Vincenzo Costanzo
@labvincenzo.bsky.social
We study mechanisms promoting genome stability altered in cancer cells
Reposted by Vincenzo Costanzo
Happy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...
September 10, 2025 at 5:32 PM
Happy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...
Reposted by Vincenzo Costanzo
Come and join us to celebrate the 10th anniversary of the BCGB, with a great selection of international speakers! Very convenient conference, open to anyone interested in the field of genome biology!
Home - Birmingham Centre for Genome Biology 2025
uobevents.eventsair.com
May 8, 2025 at 9:38 AM
Come and join us to celebrate the 10th anniversary of the BCGB, with a great selection of international speakers! Very convenient conference, open to anyone interested in the field of genome biology!
Reposted by Vincenzo Costanzo
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together! @albertociccia.bsky.social @labvincenzo.bsky.social
May 2, 2025 at 8:26 AM
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together! @albertociccia.bsky.social @labvincenzo.bsky.social
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
May 2, 2025 at 7:50 AM
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
Reposted by Vincenzo Costanzo
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
DNA Repair | The replication stress response: mechanisms and functions | ScienceDirect.com by ElsevierScienceDirect
High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...
www.sciencedirect.com
April 17, 2025 at 4:01 AM
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
Reposted by Vincenzo Costanzo
Interested in starting your cancer research career in London ?We're looking for a Scientific Officer to support our work on synthetic lethality in triple negative and BRCA1/2 mutant cancers. Ideal job for a new graduate who wants to kick start their research career. jobs.icr.ac.uk/vacancies/12...
Scientific Officer - Target Validation and DNA Damage Response Group (Prof Andrew Tutt) in Chelsea | The Institute of Cancer Research
View details and apply for this Scientific Officer - Target Validation and DNA Damage Response Group (Prof Andrew Tutt) vacancy in Chelsea .
Salary : Commencement on the salary range is s...
jobs.icr.ac.uk
April 14, 2025 at 7:51 AM
Interested in starting your cancer research career in London ?We're looking for a Scientific Officer to support our work on synthetic lethality in triple negative and BRCA1/2 mutant cancers. Ideal job for a new graduate who wants to kick start their research career. jobs.icr.ac.uk/vacancies/12...
Reposted by Vincenzo Costanzo
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
March 30, 2025 at 9:54 AM
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
Reposted by Vincenzo Costanzo
🙏 Thank you, @3reak.bsky.social, @labvincenzo.bsky.social, and Evident, for fantastic collaboration! Special thanks go to the exceptionally talented postdoc Paolo Fagherazzi and the brilliant image analysis specialist Timo Diekmann for their extraordinary efforts! 🙏
March 30, 2025 at 9:58 AM
🙏 Thank you, @3reak.bsky.social, @labvincenzo.bsky.social, and Evident, for fantastic collaboration! Special thanks go to the exceptionally talented postdoc Paolo Fagherazzi and the brilliant image analysis specialist Timo Diekmann for their extraordinary efforts! 🙏
March 28, 2025 at 4:45 PM
Reposted by Vincenzo Costanzo
Over five years of work has gone into our new preprint! The #cryoEM structure of a human RAD51 filament caught at the point of strand exchange 🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural mechanism of strand exchange by the RAD51 filament.
Homologous Recombination (HR) preserves genomic stability by repairing double-strand DNA breaks and ensuring efficient DNA replication. Central to HR is the strand-exchange reaction taking place within the three-stranded synapsis wherein a RAD51 nucleoprotein filament binds to a donor DNA. Here we present the cryoEM structure of a displacement loop of human RAD51 that captures the synaptic state when the filament has become tightly bound to the donor DNA. The structure elucidates the mechanism of strand exchange by RAD51, including the filament engagement with the donor DNA, the strand invasion and pairing with the complementary sequence of the donor DNA, the capture of the non-complementary strand and the polarity of the strand-exchange reaction. Our findings provide fundamental mechanistic insights into the biochemical reaction of eukaryotic HR. ### Competing Interest Statement The authors have declared no competing interest.
www.biorxiv.org
March 27, 2025 at 3:12 PM
Over five years of work has gone into our new preprint! The #cryoEM structure of a human RAD51 filament caught at the point of strand exchange 🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Vincenzo Costanzo
Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25.
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
KSQA: Dr. Kyungjae Myung (DNA Replication Gaps)
YouTube video by KeystoneSymposia
youtu.be
March 27, 2025 at 6:37 PM
Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25.
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Reposted by Vincenzo Costanzo
Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.
www.biorxiv.org/content/10.1...
Brief teaser:
www.biorxiv.org/content/10.1...
Brief teaser:
PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity
Genome replication in eukaryotic cells is surveyed by the S-phase checkpoint, which orchestrates sequential replication origin activation to avoid exhaustion of hitherto poorly defined rate-limiting r...
www.biorxiv.org
March 20, 2025 at 8:09 AM
Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.
www.biorxiv.org/content/10.1...
Brief teaser:
www.biorxiv.org/content/10.1...
Brief teaser:
Reposted by Vincenzo Costanzo
We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability
Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous
cells through distinct mechanisms, partly counteracting the mismatch repair factor
MLH1. In cancer cells, B...
www.cell.com
February 25, 2025 at 5:56 PM
We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Vincenzo Costanzo
📣 Register now for the next Genome Instability and Human Disease course at @institutcurie.bsky.social! Gain knowledge on genome stability, from fundamental molecular pathways up to large scale approaches.
▶️training.institut-curie.org/courses/genome-instability-and-human-disease-2025
▶️training.institut-curie.org/courses/genome-instability-and-human-disease-2025
January 10, 2025 at 9:57 AM
📣 Register now for the next Genome Instability and Human Disease course at @institutcurie.bsky.social! Gain knowledge on genome stability, from fundamental molecular pathways up to large scale approaches.
▶️training.institut-curie.org/courses/genome-instability-and-human-disease-2025
▶️training.institut-curie.org/courses/genome-instability-and-human-disease-2025
Reposted by Vincenzo Costanzo
NAR Cancer 5th anniversary symposium on manipulating DNA repair and the DDR - Session 2 this Thursday, Feb 13, noon US Eastern time. Kara Bernstein and Joanna Loizou speaking. In collaboration with Social DNAing. Information and free registration link at academic.oup.com/narcancer/pa...
February 11, 2025 at 3:56 PM
NAR Cancer 5th anniversary symposium on manipulating DNA repair and the DDR - Session 2 this Thursday, Feb 13, noon US Eastern time. Kara Bernstein and Joanna Loizou speaking. In collaboration with Social DNAing. Information and free registration link at academic.oup.com/narcancer/pa...
Reposted by Vincenzo Costanzo
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]
February 10, 2025 at 2:45 PM
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]
Reposted by Vincenzo Costanzo
Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk.
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
DNA Replication Gaps, Cancer and Disease | Keystone Symposia
Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!
www.keystonesymposia.org
January 17, 2025 at 11:35 AM
Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk.
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Reposted by Vincenzo Costanzo
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...
rdcu.be
January 21, 2025 at 5:26 PM
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk.
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
DNA Replication Gaps, Cancer and Disease | Keystone Symposia
Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!
www.keystonesymposia.org
January 17, 2025 at 11:35 AM
Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk.
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Reposted by Vincenzo Costanzo
Join Helle D. Ulrich & experts this April to explore DNA replication errors, breaks, repair, and cancer! Submit abstracts and scholarships by Jan. 28 (11:59pm MST)! keysym.us/KSDNARep25
#KSDNARep25 #DNAreplicationgaps @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
#KSDNARep25 #DNAreplicationgaps @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
January 14, 2025 at 4:52 PM
Join Helle D. Ulrich & experts this April to explore DNA replication errors, breaks, repair, and cancer! Submit abstracts and scholarships by Jan. 28 (11:59pm MST)! keysym.us/KSDNARep25
#KSDNARep25 #DNAreplicationgaps @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
#KSDNARep25 #DNAreplicationgaps @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Reposted by Vincenzo Costanzo
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
December 11, 2024 at 1:53 PM
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Reposted by Vincenzo Costanzo
Groundbreaking, first ever meeting dedicated to DNA GAPS
📅 Save the Date: April 27-30, 2025 | Daejeon, South Korea www.keystonesymposia.org/conferences/...
DNA Replication Gaps, Cancer and Disease | Keystone Symposia
Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!
www.keystonesymposia.org
November 24, 2024 at 1:17 AM
Groundbreaking, first ever meeting dedicated to DNA GAPS
📅 Save the Date: April 27-30, 2025 | Daejeon, South Korea www.keystonesymposia.org/conferences/...
Nice to be here! Take a look at our recent paper. Hope you like it: www.cell.com/molecular-ce...
RAD51 protects abasic sites to prevent replication fork breakage
Hanthi et al. found that RAD51 recognizes and binds to abasic sites. Together with
BRCA2, RAD51 prevents the accumulation of abasic site-induced replicative DNA gaps
(caused by DNA methylation, oxidat...
www.cell.com
November 12, 2024 at 10:37 AM
Nice to be here! Take a look at our recent paper. Hope you like it: www.cell.com/molecular-ce...