Lightnews — Scholar-powered news

Megan Seddon @meganismofaction.bsky.social · Dec 24

Happy Holidays from me and Echo 🩵🎄🐈

Pets of #IDSky #PharmSky #SIDP #MedSky

Echo the orange cat standing next to a Charlie Brown-esque potted fir tree. The tree is decorated with multi-colored lights, royal blue and pearl white ball ornaments, and a snow flake ornament towards the top.

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Megan Seddon @meganismofaction.bsky.social · Dec 14

😻😻😻 So cute!!!

Reposted by Megan Seddon

Carrie Freed, Pharm.D., BCIDP, AAHIVP @apothecarrie.bsky.social · Dec 14

Adding mine in 😄 happy Caturday from Wheatley and Dewey!

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Megan Seddon @meganismofaction.bsky.social · Dec 14

I aspire to my cat’s level of relaxation 🧘 Happy #Caturday from me and Echo 🩵🦋

Pets of #IDSky #PharmSky #MedSky #SIDP

Echo the orange cat asleep on a light blue fluffy blanket, the picture of ultimate rest and relaxation. He is laying on his side facing the camera and pink toe beans on one of his front paws are peaking out from folds of the blanket.

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Reposted by Megan Seddon

Anthony Lau, PharmD BCPS @alaurx.bsky.social · Dec 10

1/ 10th Day of Pharmacy Advent: IV Iron therapy in concurrent infection.
Let's delve into the complexities of using IV iron during active severe infections & potential risks involved👇

Shout out & thnx to @kirchoff.org for topic idea! 🙏

#medsky #pharmsky #EMsky #IDsky #HMsky #nephrosky

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Reposted by Megan Seddon

Stella Safo, MD MPH @ammahstarr.bsky.social · Dec 10

Happening today yall with the amazing Dr Uché Blackstock. We hope you’ll join!!

justequity.bsky.social @justequity.bsky.social · Dec 6

🗓️ Tues, Dec 10, 2024 @ 4:30 PM ET 🗓️
Don't miss a special #SocialMedicine Rounds: "Addressing Medical Racism with Dr. Uché Blackstock”

Register here: https://buff.ly/3AJfeos (1/4)

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Megan Seddon @meganismofaction.bsky.social · Dec 7

Taken by surprise by this single bloom on one of my Christmas cacti today. I can’t find another bud on the entire plant 🪴 💚

Pale, pale yellowish bloom on a Christmas cactus (maybe a Thanksgiving cactus 🤷🏼‍♀️). Hot pink stamen (pretty sure that’s the stamen?). No other buds to be found on the entire plant. A pleasant surprise.

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Megan Seddon @meganismofaction.bsky.social · Dec 7

Echo wishes you some rest on this #Caturday 😴🐈

Pets of #IDSky #PharmSky #SIDP #CatSky

Echo the orange cat, stretched out on the bed, head snuggled into my forearm, eyes closed, content, front legs reaching towards me, white whiskers catching the light coming in through the gap in the curtains.

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Reposted by Megan Seddon

Anthony Lau, PharmD BCPS @alaurx.bsky.social · Dec 6

1/ On the 6th day of Pharmacy Advent, let’s talk re: communication

Today, I’m sharing a💎I learned in palliative care that I carry into ED practice. This tool has profoundly shaped how I approach sensitive conversations w/ pts & peers. Let’s dive in👇 #medsky #pharmsky #nursesky #emimcc #HMsky #GPsky

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Reposted by Megan Seddon

Society of Infectious Diseases Pharmacists - SIDP @sidpharm.bsky.social · Dec 5

2024 is coming to a close! Check out our SIDP Wrapped! 🎊 #stewardship #infectiousdiseases

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Reposted by Megan Seddon

Erin McCreary, PharmD @erinmccreary.bsky.social · Dec 5

it’s the happiest Thursday because @sidpharm.bsky.social and the @escmid.bsky.social PK PD study group are bringing back ICAAC (in spirit)!!!!

Registration will open next week! The Midwest in the summer is magical - come join us!

sidp.org/page-1543694

#idsky #amssky #pharmsky

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Reposted by Megan Seddon

Manny Guajardo @mannyguajardo.bsky.social · Dec 5

Hi #IDSky - Tulane ID has unfilled fellowship spots. We're looking for applicants to join starting 7/2025

We offer:
-Diverse training across 3 hospital sites
-Broad clinical exposure, including HIV, tropical diseases, and transplant

(1/2)

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Reposted by Megan Seddon

Neeraja Swaminathan @neerajaswaminathan.bsky.social · Dec 4

🚨 2 Open ID Fellowship Spots at the University of Utah! 🚨
🏥 Train in a top-tier hospital with cutting-edge infrastructure
🌄 Live in stunning Salt Lake City with an unbeatable lifestyle
📩 Email [email protected] & [email protected] to apply!

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Reposted by Megan Seddon

Isaac Bogoch @isaacbogoch.bsky.social · Dec 4

High rates of Mycoplasma pneumoniae ("walking pneumonia") in Ontario, 2024, especially in those age 5-17.

16.3% of a subset of 135 specimens had mutations that suggest resistance to macrolide antibiotics.

Link: tinyurl.com/3ddnd29w #IDSky #MedSky

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Reposted by Megan Seddon

Ben Ereshefsky, PharmD @brainofbpharm.bsky.social · Dec 4

Some great references below on UTI/ASB! #IDSky #UTISky

Also, please make the “UA positive for UTI” diagnosis go away 😭

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Reposted by Megan Seddon

Megan Seddon @meganismofaction.bsky.social · Dec 2

🧵2 words likely to trigger most ID/ASP clinicians = ‘asymptomatic bacteriuria’ (ASB). 😱 Except for pregnant persons & those undergoing certain urologic procedures, there's no 🚫 clear evidence of benefit of treatment & some signal for harm in other populations. #IDSky #RxSky #MedEd #PharmEd 1/n

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Megan Seddon @meganismofaction.bsky.social · Dec 2

There are so many awesome studies in this area - what are some of your favorites?

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Megan Seddon @meganismofaction.bsky.social · Dec 2

Hopefully these data will help reframe the risk-benefit ratio of ASB treatment. Evidence suggests risks of not treating are less than feared & perhaps treating may actually increase risk of subsequent symptomatic UTI by killing off colonizing ASB strains which may have a protective role. 10/10 🔚

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Megan Seddon @meganismofaction.bsky.social · Dec 2

Perhaps in the future we will be able to distinguish colonizing ASB strains from uropathogenic strains of bacteria. 9/n
pubmed.ncbi.nlm.nih.gov/31794727/

Defining a Molecular Signature for Uropathogenic versus Urocolonizing Escherichia coli: The Status of the Field and New Clinical Opportunities - PubMed

Urinary tract infections (UTIs) represent a major burden across the population, although key facets of their pathophysiology and host interaction remain unclear. Escherichia coli epitomizes these obst...

pubmed.ncbi.nlm.nih.gov

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Megan Seddon @meganismofaction.bsky.social · Dec 2

A large cohort study suggests risk of bacteremia from a urinary source in hospitalized pts w/ASB is very low. The decision to treat or not always comes down to the risk-benefit ratio for the pt in question - perhaps these data may help further reframe that risk. 8/n
pubmed.ncbi.nlm.nih.gov/38477915/

Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria - PubMed

In patients with ASB, bacteremia from a presumed urinary source was rare, occurring in less than 1% of patients with AMS. A personalized, risk-based approach to empiric therapy could decrease unnecess...

pubmed.ncbi.nlm.nih.gov

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Megan Seddon @meganismofaction.bsky.social · Dec 2

The corollary to these data are small RCTs that have studied purposeful inoculation of ASB strains into the bladders of those at high risk of recurrent UTIs, like persons with spinal cord injury, with positive findings. 7/n
pubmed.ncbi.nlm.nih.gov/16231269/
pubmed.ncbi.nlm.nih.gov/20483149/

Bacterial interference for prevention of urinary tract infection: a prospective, randomized, placebo-controlled, double-blind pilot trial - PubMed

This prospective, randomized, placebo-controlled, double-blind pilot trial examined the efficacy of bacterial interference in preventing urinary tract infection (UTI) in 27 patients with spinal cord i...

pubmed.ncbi.nlm.nih.gov

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Megan Seddon @meganismofaction.bsky.social · Dec 2

Might this ability of ASB strains to outcompete uropathogens explain the signal in the literature for *increased* risk of symptomatic UTI following ASB treatment? 🤔 6/n
pubmed.ncbi.nlm.nih.gov/22677710/
pubmed.ncbi.nlm.nih.gov/26270684/

Kaplan-Meier curves at 12 and 40 months of follow-up, showing that patients receiving asymptomatic bacteriuria treatment were more likely to develop subsequent symptomatic UTI.

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Megan Seddon @meganismofaction.bsky.social · Dec 2

In fact, the ASB strain E. coli 83972 has been found to outcompete many uropathogens! 🦠 5/n
pubmed.ncbi.nlm.nih.gov/38780216/

Competitive fitness of asymptomatic bacteriuria E. coli strain 83972 against uropathogens in human urine - PubMed

Urinary tract infection (UTI) is one of the most common bacterial infections worldwide. The main causative agent of UTI is uropathogenic <i>Escherichia coli</i> (UPEC). There is an immediate need for ...

pubmed.ncbi.nlm.nih.gov

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Megan Seddon @meganismofaction.bsky.social · Dec 2

There are well-characterized ASB strains, like E. coli 83972, that lack virulence factors such as adhesins and are distinct from uropathogenic E. coli. 4/n
pubmed.ncbi.nlm.nih.gov/17502385/

Figure 2 from linked article that contrasts an asymptomatic bacteriuria (ASB) strain of E. coli, E. coli 83972, and uropathogenic or UPEC E. coli. The ASB strain lacks adhesins and therefore cannot ascend to the upper urinary tract. It maintains urine colonization due to its fast growth and potentially also biofilm formation. Host immune response is not triggered in response to these ASB strains.

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