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likatz.bsky.social
Liora Katz
@likatz.bsky.social
220 followers 100 following 7 posts
Associate Professor Diabetes, obesity and metabolism institute Mount Sinai, NY
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likatz.bsky.social
Liora Katz @likatz.bsky.social · 23h
Excited to share our Commentary in JCI. Exploring how SIRT2 regulates human beta cell proliferation
www.jci.org/articles/vie...
@jci.org
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Reposted by Liora Katz
deniswirtz.bsky.social
Denis Wirtz @deniswirtz.bsky.social · Mar 13
NIH is the best investment there is.

www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
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Reposted by Liora Katz
danieljdrucker.bsky.social
Daniel Drucker @danieljdrucker.bsky.social · Mar 2
A molecular glue’ compound led to potent ChREBPα/14-3-3 PPI stabilization, retained ChREBPα in the cytoplasm, and efficiently protected β-cells from glucolipotoxicity while maintaining β-cell identity. @naturecomms.bsky.social www.nature.com/articles/s41...
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications
Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...
www.nature.com
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likatz.bsky.social
Liora Katz @likatz.bsky.social · Mar 2
Excited to share our work in @naturecomms.bsky.social
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications
Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...
www.nature.com
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Reposted by Liora Katz
bskybymidge.bsky.social
Margaret Echelbarger @bskybymidge.bsky.social · Feb 27
✨NYC Stand Up for Science Rally: March 7 (12-3pm)✨ This event is a call to protect publicly funded science from political interference and to reaffirm that diversity, equity, inclusion, and access are essential to scientific progress. @standupforscience.bsky.social (permit pending for location)
Flyer for NYC Stand Up for Science Rally: March 7, 2025, Washington Square Park, 12-3pm. The flyer also reads: Science is for everyone. Find your local rally site and other ways to get involved: standupforscience2025.org. A blue Statue of Liberty is included on the left.
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likatz.bsky.social
Liora Katz @likatz.bsky.social · Jan 23
Making America great means supporting research that saves lives, improves health, and drives new technology. Freezing NIH funding hurts all of us. Let’s tell our leaders to INCREASE funding for the NIH and keep America at the forefront of science and innovation!
germhuntermd.bsky.social
Ilan Schwartz @germhuntermd.bsky.social · Jan 22
Scientific advancements aside, this is economically irresponsible

Every $1 spent by NIH generates $2.46

For example, in 2023, $47B in NIH spending generated ~$93B

Halting NIH spending will LOSE the US a lot of money (and talent)
An image of NIH campus. Text says : With annual budget of more than $47 billion, NIH is the largest single public funder of biomedical and behavioural research in the world. In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activity Every state and almost every congressional district received a share of NIH investment Each year, NIH awards over 60,000 grants that directly support more than 300,000 researchers at more than 2,500 different institutions In fiscal year 2023, every $1 of NIH funding generated approximately $2.46 of economic activity
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likatz.bsky.social
Liora Katz @likatz.bsky.social · Jan 5
Happy to be a part of this amazing interdiciplinary reseach group!
womenintpd.bsky.social
Women in TPD & Induced Proximity @womenintpd.bsky.social · Nov 22
New work led by Liora Katz at Mt. Sinai along with colleagues of a non-degrading molecular glue between a TF (ChREBP) and a 14-3-3 protein which effectively traps the TF in the nucleus, thereby preventing activation of its target genes in the nucleus. Congratulations!
www.biorxiv.org/content/10.1...
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity
The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In chronic hyperglycemia and glucolipotoxicity, C...
www.biorxiv.org
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likatz.bsky.social
Liora Katz @likatz.bsky.social · Jan 5
Happy and proud to be part of this interdisiplinary research group!
Reposted by Liora Katz
womenintpd.bsky.social
Women in TPD & Induced Proximity @womenintpd.bsky.social · Nov 22
New work led by Liora Katz at Mt. Sinai along with colleagues of a non-degrading molecular glue between a TF (ChREBP) and a 14-3-3 protein which effectively traps the TF in the nucleus, thereby preventing activation of its target genes in the nucleus. Congratulations!
www.biorxiv.org/content/10.1...
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity
The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In chronic hyperglycemia and glucolipotoxicity, C...
www.biorxiv.org
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likatz.bsky.social
Liora Katz @likatz.bsky.social · Nov 24
That is great! Can you please add me to this pack?
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likatz.bsky.social
Liora Katz @likatz.bsky.social · Nov 22
Great minds! I joined Bluesky yesterday
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