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Saskia Middeldorp

@middeldorps.bsky.social

610 followers 190 following 110 posts

Head Department of Internal Medicine at Radboudumc, Nijmegen 🇳🇱. Professor fighting venous thromboembolism. Pregnancy, thrombosis, thrombophilia. Elected council member of ISTH. Feminist with ❤️ husband & 3 sons. 🚴🏼‍♀️🏃🏻‍♀️. #Hemesky #Thrombosky

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Reposted by Saskia Middeldorp

International Society on Thrombosis and Haemostasis @isth.org · Jul 9

📰 Check it out! The @ash.hematology.org and ISTH Updated Guidelines on the Treatment of Pediatric VTE are featured in Hematology Advisor.

Don’t miss this spotlight on our collaborative effort!

📖 Read the full feature: www.hematologyadvisor.com/news/pediatr...
#PediatricVTE #Hematology #ISTH

ASH and ISTH Update Guidelines on Treatment of Pediatric VTE

The ASH and ISTH updated guidelines for treatment of pediatric venous thromboembolism, focusing on improved outcomes and patient quality of life.

www.hematologyadvisor.com

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Reposted by Saskia Middeldorp

Thomas Reiser @tomreiser.bsky.social · Jun 25

What an inspiring #ISTH2025!
It was wonderful to host the global #thrombosis & #hemostasis community in DC.
From the latest science & innovations to networking & building new collabs - it had it all!
Look out for recordings & other post- @isth.org congress updates.
Goodbye & see you @ #ISTH2026!

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Saskia Middeldorp @middeldorps.bsky.social · Jun 25

#ISTH2025

Saskia Middeldorp @middeldorps.bsky.social · Jun 25

Marc Rodger highlighting the #Highlow study and providing guidance on how to implement the results 👌🏼

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Saskia Middeldorp @middeldorps.bsky.social · Jun 25

Marc Rodger highlighting the #Highlow study and providing guidance on how to implement the results 👌🏼

Saskia Middeldorp @middeldorps.bsky.social · Jun 25

Now my favourite topic presented eloquently by prof Marc Rodger.

Answering all the questions needed for providing well-informed information to your patients.

Put the #LMWH needles away in patients with placenta-mediated complications in inherited #thrombophilia!
#AFFIRM #ALIFE2

#ISTH2025

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Saskia Middeldorp @middeldorps.bsky.social · Jun 25

It took 7 years to recruit 51 patients for the IMPACT single-arm study on certiluzomab on top of LMWH-aspirin shows adverse outcome in 20% which is lower than non-contemporary controls.

#ISTH2025

Saskia Middeldorp @middeldorps.bsky.social · Jun 25

More on pregnancy and #APS, now from obstetric perspective.

Only 1% of recurrent miscarriage patients had APS antibodies, similar to controls.

#ISTH2025

Reposted by Saskia Middeldorp

Marc Carrier, MD @marccarriermd.bsky.social · Jun 24

Implementation matters!
A guideline-driven VTE prevention program (Vermont Model) led to ~60% of high-risk cancer patients receiving prophylactic anticoagulation—resulting in a 60% reduction in VTE and 56% reduction in death. #ISTH2025 #VTEprevention 🩸
@marycushmanmd.bsky.social

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Saskia Middeldorp @middeldorps.bsky.social · Jun 25

Why do we have so little data on pregnancy and thrombotic outcomes in #APS??

Well-illustrated by State-of-the-Art lecture by dr Karen Breen.

We MUST do better!

#ISTH2025

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Saskia Middeldorp @middeldorps.bsky.social · Jun 25

Not yet published in full!

Saskia Middeldorp @middeldorps.bsky.social · Jun 24

Wow that’s pretty high!

Saskia Middeldorp @middeldorps.bsky.social · Jun 24

Thanks! I couldn’t make it to the presentation. So, no capping at a maximum dose was applied?

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Reposted by Saskia Middeldorp

Marc Carrier, MD @marccarriermd.bsky.social · Jun 24

📣 ARIVA Trial at #ISTH2025:

🧪 First RCT on antithrombotic therapy post-venous stenting for PTS
🔵 6-month primary patency rate was higher than expected
💊 No added benefit of aspirin + rivaroxaban vs. rivaroxaban alone

www.ahajournals.org/doi/10.1161/...

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Saskia Middeldorp @middeldorps.bsky.social · Jun 24

The apicat trial did study apixaban dose reduction VS full dose. That study makes me very comfortable using apixaban in this setting

Saskia Middeldorp @middeldorps.bsky.social · Jun 24

Hope you feel better!

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

In my experience, young people who don’t take any other meds and are in for the really long term sec prevention, have difficulty being adherent to the evening dose of apixaban

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Reposted by Saskia Middeldorp

Marc Carrier, MD @marccarriermd.bsky.social · Jun 23

Meta-analysis on GLP-1RA (vs. placebo) and VTE:
🔹 PE rates significantly lower 📉
🔹 VTE rates lower but not statistically significant
🔹 No difference in DVT
🔹 Study design matters: RCTs vs. observational data
Accepted for publication in JTH!
#ISTH2025 #VTE #GLP1RA #Thrombosis
@jthjournal.bsky.social

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

It’s really worth stopping by our @isth.org booth and get inspired for next year’s meeting in….. Paris!

#ISTH2025

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

What started as strong Mendelian observations, has now evolved to a strongly polygenenic etiology of #VTE. Inside and outside the coagulation cascade.

#ISTH2025

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

There is more to established #thrombophilia defects in understanding the genetics of venous thromboembolism #VTE.

Plenary lecture by Prof Pierre Morange

#ISTH2025

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

This was observed during the first 3 months after acute VTE. I’d like to keep the rivaroxaban option for extended treatment for patients who value the once daily regimen and are at low bleeding risk.

Reposted by Saskia Middeldorp

Shematologist, MD @shematologist.medsky.social · Jun 23

Tips for asking ?s as moderator #ISTH2025

Clinical talk: what future directions do you see this work taking?

Basic science: how do you envision this translating to the clinic?

Next level pro tip: contact author beforehand to see what they didn’t have time to present that they’d like you to ask

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

Adjust-DVT study. Only 5% of patients with suspected #DVT had an age-adjusted d-dimer that omits the need for compression ultrasound.

I don’t think it is worth it. What do you think?

#ISTH2025

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

This is why diagnosing, treating and investigating #APS is so complicated.
Massive differences in classification between Sydney 2006 and ACR/EULAR 2023. Only 40% of patients fulfilled the new criteria.
What are the implications for future research?

#ISTH2025

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Saskia Middeldorp @middeldorps.bsky.social · Jun 23

The effects of andexanet on enoxaparin are in line with effects on oral factorXa inhibitors.

Great presentation by PhD student Thijs van Haaps

#ISTH2025

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