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Reposted by Leonie Kollenstart

Vijay Ramani @vram142.bsky.social · 23d

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

www.biorxiv.org

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Reposted by Leonie Kollenstart

The Groth lab @grothlab.bsky.social · Aug 28

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).

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Leonie Kollenstart @lleonie.bsky.social · Aug 1

Gefeliciteerd Martijn!! 🥳

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Reposted by Leonie Kollenstart

Alessandro Costa @costalaboratory.bsky.social · Jun 20

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

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Reposted by Leonie Kollenstart

Jeroen van den Berg @jervdberg.bsky.social · May 16

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute

About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...

shorturl.at

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Reposted by Leonie Kollenstart

The Groth lab @grothlab.bsky.social · May 20

🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!

Jeroen van den Berg @jervdberg.bsky.social · May 16

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute

About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...

shorturl.at

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Reposted by Leonie Kollenstart

Anja Groth @groth-anja.bsky.social · Mar 28

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

The Groth lab @grothlab.bsky.social · Feb 12

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

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Reposted by Leonie Kollenstart

The Groth lab @grothlab.bsky.social · Mar 6

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply

Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...

rdcu.be

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Leonie Kollenstart @lleonie.bsky.social · Feb 21

Yes

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Leonie Kollenstart @lleonie.bsky.social · Feb 21

We don't find that they are susceptible to disrupted histone recycling. There is no correlation between gene length and changes in gene expression in our recycling mutants.

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Leonie Kollenstart @lleonie.bsky.social · Feb 20

Thank you so much Jenny!

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Leonie Kollenstart @lleonie.bsky.social · Feb 20

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

The Groth lab @grothlab.bsky.social · Feb 19

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

tinyurl.com

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Leonie Kollenstart @lleonie.bsky.social · Feb 17

Moving-in day at the Danish Cancer Institute! Look at this pristine, untouched lab 🤩

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Leonie Kollenstart @lleonie.bsky.social · Feb 12

Want to join us in 𝐂𝐨𝐩𝐞𝐧𝐡𝐚𝐠𝐞𝐧, 𝐃𝐞𝐧𝐦𝐚𝐫𝐤? 🇩🇰 Our new 𝐂𝐞𝐧𝐭𝐞𝐫 𝐟𝐨𝐫 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐂𝐞𝐥𝐥 𝐌𝐞𝐦𝐨𝐫𝐲 (𝐄𝐩𝐢𝐂) is hiring 6 PhDs & postdocs! This is an amazing chance to be part of a top-tier research environment in Europe. I can’t recommend these labs enough! 🔬✨📢 Apply here 👇 & spread the word! #Hiring #AcademicJobs

The Groth lab @grothlab.bsky.social · Feb 12

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

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Leonie Kollenstart @lleonie.bsky.social · Feb 10

I'm thrilled that this chapter from my PhD, completed and elevated by @sophievdhorst.bsky.social and other co-authors, is now published in Nature Communications! Check it out 👇.

Haico van Attikum @haicovanattikum.bsky.social · Feb 8

We present Repli-ID, an approach to identify proteins affecting DNA replication. Lge1 and Rox1 are new regulators of this process. Great work by @sophievdhorst.bsky.social, @lleonie.bsky.social and co-authors in collaboration with @andreichabes.bsky.social.

tinyurl.com/mvvcp3xe

Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response - Nature Communications

Cells activate various pathways to counter DNA replication stress. Using Replication-IDentifier (Repli-ID), the authors identified 423 genes, including LGE1 and ROX1, linking epigenetic and metabolic ...

tinyurl.com

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Leonie Kollenstart @lleonie.bsky.social · Dec 21

Thank you Francesca!

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Leonie Kollenstart @lleonie.bsky.social · Dec 20

Thank you Haico!

Leonie Kollenstart @lleonie.bsky.social · Dec 20

Thanks Jenny 😊

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Leonie Kollenstart @lleonie.bsky.social · Dec 20

So excited to start this project together! 🤩

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Reposted by Leonie Kollenstart

The Groth lab @grothlab.bsky.social · Dec 20

Exciting news!🌟 Together with Alexander van Oudenaarden, @jervdberg.bsky.social and @lleonie.bsky.social, we’ve been awarded a €2M NNF Synergy grant. We're thrilled to collaborate🤝 and to develop cutting-edge single-cell and single-molecule methods for replication and chromatin research! 🚀

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Reposted by Leonie Kollenstart

Hubrecht Institute @hubrechtinstitute.bsky.social · Dec 20

How reliably is the epigenome passed from one cell to its daughter cells? Alexander van Oudenaarden @jervdberg.bsky.social @grothlab.bsky.social @lleonie.bsky.social received
@novo-nordisk.bsky.social grant to study this question
➡️new strategies to prevent disease & combat aging tinyurl.com/yh925b9u

Van Oudenaarden and Groth research groups receive Novo Nordisk Foundation Synergy Grant for Epigenome Fidelity - Hubrecht Institute

www.hubrecht.eu

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Leonie Kollenstart @lleonie.bsky.social · Dec 20

Yesss! 🎉 We’ve secured a €2M Synergy grant from @novo-nordisk.bsky.social 🤯! What started as fun chats with my amazing friend @jervdberg.bsky.social, turned into an epic collaborative project 🤩. Huge thanks to Alexander and @grothlab.bsky.social for support and guidance. Can’t wait to dive in! 🚀

Hubrecht Institute @hubrechtinstitute.bsky.social · Dec 20

How reliably is the epigenome passed from one cell to its daughter cells? Alexander van Oudenaarden @jervdberg.bsky.social @grothlab.bsky.social @lleonie.bsky.social received
@novo-nordisk.bsky.social grant to study this question
➡️new strategies to prevent disease & combat aging tinyurl.com/yh925b9u

Van Oudenaarden and Groth research groups receive Novo Nordisk Foundation Synergy Grant for Epigenome Fidelity - Hubrecht Institute

www.hubrecht.eu

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Reposted by Leonie Kollenstart

The Groth lab @grothlab.bsky.social · Nov 25

The Groth lab @grothlab.bsky.social has also made the jump from X to Bluesky🤩! Please follow us for all things related to chromatin replication, epigenetic memory and (epi)genome stability in the context of mitotic cell division! We'll start on joining some relevant starter packs!

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Reposted by Leonie Kollenstart

Nilsson lab @nilssonlab.bsky.social · Nov 17

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community:
candidate.hr-manager.net/ApplicationI...

Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute

Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute Do you want to be part of a state-of-the-art core facilit

candidate.hr-manager.net

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