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MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 7d

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

Black and white portrait of John Gurdon, 1971

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Nilsson lab @nilssonlab.bsky.social · Jul 27

Arrived in Wurzburg to get the latest om phosphatases!

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Nilsson lab @nilssonlab.bsky.social · Jul 27

Nice. Intriguing with UBE2C - would think the protein is unstable so you would slow down APC/C and prolong arrest.

Nilsson lab @nilssonlab.bsky.social · Jul 4

Returning from two great days at ICR in London to visit Norman Davey and many others. Need 20 days next time!

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dfachinetti.bsky.social @dfachinetti.bsky.social · May 4

The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself

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Nilsson lab @nilssonlab.bsky.social · Apr 27

Here we go - 4 days of excellent science in Italy

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IDPSeminars @idpseminars.bsky.social · Apr 2

Back again TOMORROW (Thursday April 3rd) for another IDPSeminars!

Noon central time - sign up for the webinar here
forms.gle/3yCHeYvuuqLh...

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Nilsson lab @nilssonlab.bsky.social · Mar 26

Come join us for the phosphatase meeting this summer! Deadline approaching for signing up for this great meeting.
meetings.embo.org/event/25-pho...

Phosphatases: from basic research to translation

Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…

meetings.embo.org

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Nilsson lab @nilssonlab.bsky.social · Mar 11

this is crazy!

Nilsson lab @nilssonlab.bsky.social · Feb 18

MSK also under DOGE investigations? I thought you would be safe. Hope to see you in Italy

Nilsson lab @nilssonlab.bsky.social · Feb 16

In addition to uncovering CYB5R4 our functional map hints at many additional regulatory pathways and mechanisms that can now be explored by the community. Thanks to Norman Davey this will be facilitated through a website allowing exploration of the base editor screens slim.icr.ac.uk/base_editing...

SLiM team resources @ ICR

slim.icr.ac.uk

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Nilsson lab @nilssonlab.bsky.social · Feb 16

We find that CYB5R4 mediated activation of PP4 is critical for controlling the response to the DNA damaging agents cisplatin and Illudin S that cause elevated levels of ROS. This extends earlier important observations from the @durocher1.bsky.social lab on CYB5R4 (Olivieri et al 2020).

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Nilsson lab @nilssonlab.bsky.social · Feb 16

We uncover CYB5R4 as an activator of PP4 and PP6 but not the closely related PP2A. CYB5R4 is a dedicated reductase for the catalytic metal ions and we show that this pathway is conserved from yeast to man. Thus PP4 and PP6 activity is regulated by oxidation and reduction of the metal ions.

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Nilsson lab @nilssonlab.bsky.social · Feb 16

Happy to share our latest work on phosphoprotein phosphatase (PPP) regulation. We integrate CRISPR knockout and focused base editor screens to uncover the regulatory landscape of PPPs (more below). Great collaboration with the Zhu, Davey, Kettenbach and Ogris labs.
www.biorxiv.org/content/10.1...

A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions

Serine/Threonine phosphoprotein phosphatases (PPPs, PP1-PP7) are conserved metalloenzymes and central to intracellular signaling in eukaryotes, but the details of their regulation is poorly understood...

www.biorxiv.org

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Prasad Jallepalli, MD, PhD @prasad.bsky.social · Feb 14

www.nytimes.com/2025/02/14/o...

An eloquent defense of American science by Harold Varmus, a Nobel Prize winning scientist during his days at UCSF, former director of the NIH and NCI, and former President of Memorial Sloan Kettering Cancer Center (full disclosure — it’s where I work)

Opinion | American Science is Under Attack (Gift Article)

The Trump administration hobbles research and endangers the public health.

www.nytimes.com

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@tim_stasevich @tim-stasevich.bsky.social · Feb 12

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...

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The Groth lab @grothlab.bsky.social · Feb 12

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

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Nilsson lab @nilssonlab.bsky.social · Feb 9

Goodbye to my office for the last 14 years. Time to pack down and head for new adventures

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Ellenberg Lab @ellenberglab.bsky.social · Jan 9

Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!

We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:

In both stages big loops are built first, small ones second

Journal of Cell Biology @jcb.org · Jan 9

@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social