In animal models, transient high-frequency oscillations in synchronized neural activity, known as ripples, have been linked to memory. Reithler et al. assess the current evidence for a contribution of...

As an animal moves within its environment, self-motion signals are generated by the inner ear vestibular organs and the retina and transmitted to the CNS. In this Review, Mao and Gu describe how these...

In this Journal Club, Edwin Robertson discusses a study published in 2000 that found a link between sleep and enhancement of visual memory.

Endocannabinoids are key mediators of affective behaviour, but the neural mechanisms that underlie these effects are only beginning to be elucidated. Here, Loomba and Patel review advances in understa...

In this Tools of the Trade article, Yu Zheng describes the design of a far-red dopamine sensor that enables the simultaneous monitoring of multiple neurotransmitters in the brain.

Long non-coding RNAs are abundant in the brain, where they are proposed to regulate numerous processes. In this Review, Mattick and colleagues describe our current understanding of their mechanisms of action, focusing on their contributions to enhancer function and the organization of specialized intracellular domains, and consider their roles in brain function and dysfunction.

Nature Reviews Neuroscience - As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much...

As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much of our research is publicly funded. Here, I argue that a...

Far from being a niche concern, women’s brain health is a global issue, affecting more than half of the world’s population. Despite this, the unique aspects of how the female brain adapts, reorganizes...

The scientific enterprise depends on attracting and retaining the very best talent, yet barriers persist that perpetuate inequities in the scientific workforce. Here I discuss the efforts of the ALBA ...

Nature Reviews Neuroscience - The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine...

The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine the use of top-down conceptual and...

In this Journal Club, Nina Rzechorzek explores a 2003 article showing that, during hibernation, ground squirrels reversibly accumulate highly phosphorylated tau in the brain (a hallmark of Alzheimer’s...

In this Journal Club, Benjamin Cowley discusses a 2009 tour-de-force that provided a recipe for constructing closed-loop algorithms by letting predictive models speak for themselves.

The risk of cognitive impairment and dementia in people with chronic kidney disease (CKD) is under-recognised.

In this Journal Club, Olivia Gold discusses a 2003 study showing in rats that respiratory depression caused by the synthetic opioid fentanyl could be pharmacologically reversed without compromising it...

High-throughput volume electron microscopy and deep learning-driven automated segmentation have revolutionized the mapping of neural circuits at the level of individual neurons and synapses, revealing...

In this Tools of the Trade article, Mengting Han discusses the development of CRISPR-TO, a programmable method for perturbing endogenous RNA localization, and its use for functional screening of the s...