Manuel Friese
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manuelfriese.bsky.social
Manuel Friese
@manuelfriese.bsky.social
190 followers 240 following 5 posts

Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE

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Medicine 41%
Biology 35%
Posts Replies Media Videos

Reposted by Manuel A. Friese

hertieneurosci.bsky.social
Hertie Network (Hamburg site) @hertieneurosci.bsky.social · 9d
We’re excited to introduce the new Hamburg #HertieNetwork fellows for the 3rd funding period: @felixfischbach.bsky.social, Märit Jensen, @brissiek.bsky.social & @janasonner.bsky.social. Looking forward to inspiring projects, discussions & collaboration across sites! #UKEHamburg #HertieStiftung

manuelfriese.bsky.social
Manuel Friese @manuelfriese.bsky.social · 13d
Check out our latest research on how a neuron-immune axis modulates peripheral immune responses during multiple sclerosis. We discovered it by exploring pregnancy-associated immune modulation in multiple sclerosis. Special thanks to Jana Sonner and Audrey Kahn:

www.nature.com/articles/s41...
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology
Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...
www.nature.com

manuelfriese.bsky.social
Manuel Friese @manuelfriese.bsky.social · 29d
We are hiring dedicated and motivated new members to join our basic and clinical research team at INIMS (www.inims.de), Universitätsklinikum Hamburg-Eppendorf.

- Medical Scientist (Postdoc)
- Clinician Scientist (Neurology)

Apply here:

www.uke.jobs/index.php?ac...

www.uke.jobs/index.php?ac...

Reposted by Manuel A. Friese

thelancet.com
The Lancet @thelancet.com · Nov 5
👉 Register now: hubs.li/Q03NdTNP0
📆 Nov 20, 2025 | 2pm GMT / 9am EST / 10pm CST

Join our expert panel as they explore innate immunity’s role in neurological diseases, and therapies to prevent inflammation-driven neurodegeneration.

#neurology #brainhealth #lancetwebinar
Blue graphic with text saying: "Webinar: Innate immunity regulation of brain health on Thursday, November 20, 2025 at 2pm GMT/9am EST/10pm CST. Join Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology, Sam Rose, Scientific Editor of Neuron, David Hunt, Professor of Medicine at University of Edinburgh, Andrea Ablasser, Professor at École Polytechnique Fédérale de Lausanne, and Manuel Friese, Professor of Neurology at University Medical Center Hamburg-Eppendorf". The Cell Press and The Lancet logos appear in the top left and right corners respectively. Copyright: Elsevier Ltd.

manuelfriese.bsky.social
Manuel Friese @manuelfriese.bsky.social · Jun 17
Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...
www.cell.com

Reposted by Manuel A. Friese

labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Jun 17
Interferon-induced immunoproteasome drastically decreases proteasomal activity in neurons, leading to a switch in neuronal metabolism with increased oxidative injury and ferroptosis @cellcellpress.bsky.social @manuelfriese.bsky.social
www.cell.com/cell/fulltex...

Reposted by Manuel A. Friese

sinarosenkranz.bsky.social
Sina Rosenkranz @sinarosenkranz.bsky.social · Jun 6
We’re looking for a physician (f/m/d) with a strong interest in neuroimmunology and research in our MS outpatient clinic and day hospital team!
Join us in advancing care and science in a dynamic, interdisciplinary environment🧠

uke.jobs/index.php?ac...
Arzt/Ärztin (all genders) in Weiterbildung - Neurologie mit Schwerpunkt Neuroimmunologie
uke.jobs

Reposted by Manuel A. Friese

angelifriedmann.bsky.social
Pedro Friedmann Angeli @angelifriedmann.bsky.social · Apr 9
Important walkthrough for newcomers in the field
rdcu.be/eg58p
Recommendations for robust and reproducible research on ferroptosis
Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...
rdcu.be

Reposted by Manuel A. Friese

immunoeditor.bsky.social
Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 21
This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!
Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis
Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.
www.science.org

manuelfriese.bsky.social
Manuel Friese @manuelfriese.bsky.social · Jan 28
We are hiring (2 positions) one
Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf

uke.jobs/index.php?ac...

uke.jobs/index.php?ac...

manuelfriese.bsky.social
Manuel Friese @manuelfriese.bsky.social · Dec 4
Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between UKE Hamburg, KU Leuven, Fraunhofer ITMP, Evotec:
www.cell.com/iscience/ful...