mehmet can uçar
@mehmetcanucar.bsky.social
new PI @University of Sheffield -using mathematical models to understand living matter
https://www.sheffield.ac.uk/mps/people/all-academic-staff/mehmet-can-ucar
https://www.sheffield.ac.uk/mps/people/all-academic-staff/mehmet-can-ucar
Pinned
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
Reposted by mehmet can uçar
In May 2024 we had a great workshop on chemotaxis in the MPI PKS in Dresden! The social impressions are in the picture below, and the scientific discussions are summarised in Angewandte Chemie lnkd.in/d6ymRhGK
What a nice way to remember!
What a nice way to remember!
October 29, 2025 at 11:24 AM
In May 2024 we had a great workshop on chemotaxis in the MPI PKS in Dresden! The social impressions are in the picture below, and the scientific discussions are summarised in Angewandte Chemie lnkd.in/d6ymRhGK
What a nice way to remember!
What a nice way to remember!
Reposted by mehmet can uçar
🚨 Postdoc opportunities in Finland! Are you fascinated by leukocyte navigation and chemotaxis in different disease and tissue contexts? Apply for a 3-year postdoc fellowship with us! More info below 👇 or DM me.
University of Turku is hiring:
IMMUFELLOW Postdoctoral Researcher Positions (Researcher/Senior Researchers)
IMMUFELLOW Postdoctoral Researcher Positions (Researcher/Senior Researchers)
October 28, 2025 at 8:53 AM
🚨 Postdoc opportunities in Finland! Are you fascinated by leukocyte navigation and chemotaxis in different disease and tissue contexts? Apply for a 3-year postdoc fellowship with us! More info below 👇 or DM me.
Reposted by mehmet can uçar
Two 2-year postdoc positions in my theory group — for studying the interplay between metabolism and morphogenesis at the edge of the Calanques and the Mediterranean. More information can be found on: euraxess.ec.europa.eu/jobs/381176
#biophysics
#biophysics
Postdoc in Theoretical Biophysics
Two postdoc positions (each for two years, funded by Amidex Foundation) are available in theoretical biophysics within the theory group at DyNaMo (Aix-Marseille University).
euraxess.ec.europa.eu
October 27, 2025 at 4:19 PM
Two 2-year postdoc positions in my theory group — for studying the interplay between metabolism and morphogenesis at the edge of the Calanques and the Mediterranean. More information can be found on: euraxess.ec.europa.eu/jobs/381176
#biophysics
#biophysics
Reposted by mehmet can uçar
🤔 Can tissue patterning & tumor heterogeneity emerge in a self-organized way?
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 10:40 PM
🤔 Can tissue patterning & tumor heterogeneity emerge in a self-organized way?
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
Reposted by mehmet can uçar
Thought it would be fitting for my first post to be this little fly illustration I made. Because once a Drosophilist, always a Drosophilist 🪰
October 2, 2025 at 8:24 AM
Thought it would be fitting for my first post to be this little fly illustration I made. Because once a Drosophilist, always a Drosophilist 🪰
Reposted by mehmet can uçar
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 8:48 AM
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
Reposted by mehmet can uçar
I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com
September 9, 2025 at 5:58 PM
I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com
Reposted by mehmet can uçar
🤔 Can migrating cells 'remember' their past trajectories?
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics
Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...
www.nature.com
August 25, 2025 at 9:49 AM
🤔 Can migrating cells 'remember' their past trajectories?
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
August 22, 2025 at 6:11 AM
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
Reposted by mehmet can uçar
This is insane. Labour is making the very same mistake the Tories made but in a more catastrophic way. A left-leaning party adopting an ultra-right fascist agenda: what could go wrong?
'Every area of the immigration system - work, family and study - will be tightened up', says PM Keir Starmer
- Skill requirements raised to degree level
- English language requirements increased
- Pathway to citizenship increased from five years to 10
- Skill requirements raised to degree level
- English language requirements increased
- Pathway to citizenship increased from five years to 10
May 12, 2025 at 9:41 AM
This is insane. Labour is making the very same mistake the Tories made but in a more catastrophic way. A left-leaning party adopting an ultra-right fascist agenda: what could go wrong?
Sheffield continues to surprise -I was expecting rain and steel 🥲
May 11, 2025 at 11:28 AM
Sheffield continues to surprise -I was expecting rain and steel 🥲
..and the same day we get a definition of what a *good* theory is by @robinsall.bsky.social back here on the island 😅 @sheffielduni.bsky.social
May 7, 2025 at 2:15 PM
..and the same day we get a definition of what a *good* theory is by @robinsall.bsky.social back here on the island 😅 @sheffielduni.bsky.social
here's a plot showing the increase in the number of persons disappeared by ICE (data as posted by @msbr89.bsky.social):
May 4, 2025 at 9:58 AM
here's a plot showing the increase in the number of persons disappeared by ICE (data as posted by @msbr89.bsky.social):
Reposted by mehmet can uçar
Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good
https://go.nature.com/42nGQt6
https://go.nature.com/42nGQt6
Why an overreliance on AI-driven modelling is bad for science
Nature - Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good.
go.nature.com
April 13, 2025 at 8:32 AM
Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good
https://go.nature.com/42nGQt6
https://go.nature.com/42nGQt6
Reposted by mehmet can uçar
University of Derby faces mass job cuts as management plans to make half of senior academics redundant. Please spread the word. www.ucu.org.uk/article/1398...
University of Derby staff face mass job cuts as management plans to axe half of senior academics
University of Derby staff face mass job cuts as management plans to axe half of senior academics
www.ucu.org.uk
April 11, 2025 at 7:20 AM
University of Derby faces mass job cuts as management plans to make half of senior academics redundant. Please spread the word. www.ucu.org.uk/article/1398...
Reposted by mehmet can uçar
🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
April 6, 2025 at 10:24 PM
🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
Reposted by mehmet can uçar
The AHA has released a statement condemning "the dismantling of federal departments and agencies through the indiscriminate termination of federal employees and elimination of programs, including historical offices.” 🗃️
American Historical Association Condemns Indiscriminate Cuts to the Federal Government
The AHA has released a statement condemning "the dismantling of federal departments and agencies through the indiscriminate termination of federal employees and elimination of programs, including hist...
www.historians.org
March 24, 2025 at 5:50 PM
The AHA has released a statement condemning "the dismantling of federal departments and agencies through the indiscriminate termination of federal employees and elimination of programs, including historical offices.” 🗃️
Reposted by mehmet can uçar
NYU canceled a planned speech by the former president of Doctors Without Borders because she planned to discuss the humanitarian crisis in Gaza and cuts to US AID.
This is what actual campus censorship looks like.
This is what actual campus censorship looks like.
‘Climate of fear’: Montreal doctor says NYU cancelled her presentation
A Montreal doctor says her presentation at NYU was abruptly cancelled and believes the university did so out of fear of being pressured by the Donald Trump administration.
www.ctvnews.ca
March 30, 2025 at 5:07 PM
NYU canceled a planned speech by the former president of Doctors Without Borders because she planned to discuss the humanitarian crisis in Gaza and cuts to US AID.
This is what actual campus censorship looks like.
This is what actual campus censorship looks like.
Reposted by mehmet can uçar
another student was disappeared at the University of Minnesota
March 29, 2025 at 3:08 AM
another student was disappeared at the University of Minnesota
Reposted by mehmet can uçar
How do I even put "my doctoral students could not achieve their full scientific potential because they had to worry ICE would abduct them off the street while getting to lab" into a tenure impact statement?
March 27, 2025 at 7:18 PM
How do I even put "my doctoral students could not achieve their full scientific potential because they had to worry ICE would abduct them off the street while getting to lab" into a tenure impact statement?
Reposted by mehmet can uçar
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
March 25, 2025 at 11:21 AM
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Reposted by mehmet can uçar
Very happy to share our new preprint "MODIS: Multi-Omics Data Integration for Small and Unpaired Datasets"!
We proposed a new coupled variational auto-encoder architecture to solve the problem of data integration for small and unpaired datasets (diagonal integration)
arxiv.org/abs/2503.18856
We proposed a new coupled variational auto-encoder architecture to solve the problem of data integration for small and unpaired datasets (diagonal integration)
arxiv.org/abs/2503.18856
March 25, 2025 at 6:58 AM
Very happy to share our new preprint "MODIS: Multi-Omics Data Integration for Small and Unpaired Datasets"!
We proposed a new coupled variational auto-encoder architecture to solve the problem of data integration for small and unpaired datasets (diagonal integration)
arxiv.org/abs/2503.18856
We proposed a new coupled variational auto-encoder architecture to solve the problem of data integration for small and unpaired datasets (diagonal integration)
arxiv.org/abs/2503.18856
Reposted by mehmet can uçar
It is inherently dangerous to democracy for one man to hold as much wealth and power as Elon Musk.
It should be a primary goal of democratic states to prevent such concentrations of power, & to ensure that global plutocrats cannot shut off the arteries of democracy.
www.politico.eu/article/musk...
It should be a primary goal of democratic states to prevent such concentrations of power, & to ensure that global plutocrats cannot shut off the arteries of democracy.
www.politico.eu/article/musk...
March 22, 2025 at 10:38 PM
It is inherently dangerous to democracy for one man to hold as much wealth and power as Elon Musk.
It should be a primary goal of democratic states to prevent such concentrations of power, & to ensure that global plutocrats cannot shut off the arteries of democracy.
www.politico.eu/article/musk...
It should be a primary goal of democratic states to prevent such concentrations of power, & to ensure that global plutocrats cannot shut off the arteries of democracy.
www.politico.eu/article/musk...
Reposted by mehmet can uçar
This should be the last straw for the Turkish opposition. Unless there are mass protests, which the government is trying to prevent at all costs, Turkey is now very much a closed autocracy. www.nytimes.com/2025/03/19/w...
Turkey Arrests Istanbul Mayor, Key Rival to President Erdogan
Ekrem Imamoglu was detained at his home, according to prosecutors, who said the charges against him were related to corruption and terrorism.
www.nytimes.com
March 19, 2025 at 12:36 PM
This should be the last straw for the Turkish opposition. Unless there are mass protests, which the government is trying to prevent at all costs, Turkey is now very much a closed autocracy. www.nytimes.com/2025/03/19/w...
Reposted by mehmet can uçar
🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
A computational pipeline for spatial mechano-transcriptomics - Nature Methods
The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.
www.nature.com
March 17, 2025 at 12:53 PM
🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...