Ondine Cleaver
@ondinecleaver.bsky.social
Center for Regenerative Science and Medicine. UTSW. WISMAC. DevBio enthusiast. Editor of Developmental Biology. My thoughts. Hope.
https://labs.utsouthwestern.edu/cleaver-lab
Orcid: https://orcid.org/0000-0003-2454-6641
https://labs.utsouthwestern.edu/cleaver-lab
Orcid: https://orcid.org/0000-0003-2454-6641
Pinned
Pulsatile flow dynamics determine pulmonary arterial architecture
BACKGROUND Single ventricle congenital heart disease (SV-CHD) is a uniformly lethal condition. Survival depends upon the Glenn surgery, which shunts venous blood directly to the pulmonary arteries wit...
www.biorxiv.org
Happy to share our work on the role of biomechanical PULSATILITY on lung vessels.
Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD
Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️🩹
www.biorxiv.org/content/10.1...
Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD
Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️🩹
www.biorxiv.org/content/10.1...
Reposted by Ondine Cleaver
#DBFeature
Connecting developmental biology to societal and political issues in the classroom boosts student engagement and critical thinking, fostering a deeper understanding of both science and social justice.
- Megan Morgan Hoffman
#SpecialIssue on teaching #DevelopmentalBiology for #SocialChange
Connecting developmental biology to societal and political issues in the classroom boosts student engagement and critical thinking, fostering a deeper understanding of both science and social justice.
- Megan Morgan Hoffman
#SpecialIssue on teaching #DevelopmentalBiology for #SocialChange
September 29, 2025 at 1:27 PM
#DBFeature
Connecting developmental biology to societal and political issues in the classroom boosts student engagement and critical thinking, fostering a deeper understanding of both science and social justice.
- Megan Morgan Hoffman
#SpecialIssue on teaching #DevelopmentalBiology for #SocialChange
Connecting developmental biology to societal and political issues in the classroom boosts student engagement and critical thinking, fostering a deeper understanding of both science and social justice.
- Megan Morgan Hoffman
#SpecialIssue on teaching #DevelopmentalBiology for #SocialChange
Reposted by Ondine Cleaver
So excited to be serving as Guest Editor for a special issue in @devbiol.bsky.social on receptor tyrosine kinase signaling in development. Please consider contributing!
CALL FOR PAPERS! 🧪
DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.
Submit here: tinyurl.com/RTKDevBio
DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.
Submit here: tinyurl.com/RTKDevBio
September 18, 2025 at 4:48 PM
So excited to be serving as Guest Editor for a special issue in @devbiol.bsky.social on receptor tyrosine kinase signaling in development. Please consider contributing!
Reposted by Ondine Cleaver
Our new collaborative paper with Cyndi Bradham's lab at BU, led by first author @alexandralion.bsky.social is out in @devbiol.bsky.social & featured on the Sept 2025 cover! 😀🥳
PFAS (PFOA & GenX) disrupt sea urchin embryo development!
Cover art: embryos + flow fields
👉 doi.org/10.1016/j.yd...
PFAS (PFOA & GenX) disrupt sea urchin embryo development!
Cover art: embryos + flow fields
👉 doi.org/10.1016/j.yd...
September 17, 2025 at 8:21 PM
Our new collaborative paper with Cyndi Bradham's lab at BU, led by first author @alexandralion.bsky.social is out in @devbiol.bsky.social & featured on the Sept 2025 cover! 😀🥳
PFAS (PFOA & GenX) disrupt sea urchin embryo development!
Cover art: embryos + flow fields
👉 doi.org/10.1016/j.yd...
PFAS (PFOA & GenX) disrupt sea urchin embryo development!
Cover art: embryos + flow fields
👉 doi.org/10.1016/j.yd...
Reposted by Ondine Cleaver
Check out the latest President's Corner by SDB President Richard Behringer @rrbehringer.bsky.social on challenges. www.sdbonline.org/resource?Res...
September 15, 2025 at 5:48 PM
Check out the latest President's Corner by SDB President Richard Behringer @rrbehringer.bsky.social on challenges. www.sdbonline.org/resource?Res...
Biomechanics influence morphogenesis of the lung. Really cool paper by Shelby and Victor at UT Southwestern and UTD!
#DBFeature 🐣🫁
Increasing fluid pressure in chick embryonic airways disrupts normal branching and proliferation, while lower pressure encourages branching without affecting cell proliferation
By S Mohr-Allen, J Gleghorn, and V Varner
tinyurl.com/5fyevrd3
#SpecialIssue on Avian model systems
Increasing fluid pressure in chick embryonic airways disrupts normal branching and proliferation, while lower pressure encourages branching without affecting cell proliferation
By S Mohr-Allen, J Gleghorn, and V Varner
tinyurl.com/5fyevrd3
#SpecialIssue on Avian model systems
September 18, 2025 at 12:04 PM
Biomechanics influence morphogenesis of the lung. Really cool paper by Shelby and Victor at UT Southwestern and UTD!
Reposted by Ondine Cleaver
#DBFeature 🐣🫀
Heart cells in chick embryos emerge from a continuous field, not separate regions. Incorporation of cells into the heart depends on cell position, morphogenetic movements and break-down of tissue bridges.
tinyurl.com/2bbwtacd
#Embryology #HeartDevelopment
Heart cells in chick embryos emerge from a continuous field, not separate regions. Incorporation of cells into the heart depends on cell position, morphogenetic movements and break-down of tissue bridges.
tinyurl.com/2bbwtacd
#Embryology #HeartDevelopment
September 17, 2025 at 1:08 PM
#DBFeature 🐣🫀
Heart cells in chick embryos emerge from a continuous field, not separate regions. Incorporation of cells into the heart depends on cell position, morphogenetic movements and break-down of tissue bridges.
tinyurl.com/2bbwtacd
#Embryology #HeartDevelopment
Heart cells in chick embryos emerge from a continuous field, not separate regions. Incorporation of cells into the heart depends on cell position, morphogenetic movements and break-down of tissue bridges.
tinyurl.com/2bbwtacd
#Embryology #HeartDevelopment
Reposted by Ondine Cleaver
To all hemocyte lovers: Angela and me are hosting a special issue on Drosophila hemocytes 🪰👾We have some brillant drosophilists around the world who agreed to submit a review to this special issue! If you are also interested to contribute, reach out to us and we can give you more information!
CALL FOR PAPERS! 🪰
Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.
Submit today! tinyurl.com/357v25tj
Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.
Submit today! tinyurl.com/357v25tj
September 17, 2025 at 3:13 PM
To all hemocyte lovers: Angela and me are hosting a special issue on Drosophila hemocytes 🪰👾We have some brillant drosophilists around the world who agreed to submit a review to this special issue! If you are also interested to contribute, reach out to us and we can give you more information!
Reposted by Ondine Cleaver
CALL FOR PAPERS! 🧪
DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.
Submit here: tinyurl.com/RTKDevBio
DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.
Submit here: tinyurl.com/RTKDevBio
September 17, 2025 at 6:25 PM
CALL FOR PAPERS! 🧪
DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.
Submit here: tinyurl.com/RTKDevBio
DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.
Submit here: tinyurl.com/RTKDevBio
Reposted by Ondine Cleaver
CALL FOR PAPERS for our upcoming SPECIAL ISSUE
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice &humans #DevBio
Submit today! shorturl.at/LPMbc
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice &humans #DevBio
Submit today! shorturl.at/LPMbc
September 16, 2025 at 1:52 AM
CALL FOR PAPERS for our upcoming SPECIAL ISSUE
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice &humans #DevBio
Submit today! shorturl.at/LPMbc
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice &humans #DevBio
Submit today! shorturl.at/LPMbc
Reposted by Ondine Cleaver
#DBfeature #chick🐥
Generation of a transgenic chicken line with reporters for limb bud mesenchyme and apical ectodermal ridge cells
Yuji Atsuta, Yi-Chen Chen, Yuna Hattori, Tatsuya Takemoto, Daisuke Saito
tiom33.short.gy/DB520,53-61
Generation of a transgenic chicken line with reporters for limb bud mesenchyme and apical ectodermal ridge cells
Yuji Atsuta, Yi-Chen Chen, Yuna Hattori, Tatsuya Takemoto, Daisuke Saito
tiom33.short.gy/DB520,53-61
September 11, 2025 at 11:46 AM
#DBfeature #chick🐥
Generation of a transgenic chicken line with reporters for limb bud mesenchyme and apical ectodermal ridge cells
Yuji Atsuta, Yi-Chen Chen, Yuna Hattori, Tatsuya Takemoto, Daisuke Saito
tiom33.short.gy/DB520,53-61
Generation of a transgenic chicken line with reporters for limb bud mesenchyme and apical ectodermal ridge cells
Yuji Atsuta, Yi-Chen Chen, Yuna Hattori, Tatsuya Takemoto, Daisuke Saito
tiom33.short.gy/DB520,53-61
Join me next week, if you have interest in reviewing for the SDB's society ( @socdevbio.bsky.social 's) official journal, Developmental Biology (DB!) Always a fun and useful discussion.
Sign up today! forms.gle/4ZGYMErrA8YU...
Sign up today! forms.gle/4ZGYMErrA8YU...
September 15, 2025 at 4:59 PM
Join me next week, if you have interest in reviewing for the SDB's society ( @socdevbio.bsky.social 's) official journal, Developmental Biology (DB!) Always a fun and useful discussion.
Sign up today! forms.gle/4ZGYMErrA8YU...
Sign up today! forms.gle/4ZGYMErrA8YU...
Reposted by Ondine Cleaver
Deadline to register for Get Into Grad School Webinar approaching! Share with interested #undergraduates and #postbacs Registration Deadline: Thursday, September 18. bit.ly/3HFJ9BG
#Undergraduates #Postbacs @socdevbio.bsky.social is hosting a webinar Get Into Grad School September 21 at 3pm ET. Learn about doctoral programs, the key elements of a compelling grad school application, and the interview process. Register: bit.ly/3HFJ9BG
September 15, 2025 at 3:35 PM
Deadline to register for Get Into Grad School Webinar approaching! Share with interested #undergraduates and #postbacs Registration Deadline: Thursday, September 18. bit.ly/3HFJ9BG
Sign up and join us!
#Undergraduates #Postbacs @socdevbio.bsky.social is hosting a webinar Get Into Grad School September 21 at 3pm ET. Learn about doctoral programs, the key elements of a compelling grad school application, and the interview process. Register: bit.ly/3HFJ9BG
September 13, 2025 at 12:27 PM
Sign up and join us!
Reposted by Ondine Cleaver
#DBfeature 🐣❤️
Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to Nifedipine and Amlodipine drugs
by Carol Readhead, Simon Mahler et al
www.sciencedirect.com/science/arti...
Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to Nifedipine and Amlodipine drugs
by Carol Readhead, Simon Mahler et al
www.sciencedirect.com/science/arti...
August 15, 2025 at 1:47 PM
#DBfeature 🐣❤️
Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to Nifedipine and Amlodipine drugs
by Carol Readhead, Simon Mahler et al
www.sciencedirect.com/science/arti...
Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to Nifedipine and Amlodipine drugs
by Carol Readhead, Simon Mahler et al
www.sciencedirect.com/science/arti...
The best part about science (on top of the science) is the friendships you make on the way. 🥰
Scientists coming together to share ideas, give critical feedback, and also climb mountains 😅 Thanks Li-Kun and all for coming from so far, to meet where I grew up. 🙏
Scientists coming together to share ideas, give critical feedback, and also climb mountains 😅 Thanks Li-Kun and all for coming from so far, to meet where I grew up. 🙏
Another successful #leducq #ReVAMP meeting held at Orford, Canada! Great science, food and friendship... Thanks @ondinecleaver.bsky.social for hosting us and showing us the way up the mountain! A la prochaine!
September 13, 2025 at 12:24 PM
The best part about science (on top of the science) is the friendships you make on the way. 🥰
Scientists coming together to share ideas, give critical feedback, and also climb mountains 😅 Thanks Li-Kun and all for coming from so far, to meet where I grew up. 🙏
Scientists coming together to share ideas, give critical feedback, and also climb mountains 😅 Thanks Li-Kun and all for coming from so far, to meet where I grew up. 🙏
Reposted by Ondine Cleaver
#DBfeature #cilia
Moderate levels of folic acid benefit outcomes for cilia based neural tube defects
David Engelhardt, Juliette Petersen, Cara Martyr, Hannah Kuhn-Gale, Lee Niswander
tiom33.short.gy/DB520,62-75
Moderate levels of folic acid benefit outcomes for cilia based neural tube defects
David Engelhardt, Juliette Petersen, Cara Martyr, Hannah Kuhn-Gale, Lee Niswander
tiom33.short.gy/DB520,62-75
September 1, 2025 at 10:18 AM
#DBfeature #cilia
Moderate levels of folic acid benefit outcomes for cilia based neural tube defects
David Engelhardt, Juliette Petersen, Cara Martyr, Hannah Kuhn-Gale, Lee Niswander
tiom33.short.gy/DB520,62-75
Moderate levels of folic acid benefit outcomes for cilia based neural tube defects
David Engelhardt, Juliette Petersen, Cara Martyr, Hannah Kuhn-Gale, Lee Niswander
tiom33.short.gy/DB520,62-75
Reposted by Ondine Cleaver
#DBfeature
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
September 3, 2025 at 2:02 PM
#DBfeature
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
Reposted by Ondine Cleaver
Axolotl (Ambystoma mexicanum)🦎 can regrow limbs, tail, spinal cord, heart, and even parts of its brain. Axolotls are champions of regeneration and also shed light on limb patterning, wound healing, and developmental plasticity. Image from Prayag Murawala #ModelMonday #DevBio
September 2, 2025 at 12:11 AM
Axolotl (Ambystoma mexicanum)🦎 can regrow limbs, tail, spinal cord, heart, and even parts of its brain. Axolotls are champions of regeneration and also shed light on limb patterning, wound healing, and developmental plasticity. Image from Prayag Murawala #ModelMonday #DevBio
Reposted by Ondine Cleaver
🎉 The Midwest SDB Regional Meeting is happening soon! Join at Cincinnati Children’s Hospital Medical Center for exciting developmental biology from across the Midwest. 🧬 Registration deadline: September 2nd ✨. More information here: www.midwestsdbincincy.org #MIDWESTSDB25
August 27, 2025 at 7:06 PM
🎉 The Midwest SDB Regional Meeting is happening soon! Join at Cincinnati Children’s Hospital Medical Center for exciting developmental biology from across the Midwest. 🧬 Registration deadline: September 2nd ✨. More information here: www.midwestsdbincincy.org #MIDWESTSDB25
Reposted by Ondine Cleaver
#DBfeature #Oocyte
Transcriptomic analysis and epigenetic regulators in human oocytes at different stages of oocyte meiotic maturation
by Carla Caniçais, Joana Marques et al
www.sciencedirect.com/science/arti...
Transcriptomic analysis and epigenetic regulators in human oocytes at different stages of oocyte meiotic maturation
by Carla Caniçais, Joana Marques et al
www.sciencedirect.com/science/arti...
August 21, 2025 at 9:24 AM
#DBfeature #Oocyte
Transcriptomic analysis and epigenetic regulators in human oocytes at different stages of oocyte meiotic maturation
by Carla Caniçais, Joana Marques et al
www.sciencedirect.com/science/arti...
Transcriptomic analysis and epigenetic regulators in human oocytes at different stages of oocyte meiotic maturation
by Carla Caniçais, Joana Marques et al
www.sciencedirect.com/science/arti...
Reposted by Ondine Cleaver
🔬Two heads are better than one… even in frogs! 🐸✨
This Xenopus laevis embryo developed with two heads, offering a striking view of early developmental patterning.
🟢 actin 🟣 neural tissue 🔵 nuclei. Image by Kourtnie Whitfield. #FluorescenceFriday #DevBio #Xenopus
This Xenopus laevis embryo developed with two heads, offering a striking view of early developmental patterning.
🟢 actin 🟣 neural tissue 🔵 nuclei. Image by Kourtnie Whitfield. #FluorescenceFriday #DevBio #Xenopus
August 29, 2025 at 5:34 PM
🔬Two heads are better than one… even in frogs! 🐸✨
This Xenopus laevis embryo developed with two heads, offering a striking view of early developmental patterning.
🟢 actin 🟣 neural tissue 🔵 nuclei. Image by Kourtnie Whitfield. #FluorescenceFriday #DevBio #Xenopus
This Xenopus laevis embryo developed with two heads, offering a striking view of early developmental patterning.
🟢 actin 🟣 neural tissue 🔵 nuclei. Image by Kourtnie Whitfield. #FluorescenceFriday #DevBio #Xenopus
Reposted by Ondine Cleaver
#DBfeature 🐣
CRISPR-Cas13d enables targeted gene expression knockdown in chick embryos, expanding the experimental potential and versatility of this model system.
by Minyoung Kim and Erica Hutchins @drericabiophd.bsky.social
www.sciencedirect.com/science/arti...
#CRISPRCas #ChickEmbryo
CRISPR-Cas13d enables targeted gene expression knockdown in chick embryos, expanding the experimental potential and versatility of this model system.
by Minyoung Kim and Erica Hutchins @drericabiophd.bsky.social
www.sciencedirect.com/science/arti...
#CRISPRCas #ChickEmbryo
August 12, 2025 at 1:13 PM
#DBfeature 🐣
CRISPR-Cas13d enables targeted gene expression knockdown in chick embryos, expanding the experimental potential and versatility of this model system.
by Minyoung Kim and Erica Hutchins @drericabiophd.bsky.social
www.sciencedirect.com/science/arti...
#CRISPRCas #ChickEmbryo
CRISPR-Cas13d enables targeted gene expression knockdown in chick embryos, expanding the experimental potential and versatility of this model system.
by Minyoung Kim and Erica Hutchins @drericabiophd.bsky.social
www.sciencedirect.com/science/arti...
#CRISPRCas #ChickEmbryo
Reposted by Ondine Cleaver
CALL FOR PAPERS! 🪰
Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.
Submit today! tinyurl.com/357v25tj
Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.
Submit today! tinyurl.com/357v25tj
August 27, 2025 at 10:39 PM
CALL FOR PAPERS! 🪰
Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.
Submit today! tinyurl.com/357v25tj
Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.
Submit today! tinyurl.com/357v25tj
Reposted by Ondine Cleaver
CALL FOR PAPERS!
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice & humans.
Submit today! shorturl.at/LPMbc
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice & humans.
Submit today! shorturl.at/LPMbc
August 14, 2025 at 4:45 PM
CALL FOR PAPERS!
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice & humans.
Submit today! shorturl.at/LPMbc
Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice & humans.
Submit today! shorturl.at/LPMbc
Reposted by Ondine Cleaver
#DBfeature
Disease susceptibility implications of preferential inactivation of the paternal X chromosome in extraembryonic endoderm of the mouse
by Virginia Papaioannou
www.sciencedirect.com/science/arti...
Disease susceptibility implications of preferential inactivation of the paternal X chromosome in extraembryonic endoderm of the mouse
by Virginia Papaioannou
www.sciencedirect.com/science/arti...
August 19, 2025 at 12:07 PM
#DBfeature
Disease susceptibility implications of preferential inactivation of the paternal X chromosome in extraembryonic endoderm of the mouse
by Virginia Papaioannou
www.sciencedirect.com/science/arti...
Disease susceptibility implications of preferential inactivation of the paternal X chromosome in extraembryonic endoderm of the mouse
by Virginia Papaioannou
www.sciencedirect.com/science/arti...