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The multiplexed single-tier InBios Lyme Detect Multiplex ELISA is more sensitive than standard two-tier tests in the early stages of Lyme disease | Journal of Clinical Microbiology

Lyme Disease Biobank @lymebiobank.bsky.social · 3d

New study in @jclinmicroeic.bsky.social shows a new multiplex Lyme serology test is more sensitive than standard two-tier serology tests! Detected more cases w EM at 7 days. Great collaboration with Pete Gwynne @tuftslyme.bsky.social journals.asm.org/doi/10.1128/...

During initial Lyme disease infection, existing diagnostic tests have poor sensitivity, resulting in a high number of false-negative tests. This is due to the lag between infection and a robust immune...

Frontiers | Lyme Disease Biobank: 10 years of 3 month follow-up visits from 2014 to 2023

Lyme Disease Biobank @lymebiobank.bsky.social · 21d

Question for people who frequently publish - I just got a notification that our recent Lyme disease article published in July in Frontiers in Medicine had 500 downloads? Is that good? Thanks! www.frontiersin.org/journals/med...

IntroductionLyme Disease Biobank (LDB) enrolls participants with signs and symptoms of early Lyme disease (LD) from endemic areas and makes samples available...

www.frontiersin.org

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 20

Kephera has a poster at ICLB in September.

A novel single-tier serologic test to diagnose all stages of Lyme disease | Journal of Clinical Microbiology

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 20

I'm really excited about the single-tier assays. There are several in development that have positive results in early Lyme samples with EM that STTT and MTTT miss. These single-tier tests are more sensitive without sacrificing specificity and take less time/resources to run.
#TickSky
#MicroSky

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 20

Kephera's single-tier Lyme test published in @ASM JCM - Hybrid ELISA approach requires binding to VlsE AND C6. More sensitive in early disease while maintaining specificity. journals.asm.org/doi/10.1128/...

The diagnosis of Lyme disease, a tick-borne spirochetal infection caused by Borrelia burgdorferi sensu lato, is subject to two major limitations: the need for a two-tier serologic testing algorithm to provide adequate specificity, and the low sensitivity ...

A novel single-tier serologic test to diagnose all stages of Lyme disease | Journal of Clinical Microbiology

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Lyme Disease Biobank @lymebiobank.bsky.social · Aug 20

Kephera's single-tier Lyme test published in @ASM JCM - Hybrid ELISA approach requires binding to VlsE AND C6. More sensitive in early disease while maintaining specificity. journals.asm.org/doi/10.1128/...

The diagnosis of Lyme disease, a tick-borne spirochetal infection caused by Borrelia burgdorferi sensu lato, is subject to two major limitations: the need for a two-tier serologic testing algorithm to provide adequate specificity, and the low sensitivity ...

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Lyme Disease Biobank @lymebiobank.bsky.social · Aug 15

What a good girl! Give Jewel pets for me.

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 15

What's the cute pup's name?

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 5

There are several single-tier assays in development that I'm enthusiastic about - all posters at ICLB. I'm really looking forward to that meeting.

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 5

That is a good point - I don't know how the reporter missed that - it's on the Aces website.

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 5

Finally - an article acknowledging rashes aren't all bulls-eyes. All the Lyme and tick coverage is great - but so many articles focus on the bulls-eye and it's not what most Lyme rashes look like.

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Lyme Disease Biobank @lymebiobank.bsky.social · Aug 5

"While a bull-eye-shaped rash is telltale sign of Lyme disease, this type of EM is actually not a common presentation, said Liz Horn, PhD, MBI, principal investigator of the Lyme Disease Biobank, a biorepository of samples from people with Lyme disease."

New Lyme Blood Test Bests Standard Diagnostics

Lyme Disease Biobank @lymebiobank.bsky.social · Aug 5

Article from @medscape.com about LymeSeek - a new Lyme diagnostic in development from Aces Diagnostics plus @bayarealyme.bsky.social biobank data showing how unreliable available tests are in early disease. (They miss 7 out of 10 early Lyme cases) www.medscape.com/viewarticle/...

The single-tier test uses artificial intelligence to accurately detect Lyme disease from the first few weeks of infection through 1 year post-diagnosis.

www.medscape.com

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Lyme Disease Biobank @lymebiobank.bsky.social · Jul 16

Check out the decision tree in figure 4. Being able to identify the stage of Lyme disease would help patients and providers.

Lyme Disease Biobank @lymebiobank.bsky.social · Jul 16

New research from @gomes-solecki.bsky.social and team on using immunoglobulin class and IgG isotypes to distinguish different stages of Lyme disease. Could help identify early Lyme cases which are often missed by current serology tests. journals.asm.org/doi/10.1128/...

Class and isotype of VlsE-specific antibody differentiates Lyme disease stage | Journal of Clinical Microbiology

The order of switching between the immunoglobulin heavy chain (Fc) is time dependent, progressing from IgM/D to IgG3/IgG1/IgA1/IgG2/IgG4 and later to IgE/IgA2. In this study, we show that B. burgdorfe...

Why Don’t We Have A Vaccine For Lyme Disease?

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Lyme Disease Biobank @lymebiobank.bsky.social · Jul 15

Want to learn more about the biobank? Check out my talk about our sample collection, diagnostics in development using these samples, and finding Borrelia in tissue! Shout out to @livlyme.bsky.social for a great Summit and making these talks available!

The LivLyme Foundation @livlyme.bsky.social · Jul 15

🎥 BIG NEWS! 🎥
The 2025 LivLyme Scientific Summit speaker videos are now LIVE — and they’re completely FREE to watch!
Hear from top scientists, physicians, and advocates as they share the latest research, breakthroughs, and hope in the fight against Lyme and TBDs.
📲 Watch now at LivLymeFoundation.org

Lyme Disease Biobank @lymebiobank.bsky.social · Jul 13

Great interview with @tuftslyme.bsky.social Linden Hu! This really is the year for ticks and Lyme disease.....

Science Friday @scifri.bsky.social · Jul 13

Muscle pain with a side of brain fog: Dealing with Lyme disease isn’t a fun time, and the ticks that carry it are proliferating. An immunologist shares the ongoing quest for a vaccine against the disease.

Tick seasons are getting worse, raising concerns about the risk of Lyme disease. Dogs can get vaccinated for it. Why can't humans?

www.sciencefriday.com

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Lyme Disease Biobank @lymebiobank.bsky.social · Jun 30

Did you blow up the image to find them? Or can you see them in the pic as is?

Lyme Disease Biobank @lymebiobank.bsky.social · Jun 20

sCD163, IFN-β, and IL-10 did not change during acute Lyme but were decreased during convalescence. These results using biobank samples provide information on the inflammatory processes involved in the progression and resolution of Lyme disease.

Lyme Disease Biobank @lymebiobank.bsky.social · Jun 20

For cytokines elevated in early Lyme, IL-12, IFN-gamma, and soluble TNF receptors returned to normal levels at convalescence, while MMP-1 stayed elevated, and sIL6R, IL-26, IL-2, and IFN-alpha dropped.

EXPRESS: Key inflammatory mediators drive the resolution of acute Lyme disease - Jorge L. Cervantes, Shahrukh Chaudhry, Jose Barragan, Idris Akinlusi, Ted Zhao, Ryan Graff, Bo-young Hong, 2025

Lyme Disease Biobank @lymebiobank.bsky.social · Jun 20

New paper from Jorge Cervantes and team in J Investig Med looking at cytokines in acute and convalescent samples from patients with early acute Lyme. At convalescence, some cytokines returned to normal levels, some were elevated, and others were reduced.
journals.sagepub.com/doi/10.1177/...

Lyme disease is an inflammatory disease in response to Borrelia burgdorferi infection. We analyzed cytokines in sera from acute and convalescent LD patients, an...

journals.sagepub.com

2025 Summer LymeTimes - LymeDisease.org Member Community

Lyme Disease Biobank @lymebiobank.bsky.social · Jun 20

sCD163, IFN-β, and IL-10 did not change during acute Lyme but were decreased during convalescence. These results using biobank samples provide information on the inflammatory processes involved in the progression and resolution of early acute Lyme disease.

Lyme Disease Biobank @lymebiobank.bsky.social · Jun 12

Congratulations! @lymenews.bsky.social MyLymeData is an incredibly important resource in #LymeDisease.

LymeDisease.org @lymenews.bsky.social · Jun 12

Our latest issue celebrates MyLymeData’s 10th anniversary, highlighting its impact in reshaping Lyme disease research. It also features news updates and powerful first-person accounts of resilience and recovery from Lyme and other tick-borne diseases. www.lymedisease.org/members/lyme...

LymeTimes Summer 2025 - 10 Years of MyLymeData: A Patient-Driven Revolution in Lyme Disease Research

www.lymedisease.org

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Lyme Disease Biobank @lymebiobank.bsky.social · Jun 4

New study from long time collaborator Neal Woodbury and team at #ASU identifies #biomarkers using #Biobank samples that distinguish #LymeDisease from other febrile illnesses. #diagnostics
www.frontiersin.org/journals/imm...

Frontiers | Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding

IntroductionLyme disease (LD) is a tick-borne disease that is a substantial public health burden with estimated about 0.5 million new cases per year in the U...

www.frontiersin.org

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Lyme Disease Biobank @lymebiobank.bsky.social · Jun 4

Is that in your backyard? Are they friendly?