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Manuel Friese

@manuelfriese.bsky.social

170 followers 240 following 3 posts

Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE

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Medicine 41%

Biology 35%

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Manuel Friese @manuelfriese.bsky.social · Jun 17

Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

www.cell.com

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Reposted by Manuel A. Friese

Waggoner Lab @labwaggoner.bsky.social · Jun 17

Interferon-induced immunoproteasome drastically decreases proteasomal activity in neurons, leading to a switch in neuronal metabolism with increased oxidative injury and ferroptosis @cellcellpress.bsky.social @manuelfriese.bsky.social
www.cell.com/cell/fulltex...

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Reposted by Manuel A. Friese

Sina Rosenkranz @sinarosenkranz.bsky.social · Jun 6

We’re looking for a physician (f/m/d) with a strong interest in neuroimmunology and research in our MS outpatient clinic and day hospital team!
Join us in advancing care and science in a dynamic, interdisciplinary environment🧠

uke.jobs/index.php?ac...

Arzt/Ärztin (all genders) in Weiterbildung - Neurologie mit Schwerpunkt Neuroimmunologie

uke.jobs

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Reposted by Manuel A. Friese

Pedro Friedmann Angeli @angelifriedmann.bsky.social · Apr 9

Important walkthrough for newcomers in the field
rdcu.be/eg58p

Recommendations for robust and reproducible research on ferroptosis

Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

rdcu.be

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Reposted by Manuel A. Friese

Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 21

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis

Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.

www.science.org

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Manuel Friese @manuelfriese.bsky.social · Jan 28

We are hiring (2 positions) one
Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf

uke.jobs/index.php?ac...

uke.jobs/index.php?ac...

Manuel Friese @manuelfriese.bsky.social · Dec 4

Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between UKE Hamburg, KU Leuven, Fraunhofer ITMP, Evotec:
www.cell.com/iscience/ful...

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