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Nicolas Manel Lab @manellab.bsky.social · 1d

🔥 Mark the date! 🗓️

Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.

Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.

Submit your abstract.

Join us on 8 – 11 June 2026.

meetings.embo.org/event/26-pat...

Pathogen Immunity and Signalling

Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…

meetings.embo.org

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Nicolas Manel Lab @manellab.bsky.social · 5d

Fantastic seminar today by Norbert Pardi from @upenn.edu who did the pioneering work with Katalin Kariko and Drew Weissman to unlock mRNA nanoparticules.

mRNA nanoparticules are the therapeutics of tomorrow!

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Nicolas Manel Lab @manellab.bsky.social · Sep 4

🔥Really cool work by our neighbors @dfachinetti.bsky.social together with Stanford's only @naltemose.bsky.social showcasing the ability to tune DNA methylation specifically in centromeric DNA, in turn affecting the identity and functionality of centromeres.

dfachinetti.bsky.social @dfachinetti.bsky.social · Sep 4

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

www.nature.com

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Nicolas Manel Lab @manellab.bsky.social · Aug 7

Erika Valeri & Moriz Gaidt @impvienna.bsky.social put together a very nice "Spotlights" piece in the latest issue of Molecular Cell @cp-molcell.bsky.social about the antiviral defense system VICAR and some of the avenues of research it opens.
🙏 to the authors

www.cell.com/molecular-ce...

DIY innate immune sensing: Crafting fresh DNA to detect viruses

The innate immune receptor cGAS is geared toward detecting DNA from pathogens. In a recent Cell publication, Lahaye et al. discovered that viral infection triggers de novo synthesis of self-DNA-activa...

www.cell.com

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Nicolas Manel Lab @manellab.bsky.social · Aug 5

Thrilled to be part of the late 2025 roster of @globalimmuno.bsky.social
See you all on November 26th!

Thanks so much to the organisers for putting this together.

Global Immunotalks @globalimmuno.bsky.social · Aug 5

🧬2nd Semester 2025 lineup is here!
Join us for a new round of cutting-edge immunology seminars from top researchers around the world!

Mark your calendar & share!
For more info: linktr.ee/globalimmuno...

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Nicolas Manel Lab @manellab.bsky.social · Aug 2

Really cool highlight of our work @cp-cell.bsky.social describing VICAR, a novel antiviral defense system in humans, where centromeres take the center stage.

Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.

Esashi Lab @esashilab.bsky.social · Aug 2

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

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Reposted by Nicolas Manel Lab

Esashi Lab @esashilab.bsky.social · Aug 2

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

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Nicolas Manel Lab @manellab.bsky.social · Jul 17

Happy to let you know that the plasmids (except one, pending QC) from our study describing the VICAR antiviral defense system are now available through @addgene.bsky.social here: www.addgene.org/browse/artic...

Thanks @addgene.bsky.social for making this possible!

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Nicolas Manel Lab @manellab.bsky.social · Jun 13

Trans...genes!
Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris

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Nicolas Manel Lab @manellab.bsky.social · Jun 3

Thanks Ivan for the highlight!

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Nicolas Manel Lab @manellab.bsky.social · Jun 3

Thanks Matteo! Your previous work enabled this.

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Nicolas Manel Lab @manellab.bsky.social · Jun 3

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Nicolas Manel Lab @manellab.bsky.social · Jun 3

Thanks Rafa! This is explained in the discussion, it comes from prior work by Patrick Lomonte et al. The key paper is doi.org/10.1371/jour...

HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in Neurons

Author Summary After an initial lytic infection, many viruses establish a lifelong latent infection that hides them from the host immune system activity until reactivation. To understand the resurgenc...

doi.org

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Nicolas Manel Lab @manellab.bsky.social · Jun 2

Thanks Josh, we are so lucky to have you as a colleague, your insights have been quite helpful to take the right direction on genomics.

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Nicolas Manel Lab @manellab.bsky.social · Jun 2

Thanks Ngoc, it was great to see that part of the story unfold with you.

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Nicolas Manel Lab @manellab.bsky.social · Jun 2

Thanks Daniele & your team, your help on centromeres was instrumental! We're privileged to have colleagues like you.

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Nicolas Manel Lab @manellab.bsky.social · Jun 2

Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

www.cell.com

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Reposted by Nicolas Manel Lab

IGMM-Montpellier @igmm-montpel.bsky.social · May 28

📣 We are recruiting new group leaders in Innovative Biology!

RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology

Application and information ⬇️
application.igmm.cnrs.fr

@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

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Nicolas Manel Lab @manellab.bsky.social · May 29

How does a cell detect infection by a DNA virus in its nucleus?

Nicolas Manel Lab @manellab.bsky.social · May 26

Check out Randmice 2.0 from our colleagues @ Stimunity Biotech. It became an essential tool for us to optimize animal randomization for in vivo experiments. And it's free!
randmice.com

Randmice - Optimize animal randomization

randmice.com

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Nicolas Manel Lab @manellab.bsky.social · May 23

Beautiful picture. Bravo Sebastian, thanks @embojournal.org for the prize and @civia-aarhus.bsky.social for such an exciting meeting.

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Nicolas Manel Lab @manellab.bsky.social · May 21

Soren Paludan @civia-aarhus.bsky.social kicks off a wonderful 2-day workshop on antiviral host defense. Looking forward to catching up will all the speakers and participants!

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Nicolas Manel Lab @manellab.bsky.social · Apr 27

So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social

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Reposted by Nicolas Manel Lab

Iannacone Lab @iannaconelab.bsky.social · Mar 8

🚨 New EJI-EFIS Prize for ECRs! 🚨

🏆 €5,000 award for the best research article in EJI by an Early Career Researcher!
🎤 Winner presents at ECI + receives an EFIS–EJI travel grant!

🔗 Apply now: onlinelibrary.wiley.com/page/journal...

#ECR #Immunology #EJI #EFIS #ScienceFunding

European Journal of Immunology: EJI-EFIS Prize for the ECR Article of the Year

EJI and EFIS are thrilled to announce a new prize honoring Early Career Researchers (ECRs) whose work is published in EJI. This initiative aims to showcase the next generation of immunologists and encourage them to submit their excellent research to EJI.

onlinelibrary.wiley.com

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Nicolas Manel Lab @manellab.bsky.social · Mar 7

@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!

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