Lightnews — Scholar-powered news

Shyuan Ngo @ngoshyuan.bsky.social · Mar 2

Can’t go past some good Chinese 🤤

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Shyuan Ngo @ngoshyuan.bsky.social · Mar 2

Yes, we are trying to get onto PubMed here as well - giving it a hard thumbs down 👎

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Shyuan Ngo @ngoshyuan.bsky.social · Mar 2

#PACTALS2025

Abstract submission deadline has been extended until March 17 - join us in #Melbourne #Australia this September!

Showcasing ALS research and care across the Asia-Pacific and hearing perspectives and updates from global colleagues

pactalscongress.com

@mndaus-research.bsky.social

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Shyuan Ngo @ngoshyuan.bsky.social · Mar 2

We looked at the relationship between fatigue and metabolic rate in #ALS. Fatigue is a complex symptom - more needs to be done to understand how we can best address it.

@fredsteyn.bsky.social @ammaralchalabi.bsky.social

www.tandfonline.com/doi/full/10....

Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosis

Objective: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Little is known about factors that contribute to fatigue, and whether levels of fatigue change throughout disease cour...

www.tandfonline.com

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Reposted by Shyuan Ngo

Adrian Isaacs @adrianisaacs.bsky.social · Feb 25

Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf

Neuronal polyunsaturated fatty acids are protective in ALS/FTD

Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...

rdcu.be

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Shyuan Ngo @ngoshyuan.bsky.social · Feb 20

Looks warm to me 🤣🤣

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Shyuan Ngo @ngoshyuan.bsky.social · Feb 16

@jdpereira.bsky.social hello!

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Shyuan Ngo @ngoshyuan.bsky.social · Feb 10

Our study on the safety and tolerability of Trimetazidine in #ALS @braincomms.bsky.social
Trimetazidine reduced oxidative stress markers and energy expenditure, warranting a follow up study

@rpavaneijk.bsky.social @fredsteyn.bsky.social @ammaralchalabi.bsky.social

academic.oup.com/braincomms/a...

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Shyuan Ngo @ngoshyuan.bsky.social · Jan 16

Some new and interesting work on cell-free DNA in #ALS - insights into biomarker potential

link.springer.com/epdf/10.1186...

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons

link.springer.com

Shyuan Ngo @ngoshyuan.bsky.social · Dec 12

A timely piece that everyone should read. There are many challenges but we have a responsibility to communicate outcomes without the over sensationalisation!

Ruben van Eijk @rpavaneijk.bsky.social · Dec 10

New paper to reflect on the main challenges in phase 2 #ALS #MND trials. Key issues relate too short study durations, reliance on the wrong outcome measures, absence of biomarkers, statistical issues, over-interpretation of 'clinical trends' and miscommunication. academic.oup.com/brain/articl...

Rethinking phase 2 trials in amyotrophic lateral sclerosis

There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria

academic.oup.com

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Reposted by Shyuan Ngo

Ruben van Eijk @rpavaneijk.bsky.social · Dec 10

New paper to reflect on the main challenges in phase 2 #ALS #MND trials. Key issues relate too short study durations, reliance on the wrong outcome measures, absence of biomarkers, statistical issues, over-interpretation of 'clinical trends' and miscommunication. academic.oup.com/brain/articl...

Rethinking phase 2 trials in amyotrophic lateral sclerosis

There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria

academic.oup.com

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Shyuan Ngo @ngoshyuan.bsky.social · Nov 25

Decision email received at 00:38 - how long does one hold off from logging on to see the bad news???

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Reposted by Shyuan Ngo

Tim Mosca (he/him) @drosophilosophy.bsky.social · Nov 9

LRP4 controls SO MUCH more! And it all seems to do so from the PRESYNAPSE (answering that HUGE open question). LRP4 controls synapse growth, cytoskeletal organization, postsynaptic protein recruitment, AND maturation. Multiple processes for the price of one cell surface protein!

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Shyuan Ngo @ngoshyuan.bsky.social · Nov 17

@ammaralchalabi.bsky.social It’s the Blue Sky Effect 😬

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