LabSoap
@labsoap.bsky.social
220 followers
270 following
59 posts
S.O.A.P. Team in Nantes, France
Led by Julie Gavard & Nicolas Bidere
Signaling in Oncogenesis, Angiogenesis, and Permeability
#glioblastoma #cancer #research
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LabSoap
@labsoap.bsky.social
· 10d
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature
Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with anti-inflammatory interventions.
www.nature.com
LabSoap
@labsoap.bsky.social
· Sep 1
DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species - Nature Communications
Cancer stem-like cells contribute to tumor growth and therapy resistance in glioblastoma. Here, authors identify that DHRS13 inhibition promotes differentiation of glioma stem-like cells by activating...
www.nature.com
Reposted by LabSoap
CNRS Biologie
@cnrsbiologie.bsky.social
· Aug 27
LabSoap
@labsoap.bsky.social
· Aug 27
LabSoap
@labsoap.bsky.social
· Aug 27
LabSoap
@labsoap.bsky.social
· Jul 7
WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature
During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent...
www.nature.com
LabSoap
@labsoap.bsky.social
· Jul 1
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
LabSoap
@labsoap.bsky.social
· Jun 23
Red blood cells undergo lytic programmed cell death involving NLRP3
Complement exposure induces programmed cell death of red blood cells due to the intracellular
activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal
damage and prevents...
www.cell.com
LabSoap
@labsoap.bsky.social
· Jun 16
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs
This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement
and its regulation by non-degradative polyubiquitination within the tumor microenvironment.
The findings highlight...
www.cell.com
LabSoap
@labsoap.bsky.social
· Jun 10
Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches - Nature Cancer
Kang et al. define distinct spatial niches within glioblastoma (GBM) tumors according to their infiltrative nature and report that glioma cells induce microglia and macrophage alignments through plexi...
www.nature.com
Reposted by LabSoap
LabSoap
@labsoap.bsky.social
· May 26
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
LabSoap
@labsoap.bsky.social
· May 12
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature
Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...
www.nature.com
LabSoap
@labsoap.bsky.social
· Apr 22
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
PDGFRA is commonly altered in pediatric HGG. Mayr et al. report that the PDGFRA/KIT
inhibitor avapritinib demonstrates on-target activity, brain penetrance, and survival
benefit in pre-clinical H3K27M...
www.cell.com
LabSoap
@labsoap.bsky.social
· Apr 14
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
