Fumiaki Obata
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obataf-lab.bsky.social
Fumiaki Obata
@obataf-lab.bsky.social
98 followers 77 following 16 posts
PI studying nutritional biology at RIKEN Center for Biosystems Dynamics Research & visiting associate professor in Kyoto University. Interested in Drosophila genetics, amino acid, nutrient, microbiota, metabolism, ageing, lifespan, and many others
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obataf-lab.bsky.social
Fumiaki Obata @obataf-lab.bsky.social · Dec 24
new work out from the lab @cellreports.bsky.social
A brave phd student Ayano revealed the mechanism how immune activation disrupts renal tubules! The key is a nonsecretory antimicrobial peptide!
www.cell.com/cell-reports...
A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules
Using the power of Drosophila genetics, Oi et al. identified a nonsecretory antimicrobial peptide, Attacin-D, as an essential factor in inflammatory organ damage in the renal tubules. This study highlights a key player in inflammatory organ injury.
www.cell.com
Reposted by Fumiaki Obata
riken-bdr.bsky.social
【採用情報】
理研BDRの栄養応答研究チーム (チームディレクター: 小幡史明)から、研究員または特別研究員の公募が出ています。
栄養に関する研究に興味のある方はぜひ！
随時受付、審査を行い、ポストが埋まり次第締め切ります。
詳細は👇
www.riken.jp/careers/rese...
研究員または特別研究員募集 栄養応答研究チーム（25-1968）
www.riken.jp
November 18, 2025 at 3:38 AM
obataf-lab.bsky.social
The finding is pretty much owing to the great lipidomics team led by Arita-san and Morozumi-san at RIKEN_IMS. Very exciting to connect fly genetics, nutrient manipulation, and lipidomic profiling
December 14, 2025 at 3:24 AM
obataf-lab.bsky.social
New study from the lab posted to @biorxivpreprint.bsky.social
PhD student Yuka discovered the beautiful mechanism for overcoming nutrient deficiency by microbiota and a new metabolic pathway! Dietary requirement of choline for phospholipids is very complicated www.biorxiv.org/content/10.6...
Dual Metabolic Compensation to Dietary Choline Deficiency by the Drosophila Hologenome
Coping with an unbalanced diet is critical in animals. However, the mechanisms that mitigate deficiencies of specific nutrients, such as choline, remain poorly understood. Choline is converted to phos...
www.biorxiv.org
December 14, 2025 at 3:17 AM
Reposted by Fumiaki Obata
natmetabolism.nature.com
Fat sensory cues in early life program central response to food and obesity
Nature Metabolism, Published online: 01 December 2025; doi:10.1038/s42255-025-01405-8Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.
bit.ly
December 1, 2025 at 9:30 PM
obataf-lab.bsky.social
Our new study out @BMC Biology. The first Mosquito study from the lab, driven by a great effort of phd student Yusuke Kato with the hard work of Chisako Sakuma. Amino acid economy meets a blood-sucking insect.
link.springer.com/10.1186/s129...
Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti - BMC Biology
Background Female Aedes aegypti mosquitoes utilize host blood to support egg maturation by digesting, absorbing, and metabolizing its components. Among these, amino acids are essential as both signali...
link.springer.com
November 27, 2025 at 9:10 AM
obataf-lab.bsky.social
a tiny contribution from my lab to the great work! Amino acid biology in tumour growth. Congrats! A pint ahead in Melbourne!
chengflylab.bsky.social Louise Cheng @chengflylab.bsky.social · Nov 24
Tagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social
petermaccc.bsky.social Peter MacCallum Cancer Centre @petermaccc.bsky.social · Nov 24
🧠 New research shows the blood–brain barrier helps control #braintumour growth.

Led by Prof Louise Cheng, the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.

Read more: www.petermac.org/about-us/new...
November 24, 2025 at 4:01 AM
Reposted by Fumiaki Obata
chengflylab.bsky.social
Tagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social
petermaccc.bsky.social Peter MacCallum Cancer Centre @petermaccc.bsky.social · Nov 24
🧠 New research shows the blood–brain barrier helps control #braintumour growth.

Led by Prof Louise Cheng, the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.

Read more: www.petermac.org/about-us/new...
November 24, 2025 at 3:19 AM
Reposted by Fumiaki Obata
plosbiology.org
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.
November 19, 2025 at 10:05 AM
Reposted by Fumiaki Obata
danjhayman.bsky.social
Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...
Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan
Biological regulation is a highly intricate process and involves many layers of complexity even at the RNA level. Alternative splicing is crucial in the regulation of which components of a protein-cod...
www.biorxiv.org
September 24, 2025 at 12:01 PM
Reposted by Fumiaki Obata
natmetabolism.nature.com
Tracking dietary exposures with metabolite biomarkers
Nature Metabolism, Published online: 17 September 2025; doi:10.1038/s42255-025-01370-2Plasma metabolic variation reflects dietary exposures. We show that biomarker panels are objective and reproducible in assessing dietary intake and quality, and can accurately predict clinical phenotypes such as diabetes and hypertension.
bit.ly
September 17, 2025 at 11:05 AM
obataf-lab.bsky.social
New study out! We developed the protocol for dietary manipulation of protein and amino acids in marmoset! FGF21 induction and taurine drop observed. Achieved by intra-RIKEN collab and the first author Yuka's effort. Here comes Primate Nutritional Biology!
www.nature.com/articles/s41...
Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels - Scientific Reports
Scientific Reports - Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels
www.nature.com
September 13, 2025 at 12:15 PM
Reposted by Fumiaki Obata
nature.com
A long-standing mystery in the development of fly embryos has been resolved

go.nature.com/4nhVxaa
Flies evolved a shock-absorber tissue used during embryonic development
The role of tissue that forms between the head and trunk of a fly embryo has been unclear. It turns out that it absorbs forces when nearby cells move and divide.
go.nature.com
September 9, 2025 at 2:16 PM
Reposted by Fumiaki Obata
iwanami.co.jp
「読み進めるほどに「腹八分目」という漠然とした言葉の奥深さが沁みてくる」
「江戸時代に「腹八分目」と言い表したヒト（貝原益軒）の直感にも感心する、楽しい読書だった」

8/24読売新聞で、奈倉有里さんが小幡史明『「腹八分目」の生物学』をご書評くださいました。☞ iwnm.jp/029735

お陰さまで売れています！
August 27, 2025 at 7:39 AM
Reposted by Fumiaki Obata
iwanami-ns.bsky.social
！重版決定！

先月刊行された『「腹八分目」の生物学――健康長寿の食とはなにか』（http://iwnm.jp/029735）、早々に2刷が決定しました！

なお現在、一部ネット書店でカート落ちが発生しております。お近くのリアル書店などで、ぜひお探しいただけますと幸いです。
近日中に電子書籍版も配信開始予定ですので、そちらもぜひご利用ください🐭
August 25, 2025 at 7:43 AM
obataf-lab.bsky.social
Ayano has got her phd in March 2025! She is a postdoc right now
August 15, 2025 at 1:51 PM
Reposted by Fumiaki Obata
alexgouldlab.bsky.social
Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.
hansonmark.bsky.social Mark A. Hanson @hansonmark.bsky.social · Aug 14
A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.

www.philanthropy.cam.ac.uk/give-to-camb...
August 14, 2025 at 8:04 PM
obataf-lab.bsky.social
自分でも気に入っている部分がいくつかあるのですが、そのうちの一つがここのカロリーです。ドーナツはカロリーゼロの衝撃！
August 7, 2025 at 12:29 PM
Reposted by Fumiaki Obata
iwanami-ns.bsky.social
8/3産経新聞で、小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）が紹介されました：

「気鋭の研究者による「食の科学」の一冊」
「生存戦略とも結びついた食の奥深さに驚かされる」

www.sankei.com/article/2025...
＜書評＞長寿のカギは「タンパク質の摂取量」　『「腹八分目」の生物学』小幡史明著
「腹八分目」の戒めは、江戸時代から『養生訓』などで広く知られた健康と長寿のための経験則。20世紀に入り、ラットやミジンコといった動物を使った実験でも、食事制限…
www.sankei.com
August 4, 2025 at 4:04 AM
Reposted by Fumiaki Obata
iwanami-ns.bsky.social
『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）著者の小幡史明さんに、岩波書店本社へおいでいただきました！
ご著書と記念撮影です。

ただいま好評発売中。
腹八分目のかたも、つい食べ過ぎちゃうかたも、ぜひどうぞ。
July 23, 2025 at 7:37 AM
Reposted by Fumiaki Obata
natmetabolism.nature.com
#Throwback 🧪

COMMENT | ‪ Subcellular quantitative imaging of metabolites at the organelle level

@siuzdak.bsky.social‬
Subcellular quantitative imaging of metabolites at the organelle level - Nature Metabolism
Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.
bit.ly
July 19, 2025 at 3:02 PM
Reposted by Fumiaki Obata
iwanami-ns.bsky.social
＼　本日 ☆ 刊行　／

小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（岩波科学ライブラリー）
試し読みなどはこちら！　→ iwnm.jp/029735

長寿の鍵となる栄養素とは。腹八分目で、老化そのものも防げるか。不老長寿の薬は……！？ 飽くなき探究をいきいきと伝える。

※電子書籍は8月配信予定です。
July 15, 2025 at 2:43 AM
Reposted by Fumiaki Obata
filipedevadder.bsky.social
📢 New preprint:
“Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition”
Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social.
We’re proud to share this story.
👉 www.biorxiv.org/content/10.1...
Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition
Dietary protein sufficiency during childhood is essential for healthy growth and tissue development. Chronic protein deficiency leads to stunting, height-for-age more than two standard deviations belo...
www.biorxiv.org
July 12, 2025 at 2:36 PM
obataf-lab.bsky.social
A new review from the lab is out. A phd student Ayano and me summerises the current view of amino acid signalling, revealed by Drosophila genetics. www.sciencedirect.com/science/arti...
Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study
Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signalling pathways regulated by s…
www.sciencedirect.com
June 15, 2025 at 5:59 PM
obataf-lab.bsky.social
Thank you so much! Hope Hina will not be too busy on revision...!
May 27, 2025 at 10:17 AM
Reposted by Fumiaki Obata
crisprflydesign.bsky.social
Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough.

Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.

www.biorxiv.org/content/10.1...
Images from the linked preprint showing Wingless stainings in the Drosophila wing imaginal disc. Targeting vps15 with two indepependent RNAi lines (paper also shows the same with a third line) does not result in a phenotype. In contrast, targeting vps15 with two independent sgRNA constructs and Cas9 results in strong accumulation of Wingless protein in perturbed cells.
May 26, 2025 at 7:29 AM