Nils Kremer, MD
@nilskremermd.bsky.social
Proud to share our new CIRCULATION paper, released alongside our #AHA2025 presentation: Sotatercept rapidly lowers pulmonary pressures and RV afterload within hours.
🔗 www.ahajournals.org/doi/10.1161/...
#AHA2025 #Circulation #PAH #RVFunction #Sotatercept #PeoplesVentricle
🔗 www.ahajournals.org/doi/10.1161/...
#AHA2025 #Circulation #PAH #RVFunction #Sotatercept #PeoplesVentricle
Acute Hemodynamic Effects of Sotatercept | Circulation
www.ahajournals.org
November 8, 2025 at 11:12 PM
Proud to share our new CIRCULATION paper, released alongside our #AHA2025 presentation: Sotatercept rapidly lowers pulmonary pressures and RV afterload within hours.
🔗 www.ahajournals.org/doi/10.1161/...
#AHA2025 #Circulation #PAH #RVFunction #Sotatercept #PeoplesVentricle
🔗 www.ahajournals.org/doi/10.1161/...
#AHA2025 #Circulation #PAH #RVFunction #Sotatercept #PeoplesVentricle
Loops derived from right heart catheterization (RV pressure via Swan-Ganz) and analyzed with our newly published workflow
🔗 Paper: www.jhltonline.org/article/S105...
🛠️ PV-loop generator: pv-loop-generator.onrender.com
@khodrtello.bsky.social @hemodynamix.bsky.social @zentensivist.bsky.social
🔗 Paper: www.jhltonline.org/article/S105...
🛠️ PV-loop generator: pv-loop-generator.onrender.com
@khodrtello.bsky.social @hemodynamix.bsky.social @zentensivist.bsky.social
September 15, 2025 at 9:39 PM
Loops derived from right heart catheterization (RV pressure via Swan-Ganz) and analyzed with our newly published workflow
🔗 Paper: www.jhltonline.org/article/S105...
🛠️ PV-loop generator: pv-loop-generator.onrender.com
@khodrtello.bsky.social @hemodynamix.bsky.social @zentensivist.bsky.social
🔗 Paper: www.jhltonline.org/article/S105...
🛠️ PV-loop generator: pv-loop-generator.onrender.com
@khodrtello.bsky.social @hemodynamix.bsky.social @zentensivist.bsky.social
Key findings from the PV-loops:
➡️ Marked pressure reduction
➡️ Significant decrease in afterload (Ea)
➡️ RV-PA coupling nearly doubles (0.48 → 0.95)
➡️ Stroke work (area of PV-loop) decreases substantially
➡️ Unstressed volume (V0, intercept of Ees with x-axis) normalizes
➡️ Marked pressure reduction
➡️ Significant decrease in afterload (Ea)
➡️ RV-PA coupling nearly doubles (0.48 → 0.95)
➡️ Stroke work (area of PV-loop) decreases substantially
➡️ Unstressed volume (V0, intercept of Ees with x-axis) normalizes
September 15, 2025 at 9:39 PM
Key findings from the PV-loops:
➡️ Marked pressure reduction
➡️ Significant decrease in afterload (Ea)
➡️ RV-PA coupling nearly doubles (0.48 → 0.95)
➡️ Stroke work (area of PV-loop) decreases substantially
➡️ Unstressed volume (V0, intercept of Ees with x-axis) normalizes
➡️ Marked pressure reduction
➡️ Significant decrease in afterload (Ea)
➡️ RV-PA coupling nearly doubles (0.48 → 0.95)
➡️ Stroke work (area of PV-loop) decreases substantially
➡️ Unstressed volume (V0, intercept of Ees with x-axis) normalizes
💉 Treprostinil s.c. 60 ng/kg/min
💊 Macitentan 10 mg
💊 Tadalafil 40 mg
In this case, triple therapy not only lowers pulmonary pressures but also lets the RV work more efficiently — restoring RV-arterial coupling and reducing energetic strain.
💊 Macitentan 10 mg
💊 Tadalafil 40 mg
In this case, triple therapy not only lowers pulmonary pressures but also lets the RV work more efficiently — restoring RV-arterial coupling and reducing energetic strain.
September 15, 2025 at 9:39 PM
💉 Treprostinil s.c. 60 ng/kg/min
💊 Macitentan 10 mg
💊 Tadalafil 40 mg
In this case, triple therapy not only lowers pulmonary pressures but also lets the RV work more efficiently — restoring RV-arterial coupling and reducing energetic strain.
💊 Macitentan 10 mg
💊 Tadalafil 40 mg
In this case, triple therapy not only lowers pulmonary pressures but also lets the RV work more efficiently — restoring RV-arterial coupling and reducing energetic strain.
What does initiation of upfront triple therapy in PAH mean for the right ventricle?
👇 Pressure–volume loops tell the story:
🩺 Patient with newly diagnosed IPAH (light grey) vs. 6 months (black) on therapy.
#PulmonaryHypertension #RightVentricle #ThePeoplesVentricle #PAH
👇 Pressure–volume loops tell the story:
🩺 Patient with newly diagnosed IPAH (light grey) vs. 6 months (black) on therapy.
#PulmonaryHypertension #RightVentricle #ThePeoplesVentricle #PAH
September 15, 2025 at 9:39 PM
What does initiation of upfront triple therapy in PAH mean for the right ventricle?
👇 Pressure–volume loops tell the story:
🩺 Patient with newly diagnosed IPAH (light grey) vs. 6 months (black) on therapy.
#PulmonaryHypertension #RightVentricle #ThePeoplesVentricle #PAH
👇 Pressure–volume loops tell the story:
🩺 Patient with newly diagnosed IPAH (light grey) vs. 6 months (black) on therapy.
#PulmonaryHypertension #RightVentricle #ThePeoplesVentricle #PAH
Democratization of PV loops😉 – no conductance catheter needed
September 12, 2025 at 7:32 PM
Democratization of PV loops😉 – no conductance catheter needed
Whenever you have questions, feel free to reach out
September 12, 2025 at 7:28 PM
Whenever you have questions, feel free to reach out
Thanks, Matt! In principle, the use is quite straightforward. You can simply export CSV or TXT files from your catheterization system and upload them. Calibration can then be done by entering CO or by volumetric data (MRI or echo). We’re currently working on a built-in user guide for the tool.
September 12, 2025 at 7:26 PM
Thanks, Matt! In principle, the use is quite straightforward. You can simply export CSV or TXT files from your catheterization system and upload them. Calibration can then be done by entering CO or by volumetric data (MRI or echo). We’re currently working on a built-in user guide for the tool.
We introduce a tool that derives RV PV loops from routine right heart cath data.
✅ Simplifies advanced RV analysis with PV Loops
✅ Stroke work & coupling metrics in seconds
✅ Freely available: pv-loop-generator.onrender.com
#PulmonaryHypertension #RVFunction #Hemodynamics
#RightVentricle
✅ Simplifies advanced RV analysis with PV Loops
✅ Stroke work & coupling metrics in seconds
✅ Freely available: pv-loop-generator.onrender.com
#PulmonaryHypertension #RVFunction #Hemodynamics
#RightVentricle
September 12, 2025 at 7:14 PM
We introduce a tool that derives RV PV loops from routine right heart cath data.
✅ Simplifies advanced RV analysis with PV Loops
✅ Stroke work & coupling metrics in seconds
✅ Freely available: pv-loop-generator.onrender.com
#PulmonaryHypertension #RVFunction #Hemodynamics
#RightVentricle
✅ Simplifies advanced RV analysis with PV Loops
✅ Stroke work & coupling metrics in seconds
✅ Freely available: pv-loop-generator.onrender.com
#PulmonaryHypertension #RVFunction #Hemodynamics
#RightVentricle
Excited to share our new paper! 🎉
Method for generating right ventricular pressure–volume loops in routine practice - The Journal of Heart and Lung Transplantation www.jhltonline.org/article/S105...
@khodrtello.bsky.social @rrvdpool.bsky.social @zentensivist.bsky.social @hemodynamix.bsky.social
Method for generating right ventricular pressure–volume loops in routine practice - The Journal of Heart and Lung Transplantation www.jhltonline.org/article/S105...
@khodrtello.bsky.social @rrvdpool.bsky.social @zentensivist.bsky.social @hemodynamix.bsky.social
Method for generating right ventricular pressure–volume loops in routine practice
Analysis of pressure–volume (PV) loops from conductance catheterization is the gold standard for evaluating right ventricular (RV) function, but the complexity of conductance catheterization limits clinical implementation. This study validates a novel method for reconstructing RV PV loops from pressure waveforms acquired during routine right heart catheterization (RHC).
www.jhltonline.org
September 12, 2025 at 7:14 PM
Excited to share our new paper! 🎉
Method for generating right ventricular pressure–volume loops in routine practice - The Journal of Heart and Lung Transplantation www.jhltonline.org/article/S105...
@khodrtello.bsky.social @rrvdpool.bsky.social @zentensivist.bsky.social @hemodynamix.bsky.social
Method for generating right ventricular pressure–volume loops in routine practice - The Journal of Heart and Lung Transplantation www.jhltonline.org/article/S105...
@khodrtello.bsky.social @rrvdpool.bsky.social @zentensivist.bsky.social @hemodynamix.bsky.social
Reposted by Nils Kremer, MD
Our paper on generating right ventricular pressure–volume loops from right heart catheter data is out in @jhlt.bsky.social Proud to share this work.
Software: pv-loop-generator.onrender.com
Article: www.jhltonline.org/article/S105...
#hemodynamics #pvloops
Software: pv-loop-generator.onrender.com
Article: www.jhltonline.org/article/S105...
#hemodynamics #pvloops
Method for generating right ventricular pressure–volume loops in routine practice
Analysis of pressure–volume (PV) loops from conductance catheterization is the gold
standard for evaluating right ventricular (RV) function, but the complexity of conductance
catheterization limits cl...
www.jhltonline.org
September 12, 2025 at 5:47 PM
Our paper on generating right ventricular pressure–volume loops from right heart catheter data is out in @jhlt.bsky.social Proud to share this work.
Software: pv-loop-generator.onrender.com
Article: www.jhltonline.org/article/S105...
#hemodynamics #pvloops
Software: pv-loop-generator.onrender.com
Article: www.jhltonline.org/article/S105...
#hemodynamics #pvloops