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A human-specific regulatory mechanism revealed in a pre-implantation model

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Reposted by Matthew L. Kraushar

Adriano Bolondi @adrianobolondi.bsky.social · 6d

🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇

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Matthew L. Kraushar @matthewkraushar.bsky.social · 6d

rock on Raquel!

Raquel Fueyo @fueyoraquel.bsky.social · 7d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

Molecular basis of polyadenylated RNA fate determination in the nucleus

Matthew L. Kraushar @matthewkraushar.bsky.social · 6d

yo scientists awesome opportunity! ⬇️🔥

Adriano Bolondi @adrianobolondi.bsky.social · 6d

🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇

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Matthew L. Kraushar @matthewkraushar.bsky.social · 8d

A fantastic scientist with a bright future, Deana Haxhiraj, has graduated from her Master's in my lab at the Max Planck Institute for Molecular Genetics @molgen.mpg.de in the @freieuniversitaet.bsky.social Berlin Program. Today was her last day, with a sendoff to her next great adventure!

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Matthew L. Kraushar @matthewkraushar.bsky.social · 10d

heads up! great story from the @trayon.bsky.social lab 😍

Teresa Rayon @trayon.bsky.social · 10d

We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social

🔥 now including in vivo 🐭&👤 embryo data

www.biorxiv.org/content/10.1...

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Matthew L. Kraushar @matthewkraushar.bsky.social · 11d

Many thanks to Eugenio Fornasiero @forna.bsky.social and the great students at Università degli Studi di Trieste for hosting me this week 🇮🇹! A particularly special time to teach science, during the Trieste Next – Festival della ricerca scientifica...and some lovely weather ☀️ Arrivederci!

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Reposted by Matthew L. Kraushar

Ulrich Hohmann @hohmannulrich.bsky.social · 16d

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

A complete diploid human genome benchmark for personalized genomics

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Matthew L. Kraushar @matthewkraushar.bsky.social · 16d

latest from @aphillippy.bsky.social and the genome architects!

Adam Phillippy @aphillippy.bsky.social · 16d

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...

GPU-accelerated homology search with MMseqs2 - Nature Methods

Reposted by Matthew L. Kraushar

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 17d

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com

Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites

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Matthew L. Kraushar @matthewkraushar.bsky.social · 19d

🤘 Rock on 🤘 Katrina Meyer & Rainer Nikolay from the Kraushar Lab @molgen.mpg.de presenting at the SPP2191 & GBM Compact Meetings in Frankfurt. Was fun to see my lab's work from the audience, and be their paparazzi 📸 The decor matched the topic 😉 Thanks to @spp2191.bsky.social for funding our work!

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Matthew L. Kraushar @matthewkraushar.bsky.social · 19d

Rainer and I did our last experiment together in the Kraushar Lab @molgen.mpg.de on Sunday - like many such days since our postdocs. Rainer will soon lead a team in the Emmanuelle Charpentier Dept @MPUSP - stay tuned for more!

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Matthew L. Kraushar @matthewkraushar.bsky.social · 28d

rock on Claudi!

Max Planck Institute for Molecular Genetics @molgen.mpg.de · 28d

Congratulations to Claudia Giesecke-Thiel on her ERC Starting Grant! Her project will focus on how the site of infection influences immune responses.
She will be moving from the MPIMG to Charité, where she will launch her own research group in Jan 2026.
Read more: www.molgen.mpg.de/news-2025-er...

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Matthew L. Kraushar @matthewkraushar.bsky.social · 28d

all kinds of wonder cooking in the Kraushar Lab @molgen.mpg.de

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Matthew L. Kraushar @matthewkraushar.bsky.social · 29d

rock on @kurianlab.bsky.social !

Kurianlab @kurianlab.bsky.social · Sep 8

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

One mother for two species via obligate cross-species cloning in ants - Nature

Matthew L. Kraushar @matthewkraushar.bsky.social · Sep 4

biology reminds us constantly that norms are more fiction than fact

www.nature.com/articles/s41...

In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...

A brain-wide map of neural activity during complex behaviour - Nature

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Matthew L. Kraushar @matthewkraushar.bsky.social · Sep 4

everything, everywhere, all at once
www.nature.com/articles/s41...

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task i...

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Matthew L. Kraushar @matthewkraushar.bsky.social · Sep 4

spotify y u gotta know me like that

www.cell.com/cell/fulltex...

Matthew L. Kraushar @matthewkraushar.bsky.social · Aug 25

the Batki lab at the FMI 🔥

@juliabatki.bsky.social was a fantastic part of our community at @molgen.mpg.de

looking forward to seeing the Batki lab in action soon @fmiscience.bsky.social

Julia Batki @juliabatki.bsky.social · Aug 25

I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉

We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.

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Reposted by Matthew L. Kraushar

Geraldine Zimmer-Bensch @zimmer-bensch.bsky.social · Aug 18

🌍 Open Call! RWTH Aachen University invites postdocs from outside the EU to apply for the “Port to Europe” Fellowship (24 months funding, all disciplines). Start your research journey at one of Europe’s top universities! 🚀 Deadline: Oct 5, 2025. 👉https://rwth-aachen.de/go/id/botjje/lidx/1

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Matthew L. Kraushar @matthewkraushar.bsky.social · Aug 11

the latest from @debbysilver.bsky.social lab, on what makes us human 🧠

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Debby Silver @debbysilver.bsky.social · Aug 10

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

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Matthew L. Kraushar @matthewkraushar.bsky.social · Aug 8

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

The ability to track protein degradation kinetics across the mammalian proteome reveals that a subset of proteins is less likely to be degraded the more time has passed since synthesis. Effects of gen...

www.cell.com

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy

Matthew L. Kraushar @matthewkraushar.bsky.social · Aug 5

latest from @fjoreilly.bsky.social and the gang!

Francis O'Reilly @fjoreilly.bsky.social · Aug 5

‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...

Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...