Mark
@mkeller7.bsky.social
Reposted by Mark
It’s -9 degrees. Downtown Minneapolis is packed for the anti-ICE rally and the crowd keeps growing
January 23, 2026 at 8:16 PM
It’s -9 degrees. Downtown Minneapolis is packed for the anti-ICE rally and the crowd keeps growing
Reposted by Mark
Any one of these daily atrocities should result in a full congressional investigation and a disbanding of the agency. The fact that it’s all just shrugged off by those with the power to stop it is a national disgrace.
ICE ended up returning the man, Saly, after realizing he’s a fucking US citizen with no criminal record, per his sister-in-law. These fucking animals.
January 19, 2026 at 11:58 AM
Any one of these daily atrocities should result in a full congressional investigation and a disbanding of the agency. The fact that it’s all just shrugged off by those with the power to stop it is a national disgrace.
Reposted by Mark
Wrote a summary of a great keynote by @zey.bsky.social at NeurIPS, arguing that we’re having the wrong nightmares about AI: not AGI or superhuman benchmarks, but good-enough genAI at scale threatens "load bearing frictions" society relies on to signal effort, authenticity, sincerity, credibility.
Zeynep Tufecki on having the wrong nightmares about generative AI
I was writing a blog post where I was going to reference Zeynep Tufecki’s 2025 NeurIPS keynote, and realized there isn’t a solid synopsis online.
open.substack.com
January 9, 2026 at 4:42 PM
Wrote a summary of a great keynote by @zey.bsky.social at NeurIPS, arguing that we’re having the wrong nightmares about AI: not AGI or superhuman benchmarks, but good-enough genAI at scale threatens "load bearing frictions" society relies on to signal effort, authenticity, sincerity, credibility.
Reposted by Mark
The Congressional Progressive Caucus, a group of nearly 100 House Democrats, will announce later today that it's formally endorsing legislation to strip $175 billion from ICE and put it toward affordable housing. www.huffpost.com/entry/doj-fe...
Progressive Caucus Backs Bill To Redirect ICE Money To Affordable Housing
www.huffpost.com
January 14, 2026 at 8:00 PM
The Congressional Progressive Caucus, a group of nearly 100 House Democrats, will announce later today that it's formally endorsing legislation to strip $175 billion from ICE and put it toward affordable housing. www.huffpost.com/entry/doj-fe...
Reposted by Mark
Today at 34 & Park in Minneapolis, a woman tried to drive down the street where a protest had broken out in front of a home ICE was raiding, saying she had a doctor apt to get to. ICE agents busted out her windows, cut off her seatbelt, and pulled her out before arresting her.
January 13, 2026 at 6:56 PM
Today at 34 & Park in Minneapolis, a woman tried to drive down the street where a protest had broken out in front of a home ICE was raiding, saying she had a doctor apt to get to. ICE agents busted out her windows, cut off her seatbelt, and pulled her out before arresting her.
Reposted by Mark
Reposted by Mark
A video of ICE agents conducting door-to-door searches today in Minneapolis
The homeowner requests a warrant repeatedly, is told they don't require one, then is told they're getting it, then the agents storm in anyway
They also point a taser at her to try and disrupt filming
The homeowner requests a warrant repeatedly, is told they don't require one, then is told they're getting it, then the agents storm in anyway
They also point a taser at her to try and disrupt filming
January 12, 2026 at 1:42 AM
A video of ICE agents conducting door-to-door searches today in Minneapolis
The homeowner requests a warrant repeatedly, is told they don't require one, then is told they're getting it, then the agents storm in anyway
They also point a taser at her to try and disrupt filming
The homeowner requests a warrant repeatedly, is told they don't require one, then is told they're getting it, then the agents storm in anyway
They also point a taser at her to try and disrupt filming
Reposted by Mark
🔬 pertpy: a unified, scalable framework for single-cell perturbation analysis, now out in Nature Methods
Designed for modern perturbation data - CRISPR, drug screens, patient treatments - scaling to millions of cells and 1000s of conditions.
👉 www.nature.com/articles/s41...
Designed for modern perturbation data - CRISPR, drug screens, patient treatments - scaling to millions of cells and 1000s of conditions.
👉 www.nature.com/articles/s41...
January 8, 2026 at 4:30 PM
🔬 pertpy: a unified, scalable framework for single-cell perturbation analysis, now out in Nature Methods
Designed for modern perturbation data - CRISPR, drug screens, patient treatments - scaling to millions of cells and 1000s of conditions.
👉 www.nature.com/articles/s41...
Designed for modern perturbation data - CRISPR, drug screens, patient treatments - scaling to millions of cells and 1000s of conditions.
👉 www.nature.com/articles/s41...
Reposted by Mark
A new paper from Stanford adds further, incontrovertible evidence that LLMs memorize training data.
The authors showed that copyrighted works can be extracted from every LLM they tried: GPT-4.1, Gemini 2.5 Pro, Grok 3, and Claude 3.7 Sonnet.
🧵 1/3
arxiv.org/pdf/2601.026...
The authors showed that copyrighted works can be extracted from every LLM they tried: GPT-4.1, Gemini 2.5 Pro, Grok 3, and Claude 3.7 Sonnet.
🧵 1/3
arxiv.org/pdf/2601.026...
January 8, 2026 at 9:53 AM
A new paper from Stanford adds further, incontrovertible evidence that LLMs memorize training data.
The authors showed that copyrighted works can be extracted from every LLM they tried: GPT-4.1, Gemini 2.5 Pro, Grok 3, and Claude 3.7 Sonnet.
🧵 1/3
arxiv.org/pdf/2601.026...
The authors showed that copyrighted works can be extracted from every LLM they tried: GPT-4.1, Gemini 2.5 Pro, Grok 3, and Claude 3.7 Sonnet.
🧵 1/3
arxiv.org/pdf/2601.026...
Reposted by Mark
Too lazy for 2 clicks, here you go: tonsky.me/blog/tahoe-i...
It’s hard to justify Tahoe icons
Looking at the first principles of icon design—and how Apple failed to apply all of them in macOS Tahoe
tonsky.me
January 6, 2026 at 5:44 PM
Too lazy for 2 clicks, here you go: tonsky.me/blog/tahoe-i...
Reposted by Mark
🎉 New year, NEW PREPRINT!
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
Novel genes arise from genomic deletions across the bacterial tree of life https://www.biorxiv.org/content/10.64898/2026.01.05.697752v1
January 6, 2026 at 4:09 PM
🎉 New year, NEW PREPRINT!
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
Reposted by Mark
7/ Here's the bottom line: This is an unprecedented shift that risks weakening protection against preventable diseases at a time when outbreaks are rising and children are already being hospitalized. Vaccines don’t work without strong supporting systems...and the U.S. doesn’t have Denmark’s.
January 5, 2026 at 8:52 PM
7/ Here's the bottom line: This is an unprecedented shift that risks weakening protection against preventable diseases at a time when outbreaks are rising and children are already being hospitalized. Vaccines don’t work without strong supporting systems...and the U.S. doesn’t have Denmark’s.
Reposted by Mark
Hello moths,
The harvest has arrived: anisota.net/harvest
It's like Spotify Wrapped, but for Bluesky and the ATmosphere. 🌾
See your most-used words, discover who you interact with most, explore your posting patterns, and find all sorts of fun insights.
The harvest has arrived: anisota.net/harvest
It's like Spotify Wrapped, but for Bluesky and the ATmosphere. 🌾
See your most-used words, discover who you interact with most, explore your posting patterns, and find all sorts of fun insights.
Anisota's Annual Bluesky Harvest 2025
A recap of your year on Bluesky. Discover patterns, connections, and insights from your journey in the ATmosphere.
anisota.net
November 27, 2025 at 5:51 PM
Hello moths,
The harvest has arrived: anisota.net/harvest
It's like Spotify Wrapped, but for Bluesky and the ATmosphere. 🌾
See your most-used words, discover who you interact with most, explore your posting patterns, and find all sorts of fun insights.
The harvest has arrived: anisota.net/harvest
It's like Spotify Wrapped, but for Bluesky and the ATmosphere. 🌾
See your most-used words, discover who you interact with most, explore your posting patterns, and find all sorts of fun insights.
Reposted by Mark
If you are a resident of California, the state now has a portal where you can demand deletion of your personal data from 500+ registered data brokers with a single request form, for free.
consumer.drop.privacy.ca.gov
consumer.drop.privacy.ca.gov
consumer.drop.privacy.ca.gov
January 2, 2026 at 2:26 AM
If you are a resident of California, the state now has a portal where you can demand deletion of your personal data from 500+ registered data brokers with a single request form, for free.
consumer.drop.privacy.ca.gov
consumer.drop.privacy.ca.gov
Reposted by Mark
New record year for renewable electricity in Britain - thanks especially to strong solar output.
Read our analysis of 2025 here www.bbc.co.uk/news/article...
Read our analysis of 2025 here www.bbc.co.uk/news/article...
January 2, 2026 at 12:23 PM
New record year for renewable electricity in Britain - thanks especially to strong solar output.
Read our analysis of 2025 here www.bbc.co.uk/news/article...
Read our analysis of 2025 here www.bbc.co.uk/news/article...
Reposted by Mark
#MLCB2025 proceedings are up at proceedings.mlr.press/v311/ !
Proceedings of Machine Learning Research
Proceedings of the 20th Machine Learning in Computational Biology meeting Held in New York, NY, USA on 10-11 September 2025 Published as Volume 311 by the Proceedings of Machine Learning Research on 3...
proceedings.mlr.press
December 31, 2025 at 10:37 PM
#MLCB2025 proceedings are up at proceedings.mlr.press/v311/ !
App idea: rover, but for sourdough starters and leivito madre. it will be called doughver
December 17, 2025 at 1:10 PM
App idea: rover, but for sourdough starters and leivito madre. it will be called doughver
Reposted by Mark
See 👇 our new manuscript introducing SpaCEy, an explainable method for predicting clinical outcomes from spatial omics data 🧬
📄 Paper: www.biorxiv.org/content/10.6...
💻 Code repo: github.com/saezlab/SpaCEy
📄 Paper: www.biorxiv.org/content/10.6...
💻 Code repo: github.com/saezlab/SpaCEy
December 17, 2025 at 8:14 AM
See 👇 our new manuscript introducing SpaCEy, an explainable method for predicting clinical outcomes from spatial omics data 🧬
📄 Paper: www.biorxiv.org/content/10.6...
💻 Code repo: github.com/saezlab/SpaCEy
📄 Paper: www.biorxiv.org/content/10.6...
💻 Code repo: github.com/saezlab/SpaCEy
Reposted by Mark
The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk.
Learn more in a new #SciencePerspective: https://scim.ag/4iJPFVS
Learn more in a new #SciencePerspective: https://scim.ag/4iJPFVS
Molecular basis of DNA cross-linking by bacteria
The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk
scim.ag
December 14, 2025 at 6:18 PM
The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk.
Learn more in a new #SciencePerspective: https://scim.ag/4iJPFVS
Learn more in a new #SciencePerspective: https://scim.ag/4iJPFVS
Reposted by Mark
GLASHEEN: Antifa is our primary concern right now. That's the most immediate violent threat we're facing
BENNIE THOMPSON: Where is antifa headquartered?
GLASHEEN: ... ... ... we are building out the infrastructure right now
THOMPSON: What does that mean?
BENNIE THOMPSON: Where is antifa headquartered?
GLASHEEN: ... ... ... we are building out the infrastructure right now
THOMPSON: What does that mean?
December 11, 2025 at 3:51 PM
GLASHEEN: Antifa is our primary concern right now. That's the most immediate violent threat we're facing
BENNIE THOMPSON: Where is antifa headquartered?
GLASHEEN: ... ... ... we are building out the infrastructure right now
THOMPSON: What does that mean?
BENNIE THOMPSON: Where is antifa headquartered?
GLASHEEN: ... ... ... we are building out the infrastructure right now
THOMPSON: What does that mean?
Reposted by Mark
MAGAZINER: How many veterans have you deported?
NOEM: We haven't deported veterans
MAGAZINER: We are now joined on Zoom by a combat veteran you deported to Korea
NOEM: We haven't deported veterans
MAGAZINER: We are now joined on Zoom by a combat veteran you deported to Korea
December 11, 2025 at 4:22 PM
MAGAZINER: How many veterans have you deported?
NOEM: We haven't deported veterans
MAGAZINER: We are now joined on Zoom by a combat veteran you deported to Korea
NOEM: We haven't deported veterans
MAGAZINER: We are now joined on Zoom by a combat veteran you deported to Korea
Reposted by Mark
Massive single-cell study by Kanai et al (www.medrxiv.org/content/10.1...):
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.
November 30, 2025 at 5:06 PM
Massive single-cell study by Kanai et al (www.medrxiv.org/content/10.1...):
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.