Ondine Cleaver
@ondinecleaver.bsky.social
2.5K followers 800 following 170 posts
Center for Regenerative Science and Medicine. UTSW. WISMAC. DevBio enthusiast. Editor of Developmental Biology. My thoughts. Hope. https://labs.utsouthwestern.edu/cleaver-lab Orcid: https://orcid.org/0000-0003-2454-6641
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ondinecleaver.bsky.social
Happy to share our work on the role of biomechanical PULSATILITY on lung vessels.

Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD

Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️‍🩹

www.biorxiv.org/content/10.1...
Pulsatile flow dynamics determine pulmonary arterial architecture
BACKGROUND Single ventricle congenital heart disease (SV-CHD) is a uniformly lethal condition. Survival depends upon the Glenn surgery, which shunts venous blood directly to the pulmonary arteries wit...
www.biorxiv.org
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBFeature
Connecting developmental biology to societal and political issues in the classroom boosts student engagement and critical thinking, fostering a deeper understanding of both science and social justice.
- Megan Morgan Hoffman
#SpecialIssue on teaching #DevelopmentalBiology for #SocialChange
Hand written notes on the developmental cascade leading to ovaries, testis, and their hormonal and genetic interconnections
Reposted by Ondine Cleaver
fantauzzolab.bsky.social
So excited to be serving as Guest Editor for a special issue in @devbiol.bsky.social on receptor tyrosine kinase signaling in development. Please consider contributing!
devbiol.bsky.social
CALL FOR PAPERS! 🧪

DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.

Submit here: tinyurl.com/RTKDevBio
Image showing a CALL FOR PAPERS for a special issue of Developmental Biology on "Receptor Tyrosine Kinase signaling in Development".
Reposted by Ondine Cleaver
vprakashlab.bsky.social
Our new collaborative paper with Cyndi Bradham's lab at BU, led by first author @alexandralion.bsky.social is out in @devbiol.bsky.social & featured on the Sept 2025 cover! 😀🥳

PFAS (PFOA & GenX) disrupt sea urchin embryo development!
Cover art: embryos + flow fields
👉 doi.org/10.1016/j.yd...
Reposted by Ondine Cleaver
socdevbio.bsky.social
Check out the latest President's Corner by SDB President Richard Behringer @rrbehringer.bsky.social on challenges. www.sdbonline.org/resource?Res...
Richard Behringer pointing to the Society for Developmental Biology sign outside the SDB office.
ondinecleaver.bsky.social
Biomechanics influence morphogenesis of the lung. Really cool paper by Shelby and Victor at UT Southwestern and UTD!
devbiol.bsky.social
#DBFeature 🐣🫁

Increasing fluid pressure in chick embryonic airways disrupts normal branching and proliferation, while lower pressure encourages branching without affecting cell proliferation

By S Mohr-Allen, J Gleghorn, and V Varner

tinyurl.com/5fyevrd3

#SpecialIssue on Avian model systems
Diagram comparing chick embryonic lung branching under normal and increased fluid pressure. The left shows normal pressure with typical branching and cell proliferation. The centre depicts global increased pressure, causing altered branching and proliferation. The right shows local increased pressure from an oil droplet, leading to localised disruption of branching and proliferation. Green outlines indicate regions of cell proliferation.
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBFeature 🐣🫀

Heart cells in chick embryos emerge from a continuous field, not separate regions. Incorporation of cells into the heart depends on cell position, morphogenetic movements and break-down of tissue bridges.

tinyurl.com/2bbwtacd

#Embryology #HeartDevelopment
Diagram showing developmental stages of the chicken embryo heart, with labeled cross-sections and ventral views from stage HH6 to HH14. Coloured regions identify anatomical structures such as the paraxial and lateral head mesoderm, neural plate, neural tube, and early and late second heart field, illustrating tissue movements and the continuum between first and second heart fields during heart formation.
Reposted by Ondine Cleaver
katrinkierdorf.bsky.social
To all hemocyte lovers: Angela and me are hosting a special issue on Drosophila hemocytes 🪰👾We have some brillant drosophilists around the world who agreed to submit a review to this special issue! If you are also interested to contribute, reach out to us and we can give you more information!
devbiol.bsky.social
CALL FOR PAPERS! 🪰

Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.

Submit today! tinyurl.com/357v25tj
Drosophila blood cells - Our special issue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication. 

Submit today! https://tinyurl.com/357v25tj
Reposted by Ondine Cleaver
devbiol.bsky.social
CALL FOR PAPERS! 🧪

DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis.

Submit here: tinyurl.com/RTKDevBio
Image showing a CALL FOR PAPERS for a special issue of Developmental Biology on "Receptor Tyrosine Kinase signaling in Development".
Reposted by Ondine Cleaver
devbiol.bsky.social
CALL FOR PAPERS for our upcoming SPECIAL ISSUE

Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice &humans #DevBio

Submit today! shorturl.at/LPMbc
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBfeature #chick🐥
Generation of a transgenic chicken line with reporters for limb bud mesenchyme and apical ectodermal ridge cells

Yuji Atsuta, Yi-Chen Chen, Yuna Hattori, Tatsuya Takemoto, Daisuke Saito

tiom33.short.gy/DB520,53-61
ondinecleaver.bsky.social
Join me next week, if you have interest in reviewing for the SDB's society ( @socdevbio.bsky.social 's) official journal, Developmental Biology (DB!) Always a fun and useful discussion.

Sign up today! forms.gle/4ZGYMErrA8YU...
Reposted by Ondine Cleaver
socdevbio.bsky.social
Deadline to register for Get Into Grad School Webinar approaching! Share with interested #undergraduates and #postbacs Registration Deadline: Thursday, September 18. bit.ly/3HFJ9BG
socdevbio.bsky.social
#Undergraduates #Postbacs @socdevbio.bsky.social is hosting a webinar Get Into Grad School September 21 at 3pm ET. Learn about doctoral programs, the key elements of a compelling grad school application, and the interview process. Register: bit.ly/3HFJ9BG
SDB logo
Webinar: Get Into Grad School
September 21, 2025, 3:00 pm - 4:30 pm ET
Headshots of Carole LaBonne, Ondine Cleaver, Madison Martinez, Cristina Guerena, Jerry Wei Heng Tan, and Talia Marc
ondinecleaver.bsky.social
Sign up and join us!
socdevbio.bsky.social
#Undergraduates #Postbacs @socdevbio.bsky.social is hosting a webinar Get Into Grad School September 21 at 3pm ET. Learn about doctoral programs, the key elements of a compelling grad school application, and the interview process. Register: bit.ly/3HFJ9BG
SDB logo
Webinar: Get Into Grad School
September 21, 2025, 3:00 pm - 4:30 pm ET
Headshots of Carole LaBonne, Ondine Cleaver, Madison Martinez, Cristina Guerena, Jerry Wei Heng Tan, and Talia Marc
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBfeature 🐣❤️

Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to Nifedipine and Amlodipine drugs

by Carol Readhead, Simon Mahler et al
www.sciencedirect.com/science/arti...
Features extraction from a LSCI recording of the blood vessels in a chicken egg
ondinecleaver.bsky.social
The best part about science (on top of the science) is the friendships you make on the way. 🥰

Scientists coming together to share ideas, give critical feedback, and also climb mountains 😅 Thanks Li-Kun and all for coming from so far, to meet where I grew up. 🙏
phnglab.bsky.social
Another successful #leducq #ReVAMP meeting held at Orford, Canada! Great science, food and friendship... Thanks @ondinecleaver.bsky.social for hosting us and showing us the way up the mountain! A la prochaine!
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBfeature #cilia

Moderate levels of folic acid benefit outcomes for cilia based neural tube defects

David Engelhardt, Juliette Petersen, Cara Martyr, Hannah Kuhn-Gale, Lee Niswander

tiom33.short.gy/DB520,62-75
Figure showing the effects of different folic acid (FA) dosages on primary ciliogenesis in various mouse embryonic fibroblast genotypes. Panels A-D present box plots quantifying ciliated cells or percent cilia under moderate and fortified FA conditions at 225, 450, and 3600 ng/mL FA in Intu+/+, Intudm/dm, Rsg1+/+, and Rsg1β13/β13 MEFs, highlighting statistically significant differences at moderate doses. Panel E displays immunofluorescence images of MEFs stained for ARL13B (red), γ-tubulin (green), and DAPI (blue), showing cilia presence and structure with scale bars indicating 15 μm and zoom-ins at 5 μm.
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBfeature

Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
Reposted by Ondine Cleaver
socdevbio.bsky.social
Axolotl (Ambystoma mexicanum)🦎 can regrow limbs, tail, spinal cord, heart, and even parts of its brain. Axolotls are champions of regeneration and also shed light on limb patterning, wound healing, and developmental plasticity. Image from Prayag Murawala #ModelMonday #DevBio
Reposted by Ondine Cleaver
socdevbio.bsky.social
🎉 The Midwest SDB Regional Meeting is happening soon! Join at Cincinnati Children’s Hospital Medical Center for exciting developmental biology from across the Midwest. 🧬 Registration deadline: September 2nd ✨. More information here: www.midwestsdbincincy.org #MIDWESTSDB25
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBfeature #Oocyte

Transcriptomic analysis and epigenetic regulators in human oocytes at different stages of oocyte meiotic maturation

by Carla Caniçais, Joana Marques et al
www.sciencedirect.com/science/arti...
Characterization of human oocyte maturation stages
Reposted by Ondine Cleaver
socdevbio.bsky.social
🔬Two heads are better than one… even in frogs! 🐸✨
This Xenopus laevis embryo developed with two heads, offering a striking view of early developmental patterning.
🟢 actin 🟣 neural tissue 🔵 nuclei. Image by Kourtnie Whitfield. #FluorescenceFriday #DevBio #Xenopus
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBfeature 🐣

CRISPR-Cas13d enables targeted gene expression knockdown in chick embryos, expanding the experimental potential and versatility of this model system.

by Minyoung Kim and Erica Hutchins @drericabiophd.bsky.social

www.sciencedirect.com/science/arti...

#CRISPRCas #ChickEmbryo
Cross-section of HH9 chick embryo head showing reduced PAX7 signal on CRISPR-Cas13d knockdown side (~17% decrease, n=15), highlighted in GFP+ cells.
Reposted by Ondine Cleaver
devbiol.bsky.social
CALL FOR PAPERS! 🪰

Drosophila blood cells - Our #DBspecialissue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication.

Submit today! tinyurl.com/357v25tj
Drosophila blood cells - Our special issue highlights novel findings on hemocyte diversity in Drosophila melanogaster. The reviews explore diversity in terms of ontogeny, functional specification and organ-organ communication. 

Submit today! https://tinyurl.com/357v25tj
Reposted by Ondine Cleaver
devbiol.bsky.social
CALL FOR PAPERS!

Ion channels are emerging as critical regulators of tissue morphogenesis in diverse animals from planaria to humans. Mutations in ion channels can cause craniofacial and limb abnormalities in frogs, mice & humans.

Submit today! shorturl.at/LPMbc
Call for papers for “Ions in Morphogenesis” Special Issue!
Reposted by Ondine Cleaver
devbiol.bsky.social
#DBfeature

Disease susceptibility implications of preferential inactivation of the paternal X chromosome in extraembryonic endoderm of the mouse

by Virginia Papaioannou

www.sciencedirect.com/science/arti...
Distribution of primitive endoderm and cellular descendants until midgestation.