Manuel Pazos
@mpaz0s.bsky.social
Microbiology. Bacterial cell envelope. Junior group leader at @cbm-csic-uam.bsky.social. Lucky husband and father (X2).
Fantastic work from Cristina Flors' lab! Really happy about our fruitful collaboration.
New research from IMDEA Nanociencia, CNB & CBM reveals how bacteria "feel" the surfaces they land on!
🧫🤏Using fluorescence lifetime imaging microscopy #FLIM, scientists can watch membrane tension change in real time.
+info: nanociencia.imdea.org/home-en/news...
#IMDEAnanoPublications
🧫🤏Using fluorescence lifetime imaging microscopy #FLIM, scientists can watch membrane tension change in real time.
+info: nanociencia.imdea.org/home-en/news...
#IMDEAnanoPublications
November 18, 2025 at 9:11 PM
Fantastic work from Cristina Flors' lab! Really happy about our fruitful collaboration.
Reposted by Manuel Pazos
🦠 El grupo de Manuel Pazos en el CBM descubre una proteína clave en la división de bacterias peligrosas como E. coli. El hallazgo abre nuevas vías contra infecciones y resistencia a antibióticos.
www.cbm.uam.es/index.php/20...
www.cbm.uam.es/index.php/20...
Un hallazgo abre la puerta a frenar la división de bacterias peligrosas - Centro de Biología Molecular Severo Ochoa
Un equipo del Centro de Biología Molecular Severo Ochoa (CBM, CSIC-UAM), junto a la Universidad de Queensland (Australia) y la Universidad de Milán (Italia), ha identificado una nueva enzima llamada [...
www.cbm.uam.es
October 2, 2025 at 10:30 AM
🦠 El grupo de Manuel Pazos en el CBM descubre una proteína clave en la división de bacterias peligrosas como E. coli. El hallazgo abre nuevas vías contra infecciones y resistencia a antibióticos.
www.cbm.uam.es/index.php/20...
www.cbm.uam.es/index.php/20...
Reposted by Manuel Pazos
Archaea-on-bacteria action! @romainstrock.bsky.social @tobiaswarnecke.bsky.social &co show that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @plosbiology.org 🧪 plos.io/4lrJBBa
August 15, 2025 at 8:13 AM
Archaea-on-bacteria action! @romainstrock.bsky.social @tobiaswarnecke.bsky.social &co show that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @plosbiology.org 🧪 plos.io/4lrJBBa
Reposted by Manuel Pazos
Today for the first time in decades, a new oral antibiotic to treat urinary tract infections was approved by the FDA
Gepotidacin is a triazaacenaphthylene that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV
Trade name? BLUJEPA® !!!
www.gsk.com/en-gb/media/...
Gepotidacin is a triazaacenaphthylene that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV
Trade name? BLUJEPA® !!!
www.gsk.com/en-gb/media/...
March 26, 2025 at 1:36 AM
Today for the first time in decades, a new oral antibiotic to treat urinary tract infections was approved by the FDA
Gepotidacin is a triazaacenaphthylene that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV
Trade name? BLUJEPA® !!!
www.gsk.com/en-gb/media/...
Gepotidacin is a triazaacenaphthylene that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV
Trade name? BLUJEPA® !!!
www.gsk.com/en-gb/media/...
Reposted by Manuel Pazos
who doesn't enjoy some beautiful FtsZ rings on a sunday evening? these from 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴, from all angles, by the @jwveening.bsky.social, posted earlier on 𝕏, on may 6, 2021
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
March 23, 2025 at 6:19 PM
who doesn't enjoy some beautiful FtsZ rings on a sunday evening? these from 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴, from all angles, by the @jwveening.bsky.social, posted earlier on 𝕏, on may 6, 2021
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
Reposted by Manuel Pazos
Caulobacter crescentus is intrinsically resistant to β-lactams. This study in #mBio indicates that defects in peptidoglycan recycling compromise cell wall biogenesis, leading to antibiotic sensitivity in C. crescentus: asm.social/2kb
March 18, 2025 at 6:30 PM
Caulobacter crescentus is intrinsically resistant to β-lactams. This study in #mBio indicates that defects in peptidoglycan recycling compromise cell wall biogenesis, leading to antibiotic sensitivity in C. crescentus: asm.social/2kb
Reposted by Manuel Pazos
Looking for a PhD opportunity in Microbiology? Consider joining one of the strongest clusters of microbiology research in UK at @newcastleuni.bsky.social, Biosciences Institute, and @cbcb-newcastle.bsky.social. See thread for BBSRC DTP PhD studentships currently advertised.
March 20, 2025 at 3:00 AM
Looking for a PhD opportunity in Microbiology? Consider joining one of the strongest clusters of microbiology research in UK at @newcastleuni.bsky.social, Biosciences Institute, and @cbcb-newcastle.bsky.social. See thread for BBSRC DTP PhD studentships currently advertised.
Reposted by Manuel Pazos
How rapidly do oxygen & ROS cross biological membranes and what does this mean for their detoxification?
Jim Imlay tackles this question in a new Perspective, which provides a quantitative framework for thinking about how gases interact with cells.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
Jim Imlay tackles this question in a new Perspective, which provides a quantitative framework for thinking about how gases interact with cells.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress
Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...
onlinelibrary.wiley.com
March 18, 2025 at 8:29 PM
How rapidly do oxygen & ROS cross biological membranes and what does this mean for their detoxification?
Jim Imlay tackles this question in a new Perspective, which provides a quantitative framework for thinking about how gases interact with cells.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
Jim Imlay tackles this question in a new Perspective, which provides a quantitative framework for thinking about how gases interact with cells.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Manuel Pazos
Our lab is excited to hire a postdoctoral researcher to study the mechanisms that viruses use to ‘hijack’ TAM receptors in viral spread. We are looking for someone who is excited to learn new techniques and work in a highly collaborative team! Please share!
unc.peopleadmin.com/postings/298...
unc.peopleadmin.com/postings/298...
March 18, 2025 at 2:59 PM
Our lab is excited to hire a postdoctoral researcher to study the mechanisms that viruses use to ‘hijack’ TAM receptors in viral spread. We are looking for someone who is excited to learn new techniques and work in a highly collaborative team! Please share!
unc.peopleadmin.com/postings/298...
unc.peopleadmin.com/postings/298...
Reposted by Manuel Pazos
'Linear plasmids [in enterococci] can play a key role in the spread of oxazolidinone and glycopeptide resistance with serious consequences for public health.'
academic.oup.com/jac/advance-...
academic.oup.com/jac/advance-...
The optrA, cfr(D) and vanA genes are co-located on linear plasmids in linezolid- and vancomycin-resistant enterococcal clinical isolates in Italy
AbstractObjectives. To characterize the optrA-, cfr(D)- and vanA-carrying linear plasmids detected in three MDR enterococcal clinical isolates.Methods. Ent
academic.oup.com
March 19, 2025 at 9:33 AM
'Linear plasmids [in enterococci] can play a key role in the spread of oxazolidinone and glycopeptide resistance with serious consequences for public health.'
academic.oup.com/jac/advance-...
academic.oup.com/jac/advance-...
Reposted by Manuel Pazos
"This prompted us to name this family the Bacterial elongated entwined Rail-like protein (BeeR)."
yeah right 🍻
doi.org/10.1073/pnas...
yeah right 🍻
doi.org/10.1073/pnas...
A family of bacterial actin homologs forms a three-stranded tubular structure | PNAS
The cytoskeleton is crucial for cell organization and movement. In Eukaryotes, it
largely consists of the protein actin, that forms a double-strand...
doi.org
March 19, 2025 at 3:13 PM
"This prompted us to name this family the Bacterial elongated entwined Rail-like protein (BeeR)."
yeah right 🍻
doi.org/10.1073/pnas...
yeah right 🍻
doi.org/10.1073/pnas...
Reposted by Manuel Pazos
I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved.
Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation https://www.biorxiv.org/content/10.1101/2025.03.14.642875v1
March 15, 2025 at 6:36 PM
I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved.
Reposted by Manuel Pazos
Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...
The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress - Nature Communications
Actinobacteria grow by inserting new cell wall material at the cell poles. Here, Zhong et al. show that a stomatin-like protein modulates polar growth under hyperosmotic stress by facilitating the for...
www.nature.com
March 18, 2025 at 6:27 PM
Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...
Reposted by Manuel Pazos
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
March 12, 2025 at 12:36 PM
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
Reposted by Manuel Pazos
A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli https://www.biorxiv.org/content/10.1101/2025.02.18.638797v1
February 20, 2025 at 2:18 AM
A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli https://www.biorxiv.org/content/10.1101/2025.02.18.638797v1