Mathias V. Schmidt
@mathiasvschmidt.bsky.social
Unraveling the molecular basis of stress resilience | Group leader at MPI of Psychiatry | Secretary General Elect of FENS | Editor-in-Chief Neurobiology of Stress
Pinned
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications
Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...
www.nature.com
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
This is the path to robust, translational data. 𝐃𝐨𝐧'𝐭 𝐏𝐚𝐧𝐢𝐜! Read the full guide and join the shift to deep phenotyping.
Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social
Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social
November 10, 2025 at 2:54 PM
This is the path to robust, translational data. 𝐃𝐨𝐧'𝐭 𝐏𝐚𝐧𝐢𝐜! Read the full guide and join the shift to deep phenotyping.
Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social
Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social
We provide:
- A standardized workflow for long-term home-cage monitoring in mice.
- A practical guidance on experimental setups for 24-hour recordings.
- A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases
.. and much more!
- A standardized workflow for long-term home-cage monitoring in mice.
- A practical guidance on experimental setups for 24-hour recordings.
- A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases
.. and much more!
November 10, 2025 at 2:54 PM
We provide:
- A standardized workflow for long-term home-cage monitoring in mice.
- A practical guidance on experimental setups for 24-hour recordings.
- A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases
.. and much more!
- A standardized workflow for long-term home-cage monitoring in mice.
- A practical guidance on experimental setups for 24-hour recordings.
- A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases
.. and much more!
Check out our new paper in Neuroscience & Biobehavioral Reviews: "𝑳𝒐𝒏𝒈-𝒕𝒆𝒓𝒎 𝒅𝒆𝒆𝒑 𝒑𝒉𝒆𝒏𝒐𝒕𝒚𝒑𝒊𝒏𝒈 𝒐𝒇 𝒃𝒆𝒉𝒂𝒗𝒊𝒐𝒓𝒂𝒍 𝒕𝒓𝒂𝒊𝒕𝒔 𝒊𝒏 𝒎𝒊𝒄𝒆 𝒖𝒔𝒊𝒏𝒈 𝒉𝒐𝒎𝒆𝒄𝒂𝒈𝒆 𝒎𝒐𝒏𝒊𝒕𝒐𝒓𝒊𝒏𝒈"
This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
Long-term deep phenotyping of behavioral traits in mice using homecage monitoring
Neuropsychiatric disorders represent a significant global health challenge, and a deeper understanding of their underlying neurobiology is urgently ne…
www.sciencedirect.com
November 10, 2025 at 2:54 PM
Check out our new paper in Neuroscience & Biobehavioral Reviews: "𝑳𝒐𝒏𝒈-𝒕𝒆𝒓𝒎 𝒅𝒆𝒆𝒑 𝒑𝒉𝒆𝒏𝒐𝒕𝒚𝒑𝒊𝒏𝒈 𝒐𝒇 𝒃𝒆𝒉𝒂𝒗𝒊𝒐𝒓𝒂𝒍 𝒕𝒓𝒂𝒊𝒕𝒔 𝒊𝒏 𝒎𝒊𝒄𝒆 𝒖𝒔𝒊𝒏𝒈 𝒉𝒐𝒎𝒆𝒄𝒂𝒈𝒆 𝒎𝒐𝒏𝒊𝒕𝒐𝒓𝒊𝒏𝒈"
This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.
November 10, 2025 at 2:54 PM
To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.
Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.
November 3, 2025 at 7:17 AM
Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.
Reposted by Mathias V. Schmidt
🚨Open position at #FENS!
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
October 16, 2025 at 4:00 PM
🚨Open position at #FENS!
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8
Looking forward to this exciting conference. If you are interested in the latest science on the developmental origins of mental illness, join me and my co-chair @talliezee.bsky.social for our session on Sunday morning at 11:20am.
October 10, 2025 at 11:42 AM
Looking forward to this exciting conference. If you are interested in the latest science on the developmental origins of mental illness, join me and my co-chair @talliezee.bsky.social for our session on Sunday morning at 11:20am.
Reposted by Mathias V. Schmidt
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Redirecting
doi.org
October 7, 2025 at 8:43 AM
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Reposted by Mathias V. Schmidt
Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling
Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...
www.biorxiv.org
September 25, 2025 at 10:12 PM
Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Important initiative 👇
August 21, 2025 at 9:18 AM
Important initiative 👇
Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.
June 30, 2025 at 11:48 AM
Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.
Reposted by Mathias V. Schmidt
June 28, 2025 at 2:47 PM
Reposted by Mathias V. Schmidt
🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides
Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…
sciencedirect.com
June 10, 2025 at 10:40 PM
🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
Reposted by Mathias V. Schmidt
🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events
www.neurobiologyofgrief.org/events
Events — Neurobiology of Grief International Network
www.neurobiologyofgrief.org
May 26, 2025 at 12:07 PM
🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events
www.neurobiologyofgrief.org/events
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
The evolving neurobiology of early-life stress
This review explores the effects of early-life stress on brain development and cognitive
function, highlighting gaps in understanding perceived stress, vulnerable developmental
stages, underlying mole...
www.cell.com
May 23, 2025 at 9:35 AM
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
Reposted by Mathias V. Schmidt
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry
Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…
www.sciencedirect.com
May 5, 2025 at 2:01 PM
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...
www.psych.mpg.de/2949097/news...
Early Life Stress Can Build Resilience in Females
Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...
www.psych.mpg.de
April 23, 2025 at 1:52 PM
Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...
www.psych.mpg.de/2949097/news...
So well deserved! Congratulations 👏🏻👏🏻👏🏻
April 2, 2025 at 5:17 PM
So well deserved! Congratulations 👏🏻👏🏻👏🏻
Reposted by Mathias V. Schmidt
The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
Peter Seeburg Integrative Neuroscience Prize
www.sfn.org
March 24, 2025 at 7:58 PM
The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
Reposted by Mathias V. Schmidt
Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...
doi.org/10.1007/7854...
Intergenerational Effects of Stress – A Focus on Learning and Memory
Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in thei...
doi.org
March 23, 2025 at 12:05 PM
Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...
doi.org/10.1007/7854...
Reposted by Mathias V. Schmidt
We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
lab but aesthetic 🤩 comment how a typical day looks for you #sza #dayinlife #interviews #science #lablife #labtech #behindthescene
TikTok video by trainor lab
www.tiktok.com
March 15, 2025 at 8:09 PM
We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.
March 14, 2025 at 4:32 PM
Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.
Our data especially highlight the importance of studying sex differences in how individuals cope with stress.
March 14, 2025 at 4:32 PM
Our data especially highlight the importance of studying sex differences in how individuals cope with stress.