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natalieadye.bsky.social @natalieadye.bsky.social · 2h

I have worked on this project remotely for the last year @mbisg.bsky.social. If you like this kind of work on tissue morphogenesis, please consider joining my team in Singapore!

natalieadye.bsky.social @natalieadye.bsky.social · 2h

This was a tight collaboration between @poldresden.bsky.social and @mpipks.bsky.social. In particular, credit goes to the amazing @janafuhrmann.bsky.social, who helped conceive and lead the project. At PKS, Marko Popovic and @vicioms.bsky.social. Tremendously enjoyable collaboration (as always)!

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natalieadye.bsky.social @natalieadye.bsky.social · 2h

Then we use physical modeling and genetic perturbations to argue that the aECM has an adhesive function that stabilizes the folds and must be biochemically removed at early pupal stages to allow unfolding.

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natalieadye.bsky.social @natalieadye.bsky.social · 2h

Using electron microscopy @mpi-cbg.de, we discover extensive fibrous apical extracellular matrix (aECM) that covers the folds from top to bottom and adheres the two sides together through apical microvilli.

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natalieadye.bsky.social @natalieadye.bsky.social · 2h

We used light sheet microscopy and new analysis methods to extract the 3D apical surface of the wing disc and quantify its main folds over development.

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natalieadye.bsky.social @natalieadye.bsky.social · 2h

Tissue folds are a common occurrence during animal tissue development. While there are known mechanisms to initiate folding, we wondered, what happens after? How does the fold shape progress and what stabilizes the structure?

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natalieadye.bsky.social @natalieadye.bsky.social · 2h

How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social

Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc

Tissue folding is a fundamental process occurring in animal organ development. Here, we study the progression of fold shape and the underlying mechanics in the development of the Drosophila wing disc....

doi.org

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natalieadye.bsky.social @natalieadye.bsky.social · Aug 7

Company on my way to work #singapore #monitorlizard

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Reposted

W. Brent Derry @wbderry.bsky.social · Jul 16

Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...

Giant study finds a research field that’s mostly reproducible

Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

www.nature.com

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natalieadye.bsky.social @natalieadye.bsky.social · Jun 29

A short but sweet visit to Dresden ends. See you again in the fall! 🇩🇪 🇸🇬

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natalieadye.bsky.social @natalieadye.bsky.social · May 13

I confess, when I look at this poster, I see a wing disc on its side - but I don't know what it is actually. It's got too many folds for a Drosophila wing disc😅

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natalieadye.bsky.social @natalieadye.bsky.social · May 13

We are Ibidi's Image of the month! From my PhD student Sanika Jahagirdar @sanikajah.bsky.social @ibidicells.bsky.social
ibidi.com/content/cate...

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natalieadye.bsky.social @natalieadye.bsky.social · May 13

Join us in Singapore in September for the "Mechanobiology in Time and Space" meeting hosted by the Mechanobiology Institute at NUS @mbisg.bsky.social and Max Planck Society @maxplanck.de. Abstracts due soon! www.mbi.nus.edu.sg/events/mbico...

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Reposted

Society for Developmental Biology @socdevbio.bsky.social · Apr 9

Love developmental biology & science communication?
Join the SDB Social Media Team! Help share amazing science, connect with scientists, and gain valuable SciComm experience.

Apply by April 30, 2025
Form: docs.google.com/document/d/1...

#DevBio #SciComm #SDB #BlueskyScience

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natalieadye.bsky.social @natalieadye.bsky.social · Apr 3

Amazing news Rita! Congratulations 🎉

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natalieadye.bsky.social @natalieadye.bsky.social · Mar 1

Congrats! 🎉

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Reposted

Naomi Moris @nmoris.bsky.social · Feb 20

🧫Looking for a PhD to start Autumn 2025? We're recruiting! 🧪

The project will focus on using #embryomodels to explore #development & could cover a range of specific questions. Please RT! 🙏

Apply via the portal, and get more details here: www.crick.ac.uk/careers-stud...

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natalieadye.bsky.social @natalieadye.bsky.social · Feb 18

I'm looking for a talented+motivated person to join my team at the #MechanobiologyInstitute @NUS for a #postdoc. If you're interested in investigating collective cell behavior during 3D tissue #morphogenesis with me, please apply here or PM for Qs. Please RT! careers.nus.edu.sg/job/Research...

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Reposted

Mark Peifer (He, him) @peiferlabunc.bsky.social · Feb 8

Drosophila friends--here is fun, seemingly simple and efficient method for making small batches of fly food using--get this--a "soy milk machine" :) Thank you Wanhe Li @xseedling.bsky.social
wanheli2022.wixsite.com/wanheli/deep...

DeepCook | The Li Laboratory

Introducing DeepCook, the Soy Milk Machine Fly Food Method, which simplifies the fly food cooking process and enables greater flexibility in making diverse diets.

wanheli2022.wixsite.com

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Reposted

Florian Jug @florianjug.bsky.social · Jan 29

🚨🚨 MEGA JOB ALERT 🚨🚨
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!

Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏

More details below... check it out! 🧵 1/3

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natalieadye.bsky.social @natalieadye.bsky.social · Jan 14

If you're an undergraduate looking for a research opportunity in mechanobiology - consider coming to us in Singapore - open to local and internationals from 2nd year. It's paid, 6weeks. Deadline 31 Jan.

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natalieadye.bsky.social @natalieadye.bsky.social · Jan 7

Apply for a fully funded 4yr PhD in Mechanobiology at the MBI, NUS in Singapore! Deadline 13 Jan 2025.

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natalieadye.bsky.social @natalieadye.bsky.social · Dec 15

Congratulations!

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natalieadye.bsky.social @natalieadye.bsky.social · Dec 11

Fantastic thread about our latest paper from earlier this year!

Jana Fuhrmann @janafuhrmann.bsky.social · Dec 11

I love seeing so many interesting papers on Bluesky and my reading list keeps growing. So I would like to share a thread about our paper from this year. It was published when we were still at *the other place*, and I didn't feel like writing about it there.
www.science.org/doi/full/10....
1/n

natalieadye.bsky.social @natalieadye.bsky.social · Dec 3

Congratulations 🎉👏

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