Luke Pilling
@lcpilling.bsky.social
PhD. Genetic epidemiologist
Researching mechanisms of chronic long-term conditions, ageing, and drugs @ University of Exeter, UK
❤Rstats. UCU rep✊. Views my own
He/him. 🏳️🌈ally. 🇬🇧🇪🇺
📷 ShowYourStripes.info
W: https://experts.exeter.ac.uk/19304-luke-pilling
Researching mechanisms of chronic long-term conditions, ageing, and drugs @ University of Exeter, UK
❤Rstats. UCU rep✊. Views my own
He/him. 🏳️🌈ally. 🇬🇧🇪🇺
📷 ShowYourStripes.info
W: https://experts.exeter.ac.uk/19304-luke-pilling
Reposted by Luke Pilling
There’s a new kid in town!
Companies are now selling IVF and embryo selection based on genetic testing for traits related to health and even intelligence.
We outline methodological and ethical concerns, and warn against risks for social inequality.
With the fantastic @gaiaghirardi.bsky.social
Companies are now selling IVF and embryo selection based on genetic testing for traits related to health and even intelligence.
We outline methodological and ethical concerns, and warn against risks for social inequality.
With the fantastic @gaiaghirardi.bsky.social
Embryo selection based on polygenic prediction risks reinforcing social inequality
The rise of companies offering embryo selection based on genetic testing has triggered heated debate about ethical acceptability, as well as the accuracy and scientific validity of these techniques. W...
www.fertstert.org
November 13, 2025 at 8:09 AM
There’s a new kid in town!
Companies are now selling IVF and embryo selection based on genetic testing for traits related to health and even intelligence.
We outline methodological and ethical concerns, and warn against risks for social inequality.
With the fantastic @gaiaghirardi.bsky.social
Companies are now selling IVF and embryo selection based on genetic testing for traits related to health and even intelligence.
We outline methodological and ethical concerns, and warn against risks for social inequality.
With the fantastic @gaiaghirardi.bsky.social
Reposted by Luke Pilling
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Reposted by Luke Pilling
Post-doc opportunity in Exeter 🌟 studying genetic modifiers of haemochromatosis 🩸
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
September 16, 2025 at 3:11 PM
Post-doc opportunity in Exeter 🌟 studying genetic modifiers of haemochromatosis 🩸
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
Reposted by Luke Pilling
@ewanbirney.bsky.social on the new version of Alphafold at the @emblebi.bsky.social
www.ebi.ac.uk/about/news/t...
AlphaFold has been a transformation not just in structural biology but also - due to its ability to be applied to all proteins - to molecular biology as a whole.
www.ebi.ac.uk/about/news/t...
AlphaFold has been a transformation not just in structural biology but also - due to its ability to be applied to all proteins - to molecular biology as a whole.
EMBL-EBI and Google DeepMind renew partnership and release update to AlphaFold Database
Deeper collaboration between EMBL-EBI and Google DeepMind brings updates to the AlphaFold Database.
www.ebi.ac.uk
October 8, 2025 at 10:38 AM
@ewanbirney.bsky.social on the new version of Alphafold at the @emblebi.bsky.social
www.ebi.ac.uk/about/news/t...
AlphaFold has been a transformation not just in structural biology but also - due to its ability to be applied to all proteins - to molecular biology as a whole.
www.ebi.ac.uk/about/news/t...
AlphaFold has been a transformation not just in structural biology but also - due to its ability to be applied to all proteins - to molecular biology as a whole.
One of the biggest increases in my analysis/coding productivity in recent years is completely embracing git repos 🐧
Coupled with GitHub it is *so easy* to be open, reproducible, efficient, and accountable to myself and colleagues 👨💻
No more chaotic servers wondering which script led to what! 😵💫
Coupled with GitHub it is *so easy* to be open, reproducible, efficient, and accountable to myself and colleagues 👨💻
No more chaotic servers wondering which script led to what! 😵💫
October 3, 2025 at 9:00 AM
One of the biggest increases in my analysis/coding productivity in recent years is completely embracing git repos 🐧
Coupled with GitHub it is *so easy* to be open, reproducible, efficient, and accountable to myself and colleagues 👨💻
No more chaotic servers wondering which script led to what! 😵💫
Coupled with GitHub it is *so easy* to be open, reproducible, efficient, and accountable to myself and colleagues 👨💻
No more chaotic servers wondering which script led to what! 😵💫
Reposted by Luke Pilling
What an amazing place to present GEMINI research on steroid pharmacogenomics and osteoporosis by @denizturkmen.bsky.social @lcpilling.bsky.social and the GEMINI #MLTC team @universityofexeter.bsky.social #EUGMS2025
September 24, 2025 at 3:56 PM
What an amazing place to present GEMINI research on steroid pharmacogenomics and osteoporosis by @denizturkmen.bsky.social @lcpilling.bsky.social and the GEMINI #MLTC team @universityofexeter.bsky.social #EUGMS2025
Post-doc opportunity in Exeter 🌟 studying genetic modifiers of haemochromatosis 🩸
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
September 16, 2025 at 3:11 PM
Post-doc opportunity in Exeter 🌟 studying genetic modifiers of haemochromatosis 🩸
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
Closing date 30 Oct!
Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️
jobs.exeter.ac.uk/hrpr_webrecr...
Number 1 way journals make me happy at the moment:
"YOU DO NOT NEED TO SPECIFICALLY FORMAT YOUR MANUSCRIPT FOR FIRST SUBMISSION"
#AcademicLife #AcademicChat
"YOU DO NOT NEED TO SPECIFICALLY FORMAT YOUR MANUSCRIPT FOR FIRST SUBMISSION"
#AcademicLife #AcademicChat
a man with long hair and a beard is sitting in the driver 's seat of a car .
ALT: a man with long hair and a beard is sitting in the driver 's seat of a car .
media.tenor.com
September 10, 2025 at 1:52 PM
Number 1 way journals make me happy at the moment:
"YOU DO NOT NEED TO SPECIFICALLY FORMAT YOUR MANUSCRIPT FOR FIRST SUBMISSION"
#AcademicLife #AcademicChat
"YOU DO NOT NEED TO SPECIFICALLY FORMAT YOUR MANUSCRIPT FOR FIRST SUBMISSION"
#AcademicLife #AcademicChat
Latest preprint by PhD student Mitch Lucas on the genetic iron overload disease #haemochromatosis doi.org/10.1101/2025...
Massive study of factors affecting clinical outcomes in HFE carriers, including genetic predisposition to higher transferrin saturation
@janicelatkins.bsky.social
@exeter.ac.uk
Massive study of factors affecting clinical outcomes in HFE carriers, including genetic predisposition to higher transferrin saturation
@janicelatkins.bsky.social
@exeter.ac.uk
September 3, 2025 at 10:46 AM
Latest preprint by PhD student Mitch Lucas on the genetic iron overload disease #haemochromatosis doi.org/10.1101/2025...
Massive study of factors affecting clinical outcomes in HFE carriers, including genetic predisposition to higher transferrin saturation
@janicelatkins.bsky.social
@exeter.ac.uk
Massive study of factors affecting clinical outcomes in HFE carriers, including genetic predisposition to higher transferrin saturation
@janicelatkins.bsky.social
@exeter.ac.uk
Very exciting to have access to "Our Future Health" data and begin understanding what is available and how to access it
Many thanks to the volunteers so far. Still a long way to go - consider signing up if you haven't already!
This is a greater primer on the aims www.nature.com/articles/s41...
Many thanks to the volunteers so far. Still a long way to go - consider signing up if you haven't already!
This is a greater primer on the aims www.nature.com/articles/s41...
Our Future Health: a unique global resource for discovery and translational research - Nature Medicine
Our Future Health has recruited more than 1 million participants in the UK, with biobanked bloods, making it the largest consented cohort of its type in the world.
www.nature.com
August 29, 2025 at 12:59 PM
Very exciting to have access to "Our Future Health" data and begin understanding what is available and how to access it
Many thanks to the volunteers so far. Still a long way to go - consider signing up if you haven't already!
This is a greater primer on the aims www.nature.com/articles/s41...
Many thanks to the volunteers so far. Still a long way to go - consider signing up if you haven't already!
This is a greater primer on the aims www.nature.com/articles/s41...
Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating!
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 22, 2025 at 11:01 AM
Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating!
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
My latest data hobby: my Spotify listening history!
Had no idea until recently that you could download a history over ever song you've ever listened to. Cue some fun R hours!
Some surprising trends and top picks. Dominated by my work listening rather than "favourites"
lcpilling.github.io/spotify
Had no idea until recently that you could download a history over ever song you've ever listened to. Cue some fun R hours!
Some surprising trends and top picks. Dominated by my work listening rather than "favourites"
lcpilling.github.io/spotify
August 21, 2025 at 12:34 PM
My latest data hobby: my Spotify listening history!
Had no idea until recently that you could download a history over ever song you've ever listened to. Cue some fun R hours!
Some surprising trends and top picks. Dominated by my work listening rather than "favourites"
lcpilling.github.io/spotify
Had no idea until recently that you could download a history over ever song you've ever listened to. Cue some fun R hours!
Some surprising trends and top picks. Dominated by my work listening rather than "favourites"
lcpilling.github.io/spotify
Love a good DAG ❤️
Link broke! Here is the current link: www.r-causal.org/chapters/04-...
July 9, 2025 at 2:37 PM
Love a good DAG ❤️
Exciting session on using the (appropriately named) "Epic" secondary care electronic healthcare records data for research by Prof Jane Masoli (pictured), Dr Nick kennedy and Michelle Ledbetter at the @swaih.bsky.social 2025 meeting
@janemasoli.bsky.social
@drnickkennedy.bsky.social
@janemasoli.bsky.social
@drnickkennedy.bsky.social
July 9, 2025 at 11:04 AM
Exciting session on using the (appropriately named) "Epic" secondary care electronic healthcare records data for research by Prof Jane Masoli (pictured), Dr Nick kennedy and Michelle Ledbetter at the @swaih.bsky.social 2025 meeting
@janemasoli.bsky.social
@drnickkennedy.bsky.social
@janemasoli.bsky.social
@drnickkennedy.bsky.social
Inspiring talk by @jessrmorley.bsky.social at the @swaih.bsky.social annual meeting
Really important issues to consider. Especially liked the "data availability law" (availability of high quality health data inverse to the health/care needs of the individual)
Really important issues to consider. Especially liked the "data availability law" (availability of high quality health data inverse to the health/care needs of the individual)
July 9, 2025 at 10:03 AM
Inspiring talk by @jessrmorley.bsky.social at the @swaih.bsky.social annual meeting
Really important issues to consider. Especially liked the "data availability law" (availability of high quality health data inverse to the health/care needs of the individual)
Really important issues to consider. Especially liked the "data availability law" (availability of high quality health data inverse to the health/care needs of the individual)
Reposted by Luke Pilling
Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
June 27, 2025 at 10:00 AM
Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
Is there anything as grossly unappealing yet probably quite important as mandatory H&S training?
June 27, 2025 at 1:58 PM
Is there anything as grossly unappealing yet probably quite important as mandatory H&S training?
At the UK Human Functional Genomics Initiative @uk-fgx.bsky.social symposium @exeter.ac.uk, currently listening to intro from @jonathanmill.bsky.social
Picked up my first fidget spinner from BioFAIR @biofair.bsky.social which sounds a really cool initiative for open data and methods 🌟
Picked up my first fidget spinner from BioFAIR @biofair.bsky.social which sounds a really cool initiative for open data and methods 🌟
June 16, 2025 at 9:55 AM
At the UK Human Functional Genomics Initiative @uk-fgx.bsky.social symposium @exeter.ac.uk, currently listening to intro from @jonathanmill.bsky.social
Picked up my first fidget spinner from BioFAIR @biofair.bsky.social which sounds a really cool initiative for open data and methods 🌟
Picked up my first fidget spinner from BioFAIR @biofair.bsky.social which sounds a really cool initiative for open data and methods 🌟
So nice to be able to return a postive review. Great work authors, absolutely loved it ❤️
June 12, 2025 at 7:59 AM
So nice to be able to return a postive review. Great work authors, absolutely loved it ❤️
Just submitted responses to reviews on a grant we have in submission. Not sure how I will get anything done in the next few weeks with all my fingers crossed 🤞
June 5, 2025 at 11:36 AM
Just submitted responses to reviews on a grant we have in submission. Not sure how I will get anything done in the next few weeks with all my fingers crossed 🤞
First time my donated blood has made it to Swindon! 🤩
Love getting these e-mails of where my blood was used 🩸
Easiest way to save a life. Give blood! 🌟
www.blood.co.uk
Love getting these e-mails of where my blood was used 🩸
Easiest way to save a life. Give blood! 🌟
www.blood.co.uk
May 14, 2025 at 1:41 PM
First time my donated blood has made it to Swindon! 🤩
Love getting these e-mails of where my blood was used 🩸
Easiest way to save a life. Give blood! 🌟
www.blood.co.uk
Love getting these e-mails of where my blood was used 🩸
Easiest way to save a life. Give blood! 🌟
www.blood.co.uk
Last session but certainly not least at multimorbidity MLTC symposium has reflections from stakeholders including one of our amazing public collaborators @marymanc.bsky.social
This is my first project with such integrated patient perspectives and it has transformed the work. I'm really enjoying it!
This is my first project with such integrated patient perspectives and it has transformed the work. I'm really enjoying it!
May 8, 2025 at 2:26 PM
Last session but certainly not least at multimorbidity MLTC symposium has reflections from stakeholders including one of our amazing public collaborators @marymanc.bsky.social
This is my first project with such integrated patient perspectives and it has transformed the work. I'm really enjoying it!
This is my first project with such integrated patient perspectives and it has transformed the work. I'm really enjoying it!
Next from GEMINI is Dr Olivia Murrin giving a deep dive on observational (from primary care) and genetic relationships between lung and musculoskeletal conditions
@exeterage.bsky.social
Follow us here and see our GitHub for resources and updates bsky.app/profile/lcpi...
@exeterage.bsky.social
Follow us here and see our GitHub for resources and updates bsky.app/profile/lcpi...
May 8, 2025 at 1:48 PM
Next from GEMINI is Dr Olivia Murrin giving a deep dive on observational (from primary care) and genetic relationships between lung and musculoskeletal conditions
@exeterage.bsky.social
Follow us here and see our GitHub for resources and updates bsky.app/profile/lcpi...
@exeterage.bsky.social
Follow us here and see our GitHub for resources and updates bsky.app/profile/lcpi...
Reposted by Luke Pilling
Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%!
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
May 8, 2025 at 12:01 PM
Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%!
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
Overview of our genetics of multimorbidity (GEMINI) project by @timfrayling.bsky.social at the MLTC symposium
We are studying 72 common long-term chronic conditions with a heritable (genetic) component. Our seminal paper is now published (doi.org/10.1016/j.eb...) and our public resources are below:
We are studying 72 common long-term chronic conditions with a heritable (genetic) component. Our seminal paper is now published (doi.org/10.1016/j.eb...) and our public resources are below:
May 8, 2025 at 1:04 PM
Overview of our genetics of multimorbidity (GEMINI) project by @timfrayling.bsky.social at the MLTC symposium
We are studying 72 common long-term chronic conditions with a heritable (genetic) component. Our seminal paper is now published (doi.org/10.1016/j.eb...) and our public resources are below:
We are studying 72 common long-term chronic conditions with a heritable (genetic) component. Our seminal paper is now published (doi.org/10.1016/j.eb...) and our public resources are below: