Nicolas Manel Lab
@manellab.bsky.social
Institut Curie, Paris, France
https://minilien.curie.fr/ejggfa
https://minilien.curie.fr/ejggfa
Pinned
Pathogen Immunity and Signalling
Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…
meetings.embo.org
🔥 Mark the date! 🗓️
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
🔥In two days!
Looking forward to our next #globalimmuno talk this Wednesday, November 26th, at 9am PST, noon EST, 5pm GMT by Dr. Nicolas Manel.
Title: “Centromeres reimagined in the immune system”
ZOOM LINK: us06web.zoom.us/webinar/regi...
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS
Title: “Centromeres reimagined in the immune system”
ZOOM LINK: us06web.zoom.us/webinar/regi...
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS
November 24, 2025 at 9:45 PM
🔥In two days!
You bet.
Thanks so much to the amazing @erc.europa.eu, the panel members and the reviewers!
Thanks so much to the amazing @erc.europa.eu, the panel members and the reviewers!
Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!
November 6, 2025 at 9:22 PM
You bet.
Thanks so much to the amazing @erc.europa.eu, the panel members and the reviewers!
Thanks so much to the amazing @erc.europa.eu, the panel members and the reviewers!
🔥👇 The place to be.
My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression.
info and application here
institut-curie.org/job/study-en....
info and application here
institut-curie.org/job/study-en....
Study Engineer (F/M) - Institut Curie
The Curie Institute Research CenterThe Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a str...
institut-curie.org
November 4, 2025 at 9:53 PM
🔥👇 The place to be.
Reposted by Nicolas Manel Lab
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
October 18, 2025 at 6:55 AM
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
🔥 Mark the date! 🗓️
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Pathogen Immunity and Signalling
Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…
meetings.embo.org
October 7, 2025 at 2:48 PM
🔥 Mark the date! 🗓️
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Fantastic seminar today by Norbert Pardi from @upenn.edu who did the pioneering work with Katalin Kariko and Drew Weissman to unlock mRNA nanoparticules.
mRNA nanoparticules are the therapeutics of tomorrow!
mRNA nanoparticules are the therapeutics of tomorrow!
October 3, 2025 at 11:33 AM
Fantastic seminar today by Norbert Pardi from @upenn.edu who did the pioneering work with Katalin Kariko and Drew Weissman to unlock mRNA nanoparticules.
mRNA nanoparticules are the therapeutics of tomorrow!
mRNA nanoparticules are the therapeutics of tomorrow!
🔥Really cool work by our neighbors @dfachinetti.bsky.social together with Stanford's only @naltemose.bsky.social showcasing the ability to tune DNA methylation specifically in centromeric DNA, in turn affecting the identity and functionality of centromeres.
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 7:41 PM
🔥Really cool work by our neighbors @dfachinetti.bsky.social together with Stanford's only @naltemose.bsky.social showcasing the ability to tune DNA methylation specifically in centromeric DNA, in turn affecting the identity and functionality of centromeres.
Erika Valeri & Moriz Gaidt @impvienna.bsky.social put together a very nice "Spotlights" piece in the latest issue of Molecular Cell @cp-molcell.bsky.social about the antiviral defense system VICAR and some of the avenues of research it opens.
🙏 to the authors
www.cell.com/molecular-ce...
🙏 to the authors
www.cell.com/molecular-ce...
DIY innate immune sensing: Crafting fresh DNA to detect viruses
The innate immune receptor cGAS is geared toward detecting DNA from pathogens. In
a recent Cell publication, Lahaye et al. discovered that viral infection triggers
de novo synthesis of self-DNA-activa...
www.cell.com
August 7, 2025 at 7:13 PM
Erika Valeri & Moriz Gaidt @impvienna.bsky.social put together a very nice "Spotlights" piece in the latest issue of Molecular Cell @cp-molcell.bsky.social about the antiviral defense system VICAR and some of the avenues of research it opens.
🙏 to the authors
www.cell.com/molecular-ce...
🙏 to the authors
www.cell.com/molecular-ce...
Thrilled to be part of the late 2025 roster of @globalimmuno.bsky.social
See you all on November 26th!
Thanks so much to the organisers for putting this together.
See you all on November 26th!
Thanks so much to the organisers for putting this together.
🧬2nd Semester 2025 lineup is here!
Join us for a new round of cutting-edge immunology seminars from top researchers around the world!
Mark your calendar & share!
For more info: linktr.ee/globalimmuno...
Join us for a new round of cutting-edge immunology seminars from top researchers around the world!
Mark your calendar & share!
For more info: linktr.ee/globalimmuno...
August 5, 2025 at 11:54 AM
Thrilled to be part of the late 2025 roster of @globalimmuno.bsky.social
See you all on November 26th!
Thanks so much to the organisers for putting this together.
See you all on November 26th!
Thanks so much to the organisers for putting this together.
Really cool highlight of our work @cp-cell.bsky.social describing VICAR, a novel antiviral defense system in humans, where centromeres take the center stage.
Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.
Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.
Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social
August 2, 2025 at 2:09 PM
Really cool highlight of our work @cp-cell.bsky.social describing VICAR, a novel antiviral defense system in humans, where centromeres take the center stage.
Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.
Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.
Reposted by Nicolas Manel Lab
Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social
August 2, 2025 at 8:07 AM
Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social
Happy to let you know that the plasmids (except one, pending QC) from our study describing the VICAR antiviral defense system are now available through @addgene.bsky.social here: www.addgene.org/browse/artic...
Thanks @addgene.bsky.social for making this possible!
Thanks @addgene.bsky.social for making this possible!
July 17, 2025 at 4:09 PM
Happy to let you know that the plasmids (except one, pending QC) from our study describing the VICAR antiviral defense system are now available through @addgene.bsky.social here: www.addgene.org/browse/artic...
Thanks @addgene.bsky.social for making this possible!
Thanks @addgene.bsky.social for making this possible!
Trans...genes!
Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris
Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris
June 13, 2025 at 5:50 PM
Trans...genes!
Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris
Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 3:14 PM
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Reposted by Nicolas Manel Lab
📣 We are recruiting new group leaders in Innovative Biology!
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
May 28, 2025 at 12:12 PM
📣 We are recruiting new group leaders in Innovative Biology!
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
How does a cell detect infection by a DNA virus in its nucleus?
May 29, 2025 at 4:25 PM
How does a cell detect infection by a DNA virus in its nucleus?
Check out Randmice 2.0 from our colleagues @ Stimunity Biotech. It became an essential tool for us to optimize animal randomization for in vivo experiments. And it's free!
randmice.com
randmice.com
Randmice - Optimize animal randomization
randmice.com
May 26, 2025 at 9:28 PM
Check out Randmice 2.0 from our colleagues @ Stimunity Biotech. It became an essential tool for us to optimize animal randomization for in vivo experiments. And it's free!
randmice.com
randmice.com
Soren Paludan @civia-aarhus.bsky.social kicks off a wonderful 2-day workshop on antiviral host defense. Looking forward to catching up will all the speakers and participants!
May 21, 2025 at 8:05 AM
Soren Paludan @civia-aarhus.bsky.social kicks off a wonderful 2-day workshop on antiviral host defense. Looking forward to catching up will all the speakers and participants!
So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social
April 27, 2025 at 12:17 PM
So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social
Reposted by Nicolas Manel Lab
🚨 New EJI-EFIS Prize for ECRs! 🚨
🏆 €5,000 award for the best research article in EJI by an Early Career Researcher!
🎤 Winner presents at ECI + receives an EFIS–EJI travel grant!
🔗 Apply now: onlinelibrary.wiley.com/page/journal...
#ECR #Immunology #EJI #EFIS #ScienceFunding
🏆 €5,000 award for the best research article in EJI by an Early Career Researcher!
🎤 Winner presents at ECI + receives an EFIS–EJI travel grant!
🔗 Apply now: onlinelibrary.wiley.com/page/journal...
#ECR #Immunology #EJI #EFIS #ScienceFunding
European Journal of Immunology: EJI-EFIS Prize for the ECR Article of the Year
EJI and EFIS are thrilled to announce a new prize honoring Early Career Researchers (ECRs) whose work is published in EJI. This initiative aims to showcase the next generation of immunologists and encourage them to submit their excellent research to EJI.
onlinelibrary.wiley.com
March 8, 2025 at 6:45 AM
🚨 New EJI-EFIS Prize for ECRs! 🚨
🏆 €5,000 award for the best research article in EJI by an Early Career Researcher!
🎤 Winner presents at ECI + receives an EFIS–EJI travel grant!
🔗 Apply now: onlinelibrary.wiley.com/page/journal...
#ECR #Immunology #EJI #EFIS #ScienceFunding
🏆 €5,000 award for the best research article in EJI by an Early Career Researcher!
🎤 Winner presents at ECI + receives an EFIS–EJI travel grant!
🔗 Apply now: onlinelibrary.wiley.com/page/journal...
#ECR #Immunology #EJI #EFIS #ScienceFunding
@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!
March 7, 2025 at 5:39 PM
@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!
#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch.
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
February 26, 2025 at 8:34 PM
#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch.
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Reposted by Nicolas Manel Lab
📢 En 2025, nous renouvelons notre appel à projets « Passerelle » afin de soutenir des chercheurs non statutaires préparant les concours à un poste de chercheur au sein d’un EPST français.
🏆 Les lauréat(e)s recevront un soutien de 100 000 € pour un an.
👉 urlz.fr/pR3x
🏆 Les lauréat(e)s recevront un soutien de 100 000 € pour un an.
👉 urlz.fr/pR3x
February 24, 2025 at 8:39 AM
📢 En 2025, nous renouvelons notre appel à projets « Passerelle » afin de soutenir des chercheurs non statutaires préparant les concours à un poste de chercheur au sein d’un EPST français.
🏆 Les lauréat(e)s recevront un soutien de 100 000 € pour un an.
👉 urlz.fr/pR3x
🏆 Les lauréat(e)s recevront un soutien de 100 000 € pour un an.
👉 urlz.fr/pR3x
Unexpected conservation: Rick Rubin interviews Richard Feynman. Loving this chat btwn 2 titans, defying the laws of time. Plenty of cool topics: curiosity, solving 'simple' problems, avoiding admin duties, teaching != research, religion, social studies....
www.tetragrammaton.com/content/rich...
www.tetragrammaton.com/content/rich...
Richard Feynman - Tetragrammaton
52m 11.30.24
www.tetragrammaton.com
February 11, 2025 at 6:21 PM
Unexpected conservation: Rick Rubin interviews Richard Feynman. Loving this chat btwn 2 titans, defying the laws of time. Plenty of cool topics: curiosity, solving 'simple' problems, avoiding admin duties, teaching != research, religion, social studies....
www.tetragrammaton.com/content/rich...
www.tetragrammaton.com/content/rich...
Reposted by Nicolas Manel Lab
Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
January 28, 2025 at 2:33 PM
Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social