Pinned
Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology
Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.
www.nature.com
#microsky
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
The diderm cell envelope is not a stack of layers but a unified scaffold of Inner Membrane–Peptidoglycan–Outer Membrane.
We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria.
Curr Opin Microbiol: doi.org/10.1016/j.mi...
#microsky 🔬
We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria.
Curr Opin Microbiol: doi.org/10.1016/j.mi...
#microsky 🔬
Redirecting
doi.org
November 13, 2025 at 12:17 PM
The diderm cell envelope is not a stack of layers but a unified scaffold of Inner Membrane–Peptidoglycan–Outer Membrane.
We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria.
Curr Opin Microbiol: doi.org/10.1016/j.mi...
#microsky 🔬
We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria.
Curr Opin Microbiol: doi.org/10.1016/j.mi...
#microsky 🔬
Most stories don’t really start the way we write them in papers—and ours is no exception. To find out how it really began with a simple PCR trick, check out our Behind the Paper: « Out Of The Blue, It Came To Me »
👉 communities.springernature.com/posts/out-of...
#MicroSky
👉 communities.springernature.com/posts/out-of...
#MicroSky
July 31, 2025 at 1:49 PM
Most stories don’t really start the way we write them in papers—and ours is no exception. To find out how it really began with a simple PCR trick, check out our Behind the Paper: « Out Of The Blue, It Came To Me »
👉 communities.springernature.com/posts/out-of...
#MicroSky
👉 communities.springernature.com/posts/out-of...
#MicroSky
#microsky
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology
Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.
www.nature.com
July 29, 2025 at 1:23 PM
#microsky
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...