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Nils Kremer, MD @nilskremermd.bsky.social · 25d

Loops derived from right heart catheterization (RV pressure via Swan-Ganz) and analyzed with our newly published workflow

🔗 Paper: www.jhltonline.org/article/S105...
🛠️ PV-loop generator: pv-loop-generator.onrender.com

@khodrtello.bsky.social @hemodynamix.bsky.social @zentensivist.bsky.social

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Nils Kremer, MD @nilskremermd.bsky.social · 25d

Key findings from the PV-loops:
➡️ Marked pressure reduction
➡️ Significant decrease in afterload (Ea)
➡️ RV-PA coupling nearly doubles (0.48 → 0.95)
➡️ Stroke work (area of PV-loop) decreases substantially
➡️ Unstressed volume (V0, intercept of Ees with x-axis) normalizes

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Nils Kremer, MD @nilskremermd.bsky.social · 25d

💉 Treprostinil s.c. 60 ng/kg/min
💊 Macitentan 10 mg
💊 Tadalafil 40 mg

In this case, triple therapy not only lowers pulmonary pressures but also lets the RV work more efficiently — restoring RV-arterial coupling and reducing energetic strain.

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Nils Kremer, MD @nilskremermd.bsky.social · 25d

What does initiation of upfront triple therapy in PAH mean for the right ventricle?

👇 Pressure–volume loops tell the story:

🩺 Patient with newly diagnosed IPAH (light grey) vs. 6 months (black) on therapy.

#PulmonaryHypertension #RightVentricle #ThePeoplesVentricle #PAH

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Nils Kremer, MD @nilskremermd.bsky.social · 28d

Democratization of PV loops😉 – no conductance catheter needed

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Nils Kremer, MD @nilskremermd.bsky.social · 28d

Whenever you have questions, feel free to reach out

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Nils Kremer, MD @nilskremermd.bsky.social · 28d

Thanks, Matt! In principle, the use is quite straightforward. You can simply export CSV or TXT files from your catheterization system and upload them. Calibration can then be done by entering CO or by volumetric data (MRI or echo). We’re currently working on a built-in user guide for the tool.

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Nils Kremer, MD @nilskremermd.bsky.social · 28d

We introduce a tool that derives RV PV loops from routine right heart cath data.
✅ Simplifies advanced RV analysis with PV Loops
✅ Stroke work & coupling metrics in seconds
✅ Freely available: pv-loop-generator.onrender.com

#PulmonaryHypertension #RVFunction #Hemodynamics
#RightVentricle

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Nils Kremer, MD @nilskremermd.bsky.social · 28d

Excited to share our new paper! 🎉
Method for generating right ventricular pressure–volume loops in routine practice - The Journal of Heart and Lung Transplantation www.jhltonline.org/article/S105...

@khodrtello.bsky.social @rrvdpool.bsky.social @zentensivist.bsky.social @hemodynamix.bsky.social

Method for generating right ventricular pressure–volume loops in routine practice

Analysis of pressure–volume (PV) loops from conductance catheterization is the gold standard for evaluating right ventricular (RV) function, but the complexity of conductance catheterization limits clinical implementation. This study validates a novel method for reconstructing RV PV loops from pressure waveforms acquired during routine right heart catheterization (RHC).

www.jhltonline.org

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Reposted by Nils Kremer, MD

Felix Glocker @hemodynamix.bsky.social · 28d

Our paper on generating right ventricular pressure–volume loops from right heart catheter data is out in @jhlt.bsky.social Proud to share this work.

Software: pv-loop-generator.onrender.com

Article: www.jhltonline.org/article/S105...

#hemodynamics #pvloops

Method for generating right ventricular pressure–volume loops in routine practice

Analysis of pressure–volume (PV) loops from conductance catheterization is the gold standard for evaluating right ventricular (RV) function, but the complexity of conductance catheterization limits cl...

www.jhltonline.org

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