Laura Medlock
@lauramedlock.bsky.social
Postdoctoral Fellow at @uhn.ca & Krembil Brain Institute in the Bains Lab. Comp neuro, touch, and pain. 🧠🧑💻 they/them.
🔗 lauramedlock.com
🔗 lauramedlock.com
Join me this Tuesday at @kcnhub.bsky.social, where I’ll be sharing new computational insights into how the spinal cord processes complex touch—and what this reveals about allodynia and spinal cord stimulation.
🕔 Nov 25th 9:30-11am
📍 Krembil Brain Institute (@uhnresearch.ca)
🔗 tinyurl.com/287wdypa
🕔 Nov 25th 9:30-11am
📍 Krembil Brain Institute (@uhnresearch.ca)
🔗 tinyurl.com/287wdypa
November 20, 2025 at 8:44 PM
Join me this Tuesday at @kcnhub.bsky.social, where I’ll be sharing new computational insights into how the spinal cord processes complex touch—and what this reveals about allodynia and spinal cord stimulation.
🕔 Nov 25th 9:30-11am
📍 Krembil Brain Institute (@uhnresearch.ca)
🔗 tinyurl.com/287wdypa
🕔 Nov 25th 9:30-11am
📍 Krembil Brain Institute (@uhnresearch.ca)
🔗 tinyurl.com/287wdypa
Reposted by Laura Medlock
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
A neural manifold view of the brain - Nature Neuroscience
Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...
www.nature.com
July 29, 2025 at 7:06 PM
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
Reposted by Laura Medlock
My first-ever 1st author paper is now on bioRxiv 🙂 www.biorxiv.org/content/10.1...
Special thanks to my masters supervisor Steve Prescott!
Also with @lauramedlock.bsky.social , @cdedek.bsky.social & more
Special thanks to my masters supervisor Steve Prescott!
Also with @lauramedlock.bsky.social , @cdedek.bsky.social & more
Adaptation in somatosensory afferents improves rate and temporal coding of vibrotactile stimulus features
Adaptation is a common neural phenomenon wherein sustained stimulation evokes fewer action potentials (spikes) over time. Rather than simply reduce firing rate, adaptation may help neurons form better...
www.biorxiv.org
May 15, 2025 at 10:25 AM
My first-ever 1st author paper is now on bioRxiv 🙂 www.biorxiv.org/content/10.1...
Special thanks to my masters supervisor Steve Prescott!
Also with @lauramedlock.bsky.social , @cdedek.bsky.social & more
Special thanks to my masters supervisor Steve Prescott!
Also with @lauramedlock.bsky.social , @cdedek.bsky.social & more
Probably my favourite work of my PhD out now on #bioRxiv 🎯
Spinal processing of spatiotemporally diverse tactile stimuli: Implications for allodynia and spinal cord stimulation https://www.biorxiv.org/content/10.1101/2025.03.10.642392v1
March 20, 2025 at 2:28 AM
Probably my favourite work of my PhD out now on #bioRxiv 🎯
Reposted by Laura Medlock
"Denial that certain diversities exist or banning the use of terminologies and classifications along spectrums does not negate the reality of personal identity and the underlying neurobiology". Thank you @iasp.bsky.social and @karenddavis.bsky.social 🧪#PainResearch
journals.lww.com/pain/fulltex...
journals.lww.com/pain/fulltex...
The value of equity, diversity, and inclusion principles... : PAIN
An abstract is unavailable.
journals.lww.com
February 19, 2025 at 2:07 PM
"Denial that certain diversities exist or banning the use of terminologies and classifications along spectrums does not negate the reality of personal identity and the underlying neurobiology". Thank you @iasp.bsky.social and @karenddavis.bsky.social 🧪#PainResearch
journals.lww.com/pain/fulltex...
journals.lww.com/pain/fulltex...
Reposted by Laura Medlock
Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...
Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use
Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...
www.biorxiv.org
January 20, 2025 at 2:05 PM
Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...
Reposted by Laura Medlock
In-depth article on chronic pain, with my friend @robgereau.bsky.social and Allan Basbaum heavily interviewed as scientists studying pain: ‘We die in pain, we don’t die of pain.’
www.nytimes.com/2025/01/12/m...
www.nytimes.com/2025/01/12/m...
Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.
As many as two billion people suffer from it — including me. Can science finally bring us relief?
www.nytimes.com
January 12, 2025 at 12:11 PM
In-depth article on chronic pain, with my friend @robgereau.bsky.social and Allan Basbaum heavily interviewed as scientists studying pain: ‘We die in pain, we don’t die of pain.’
www.nytimes.com/2025/01/12/m...
www.nytimes.com/2025/01/12/m...
Latest work out of the Prescott Lab on #pain sensitivity in different (nociceptive vs. non-nociceptive) afferents. 🔦
Quantifying the contribution of somatosensory afferent types and changes therein to pain sensitivity using transcutaneous optogenetic stimulation in behaving mice https://www.biorxiv.org/content/10.1101/2024.12.13.628414v1
December 23, 2024 at 4:37 PM
Latest work out of the Prescott Lab on #pain sensitivity in different (nociceptive vs. non-nociceptive) afferents. 🔦
Out now in @sfnjournals.bsky.social! 👋 Our latest work on #touch and vibration sensing in rodent #mechanoreceptors.
A beautiful experimental and computational collaboration thanks to the whole Prescott Lab team.
www.jneurosci.org/content/44/4...
A beautiful experimental and computational collaboration thanks to the whole Prescott Lab team.
www.jneurosci.org/content/44/4...
Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin
Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in the rodent glabrous skin has received sc...
www.jneurosci.org
December 10, 2024 at 12:17 PM
Out now in @sfnjournals.bsky.social! 👋 Our latest work on #touch and vibration sensing in rodent #mechanoreceptors.
A beautiful experimental and computational collaboration thanks to the whole Prescott Lab team.
www.jneurosci.org/content/44/4...
A beautiful experimental and computational collaboration thanks to the whole Prescott Lab team.
www.jneurosci.org/content/44/4...