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Reposted by Darrell Kotton

Angie Serrano @mangieserrano.bsky.social · 3d

Yesterday, October 7, Sir John Gurdon passed away.
Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka.
Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.

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Reposted by Darrell Kotton

Killian Hurley @killianhurley.bsky.social · Jul 14

Delighted to give a talk at the Vermont Lung Stem Cell Conference last week.

Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social

#CureIPF

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Darrell Kotton @kottond.bsky.social · 2d

Thrilled to host Dr. Hao Zhu
@crem-boston.bsky.social
as this year's 10th anniversary Annual Anita Kurmann Memorial Lecturer! Inspiring science from the
@Zhu_Lab
in Anita's honor. #itsthecells

Darrell Kotton @kottond.bsky.social · 8d

Excited to help spread the word about the latest advances in stem cell research! #itsthecells!

Boston University Chobanian & Avedisian School of Medicine @bumedicine.bsky.social · 8d

Congratulations to BU's Darrel Kotton, MD, who has joined 12 other distinguished researchers on the editorial board for Stem Cell Reports, the official journal of the International Society for Stem Cell Research.

Stem Cell Reports @stemcellreports.bsky.social · 8d

Stem Cell Reports welcomes new researchers to its Editorial Board. Their appointments reinforce the Board’s commitment to championing the journal, raising its global visibility, and ensuring rigorous, high-quality peer review. Read more: ow.ly/YicL50X5QJF

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Darrell Kotton @kottond.bsky.social · 10d

Great research by our own, Dr. Elizabeth Taglauer @The_BMC @CReM_Boston, featured today: "One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies" healthcity.bmc.org/one-nicu-doc... #itsthecells #helpisontheway!

One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies

Dr. Elizabeth Taglauer uses lung cells to study placental biology and how the placenta can disrupt babies’ development in preeclampsia.

healthcity.bmc.org

Darrell Kotton @kottond.bsky.social · 10d

Announcing our latest publication, just out today
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications

The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.

www.nature.com

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Reposted by Darrell Kotton

Rod Rahimi @rodrahimi.bsky.social · Sep 7

“David Baltimore, a biologist who in 1975 won a Nobel Prize for a startling discovery that seemed to rock the foundations of the fledgling field of molecular biology, died on Saturday at his home in Woods Hole, Mass. He was 87.”🧪🩺

www.nytimes.com

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Darrell Kotton @kottond.bsky.social · Sep 8

An incredible advance in regenerative medicine, published this week: Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM: www.nejm.org/doi/full/10....

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

www.nejm.org

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Darrell Kotton @kottond.bsky.social · Aug 7

Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: #itsthecells! #helpisontheway! Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | www.nejm.org/doi/full/10....

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM

The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

www.nejm.org

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Darrell Kotton @kottond.bsky.social · Aug 5

So great to be together with so many @CReM_Boston alumni and current members at the #2025LungGRC!

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Reposted by Darrell Kotton

Bernard Mari @bernard-mari.bsky.social · Aug 1

The #RespirERA IHU was out in force at the #2025LungGRC in Lucca with Manon Durandy, Laetitia Seguin (IRCAN) and @laure-em.bsky.social #IPMC Great science, wonderful exchanges with old colleagues and new connections and what a gorgeous place ! #LungResearch

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Darrell Kotton @kottond.bsky.social · Aug 1

Farewell #2025LungGRC! Great memories as we say farewell, handing off the ball to our new Chairs. #2025LungGRC. @GordonConf

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Darrell Kotton @kottond.bsky.social · Aug 1

The traditional epithelium vs mesenchyme soccer game, won this year by a new team, Bronchospurs at the 2025 Lung Gordon Research Conference! #2025LungGRC. @GordonConf

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Darrell Kotton @kottond.bsky.social · Jul 31

Today we officially hand over our meeting Chair roles to the next Chairs: Drs. Cardoso and Crotty Alexander on Day 5 of the 2025 Lung Gordon Research Conference. Special thanks to Dr. Sue Majka, current Chair!

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Darrell Kotton @kottond.bsky.social · Jul 28

And we are live at the #grclung2025 in Tuscany!

KaminskiMed @kaminskimed.bsky.social · Jul 27

At 9:45PM, the lecture hall in Tuscany is still full, discussion going strong, although half of the attendees just flew across the Atlantic. That’s the spirit of science I love
Gordon Conference of Lung Development, Injury and Repair.
#GRCLung2025
#ScienceMatters
#LungResearchersAreBest

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Darrell Kotton @kottond.bsky.social · Jul 11

Our latest work, just out now at JCI Insight on iPSC modeling of pulmonary fibrosis. The latest chapter in the Kotton-Beers collaboration! Congrats to co-first authors Drs. Rodriguez and Alysandratos for leading the way! insight.jci.org/articles/vie...

JCI Insight - Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis

insight.jci.org

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Darrell Kotton @kottond.bsky.social · Jun 30

Congrats @MingxiaGu and all the teams collaborating on this latest advance in stem cell and lung organoid research, just out @CellCellPress! and thanks for including our iPSCs! www.cell.com/cell/fulltex...

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

Recapitulating the concurrent development of germ layers through the co-differentiation of mesoderm and endoderm within a single spheroid enabled the generation of vascularized lung and intestinal org...

www.cell.com

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Darrell Kotton @kottond.bsky.social · Jun 21

Truly amazing pluripotent stem cell clinical trial results for diabetes! “Off-the-shelf stem cell therapy for type 1 diabetes yields more positive results”. Also published in ⁦‪@NEJM‬⁩ this week. #helpisontheway!
www.statnews.com/2025/06/20/s...

Off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results

An off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results, according to a new study.

www.statnews.com

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Reposted by Darrell Kotton

Stand Up for Science! @standupforscience.bsky.social · May 28

RFK Jr. plans to bar NIH scientists from top journals like NEJM & JAMA, replacing them with government-run outlets.

This would delegitimize taxpayer-funded research, warns Dr. Adam Gaffney of Harvard Medical School.

www.washingtonpost.com/health/2025/...

RFK Jr. says he may bar scientists from publishing in top medical journals

Health Secretary Robert F. Kennedy Jr. took aim at reputed journals such as the Lancet and said his agency will create “in-house” publications instead.

www.washingtonpost.com

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Darrell Kotton @kottond.bsky.social · May 18

“This is incredibly disappointing,” said Dr. Camille Kotton, an infectious diseases physician who cares for immunocompromised patients, and a former adviser to the CDC

”I don’t know why they would make this restriction; I don’t know of any indication to make this change,”

F.D.A. Approves Novavax Covid Vaccine With Stricter New Conditions

www.nytimes.com

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Darrell Kotton @kottond.bsky.social · May 15

An amazing clinical triumph for regenerative medicine! A great example of how federal funding results in patient cures. Let’s keep these stories going, America! “World's First Patient Treated with Personalized CRISPR Therapy” #helpisontheway!

www.pennmedicine.org/news/news-re...

World's First Patient Treated with Personalized CRISPR Therapy

In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children’s Hospital of Phila...

www.pennmedicine.org

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Reposted by Darrell Kotton

American Thoracic Society (ATS) @atscommunity.bsky.social · Apr 16

The ATS is pleased to recognize Lauren Kearney, MD, as the 2025 Ziskind Clinical Research Scholar Award winner. Dr. Kearney aims to advance early detection of lung cancer, increase access to preventive care and treatment, and reduce health disparities.

Read more: www.thoracic.org/professional...

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Reposted by Darrell Kotton

Astronomy 🔭 @astronomy.bsky.social · Apr 8

"There is perhaps no better demonstration of the folly of human conceits than this distant image of our tiny world. To me, it underscores our responsibility to deal more kindly with one another, and to preserve and cherish the pale blue dot, the only home we've ever known." - Carl Sagan

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Reposted by Darrell Kotton

crem-boston.bsky.social @crem-boston.bsky.social · May 2

We are so proud of our director, @kottond.bsky.social, for being awarded BU’s Innovator of the Year!

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Darrell Kotton @kottond.bsky.social · May 6

So grateful to all our team- current and past graduates of our lab — and to all the 10 faculty leaders who each lead teams of innovators at the CReM #itsthecells!

crem-boston.bsky.social @crem-boston.bsky.social · May 2

🎉 Pulmonologist Darrell Kotton is BU’s Innovator of the Year:
www.bu.edu/articles/202...

Pulmonologist Darrell Kotton Is BU’s Innovator of the Year

Regenerative medicine researcher is recognized for his work in pioneering lung disease treatments with stem cell technology and accelerating scientific discovery with open-access resources

www.bu.edu

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