Lightnews — Scholar-powered news

LightNews

Mathias V. Schmidt

@mathiasvschmidt.bsky.social

1.7K followers 450 following 45 posts

Unraveling the molecular basis of stress resilience | Group leader at MPI of Psychiatry | Secretary General Elect of FENS | Editor-in-Chief Neurobiology of Stress

History 35%

Political science 18%

more

Posts Media Videos Starter Packs

Pinned

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 14

New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...

FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications

Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...

Reposted by Mathias Schmidt

Carmen Sandi @carmensandi10.bsky.social · 3d

Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.

Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!

🔗 Paper: doi.org/10.1016/j.bi...

Reposted by Mathias Schmidt

Natalie Matosin @nataliematosin.bsky.social · 14d

Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:

www.biorxiv.org/content/10.1...

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling

Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...

www.biorxiv.org

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Aug 21

Important initiative 👇

Reposted by Peter Rodgers, Mathias Schmidt

Tim Behrens @behrenstimb.bsky.social · Jan 30

Hope you'll forgive a quick thread as I take over as the new EiC of @elife.bsky.social

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Jun 30

Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.

Reposted by Mathias Schmidt

ebbsociety.bsky.social @ebbsociety.bsky.social · Jun 28

The heat won’t stop the energy — science (and fans!) in full swing!
🔆🪭💪
#EBBS2025

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Jun 28

In Bordeaux for the #EBBS meeting. Looking forward to 4 exciting days of science

Reposted by Mathias Schmidt

Natalie Matosin @nataliematosin.bsky.social · Jun 10

🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...

Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides

Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…

sciencedirect.com

Reposted by Mathias Schmidt

EARA @eara.eu · Jun 2

The Be Open about Animal Research Day is starting now!
Show your support and share on #BOARD25

Reposted by Mathias Schmidt

Oliver Bosch @olibosch.bsky.social · May 26

🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events

Events — Neurobiology of Grief International Network

www.neurobiologyofgrief.org

Mathias V. Schmidt @mathiasvschmidt.bsky.social · May 23

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

The evolving neurobiology of early-life stress

This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...

Reposted by Mathias Schmidt

Jamie Hanson @jamielarsh.bsky.social · May 5

Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...

Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry

Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…

www.sciencedirect.com

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Apr 23

Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...

Early Life Stress Can Build Resilience in Females

Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...

www.psych.mpg.de

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Apr 2

So well deserved! Congratulations 👏🏻👏🏻👏🏻

Reposted by Mathias Schmidt

Camilla Bellone @bellonec.bsky.social · Mar 24

The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch

www.sfn.org/careers/awar...

Peter Seeburg Integrative Neuroscience Prize

Reposted by Mathias Schmidt

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Mar 23

Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...

Intergenerational Effects of Stress – A Focus on Learning and Memory

Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in thei...

Reposted by Mathias Schmidt

Brian Trainor @briantrainor.bsky.social · Mar 15

We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/

lab but aesthetic 🤩 comment how a typical day looks for you #sza #dayinlife #interviews #science #lablife #labtech #behindthescene

TikTok video by trainor lab

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 14

Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 14

Our data especially highlight the importance of studying sex differences in how individuals cope with stress.

Reposted by Mathias Schmidt

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Mar 10

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
www.nature.com/articles/s41...

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis - Nature Communications

Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promo...

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 5

Very interesting paper on social behavior analysis 👇🏻

Bence Ölveczky @olveczky.bsky.social · Mar 4

Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 5

European Neuroscience Societies stand up for science to support our U.S. colleagues 💪🏻

Federation of European Neuroscience Societies - FENS @fens.org · Mar 5

📣 Science matters!

#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬

🔗 Read the full statement: loom.ly/cn7vJR4

#sciencematters #standupforscience #sciencenotsilence #scienceforall

Reposted by Mathias Schmidt

Federation of European Neuroscience Societies - FENS @fens.org · Mar 5

📣 Science matters!

#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬

🔗 Read the full statement: loom.ly/cn7vJR4

#sciencematters #standupforscience #sciencenotsilence #scienceforall

Reposted by Mathias Schmidt

KalischLab @kalischlab.bsky.social · Mar 5

A new initiative to connect #stress and #resilience researchers around the world. A global platform, needed more than ever in these times: gsr-net.org @gsrnet.bsky.social

Resources to learn, teach, find labs, methods, conferences, workshops, jobs. Benefits for early-career researchers.

1/3

GSRNet - Empowering collaboration and knowledge sharing

The Global Stress & Resilience Network (GSRNet) is a global community connecting stress and resilience researchers and national networks.

Reposted by Mathias Schmidt

Bence Ölveczky @olveczky.bsky.social · Mar 4

Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8

Mathias V. Schmidt @mathiasvschmidt.bsky.social · Mar 2

The systematic undermining of science by the US administration is absolutely horrifying. The global science community needs to stand up for science and support our US colleagues in this time of crisis.

Reposted by Mathias Schmidt

Surfin' NuRD @surfinnurd.bsky.social · Mar 2

Remember, EuropePMC is actually better than #PubMed because it includes ALL preprints in search results, not just those including NIH-funded research.

europepmc.org

Europe PMCHome - Europe PMC

Europe PMC is an archive of life sciences journal literature.

Reposted by Mathias Schmidt

Caroline Menard @caromenard666.bsky.social · Feb 27

So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI

www.nature.com/articles/s41...

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience

The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

Reposted by Mathias Schmidt

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Feb 21

Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents
www.science.org/doi/10.1126/...

Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents

Whereas humans exhibit emergency responses to assist unconscious individuals, how nonhuman animals react to unresponsive conspecifics is less well understood. We report that mice exhibit stereotypic b...

www.science.org