MRC PPU
@mrcppu.bsky.social
The MRC Protein Phosphorylation & Ubiquitylation Unit is a world leader in finding the causes of neurodegeneration, cancer, hypertension & immune disorders
https://www.ppu.mrc.ac.uk/
Pinned
MRC PPU
@mrcppu.bsky.social
· Apr 2
Further £30 million, five-year funding boost from Medical Research Council | MRC PPU
The government’s Science and Technology Secretary, Peter Kyle, has announced a further five-year funding boost from the Medical Research Council (MRC) to continue our vital work.
www.ppu.mrc.ac.uk
We are enormously grateful to the Medical Research Council (MRC)/UKRI for their generous long-term support - 34 years and counting - for our research Unit at the University of Dundee www.ppu.mrc.ac.uk/news/further... @dundee.ac.uk @ukri.org #Dundee
Join us! Research Technician position available with Virginia De Cesare www.ppu.mrc.ac.uk/careers/recr...
Research Technician | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
www.ppu.mrc.ac.uk
February 3, 2026 at 2:43 PM
Join us! Research Technician position available with Virginia De Cesare www.ppu.mrc.ac.uk/careers/recr...
Reposted by MRC PPU
Want to see what we do up close?
Sign up for the tour and networking event with us and #biodundee. See the link for details and tickets!
#DDUat20
www.eventbrite.co.uk/e/drug-disco...
Sign up for the tour and networking event with us and #biodundee. See the link for details and tickets!
#DDUat20
www.eventbrite.co.uk/e/drug-disco...
Drug Discovery Unit Tour and Networking
BioDundee is delighted to kick of the year of celebrations for #DDUat20 with Networking and a guided tour of the Drug Discovery Unit.
www.eventbrite.co.uk
January 30, 2026 at 2:35 PM
Want to see what we do up close?
Sign up for the tour and networking event with us and #biodundee. See the link for details and tickets!
#DDUat20
www.eventbrite.co.uk/e/drug-disco...
Sign up for the tour and networking event with us and #biodundee. See the link for details and tickets!
#DDUat20
www.eventbrite.co.uk/e/drug-disco...
Reposted by MRC PPU
👏 Huge congratulations to UK DRI Group Leader Prof Giampietro Schiavo who has received the 2026 Basic Science Lifetime Achievement Award from the International Neurotoxin Association 👏
Read more 👉 www.ucl.ac.uk/brain-scienc...
Read more 👉 www.ucl.ac.uk/brain-scienc...
Professor Giampetro Schiavo wins 2026 International Neurotoxin Association (INA) award
Professor Schiavo (UCL Queen Square Institute of Neurology) received the 2026 INA Basic Science Lifetime Achievement Award from the President at the bi-annual congress of the society.
www.ucl.ac.uk
February 2, 2026 at 9:25 AM
👏 Huge congratulations to UK DRI Group Leader Prof Giampietro Schiavo who has received the 2026 Basic Science Lifetime Achievement Award from the International Neurotoxin Association 👏
Read more 👉 www.ucl.ac.uk/brain-scienc...
Read more 👉 www.ucl.ac.uk/brain-scienc...
Reposted by MRC PPU
Born #OnThisDay in 1903 was Kathleen Lonsdale FRS. She was a pioneer of X-ray crystallography, discovering the structure of benzene, and was one of the first two women elected to the Fellowship of the Royal Society. Find out more about her life and work: #WomenInSTEM www.youtube.com/watch?v=Jwcf...
January 28, 2026 at 11:24 AM
Born #OnThisDay in 1903 was Kathleen Lonsdale FRS. She was a pioneer of X-ray crystallography, discovering the structure of benzene, and was one of the first two women elected to the Fellowship of the Royal Society. Find out more about her life and work: #WomenInSTEM www.youtube.com/watch?v=Jwcf...
Reposted by MRC PPU
Could targeting the gut's immune system tackle the early stages of Parkinson's? 🧠
A new study from @soyonhonglab.bsky.social & Tim Bartels (UK DRI at UCL) has revealed how Parkinson’s spreads from the gut to the brain - with the help of immune cells.
Read more 👉 www.ukdri.ac.uk/news-and-eve...
A new study from @soyonhonglab.bsky.social & Tim Bartels (UK DRI at UCL) has revealed how Parkinson’s spreads from the gut to the brain - with the help of immune cells.
Read more 👉 www.ukdri.ac.uk/news-and-eve...
Targeting the gut's immune system could tackle early stages of Parkinson's
New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut to the brain, with the hel
www.ukdri.ac.uk
January 28, 2026 at 4:25 PM
Could targeting the gut's immune system tackle the early stages of Parkinson's? 🧠
A new study from @soyonhonglab.bsky.social & Tim Bartels (UK DRI at UCL) has revealed how Parkinson’s spreads from the gut to the brain - with the help of immune cells.
Read more 👉 www.ukdri.ac.uk/news-and-eve...
A new study from @soyonhonglab.bsky.social & Tim Bartels (UK DRI at UCL) has revealed how Parkinson’s spreads from the gut to the brain - with the help of immune cells.
Read more 👉 www.ukdri.ac.uk/news-and-eve...
Reposted by MRC PPU
CRN Teams Harper & Alessi used cryo-electron tomography to show how PINK1-activating stress disrupts mitochondrial structure, revealing protein aggregation, cristae loss, and key changes linked to #Parkinsons 🧬
🔗 Read the full #preprint: bit.ly/49N4mmW
✏️ @denkenny.bsky.social
🔗 Read the full #preprint: bit.ly/49N4mmW
✏️ @denkenny.bsky.social
January 27, 2026 at 4:37 PM
CRN Teams Harper & Alessi used cryo-electron tomography to show how PINK1-activating stress disrupts mitochondrial structure, revealing protein aggregation, cristae loss, and key changes linked to #Parkinsons 🧬
🔗 Read the full #preprint: bit.ly/49N4mmW
✏️ @denkenny.bsky.social
🔗 Read the full #preprint: bit.ly/49N4mmW
✏️ @denkenny.bsky.social
Reposted by MRC PPU
As part of our #20thBirthday celebrations, we hear from our cofounders Sir Mike Ferguson and Alan Fairlamb
#ScienceNeverStops
www.youtube.com/watch?v=_Skb...
#ScienceNeverStops
www.youtube.com/watch?v=_Skb...
DDU at 20 | Founders Sir Michael Ferguson & Alan Fairlamb on Past, Present and Future
YouTube video by Drug Discovery Unit Dundee
www.youtube.com
January 27, 2026 at 2:33 PM
As part of our #20thBirthday celebrations, we hear from our cofounders Sir Mike Ferguson and Alan Fairlamb
#ScienceNeverStops
www.youtube.com/watch?v=_Skb...
#ScienceNeverStops
www.youtube.com/watch?v=_Skb...
Best of luck today to Rebecca Pemberton of the Swamy lab, defending her PhD thesis 'Investigating the role of Crohn's disease associated kinase LRRK2 in immune and intestinal cells' @mahimaswamy.bsky.social @ajmhowden.bsky.social @bealelab.bsky.social @henrymcsorley.bsky.social
January 28, 2026 at 8:50 AM
Best of luck today to Rebecca Pemberton of the Swamy lab, defending her PhD thesis 'Investigating the role of Crohn's disease associated kinase LRRK2 in immune and intestinal cells' @mahimaswamy.bsky.social @ajmhowden.bsky.social @bealelab.bsky.social @henrymcsorley.bsky.social
Join us! Postdoctoral Research Assistant position available in the Muqit lab www.ppu.mrc.ac.uk/careers/recr... #neurobiology #CRISPR #PINK1 #Parkinsons
Postdoctoral Research Assistant | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
www.ppu.mrc.ac.uk
January 20, 2026 at 3:41 PM
Join us! Postdoctoral Research Assistant position available in the Muqit lab www.ppu.mrc.ac.uk/careers/recr... #neurobiology #CRISPR #PINK1 #Parkinsons
Best of luck today to Iona Wallace of the Swatek lab, defending her PhD thesis 'Mechanistic and Proteomic Exploration of the ISG15 Modification Pathway'
January 20, 2026 at 9:17 AM
Best of luck today to Iona Wallace of the Swatek lab, defending her PhD thesis 'Mechanistic and Proteomic Exploration of the ISG15 Modification Pathway'
Reposted by MRC PPU
How do you deal with missing values and "unique" proteins that were only identified in one condition in proteomics data?
Mengchun Li, an amazing PhD student in my lab, developed this great Bayesian approach. Please try it and give feedback!
www.biorxiv.org/content/10.6...
Mengchun Li, an amazing PhD student in my lab, developed this great Bayesian approach. Please try it and give feedback!
www.biorxiv.org/content/10.6...
Empirical-Bayes and Bayesian Hierarchical Modelling for Missingness and Differential Expression in Proteomics
Mass spectrometry-based label-free proteomics data often suffer from missing values, especially for low-abundance proteins or when a protein is completely absent in one condition. This makes it challe...
www.biorxiv.org
January 15, 2026 at 7:24 PM
How do you deal with missing values and "unique" proteins that were only identified in one condition in proteomics data?
Mengchun Li, an amazing PhD student in my lab, developed this great Bayesian approach. Please try it and give feedback!
www.biorxiv.org/content/10.6...
Mengchun Li, an amazing PhD student in my lab, developed this great Bayesian approach. Please try it and give feedback!
www.biorxiv.org/content/10.6...
Reposted by MRC PPU
From mesmerising threads of spider's web to the first glint of sun after a polar winter, take a look at the winners and runners up from the 2025 Royal Society Publishing Photography Competition: https://royalsociety.org/journals/publishing-activities/photo-competition/2025-winners-runners-up/
January 15, 2026 at 10:57 AM
From mesmerising threads of spider's web to the first glint of sun after a polar winter, take a look at the winners and runners up from the 2025 Royal Society Publishing Photography Competition: https://royalsociety.org/journals/publishing-activities/photo-competition/2025-winners-runners-up/
Reposted by MRC PPU
A brief history of the BioRxiv and MedRxiv preprint services, their meteoric growth and supportive role during the pandemic. Submitting preprints should be the primary step for scientific dissemination. journals.asm.org/doi/10.1128/...
The Story behind the Science: Preprints of pandemic potential—how bioRxiv and medRxiv brought preprints to the life sciences | mBio
When we launched medRxiv in mid-2019, we never could have anticipated that just a
few months later, New York would be at the epicenter of a rapidly escalating global
pandemic, and we would be handling...
journals.asm.org
January 15, 2026 at 1:46 PM
A brief history of the BioRxiv and MedRxiv preprint services, their meteoric growth and supportive role during the pandemic. Submitting preprints should be the primary step for scientific dissemination. journals.asm.org/doi/10.1128/...
Reposted by MRC PPU
Join Sir Michael Ferguson FRS for the Leeuwenhoek Prize Lecture on 26 January 2026, as he explores how science can provide opportunities to make better, safer medicines and diagnostics for neglected infectious diseases. Register now: https://bit.ly/4j9U58P
January 14, 2026 at 4:25 PM
Join Sir Michael Ferguson FRS for the Leeuwenhoek Prize Lecture on 26 January 2026, as he explores how science can provide opportunities to make better, safer medicines and diagnostics for neglected infectious diseases. Register now: https://bit.ly/4j9U58P
Reposted by MRC PPU
🎉 Happy #new #year to everyone!
📢 No better way to kickstart 2026 than by sharing our latest work, now available on #Open #Biology by @royalsociety.org. The title is "Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish ints interaction with the Ser/Thr kinase CK1α".
📢 No better way to kickstart 2026 than by sharing our latest work, now available on #Open #Biology by @royalsociety.org. The title is "Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish ints interaction with the Ser/Thr kinase CK1α".
January 9, 2026 at 10:37 AM
🎉 Happy #new #year to everyone!
📢 No better way to kickstart 2026 than by sharing our latest work, now available on #Open #Biology by @royalsociety.org. The title is "Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish ints interaction with the Ser/Thr kinase CK1α".
📢 No better way to kickstart 2026 than by sharing our latest work, now available on #Open #Biology by @royalsociety.org. The title is "Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish ints interaction with the Ser/Thr kinase CK1α".
Join us! Research Technician position available in Sapkota lab www.ppu.mrc.ac.uk/careers/recr...
Research Technician | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
www.ppu.mrc.ac.uk
December 15, 2025 at 3:47 PM
Join us! Research Technician position available in Sapkota lab www.ppu.mrc.ac.uk/careers/recr...
Esther Sammler positions Dundee among the first global sites to launch a Phase 3 Parkinson’s disease trial www.ppu.mrc.ac.uk/news/esther-...
Esther Sammler positions Dundee among the first global sites to launch a Phase 3 Parkinson’s disease trial | MRC PPU
Dr Esther Sammler, clinician scientist within the MRC Protein Phosphorylation and Ubiquitylation Unit and consultant neurologist at NHS Tayside, has played a central role in establishing the Universit...
www.ppu.mrc.ac.uk
December 15, 2025 at 1:55 PM
Esther Sammler positions Dundee among the first global sites to launch a Phase 3 Parkinson’s disease trial www.ppu.mrc.ac.uk/news/esther-...
Best of luck today to Karolina Zeneviciute of the Sammler lab, defending her PhD thesis 'GBA1 and #Parkinsons Disease: Development of a Comprehensive Assay Framework and its Application in Clinical Sample Analysis'
December 11, 2025 at 9:00 AM
Best of luck today to Karolina Zeneviciute of the Sammler lab, defending her PhD thesis 'GBA1 and #Parkinsons Disease: Development of a Comprehensive Assay Framework and its Application in Clinical Sample Analysis'
Best of luck today to Neringa Pratuseviciute of the Sammler lab, defending her PhD thesis 'From genetic predisposition to biochemical validation: investigating the role of LRRK2 signalling in #Parkinsons Disease'
November 27, 2025 at 9:05 AM
Best of luck today to Neringa Pratuseviciute of the Sammler lab, defending her PhD thesis 'From genetic predisposition to biochemical validation: investigating the role of LRRK2 signalling in #Parkinsons Disease'
Reposted by MRC PPU
Interested in LRRK2? Join us in beautiful Scotland for the biennial LRRK2 meeting. Abstract submission is now open: bit.ly/LRRK2-26
November 26, 2025 at 9:56 AM
Interested in LRRK2? Join us in beautiful Scotland for the biennial LRRK2 meeting. Abstract submission is now open: bit.ly/LRRK2-26
Congratulations to Dr Prosenjit Pal on winning Best ECR Poster Award at the 11th International Symposium on Autophagy 2025, Lorne, Australia: 'Novel Motif in Several Proteins Interacting with a Lysosomal Membrane Integral Protein Implies a Link between Ubiquitylation, Autophagy, and Ciliogenesis'
November 25, 2025 at 3:11 PM
Congratulations to Dr Prosenjit Pal on winning Best ECR Poster Award at the 11th International Symposium on Autophagy 2025, Lorne, Australia: 'Novel Motif in Several Proteins Interacting with a Lysosomal Membrane Integral Protein Implies a Link between Ubiquitylation, Autophagy, and Ciliogenesis'
Dr. Ralitsa Madsen awarded the Royal Society of Edinburgh’s 2025 Dame Anne McLaren Medal www.ppu.mrc.ac.uk/news/dr-rali...
Dr. Ralitsa Madsen awarded the Royal Society of Edinburgh’s 2025 Dame Anne McLaren Medal | MRC PPU
Dr. Ralitsa Madsen, UKRI Future Leaders Fellow and Principal Investigator in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU), has been awarded the Royal Society of Edinburgh Dame Ann...
www.ppu.mrc.ac.uk
November 20, 2025 at 10:40 AM
Dr. Ralitsa Madsen awarded the Royal Society of Edinburgh’s 2025 Dame Anne McLaren Medal www.ppu.mrc.ac.uk/news/dr-rali...
Best of luck today to Temi Thompson, defending her MRes research 'Developing and Characterising PROTACs against Ser/Thr Protein kinase CK1δ/ε'
November 19, 2025 at 9:35 AM
Best of luck today to Temi Thompson, defending her MRes research 'Developing and Characterising PROTACs against Ser/Thr Protein kinase CK1δ/ε'
Reposted by MRC PPU
What happens in nature in eight minutes? What does a frog look like on the inside? What was the first written language? These questions, and many more, are answered in the books shortlisted for the 2025 Royal Society Young People’s Book Prize: #YoungSciBooks royalsociety.org/news/2025/11...
November 19, 2025 at 9:18 AM
What happens in nature in eight minutes? What does a frog look like on the inside? What was the first written language? These questions, and many more, are answered in the books shortlisted for the 2025 Royal Society Young People’s Book Prize: #YoungSciBooks royalsociety.org/news/2025/11...
Accelerating Parkinson’s Trials: The EJS ACT-PD Clinical Trial and How You Can Get Involved
🗓 Thu 6 Nov, 5pm (Zoom)
🎙 Speaker: Prof Camille Carroll, Chief Investigator, ACT-PD
💬 Updates from Dundee Parkinson’s research and trials teams
➡️ More info here:
parkinsons-org-uk.zoom.us/meeting/regi...
🗓 Thu 6 Nov, 5pm (Zoom)
🎙 Speaker: Prof Camille Carroll, Chief Investigator, ACT-PD
💬 Updates from Dundee Parkinson’s research and trials teams
➡️ More info here:
parkinsons-org-uk.zoom.us/meeting/regi...
Welcome! You are invited to join a meeting: The Dundee Research Interest Group hosts Professor Camille Carroll: 'Revolutionising Clinical Trial Design in Parkinson’s: The EJS ACT-PD Trial'. After regi...
The Parkinson's UK Dundee Research Interest Group (DRIG) is very pleased to be able to invite you to our first annual Autumn Webinar event where we invite a Parkinson’s research expert from outside Du...
parkinsons-org-uk.zoom.us
November 3, 2025 at 11:38 AM
Accelerating Parkinson’s Trials: The EJS ACT-PD Clinical Trial and How You Can Get Involved
🗓 Thu 6 Nov, 5pm (Zoom)
🎙 Speaker: Prof Camille Carroll, Chief Investigator, ACT-PD
💬 Updates from Dundee Parkinson’s research and trials teams
➡️ More info here:
parkinsons-org-uk.zoom.us/meeting/regi...
🗓 Thu 6 Nov, 5pm (Zoom)
🎙 Speaker: Prof Camille Carroll, Chief Investigator, ACT-PD
💬 Updates from Dundee Parkinson’s research and trials teams
➡️ More info here:
parkinsons-org-uk.zoom.us/meeting/regi...