Matthew L. Kraushar
@matthewkraushar.bsky.social
eukaryote, scientist, group leader at the Max Planck Institute for Molecular Genetics in Berlin, here to support ideas and the people who have them
https://www.molgen.mpg.de/kraushar-lab
https://www.molgen.mpg.de/kraushar-lab
Pinned
i cobbled together a science starter pack:
Neuronal Post-transcriptional / Protein Synthesis
agonizingly incomplete - join our growing community!
go.bsky.app/Qqq9HTw
Neuronal Post-transcriptional / Protein Synthesis
agonizingly incomplete - join our growing community!
go.bsky.app/Qqq9HTw
ribo💥ribo ⬅️ ZAK
a sight to behold!
revealed by the ribo dream team Vienna Huso @doubleshuang.bsky.social @greenlab.bsky.social @beckmannlab.bsky.social
a sight to behold!
revealed by the ribo dream team Vienna Huso @doubleshuang.bsky.social @greenlab.bsky.social @beckmannlab.bsky.social
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
November 24, 2025 at 8:08 AM
ribo💥ribo ⬅️ ZAK
a sight to behold!
revealed by the ribo dream team Vienna Huso @doubleshuang.bsky.social @greenlab.bsky.social @beckmannlab.bsky.social
a sight to behold!
revealed by the ribo dream team Vienna Huso @doubleshuang.bsky.social @greenlab.bsky.social @beckmannlab.bsky.social
heads up neuro bsky 😎 must-read seminal discoveries:
ultimate translation of genetic information in the farthest reaches of the neuron ➡️ @erin-schuman.bsky.social
& in cortex development ➡️ @debbysilver.bsky.social
thanks again 🤝 @natrevneuro.nature.com Darran Yates for editorial collaboration
ultimate translation of genetic information in the farthest reaches of the neuron ➡️ @erin-schuman.bsky.social
& in cortex development ➡️ @debbysilver.bsky.social
thanks again 🤝 @natrevneuro.nature.com Darran Yates for editorial collaboration
The on-site, on-demand, neuronal gene machine — a Journal Club article by Matthew L. Kraushar
@matthewkraushar.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@matthewkraushar.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
November 19, 2025 at 6:00 PM
heads up neuro bsky 😎 must-read seminal discoveries:
ultimate translation of genetic information in the farthest reaches of the neuron ➡️ @erin-schuman.bsky.social
& in cortex development ➡️ @debbysilver.bsky.social
thanks again 🤝 @natrevneuro.nature.com Darran Yates for editorial collaboration
ultimate translation of genetic information in the farthest reaches of the neuron ➡️ @erin-schuman.bsky.social
& in cortex development ➡️ @debbysilver.bsky.social
thanks again 🤝 @natrevneuro.nature.com Darran Yates for editorial collaboration
check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
The on-site, on-demand, neuronal gene machine - Nature Reviews Neuroscience
In this Journal Club, Matthew Kraushar discusses a study published in 1996 that found a role for local protein translation in hippocampal synaptic plasticity.
www.nature.com
November 18, 2025 at 6:35 PM
check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
Berlin macht Dampf!
November 16, 2025 at 10:37 PM
Berlin macht Dampf!
Join us to hear about writing and re-writing the central dogma! Looking forward to hosting Samuel Sternberg @sternberglab.bsky.social from @columbiauniversity.bsky.social for our Dahlem Colloquium Seminar at the MPI for Molecular Genetics @molgen.mpg.de - see below 👇
November 2, 2025 at 11:18 PM
Join us to hear about writing and re-writing the central dogma! Looking forward to hosting Samuel Sternberg @sternberglab.bsky.social from @columbiauniversity.bsky.social for our Dahlem Colloquium Seminar at the MPI for Molecular Genetics @molgen.mpg.de - see below 👇
proud PI with two of our students giving their last presentation before moving on to very bright scientific futures. their sendoff included a very bright homemade meal, courtesy of our postdoc (Zhuqing Xiong)
Nadine Brombacher (Master's)
Ekaterina German (Bachelor's)
Nadine Brombacher (Master's)
Ekaterina German (Bachelor's)
October 30, 2025 at 11:37 AM
proud PI with two of our students giving their last presentation before moving on to very bright scientific futures. their sendoff included a very bright homemade meal, courtesy of our postdoc (Zhuqing Xiong)
Nadine Brombacher (Master's)
Ekaterina German (Bachelor's)
Nadine Brombacher (Master's)
Ekaterina German (Bachelor's)
immensely grateful to @erin-schuman.bsky.social and @mpibrain.bsky.social for hosting me yesterday 🤝 MPI Brain has always been a guiding light - exceptional in neuroscience research, and courageous as a voice for science in society. the future is bright here, thank you for sharing that with me 🫶
October 28, 2025 at 3:12 PM
immensely grateful to @erin-schuman.bsky.social and @mpibrain.bsky.social for hosting me yesterday 🤝 MPI Brain has always been a guiding light - exceptional in neuroscience research, and courageous as a voice for science in society. the future is bright here, thank you for sharing that with me 🫶
post-translational control in the spotlight! rock on @hassanbraindevlab.bsky.social 🤩
www.biorxiv.org/content/10.1...
Our latest: Julien Pigeon and colleagues discover a mechanism linking post-translational modification of transcription factors to remodeling the chromatin landscape to regulate human cortical neurogenesis
Our latest: Julien Pigeon and colleagues discover a mechanism linking post-translational modification of transcription factors to remodeling the chromatin landscape to regulate human cortical neurogenesis
Post-translational Tuning of Human Cortical Progenitor Neuronal Output
The striking expansion of the human neocortex is driven by the ability of radial glial cells (RGCs) to prolong neurogenesis without exhausting their progenitor pool, thereby producing more neurons, pa...
www.biorxiv.org
October 28, 2025 at 9:00 AM
post-translational control in the spotlight! rock on @hassanbraindevlab.bsky.social 🤩
Reposted by Matthew L. Kraushar
Our Metabuli taxonomic classifier is now available as an app compatible with Windows, Linux, and macOS. It features an interactive visualization developed by @sunjaelee.bsky.social, along with improvements to Metabuli by @jbeom.bsky.social.
📄 academic.oup.com/bioinformati...
📄 academic.oup.com/bioinformati...
October 16, 2025 at 1:01 PM
Our Metabuli taxonomic classifier is now available as an app compatible with Windows, Linux, and macOS. It features an interactive visualization developed by @sunjaelee.bsky.social, along with improvements to Metabuli by @jbeom.bsky.social.
📄 academic.oup.com/bioinformati...
📄 academic.oup.com/bioinformati...
🔥 hot off the press from the Silver Lab 🔥
🤩😎😍
🤩😎😍
I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
October 11, 2025 at 6:35 AM
🔥 hot off the press from the Silver Lab 🔥
🤩😎😍
🤩😎😍
Reposted by Matthew L. Kraushar
If you’re interested in a PhD that explores the ins and outs of genomes and the nucleus - don’t look further but apply here!!!
It is excellent 👌
It is excellent 👌
🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
October 9, 2025 at 12:49 PM
If you’re interested in a PhD that explores the ins and outs of genomes and the nucleus - don’t look further but apply here!!!
It is excellent 👌
It is excellent 👌
Reposted by Matthew L. Kraushar
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
October 5, 2025 at 12:16 PM
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
Reposted by Matthew L. Kraushar
We have an open group leader position in diabetes 1 research.
Please circulate!
www.nature.com/naturecareer....
Please circulate!
www.nature.com/naturecareer....
164887 Professor or Associate Professor and Research Group Leader with special focus on molecular me - Copenhagen, Hovedstaden (DK) job with The Biotech Research and Innovation Centre (BRIC), Universi...
BRIC wishes to recruit a strongly motivated scientist at Associate Professor or Professor level for an independent research group leader position. ...
www.nature.com
October 3, 2025 at 5:15 PM
We have an open group leader position in diabetes 1 research.
Please circulate!
www.nature.com/naturecareer....
Please circulate!
www.nature.com/naturecareer....
Reposted by Matthew L. Kraushar
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:00 AM
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
rock on Raquel!
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 2, 2025 at 2:57 PM
rock on Raquel!
yo scientists awesome opportunity! ⬇️🔥
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:39 AM
yo scientists awesome opportunity! ⬇️🔥
A fantastic scientist with a bright future, Deana Haxhiraj, has graduated from her Master's in my lab at the Max Planck Institute for Molecular Genetics @molgen.mpg.de in the @freieuniversitaet.bsky.social Berlin Program. Today was her last day, with a sendoff to her next great adventure!
September 30, 2025 at 6:37 PM
A fantastic scientist with a bright future, Deana Haxhiraj, has graduated from her Master's in my lab at the Max Planck Institute for Molecular Genetics @molgen.mpg.de in the @freieuniversitaet.bsky.social Berlin Program. Today was her last day, with a sendoff to her next great adventure!
heads up! great story from the @trayon.bsky.social lab 😍
We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social
🔥 now including in vivo 🐭&👤 embryo data
www.biorxiv.org/content/10.1...
🔥 now including in vivo 🐭&👤 embryo data
www.biorxiv.org/content/10.1...
September 28, 2025 at 4:34 PM
heads up! great story from the @trayon.bsky.social lab 😍
Many thanks to Eugenio Fornasiero @forna.bsky.social and the great students at Università degli Studi di Trieste for hosting me this week 🇮🇹! A particularly special time to teach science, during the Trieste Next – Festival della ricerca scientifica...and some lovely weather ☀️ Arrivederci!
September 27, 2025 at 11:38 AM
Many thanks to Eugenio Fornasiero @forna.bsky.social and the great students at Università degli Studi di Trieste for hosting me this week 🇮🇹! A particularly special time to teach science, during the Trieste Next – Festival della ricerca scientifica...and some lovely weather ☀️ Arrivederci!
Reposted by Matthew L. Kraushar
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...
www.biorxiv.org
September 22, 2025 at 11:23 PM
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
latest from @aphillippy.bsky.social and the genome architects!
Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]
A complete diploid human genome benchmark for personalized genomics
Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...
www.biorxiv.org
September 22, 2025 at 5:24 PM
latest from @aphillippy.bsky.social and the genome architects!
Reposted by Matthew L. Kraushar
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com
📄 www.nature.com/articles/s41...
💿 mmseqs.com
GPU-accelerated homology search with MMseqs2 - Nature Methods
Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...
www.nature.com
September 21, 2025 at 8:06 AM
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com
📄 www.nature.com/articles/s41...
💿 mmseqs.com
🤘 Rock on 🤘 Katrina Meyer & Rainer Nikolay from the Kraushar Lab @molgen.mpg.de presenting at the SPP2191 & GBM Compact Meetings in Frankfurt. Was fun to see my lab's work from the audience, and be their paparazzi 📸 The decor matched the topic 😉 Thanks to @spp2191.bsky.social for funding our work!
September 19, 2025 at 5:12 PM
🤘 Rock on 🤘 Katrina Meyer & Rainer Nikolay from the Kraushar Lab @molgen.mpg.de presenting at the SPP2191 & GBM Compact Meetings in Frankfurt. Was fun to see my lab's work from the audience, and be their paparazzi 📸 The decor matched the topic 😉 Thanks to @spp2191.bsky.social for funding our work!
Rainer and I did our last experiment together in the Kraushar Lab @molgen.mpg.de on Sunday - like many such days since our postdocs. Rainer will soon lead a team in the Emmanuelle Charpentier Dept @MPUSP - stay tuned for more!
September 19, 2025 at 8:05 AM
Rainer and I did our last experiment together in the Kraushar Lab @molgen.mpg.de on Sunday - like many such days since our postdocs. Rainer will soon lead a team in the Emmanuelle Charpentier Dept @MPUSP - stay tuned for more!
rock on Claudi!
Congratulations to Claudia Giesecke-Thiel on her ERC Starting Grant! Her project will focus on how the site of infection influences immune responses.
She will be moving from the MPIMG to Charité, where she will launch her own research group in Jan 2026.
Read more: www.molgen.mpg.de/news-2025-er...
She will be moving from the MPIMG to Charité, where she will launch her own research group in Jan 2026.
Read more: www.molgen.mpg.de/news-2025-er...
September 10, 2025 at 10:35 AM
rock on Claudi!