ur latest in Clinical and Molecular Hepatology is out: “Tracking the trajectory of kidney dysfunction in cirrhosis: the AKI–CKD spectrum.”
time to rethink kidney injury as a continuum.

pubmed.ncbi.nlm.nih.gov/40138802/

A new #PSC review from @f8martine.bsky.social , et al.

PSC-IBD is probably a distinct form of IBD with UC and Crohn's.

"on a molecular level, almost all people with PSC have underlying colitis"

2024 = 100th anniversary of the description of PSC

journals.lww.com/hep/abstract...

#liversky

🧪New paper on immune signatures in alcohol-related liver disease (ALD):

⬆️Accumulation of CD4 T cells
🧬CD4 T cells marked by GZMK, tissue-resident signature
🎯GZMK+CD4+ T cells in fibrotic zones
🔑Immune cell populations in ALD may be key

#liversky

www.cmghjournal.org/article/S235...

🆕 AGA Clinical Practice Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation in At-Risk Individuals

@amergastroassn.bsky.social
#IDsky #Liversky

www.gastrojournal.org/action/showP...

Admittedly the cool name of the study group first caught my 👁️

POSEIDON study group showed
✅alfapump 📉need for LVP
✅similar complications
✅improved QOL
@amcollegegastro.bsky.social

journals.lww.com/ajg/abstract...

#liversky

Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social

📢Thrilled to share our latest review article. Greatful to Prof. Rakhi Maiwall. We explore challenges of managing septic shock in cirrhosis and advocate for personalized approaches
pubmed.ncbi.nlm.nih.gov/39744868/

#liversky #Medsky #GIsky

@anandvkulkarni.bsky.social

Great look into the future on HCC surveillance by George Ioannou at AASLD #TLM24

Seems likely that blood based biomarkers and aMRI will play some role but, despite its significant flaws, ultrasound has so far stood the test of time

Some Resmetirom considerations @SonalKumarMD for #MASLD #MASH at #TLM24

🟢 Dosing is weight-based
🔴 Beware of drug interactions: Gemfibrozil, Plavix, and statins
🔵 Mostly GI side effects, mostly short-lived

Did you know...

There are nifty one page summaries of selected ACG guidelines available at gi.org/guidelines

Just click on the "Summary" tab under the guidelines

Here are some examples with many more in development

#GISky #LiverSky

Could you kindly add me to #liversky? I'm still getting the hang of the app and would love to contribute and learn more. Thanks!