Matt Slein
@mattslein.bsky.social
Postdoctoral Fellow in the McLellan Lab at the University of Texas at Austin
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice
HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.
www.science.org
November 19, 2025 at 7:04 PM
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
Reposted by Matt Slein
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
UT Austin has a new “genius grant” recipient!
Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation.
#TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social
cns.utexas.edu/news/accolad...
Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation.
#TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social
cns.utexas.edu/news/accolad...
Virus Slayer Awarded ‘Genius Grant’ by MacArthur Foundation
The award recognizes Jason McLellan’s work to investigate how viruses infect our cells and to develop new treatments for infectious disease.
cns.utexas.edu
October 8, 2025 at 7:59 PM
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
Excited to have contributed to Volume 12 of Annual Review of Virology! www.annualreviews.org/content/jour...
October 9, 2025 at 12:39 PM
Excited to have contributed to Volume 12 of Annual Review of Virology! www.annualreviews.org/content/jour...
Excited to share a portion of my PhD work describing the mechanisms of antibody-mediated protection against HSV infection. Here we show that a panel of 5 mAbs targeting gB all required Fc effector functions to be protective in a mouse model of neonatal HSV infection. www.biorxiv.org/content/10.1...
Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice
Glycoprotein B (gB) serves as the viral fusion protein for herpes simplex virus (HSV), mediating fusion between viral and host membranes resulting in infection. As such, gB represents a potentially cr...
www.biorxiv.org
July 30, 2025 at 7:29 PM
Excited to share a portion of my PhD work describing the mechanisms of antibody-mediated protection against HSV infection. Here we show that a panel of 5 mAbs targeting gB all required Fc effector functions to be protective in a mouse model of neonatal HSV infection. www.biorxiv.org/content/10.1...
Reposted by Matt Slein
A paper from our pancoronavirus vaccine P01 grant group is now out in Science Translational Medicine.
Here we show that non-stabilized spike delivered as mRNA is sufficient to elicit broadly neutralizing antibodies in monkeys.
@alexschaefer.bsky.social
www.science.org/doi/10.1126/...
Here we show that non-stabilized spike delivered as mRNA is sufficient to elicit broadly neutralizing antibodies in monkeys.
@alexschaefer.bsky.social
www.science.org/doi/10.1126/...
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates
Nonstabilized SARS-CoV-2 spike mRNA vaccination elicited distinct antibodies to either Omicron variants of concern or preemergent sarbecoviruses.
www.science.org
June 12, 2025 at 2:15 PM
A paper from our pancoronavirus vaccine P01 grant group is now out in Science Translational Medicine.
Here we show that non-stabilized spike delivered as mRNA is sufficient to elicit broadly neutralizing antibodies in monkeys.
@alexschaefer.bsky.social
www.science.org/doi/10.1126/...
Here we show that non-stabilized spike delivered as mRNA is sufficient to elicit broadly neutralizing antibodies in monkeys.
@alexschaefer.bsky.social
www.science.org/doi/10.1126/...
Reposted by Matt Slein
Antibody-mediated restriction of M. tuberculosis is associated with reorganization of the tissue-level immune response to infection and depends on the collaboration of antibody Fab and Fc @cp-immunity.bsky.social Alter/Fortune
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
May 30, 2025 at 5:56 PM
Antibody-mediated restriction of M. tuberculosis is associated with reorganization of the tissue-level immune response to infection and depends on the collaboration of antibody Fab and Fc @cp-immunity.bsky.social Alter/Fortune
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
A review I wrote for the upcoming issue of Annual Review of Virology is now live as a Review in Advance! tinyurl.com/ARV2025 Here we talk about the multifaceted role of maternal antibodies in protection against three important congenital viral infections. #virology
Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues | Annual Reviews
Infection by neurovirulent pathogens in utero and during the neonatal period can lead to fetal and neonatal mortality as well as neurological morbidity with lifelong consequences. Fortunately, materna...
tinyurl.com
April 21, 2025 at 1:21 PM
A review I wrote for the upcoming issue of Annual Review of Virology is now live as a Review in Advance! tinyurl.com/ARV2025 Here we talk about the multifaceted role of maternal antibodies in protection against three important congenital viral infections. #virology
Successfully defended my thesis two weeks ago! Couldn’t have asked for better labs to do my PhD work in
March 28, 2025 at 8:06 PM
Successfully defended my thesis two weeks ago! Couldn’t have asked for better labs to do my PhD work in