gold Coast campus.
🤩 I’m biased but… so sorry to have missed this.
Tom Litfin on LMIBoltz -optimising VRAM in the AF3-like model Boltz2 in modelling huge complexes - saving us from getting a bigger GPU! #ABACBS2025
November 26, 2025 at 3:14 AM
🤩 I’m biased but… so sorry to have missed this.
DECRAs are out! Good luck young investigators. If you are unlucky- please don't let this moment define you.
#ARC
#ARC
Research Management System - Scheme Round Statistics for Approved Applications - Discovery Early Career Researcher Award 2026 round 1
RMS is the ARC's Research Management System, a web-based system used by eligible researchers to prepare and submit research proposals and assessments under the ARC National Competitive Grants Program ...
rms.arc.gov.au
November 25, 2025 at 12:15 AM
DECRAs are out! Good luck young investigators. If you are unlucky- please don't let this moment define you.
#ARC
#ARC
Reposted by Kate Michie
Registration for #APSPM2026 closes soon.
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
November 23, 2025 at 10:03 PM
Registration for #APSPM2026 closes soon.
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
Reposted by Kate Michie
The Wollongong crew have arrived in the gold coast for the #ASB2025 meeting! Just missing @lisannes.bsky.social who had presidential matters to attend to.
Looking forward to the week of great science and catching up with the biophysics community in Aus!
Looking forward to the week of great science and catching up with the biophysics community in Aus!
November 23, 2025 at 4:38 AM
The Wollongong crew have arrived in the gold coast for the #ASB2025 meeting! Just missing @lisannes.bsky.social who had presidential matters to attend to.
Looking forward to the week of great science and catching up with the biophysics community in Aus!
Looking forward to the week of great science and catching up with the biophysics community in Aus!
Reposted by Kate Michie
Congratulations to Prof. Adelle Coster, UNSW, to whom I was honoured to present the 2025 Australian Society for Biophysics (ASB) Bob Roberston medal during ASB2025 at @griffith.edu.au. Adelle is pictured with ASB President, @lisannes.bsky.social; inaugural awardee Hans Coster; & myself 2009 medal.
November 23, 2025 at 10:42 AM
Congratulations to Prof. Adelle Coster, UNSW, to whom I was honoured to present the 2025 Australian Society for Biophysics (ASB) Bob Roberston medal during ASB2025 at @griffith.edu.au. Adelle is pictured with ASB President, @lisannes.bsky.social; inaugural awardee Hans Coster; & myself 2009 medal.
@costalaboratory.bsky.social Nice presentation at the Australian Biophysics conference. Amazing series of Cryo EM structures.
November 23, 2025 at 6:32 AM
@costalaboratory.bsky.social Nice presentation at the Australian Biophysics conference. Amazing series of Cryo EM structures.
🤩🥰 Exciting! Good luck 😉
November 15, 2025 at 1:47 AM
🤩🥰 Exciting! Good luck 😉
Our ‘conservatives’ in Oz are debating dropping ‘net zero’ in favour apparently of burning Rome for personal gain. I do wonder at times if they can read, or if they ever go outside. Too busy counting their own pennies to see the bigger picture. How does this sit with Gen Y and Z? 🤔
November 3, 2025 at 6:14 AM
Our ‘conservatives’ in Oz are debating dropping ‘net zero’ in favour apparently of burning Rome for personal gain. I do wonder at times if they can read, or if they ever go outside. Too busy counting their own pennies to see the bigger picture. How does this sit with Gen Y and Z? 🤔
This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬
LMI4Boltz: Optimizing VRAM utilization to predict large macromolecular complexes with consumer grade hardware
AlphaFold2 has revolutionized structural biology by enabling the prediction of protein structures approaching experimental quality. AlphaFold3 extends this framework to support modelling broad biomole...
www.biorxiv.org
October 31, 2025 at 9:40 PM
This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬
Reposted by Kate Michie
🧶🧬 We present LMi4Boltz:
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
October 31, 2025 at 8:54 PM
🧶🧬 We present LMi4Boltz:
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
Hey Tristan @crolltristan.bsky.social - thought you might have a giggle at this bit of AI... while Googling for a video to show someone Isolde, this AI summary about came up- are you feeling like a action-romance hero? 🤣🧶🧬
October 14, 2025 at 9:53 PM
Hey Tristan @crolltristan.bsky.social - thought you might have a giggle at this bit of AI... while Googling for a video to show someone Isolde, this AI summary about came up- are you feeling like a action-romance hero? 🤣🧶🧬
I’m finding it harder and harder to be here- not a statement about the state of bluesky, rather a statement about the world. What the hell went wrong with everyone??? I’m so sorry 😞. Our children deserve better. It’s so embarrassing for me to try to explain to my kids how we ended up here.
October 8, 2025 at 6:46 AM
I’m finding it harder and harder to be here- not a statement about the state of bluesky, rather a statement about the world. What the hell went wrong with everyone??? I’m so sorry 😞. Our children deserve better. It’s so embarrassing for me to try to explain to my kids how we ended up here.
Just a heads up to anyone interested. @joshuamhardy.bsky.social will be presenting Protein DJ next week at the Australian Structural Biology Computing “Protein Design Seminars” hosted by @ausbiocommons.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
WEBINAR SERIES: Leveraging deep learning to design custom protein-binding proteins — Australian BioCommons
Be inspired by case studies that show you how deep learning methods are speeding up the process of designing proteins with desirable biophysical properties. More information Register
www.biocommons.org.au
October 2, 2025 at 10:19 PM
Just a heads up to anyone interested. @joshuamhardy.bsky.social will be presenting Protein DJ next week at the Australian Structural Biology Computing “Protein Design Seminars” hosted by @ausbiocommons.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Do you like working on diverse projects with a range of researchers? New hire for a genomics/proteomics ( not structural biology) bioinformatician in the Mark Wainwright Analytical Centre at UNSW in sunny Sydney. Position hosted by the Stats Central team.
Bioinformatician (Level A or B)
Join the highly successful Mark Wainwright Analytical Centre and build the capacity of UNSW researchers and research students to process and analyse complex genomic and proteomic datasets.
external-careers.jobs.unsw.edu.au
October 2, 2025 at 2:32 AM
Do you like working on diverse projects with a range of researchers? New hire for a genomics/proteomics ( not structural biology) bioinformatician in the Mark Wainwright Analytical Centre at UNSW in sunny Sydney. Position hosted by the Stats Central team.
@sofiaisella.bsky.social “I can be your mother + the singles”. Amazing album. Spinning on the turntable on repeat.
October 1, 2025 at 9:50 PM
@sofiaisella.bsky.social “I can be your mother + the singles”. Amazing album. Spinning on the turntable on repeat.
🥳🧶🧬
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
September 28, 2025 at 10:49 PM
🥳🧶🧬
So lovely to see this story yesterday on SMC complexes presented by Prof Jan Löwe ( MRC LMB). It’s been a long journey and is still evolving but is a structural biology tour de force. @mrclmb.bsky.social @unswbabs.bsky.social
September 19, 2025 at 4:29 AM
So lovely to see this story yesterday on SMC complexes presented by Prof Jan Löwe ( MRC LMB). It’s been a long journey and is still evolving but is a structural biology tour de force. @mrclmb.bsky.social @unswbabs.bsky.social
🧶🧬
🚨🧠🔬 A major breakthrough in molecular neuroscience:
I am excited to share a new story from our lab, published in accelerated format today by @nature.com:
"Delta-type glutamate receptors are ligand-gated ion channels"
Read more here (free article link): rdcu.be/eGIKz
I am excited to share a new story from our lab, published in accelerated format today by @nature.com:
"Delta-type glutamate receptors are ligand-gated ion channels"
Read more here (free article link): rdcu.be/eGIKz
September 16, 2025 at 9:33 PM
🧶🧬
🤩🧶🧬
Molecular structure of the ESCRT III-based archaeal CdvAB cell division machinery https://www.biorxiv.org/content/10.1101/2025.09.15.676241v1
September 16, 2025 at 5:30 AM
🤩🧶🧬
😳😬 careful folks.
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 16, 2025 at 5:12 AM
😳😬 careful folks.
🤩🧬🧶
💥 We are *also* organizing Machine Learning for Structural Biology @ EurIPS, Copenhagen!!
Topics include anything in the ML+bio intersection.
Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀
Topics include anything in the ML+bio intersection.
Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀
You asked and we listened... @workshopmlsb.bsky.social is excited to be expanding to Copenhagen, DK at @euripsconf.bsky.social 🎉
Two workshops (San Diego & Copenhagen) will run concurrently to support broader attendance. You can indicate your location preference(s) in the submission portal💫
Two workshops (San Diego & Copenhagen) will run concurrently to support broader attendance. You can indicate your location preference(s) in the submission portal💫
September 13, 2025 at 8:43 AM
🤩🧬🧶
🧬🧶 This is a really nice story integrating a number of methods to look at the evolution of a cool protein complex with a focus on protein structure. I love how biology keeps using the same tricks.
🧵In collaboration with Caroline Puente-Lelievre, Ed Moody, Rosie Cater, and Tom Williams we just submitted a new paper describing the prokaryotic origins of the COMMD protein family. @cpuentelelievre.bsky.social, @rosemaryjcater.bsky.social. @kmichie.bsky.social. 1/n
The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking
The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domai...
www.biorxiv.org
September 4, 2025 at 10:42 PM
🧬🧶 This is a really nice story integrating a number of methods to look at the evolution of a cool protein complex with a focus on protein structure. I love how biology keeps using the same tricks.